Erosion Rate of the Aliano Biancana Badlands Based on a 3D Multi-Temporal High-Resolution Survey and Implications for Wind-Driven Rain

Biancana badlands are peculiar landforms in the Basilicata region of Italy resulting from the local combination of geological, geomorphological, and climatic settings. The evolution of badlands mainly depends on slope erosion, which is controlled by the angle, exposure, and vegetation of the slope and its interactions with insolation, rain, and wind. Multi-temporal, detailed, high-resolution surveys have led researchers to assess changes in slopes to investigate the spatial distributions of erosion and deposition and the influence of wind-driven rain (WDR). A comparison between two terrestrial laser scanner (TLS) point clouds surveyed during 2006 and 2016 fieldwork showed that the study area suffers from intense erosion that is not spatially uniform on all sides of biancane. By combining slope and exposure data and the cloud of difference (CoD), derived from a 3D model, we showed that all the steepest southern sides of biancane suffered the most intense erosion. Because splash and sheet erosion triggers sediment displacement, the analysis was also focused on the intensity and direction of WDR. We performed a real field experiment analysing erosion rates over 10 years in relation to daily and hourly wind data (direction and speed), and we found that frequent winds of moderate force, combined with moderate to heavy rainfall, contributed to the observed increase in soil erosion when combined with the insolation effect. Our results show how all the considered factors interact in a complex pattern to control the spatial distribution of erosion

Histology-directed and imaging mass spectrometry: An emerging technology in ectopic calcification

The present study was designed to demonstrate the potential of an optimized histology directed protein identification combined with imaging mass spectrometry technology to reveal and identify molecules associated to ectopic calcification in human tissue. As a proof of concept, mineralized and non-mineralized areas were compared within the same dermal tissue obtained from a patient affected by Pseudoxanthoma elasticum, a genetic disorder characterized by calcification only at specific sites of soft connective tissues. Data have been technically validated on a contralateral dermal tissue from the same subject and compared with those from control healthy skin. Results demonstrate that this approach 1) significantly reduces the effects generated by techniques that, disrupting tissue organization, blend data from affected and unaffected areas; 2) demonstrates that, abolishing differences due to inter-individual variability, mineralized and non-mineralized areas within the same sample have a specific protein profile and have a different distribution of molecules; and 3) avoiding the bias of focusing on already known molecules, reveals a number of proteins that have been never related to the disease nor to the calcification process, thus paving the way for the selection of new molecules to be validated as pathogenic or as potential pharmacological targets

Lean body weight-tailored Iodinated contrast Injection in obese patient. boer versus James Formula

Purpose. To prospectively compare the performance of James and Boer formula in contrast media (CM) administration, in terms of image quality and parenchymal enhancement in obese patients undergoing CT of the abdomen. Materials and Methods. Fifty-five patients with a body mass index (BMI) greater than 35 kg/m2were prospectively included in the study. All patients underwent 64-row CT examination and were randomly divided in two groups: 26 patients in Group A and 29 patients in Group B. The amount of injected CM was computed according to the patient's lean body weight (LBW), estimated using either Boer formula (Group A) or James formula (Group B). Patient's characteristics, CM volume, contrast-to-noise ratio (CNR) of liver, aorta and portal vein, and liver contrast enhancement index (CEI) were compared between the two groups. For subjective image analysis readers were asked to rate the enhancement of liver, kidneys, and pancreas based on a 5-point Likert scale. Results. Liver CNR, aortic CNR, and portal vein CNR showed no significant difference between Group A and Group B (all P ≥ 0.177). Group A provided significantly higher CEI compared to Group B (P = 0.007). Group A and Group B returned comparable overall subjective enhancement values (3.54 and vs 3.20, all P ≥ 0.199). Conclusions. Boer formula should be the method of choice for LBW estimation in obese patients, leading to an accurate CM amount calculation and an optimal liver contrast enhancement in CT

Kaon physics with the KLOE detector

In this paper we discuss the recent finalized analyses by the KLOE experiment at DA$\Phi$NE: the CPT and Lorentz invariance test with entangled $K^0 \bar{K}^0$ pairs, and the precision measurement of the branching fraction of the decay ${ K^+} \rightarrow \pi^+\pi^-\pi^+(\gamma)$. We also present the status of an ongoing analysis aiming to precisely measure the $K^{\pm}$ mass

Shake table testing of a low-impact technology for the seismic protection of stone masonry

This paper presents a novel low-impact technique for the seismic protection of fair-face masonry walls. The proposed strengthening solution involves the use of carbon-fibre reinforced polymer (CFRP) connectors installed from the outside by perforating the stone elements, combined with grout injections. The connectors cover ¾ of the wall thickness, so as to leave the inner surface undisturbed. Once the work is completed, they are also substantially invisible. Shake table tests were carried out under natural accelerograms on two full-scale irregular multi-leaf stone masonry wall specimens. In order to replicate materials and construction technique of the Apennine historical buildings, the prototypes were made from stones recovered from the debris of a settlement in the municipality of Accumoli (RI, Italy), and the mortar was designed to reproduce lime-poor mortars surveyed in the field. The experimental setup was designed to induce out-of-plane vertical bending under base seismic motion, while allowing the vertical displacement of the wall top. One specimen was tested “as-built” and the other one was tested strengthened, to investigate the gain in seismic performance, the limitation of progressive damage accumulation and the effects on dynamic properties

