19,923 research outputs found
Explaining city branding practices in China’s three mega-city regions: The role of ecological modernization
As global cities, Hong Kong, Shanghai and Beijing operate in international economic networks; however, they are also each firmly embedded within a regional context and are surrounded by less populous and less internationally recognized neighbors. Together they form so-called mega-city regions referred to as the Greater Pearl River Delta, the Yangtze River Delta, and the Bohai Rim, each encompassing a dozen or so cities. In the wake of staggering economic growth and threatening pollution, these cities are compelled to respond to the challenge of ecological modernization (EM): aim for higher economic value added at lower environmental cost. Cities have particular industrial and regional profiles; consequently they follow different developmental pathways. In order to attract coveted investors, green and high-tech corporations, well-endowed residents and talented workforce, these cities engage in city branding practices. In this contribution, a typology of EM developmental pathways is presented and the 41 cities in the three Chinese mega-city regions are analyzed in terms of their respective pathways and city branding practices. We argue that different industrial and regional profiles allow for different developmental pathways making different city branding strategies likely. Most cities brand themselves in comformity with what their pathway would lead us to predict, except cities with a strongly manufacturing oriented profile; the brands of the latter type deviate markedly from their current reality. Cities adopting branding strategies that contrast sharply with their historical legacy and current profile risk promoting themselves in ways that the outside world is likely to perceive as lacking in credibility
A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis
DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation signature of t(8;21)(+) AML blasts differs from that of t(8;21)(-) AMLs. This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target gene and can be epigenetically suppressed by AML1-ETO at the transcriptional level in t(8;21) AML. Our findings also show that THAP10 is a bona fide target of miR-383 that can be epigenetically activated by the AML1-ETO recruiting co-activator p300. In this study, we demonstrated that epigenetic suppression of THAP10 is the mechanistic link between AML1-ETO fusion proteins and tyrosine kinase cascades. In addition, we showed that THAP10 is a nuclear protein that inhibits myeloid proliferation and promotes differentiation both in vitro and in vivo Altogether, our results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) AML, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target
Integer and half-integer flux-quantum transitions in a niobium/iron-pnictide loop
The recent discovery of iron-based superconductors challenges the existing
paradigm of high-temperature superconductivity. Owing to their unusual
multi-orbital band structure, magnetism, and electron correlation, theories
propose a unique sign reversed s-wave pairing state, with the order parameter
changing sign between the electron and hole Fermi pockets. However, because of
the complex Fermi surface topology and material related issues, the predicted
sign reversal remains unconfirmed. Here we report a novel phase-sensitive
technique for probing unconventional pairing symmetry in the polycrystalline
iron-pnictides. Through the observation of both integer and half-integer
flux-quantum transitions in composite niobium/iron-pnictide loops, we provide
the first phase-sensitive evidence of the sign change of the order parameter in
NdFeAsO0.88F0.12, lending strong support for microscopic models predicting
unconventional s-wave pairing symmetry. These findings have important
implications on the mechanism of pnictide superconductivity, and lay the
groundwork for future studies of new physics arising from the exotic order in
the FeAs-based superconductors.Comment: 23 pages, including 4 figures and supplementary informatio
Next-to-leading order QCD evolution of transversity fragmentation functions
We derive the next-to-leading order splitting kernels for the scale evolution
of fragmentation functions for transversely polarized quarks into transversely
polarized hadrons.Comment: 9 pages, LaTe
Development of Shanghai satellite laser ranging station
The topics covered include the following: improvement of the system hardware; upgrading of the software; the observation status; preliminary daylight tracking capability; testing the new type of laser; and future plans
The DArk Matter Particle Explorer mission
The DArk Matter Particle Explorer (DAMPE), one of the four scientific space
science missions within the framework of the Strategic Pioneer Program on Space
Science of the Chinese Academy of Sciences, is a general purpose high energy
cosmic-ray and gamma-ray observatory, which was successfully launched on
December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE
scientific objectives include the study of galactic cosmic rays up to
TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the
search for dark matter signatures in their spectra. In this paper we illustrate
the layout of the DAMPE instrument, and discuss the results of beam tests and
calibrations performed on ground. Finally we present the expected performance
in space and give an overview of the mission key scientific goals.Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart.
Phy
On Vanishing Theorems For Vector Bundle Valued p-Forms And Their Applications
Let be a strictly increasing function
with . We unify the concepts of -harmonic maps, minimal
hypersurfaces, maximal spacelike hypersurfaces, and Yang-Mills Fields, and
introduce -Yang-Mills fields, -degree, -lower degree, and generalized
Yang-Mills-Born-Infeld fields (with the plus sign or with the minus sign) on
manifolds. When and
the -Yang-Mills field becomes an ordinary Yang-Mills field,
-Yang-Mills field, a generalized Yang-Mills-Born-Infeld field with the plus
sign, and a generalized Yang-Mills-Born-Infeld field with the minus sign on a
manifold respectively. We also introduce the energy functional (resp.
