La Fin du monde. Essai sur les apocalypses culturelles (extraits)

Lorsqu’il disparaît brutalement en mai 1965, l’anthropologue italien Ernesto De Martino laisse le manuscrit inachevé d’une vaste enquête qui sera publiée douze ans plus tard par l’éditeur Einaudi : La fine del mondo. Contributo all’analisi delle apocalissi culturali [La Fin du monde. Essai sur les apocalypses culturelles]. Une version réduite, et recomposée à partir des dossiers d’archives, de cette recherche méconnue dans le monde intellectuel français paraîtra dans la collection « Translations » des éditions de l’EHESS, sous la direction de Giordana Charuty, Daniel Fabre et Marcello Massenzio. Nous en présentons ici quelques extraits.When he suddenly died in May 1965, the Italian anthropologist Ernesto De Martino left behind an unfinished manuscript on a vast study which would be published twelve years later by the publisher Einaudi: La fine del mondo. Contributo all’analisi delle apocalissi culturali [The End of the World. Essay on Cultural Apocalypses]. An abridged version, and one rewritten based on archival files, of this work, largely unknown in the French intellectual world, is forthcoming and will be published by the EHESS (Giordana Charuty, Daniel Fabre and Marcello Massenzio eds.). A few extracts will be introduced here

El humanismo etnográfico

Small, but significant chapter of his posthumous book on Cultural Apocalypses, in which Ernesto de Martino expands on the concepts of ethnocentrism and critical thinking.Pequeño, pero significativo capítulo de su libro póstumo sobre los Apocalipsis culturales, en el que Ernesto de Martino se extiende sobre los conceptos de etnocentrismo y pensamiento crítico

Crystal structure and EPR spectrum of dimeric di-μ-azide-bis[cyanide(N,N-diethylethylenediamine)]-copper(II), [Cu(N₃)(NCO)(diEten)]₂

The title compound, [Cu(N₃)(NCO)(C₆H₁₆N₂)]₂, crystallizes in the space groupP2₁/n, witha=8.336(1),b=17.405(3),c=8.376(1) Å, β=109.73(2)o andZ=4. The molecules are arranged as centrosymmetric dimers in which two azide ligands bridge neighboring copper ions in an asymmetric head-on fashion. The Cu(II) ion is coordinated to five nitrogen atoms which form a distorted tetragonal pyramid. At the pyramid base are the two N atoms of a diEten molecule [Cu−N=2.00(1), 2.130(9) Å], an azide end atom [Cu−N=1.99(1) Å] and a NCO group [Cu−N=1.93(1) Å]. At the pyramid apex is the other, inversion related, azide N atom in the dimer [Cu−N=2.38(1) Å]. This Cu−N contact links the monomers within a dimer. Neighboring dimers are coupled by weak N−H…O contacts. Single crystal EPR data at X-band show that the pair of resonances expected for neighboring, magnetically nonequivalents dimers, collapse into a single line, a signature of inter-dimers superexchange coupling. The observed crystal gyromagnetic tensor is used to disclose the electronic and magnetic structure around Cu(II) ions.Facultad de Ciencias Exacta

Desarrollo de un shRNA en un vector lentiviral para la inhibición específica de la isoforma electrogénica del cotransportador sodio/bicarbonato cardíaco

El cotransportador Na+/HCO3- cardíaco (NBC) es uno de los principales mecanismos alcalinizantes que tienen los miocitos para regular el pH intracelular (pHi). En el corazón se ha demostrado la presencia de dos isoformas del NBC. Una isoforma electrogénica, NBCe1 (2 HCO3 -: 1 Na+) y otra electroneutra, NBCn1 (1 HCO3 -: 1 Na+). Si bien en cada ciclo ambas isoformas incorporan Na+ al interior celular, la isoforma electrogénica lo hace de un modo más eficiente ya que contribuye con la mitad del Na+ por cada HCO3 - que ingresa. Es conocido que el incremento del Na+ intracelular puede activar al intercambiador Na+/Ca2+ (NCX) en su modo reverso incrementando la concentración de Ca2+ intracelular y así conducir a la hipertrofia cardíaca (HC).Facultad de Ciencias Médica

Invasive micropapillary carcinoma of the breast overexpresses MUC4 and is associated with poor outcome to adjuvant trastuzumab in HER2-positive breast cancer