Digital literacy e digital divide: due facce della stessa medaglia

Abstract: Digital literacy has assumed a key role in European governance. In Italy, ISTAT data note how school communities across the country need more digital literacy development. The purpose of this contribution is to propose an analysis of current levels of Digital Literacy, following national and supranational initiatives, and to understand whether these levels are adequate with respect to an informed use of new technologies.Keywords: Digital literacy, Digital skills, Minors, Digital Divide, DigCompEduRiassunto: L’alfabetizzazione digitale ha assunto un ruolo fondamentale nella governance europea. In Italia, i dati ISTAT rilevano come le comunità scolastiche sul territorio nazionale necessitino di un maggiore sviluppo delle competenze digitali. Lo scopo di questo contributo è proporre un’analisi degli attuali livelli di Digital Literacy, a seguito delle iniziative nazionali e sovranazionali, e comprendere se tali livelli siano adeguati rispetto ad un uso consapevole delle nuove tecnologie

The Low Energy Tagger for the KLOE-2 experiment

The KLOE experiment at the upgraded DAFNE e+e- collider in Frascati (KLOE-2) is going to start a new data taking at the beginning of 2010 with its detector upgraded with a tagging system for the identification of gamma-gamma interactions. The tagging stations for low-energy e+e- will consist in two calorimeters The calorimeter used to detect low-energy e+e- will be placed between the beam-pipe outer support structure and the inner wall of the KLOE drift chamber. This calorimeter will be made of LYSO crystals readout by Silicon Photomultipliers, to achieve an energy resolution better than 8% at 200 MeV.Comment: 4 pages, 5 figures, in the proceedings of "Frontier detectors for frontier physics", isola d'Elba, Italy, May 200

Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype

Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs). Nevertheless, a quantitative correlation between biofilm production and the profile of antimicrobial drug resistance in delayed wound healing remains to be determined. Microbial identification, antibiotic susceptibility and biofilm production were assessed in 135 clinical isolates from 87 patients. Gram-negative bacteria were the most represented microorganisms (60.8%) with MDROs accounting for 31.8% of the total isolates. Assessment of biofilm production revealed that 80% of the strains were able to form biofilm. A comparable level of biofilm production was found with both MDRO and not-MDRO with no significant differences between groups. All the methicillin-resistant Staphylococcus aureus (MRSA) and 80% of Pseudomonas aeruginosa MDR strains were found as moderate/high biofilm producers. Conversely, less than 17% of Klebsiella pneumoniae extended-spectrum beta-lactamase (ESBL), Escherichia coli-ESBL and Acinetobacter baumannii were moderate/high biofilm producers. Notably, those strains classified as non-biofilm producers, were always associated with biofilm producer bacteria in polymicrobial colonization. This study shows that biofilm producers were present in all chronic skin ulcers, suggesting that biofilm represents a key virulence determinant in promoting bacterial persistence and chronicity of ulcerative lesions independently from the MDRO phenotype

Development and validation of artificial-intelligence-based radiomics model using computed tomography features for preoperative risk stratification of gastrointestinal stromal tumors

Background: preoperative risk assessment of gastrointestinal stromal tumors (GISTS) is required for optimal and personalized treatment planning. Radiomics features are promising tools to predict risk assessment. The purpose of this study is to develop and validate an artificial intelligence classification algorithm, based on CT features, to define GIST's prognosis as determined by the Miettinen classification. Methods: patients with histological diagnosis of GIST and CT studies were retrospectively enrolled. Eight morphologic and 30 texture CT features were extracted from each tumor and combined to obtain three models (morphologic, texture and combined). Data were analyzed using a machine learning classification (WEKA). For each classification process, sensitivity, specificity, accuracy and area under the curve were evaluated. Inter- and intra-reader agreement were also calculated. Results: 52 patients were evaluated. In the validation population, highest performances were obtained by the combined model (SE 85.7%, SP 90.9%, ACC 88.8%, and AUC 0.954) followed by the morphologic (SE 66.6%, SP 81.8%, ACC 76.4%, and AUC 0.742) and texture (SE 50%, SP 72.7%, ACC 64.7%, and AUC 0.613) models. Reproducibility was high of all manual evaluations. Conclusions: the AI-based radiomics model using a CT feature demonstrates good predictive performance for preoperative risk stratification of GISTs

Updates on Quantitative MRI of Diffuse Liver Disease. A Narrative Review

Diffuse liver diseases are highly prevalent conditions around the world, including pathological liver changes that occur when hepatocytes are damaged and liver function declines, often leading to a chronic condition. In the last years, Magnetic Resonance Imaging (MRI) is reaching an important role in the study of diffuse liver diseases moving from qualitative to quantitative assessment of liver parenchyma. In fact, this can allow noninvasive accurate and standardized assessment of diffuse liver diseases and can represent a concrete alternative to biopsy which represents the current reference standard. MRI approach already tested for other pathologies include diffusion-weighted imaging (DWI) and radiomics, able to quantify different aspects of diffuse liver disease. New emerging MRI quantitative methods include MR elastography (MRE) for the quantification of the hepatic stiffness in cirrhotic patients, dedicated gradient multiecho sequences for the assessment of hepatic fat storage, and iron overload. Thus, the aim of this review is to give an overview of the technical principles and clinical application of new quantitative MRI techniques for the evaluation of diffuse liver disease