-Yang-Mills functional) and derive the first variational formula of the
energy functional (resp. -Yang-Mills functional) with
applications. In a more general frame, we use a unified method to study the
stress-energy tensors that arise from calculating the rate of change of various
functionals when the metric of the domain or base manifold is changed. These
stress-energy tensors, linked to -conservation laws yield monotonicity
formulae. A "macroscopic" version of these monotonicity inequalities enables us
to derive some Liouville type results and vanishing theorems for forms with
values in vector bundles, and to investigate constant Dirichlet boundary value
problems for 1-forms. In particular, we obtain Liouville theorems for
harmonic maps (e.g. -harmonic maps), and Yang-Mills fields (e.g.
generalized Yang-Mills-Born-Infeld fields on manifolds). We also obtain
generalized Chern type results for constant mean curvature type equations for
forms on and on manifolds with the global doubling property
by a different approach. The case and is due to Chern.Comment: 1. This is a revised version with several new sections and an
appendix that will appear in Communications in Mathematical Physics. 2. A
"microscopic" approach to some of these monotonicity formulae leads to
celebrated blow-up techniques and regularity theory in geometric measure
theory. 3. Our unique solution of the Dirichlet problems generalizes the work
of Karcher and Wood on harmonic map
4.5 years multi-wavelength observations of Mrk 421 during the ARGO-YBJ and Fermi common operation time
We report on the extensive multi-wavelength observations of the blazar
Markarian 421 (Mrk 421) covering radio to gamma-rays, during the 4.5 year
period of ARGO-YBJ and Fermi common operation time, from August 2008 to
February 2013. In particular, thanks to the ARGO-YBJ and Fermi data, the whole
energy range from 100 MeV to 10 TeV is covered without any gap. In the
observation period, Mrk 421 showed both low and high activity states at all
wavebands. The correlations among flux variations in different wavebands were
analyzed. Seven large flares, including five X-ray flares and two GeV gamma-ray
flares with variable durations (3-58 days), and one X-ray outburst phase were
identified and used to investigate the variation of the spectral energy
distribution with respect to a relative quiescent phase. During the outburst
phase and the seven flaring episodes, the peak energy in X-rays is observed to
increase from sub-keV to few keV. The TeV gamma-ray flux increases up to
0.9-7.2 times the flux of the Crab Nebula. The behavior of GeV gamma-rays is
found to vary depending on the flare, a feature that leads us to classify
flares into three groups according to the GeV flux variation. Finally, the
one-zone synchrotron self-Compton model was adopted to describe the emission
spectra. Two out of three groups can be satisfactorily described using injected
electrons with a power-law spectral index around 2.2, as expected from
relativistic diffuse shock acceleration, whereas the remaining group requires a
harder injected spectrum. The underlying physical mechanisms responsible for
different groups may be related to the acceleration process or to the
environment properties.Comment: 17 pages, 9 figures, 5 tables, Accepted for publication in ApJ
The cosmic ray proton plus helium energy spectrum measured by the ARGO-YBJ experiment in the energy range 3-300 TeV
The ARGO-YBJ experiment is a full-coverage air shower detector located at the
Yangbajing Cosmic Ray Observatory (Tibet, People's Republic of China, 4300 m
a.s.l.). The high altitude, combined with the full-coverage technique, allows
the detection of extensive air showers in a wide energy range and offer the
possibility of measuring the cosmic ray proton plus helium spectrum down to the
TeV region, where direct balloon/space-borne measurements are available. The
detector has been in stable data taking in its full configuration from November
2007 to February 2013. In this paper the measurement of the cosmic ray proton
plus helium energy spectrum is presented in the region 3-300 TeV by analyzing
the full collected data sample. The resulting spectral index is . These results demonstrate the possibility of performing an accurate
measurement of the spectrum of light elements with a ground based air shower
detector.Comment: 18 pages, 8 figures, preprint submitted to Phys. Rev.
EAS age determination from the study of the lateral distribution of charged particles near the shower axis with the ARGO-YBJ experiment
The ARGO-YBJ experiment, a full coverage extensive air shower (EAS) detector
located at high altitude (4300 m a.s.l.) in Tibet, China, has smoothly taken
data, with very high stability, since November 2007 to the beginning of 2013.
The array consisted of a carpet of about 7000 m Resistive Plate Chambers
(RPCs) operated in streamer mode and equipped with both digital and analog
readout, providing the measurement of particle densities up to few particles
per cm. The unique detector features (full coverage, readout granularity,
wide dynamic range, etc) and location (very high altitude) allowed a detailed
study of the lateral density profile of charged particles at ground very close
to the shower axis and its description by a proper lateral distribution
function (LDF). In particular, the information collected in the first 10 m from
the shower axis have been shown to provide a very effective tool for the
determination of the shower development stage ("age") in the energy range 50
TeV - 10 PeV. The sensitivity of the age parameter to the mass composition of
primary Cosmic Rays is also discussed
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