19,923 research outputs found

    Explaining city branding practices in China’s three mega-city regions: The role of ecological modernization

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    As global cities, Hong Kong, Shanghai and Beijing operate in international economic networks; however, they are also each firmly embedded within a regional context and are surrounded by less populous and less internationally recognized neighbors. Together they form so-called mega-city regions referred to as the Greater Pearl River Delta, the Yangtze River Delta, and the Bohai Rim, each encompassing a dozen or so cities. In the wake of staggering economic growth and threatening pollution, these cities are compelled to respond to the challenge of ecological modernization (EM): aim for higher economic value added at lower environmental cost. Cities have particular industrial and regional profiles; consequently they follow different developmental pathways. In order to attract coveted investors, green and high-tech corporations, well-endowed residents and talented workforce, these cities engage in city branding practices. In this contribution, a typology of EM developmental pathways is presented and the 41 cities in the three Chinese mega-city regions are analyzed in terms of their respective pathways and city branding practices. We argue that different industrial and regional profiles allow for different developmental pathways making different city branding strategies likely. Most cities brand themselves in comformity with what their pathway would lead us to predict, except cities with a strongly manufacturing oriented profile; the brands of the latter type deviate markedly from their current reality. Cities adopting branding strategies that contrast sharply with their historical legacy and current profile risk promoting themselves in ways that the outside world is likely to perceive as lacking in credibility

    A novel epigenetic AML1-ETO/THAP10/miR-383 mini-circuitry contributes to t(8;21) leukaemogenesis

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    DNA methylation patterns are frequently deregulated in t(8;21) acute myeloid leukaemia (AML), but little is known of the mechanisms by which specific gene sets become aberrantly methylated. Here, we found that the promoter DNA methylation signature of t(8;21)(+) AML blasts differs from that of t(8;21)(-) AMLs. This study demonstrated that a novel hypermethylated zinc finger-containing protein, THAP10, is a target gene and can be epigenetically suppressed by AML1-ETO at the transcriptional level in t(8;21) AML. Our findings also show that THAP10 is a bona fide target of miR-383 that can be epigenetically activated by the AML1-ETO recruiting co-activator p300. In this study, we demonstrated that epigenetic suppression of THAP10 is the mechanistic link between AML1-ETO fusion proteins and tyrosine kinase cascades. In addition, we showed that THAP10 is a nuclear protein that inhibits myeloid proliferation and promotes differentiation both in vitro and in vivo Altogether, our results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) AML, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target

    Integer and half-integer flux-quantum transitions in a niobium/iron-pnictide loop

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    The recent discovery of iron-based superconductors challenges the existing paradigm of high-temperature superconductivity. Owing to their unusual multi-orbital band structure, magnetism, and electron correlation, theories propose a unique sign reversed s-wave pairing state, with the order parameter changing sign between the electron and hole Fermi pockets. However, because of the complex Fermi surface topology and material related issues, the predicted sign reversal remains unconfirmed. Here we report a novel phase-sensitive technique for probing unconventional pairing symmetry in the polycrystalline iron-pnictides. Through the observation of both integer and half-integer flux-quantum transitions in composite niobium/iron-pnictide loops, we provide the first phase-sensitive evidence of the sign change of the order parameter in NdFeAsO0.88F0.12, lending strong support for microscopic models predicting unconventional s-wave pairing symmetry. These findings have important implications on the mechanism of pnictide superconductivity, and lay the groundwork for future studies of new physics arising from the exotic order in the FeAs-based superconductors.Comment: 23 pages, including 4 figures and supplementary informatio

    Development of Shanghai satellite laser ranging station

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    The topics covered include the following: improvement of the system hardware; upgrading of the software; the observation status; preliminary daylight tracking capability; testing the new type of laser; and future plans

    The DArk Matter Particle Explorer mission

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    The DArk Matter Particle Explorer (DAMPE), one of the four scientific space science missions within the framework of the Strategic Pioneer Program on Space Science of the Chinese Academy of Sciences, is a general purpose high energy cosmic-ray and gamma-ray observatory, which was successfully launched on December 17th, 2015 from the Jiuquan Satellite Launch Center. The DAMPE scientific objectives include the study of galactic cosmic rays up to 10\sim 10 TeV and hundreds of TeV for electrons/gammas and nuclei respectively, and the search for dark matter signatures in their spectra. In this paper we illustrate the layout of the DAMPE instrument, and discuss the results of beam tests and calibrations performed on ground. Finally we present the expected performance in space and give an overview of the mission key scientific goals.Comment: 45 pages, including 29 figures and 6 tables. Published in Astropart. Phy

    On Vanishing Theorems For Vector Bundle Valued p-Forms And Their Applications

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    Let F:[0,)[0,)F: [0, \infty) \to [0, \infty) be a strictly increasing C2C^2 function with F(0)=0F(0)=0. We unify the concepts of FF-harmonic maps, minimal hypersurfaces, maximal spacelike hypersurfaces, and Yang-Mills Fields, and introduce FF-Yang-Mills fields, FF-degree, FF-lower degree, and generalized Yang-Mills-Born-Infeld fields (with the plus sign or with the minus sign) on manifolds. When F(t)=t,1p(2t)p2,1+2t1,F(t)=t, \frac 1p(2t)^{\frac p2}, \sqrt{1+2t} -1, and 112t,1-\sqrt{1-2t}, the FF-Yang-Mills field becomes an ordinary Yang-Mills field, pp-Yang-Mills field, a generalized Yang-Mills-Born-Infeld field with the plus sign, and a generalized Yang-Mills-Born-Infeld field with the minus sign on a manifold respectively. We also introduce the EF,gE_{F,g}-energy functional (resp. FF-Yang-Mills functional) and derive the first variational formula of the EF,gE_{F,g}-energy functional (resp. FF-Yang-Mills functional) with applications. In a more general frame, we use a unified method to study the stress-energy tensors that arise from calculating the rate of change of various functionals when the metric of the domain or base manifold is changed. These stress-energy tensors, linked to FF-conservation laws yield monotonicity formulae. A "macroscopic" version of these monotonicity inequalities enables us to derive some Liouville type results and vanishing theorems for pp-forms with values in vector bundles, and to investigate constant Dirichlet boundary value problems for 1-forms. In particular, we obtain Liouville theorems for FF-harmonic maps (e.g. pp-harmonic maps), and FF-Yang-Mills fields (e.g. generalized Yang-Mills-Born-Infeld fields on manifolds). We also obtain generalized Chern type results for constant mean curvature type equations for pp-forms on Rm\Bbb{R}^m and on manifolds MM with the global doubling property by a different approach. The case p=0p=0 and M=RmM=\mathbb{R}^m is due to Chern.Comment: 1. This is a revised version with several new sections and an appendix that will appear in Communications in Mathematical Physics. 2. A "microscopic" approach to some of these monotonicity formulae leads to celebrated blow-up techniques and regularity theory in geometric measure theory. 3. Our unique solution of the Dirichlet problems generalizes the work of Karcher and Wood on harmonic map

    4.5 years multi-wavelength observations of Mrk 421 during the ARGO-YBJ and Fermi common operation time

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    We report on the extensive multi-wavelength observations of the blazar Markarian 421 (Mrk 421) covering radio to gamma-rays, during the 4.5 year period of ARGO-YBJ and Fermi common operation time, from August 2008 to February 2013. In particular, thanks to the ARGO-YBJ and Fermi data, the whole energy range from 100 MeV to 10 TeV is covered without any gap. In the observation period, Mrk 421 showed both low and high activity states at all wavebands. The correlations among flux variations in different wavebands were analyzed. Seven large flares, including five X-ray flares and two GeV gamma-ray flares with variable durations (3-58 days), and one X-ray outburst phase were identified and used to investigate the variation of the spectral energy distribution with respect to a relative quiescent phase. During the outburst phase and the seven flaring episodes, the peak energy in X-rays is observed to increase from sub-keV to few keV. The TeV gamma-ray flux increases up to 0.9-7.2 times the flux of the Crab Nebula. The behavior of GeV gamma-rays is found to vary depending on the flare, a feature that leads us to classify flares into three groups according to the GeV flux variation. Finally, the one-zone synchrotron self-Compton model was adopted to describe the emission spectra. Two out of three groups can be satisfactorily described using injected electrons with a power-law spectral index around 2.2, as expected from relativistic diffuse shock acceleration, whereas the remaining group requires a harder injected spectrum. The underlying physical mechanisms responsible for different groups may be related to the acceleration process or to the environment properties.Comment: 17 pages, 9 figures, 5 tables, Accepted for publication in ApJ

    The cosmic ray proton plus helium energy spectrum measured by the ARGO-YBJ experiment in the energy range 3-300 TeV

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    The ARGO-YBJ experiment is a full-coverage air shower detector located at the Yangbajing Cosmic Ray Observatory (Tibet, People's Republic of China, 4300 m a.s.l.). The high altitude, combined with the full-coverage technique, allows the detection of extensive air showers in a wide energy range and offer the possibility of measuring the cosmic ray proton plus helium spectrum down to the TeV region, where direct balloon/space-borne measurements are available. The detector has been in stable data taking in its full configuration from November 2007 to February 2013. In this paper the measurement of the cosmic ray proton plus helium energy spectrum is presented in the region 3-300 TeV by analyzing the full collected data sample. The resulting spectral index is γ=2.64±0.01\gamma = -2.64 \pm 0.01. These results demonstrate the possibility of performing an accurate measurement of the spectrum of light elements with a ground based air shower detector.Comment: 18 pages, 8 figures, preprint submitted to Phys. Rev.

    EAS age determination from the study of the lateral distribution of charged particles near the shower axis with the ARGO-YBJ experiment

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    The ARGO-YBJ experiment, a full coverage extensive air shower (EAS) detector located at high altitude (4300 m a.s.l.) in Tibet, China, has smoothly taken data, with very high stability, since November 2007 to the beginning of 2013. The array consisted of a carpet of about 7000 m2^2 Resistive Plate Chambers (RPCs) operated in streamer mode and equipped with both digital and analog readout, providing the measurement of particle densities up to few particles per cm2^2. The unique detector features (full coverage, readout granularity, wide dynamic range, etc) and location (very high altitude) allowed a detailed study of the lateral density profile of charged particles at ground very close to the shower axis and its description by a proper lateral distribution function (LDF). In particular, the information collected in the first 10 m from the shower axis have been shown to provide a very effective tool for the determination of the shower development stage ("age") in the energy range 50 TeV - 10 PeV. The sensitivity of the age parameter to the mass composition of primary Cosmic Rays is also discussed
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