Invasive micropapillary carcinoma of the breast (IMPC) is a histological tumor variant that occurs with low frequency characterized by an inside-out formation of tumor clusters with a pseudopapillary arrangement. IMPC is an aggressive tumor with poor clinical outcome. In addition, this histological subtype usually expresses human epidermal growth factor receptor 2 (HER2) which also correlates with a more aggressive tumor. In this work we studied the clinical significance of IMPC in HER2-positive breast cancer patients treated with adjuvant trastuzumab. We also analyzed mucin 4 (MUC4) expression as a novel biomarker to identify IMPC.Fil: Mercogliano, María Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Inurrigarro, Gloria. Sanatorio Mater Dei Hermanas de María de Schoenstatt; ArgentinaFil: de Martino, Mara. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Venturutti, Leandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Rivas, Martin Alfredo. Cornell University; Estados UnidosFil: Cordo Russo, Rosalia Ines. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Proietti Anastasi, Cecilia Jazmín. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Fernandez, Elmer Andres. Universidad Católica de Córdoba; ArgentinaFil: Frahm, Isabel. Sanatorio Mater Dei Hermanas de María de Schoenstatt; ArgentinaFil: Barchuk, Sabrina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Allemand, Daniel H.. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Figurelli, Silvina. Gobierno de la Ciudad de Buenos Aires. Hospital General de Agudos ; ArgentinaFil: Gil Deza, Ernesto. Instituto Oncológico Henry Moore; ArgentinaFil: Ares, Sandra. Instituto Oncológico Henry Moore; ArgentinaFil: Gercovich, Felipe G.. Instituto Oncológico Henry Moore; ArgentinaFil: Cortese, Eduardo. Ministerio de Defensa. Fuerza Aérea Argentina. Hospital Aeronáutico Central ; ArgentinaFil: Amasino, Matías. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Guzmán, Pablo. Universidad de La Frontera; ChileFil: Roa, Juan C.. Universidad de La Frontera; ChileFil: Elizalde, Patricia Virginia. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; ArgentinaFil: Schillaci, Roxana. Consejo Nacional de Investigaciones Científicas y Técnicas. Instituto de Biología y Medicina Experimental. Fundación de Instituto de Biología y Medicina Experimental. Instituto de Biología y Medicina Experimental; Argentin

To Be Re-Bitten and to Re-Become: examining repeated embodied acts in ritual performance

Image courtesy of Wellcome Trust: http://catalogue.wellcomelibrary.org/record=b1465534This article will examine the use of repetition through two ritual performance contexts: the rimorso repetition of the ritual of tarantism in Salento, Southern Italy, and the deity yoga practice incorporating mudras, mantras and mandalas found in the Vajrayana tradition of Tibetan Buddhism. The two contexts will offer differing approaches to the practice and experience of repetition, whilst also demonstrating how repeating a movement, sound and image can be used to develop a greater bodymind connection that reinforces a sense of identity, belonging and devotion through the act of repeating. The use of repetition in these two ritual performance contexts will be explored through aspects of Buddhist philosophy, in particular how that repetition can create an altering effect on the ‘self’ of the practitioner through an understanding of the ways in which that ‘self’ is constructed. This will involve examining notions such as anatta (non-self) and the skhandas to show how the practice of repetition is a means to create a transformation of the ‘self’ through the action of repeating. This offers the potential for applying this understanding to actors, both at a somatic level of personal development, and also as a means for ‘be-coming’ a character through repeated actions that can alter the bodymind to align to that of the character. This all examines a paradox inherent in repetition in ritual performance: that it is through the action of repeating the same thing that leads to a process of transformation in the bodymind

Flow cytometric immunobead assay for detection of BCR-ABL1 fusion proteins in chronic myleoid leukemia: Comparison with FISH and PCR techniques

Chronic Myeloid Leukemia (CML) is characterized by a balanced translocation juxtaposing the Abelson (ABL) and breakpoint cluster region (BCR) genes. The resulting BCR-ABL1 oncogene leads to increased proliferation and survival of leukemic cells. Successful treatment of CML has been accompanied by steady improvements in our capacity to accurately and sensitively monitor therapy response. Currently, measurement of BCR-ABL1 mRNA transcript levels by real-time quantitative PCR (RQ-PCR) defines critical response endpoints. An antibody-based technique for BCR-ABL1 protein recognition could be an attractive alternative to RQ-PCR. To date, there have been no studies evaluating whether flow-cytometry based assays could be of clinical utility in evaluating residual disease in CML patients. Here we describe a flow-cytometry assay that detects the presence of BCR-ABL1 fusion proteins in CML lysates to determine the applicability, reliability, and specificity of this method for both diagnosis and monitoring of CML patients for initial response to therapy. We show that: i) CML can be properly diagnosed at onset, (ii) follow-up assessments show detectable fusion protein (i.e. relative mean fluorescent intensity, rMFI%>1) when BCR-ABL1IS transcripts are between 1-10%, and (iii) rMFI% levels predict CCyR as defined by FISH analysis. Overall, the FCBA assay is a rapid technique, fully translatable to the routine management of CML patients

Archivio storico della provincia di Salerno. A.1, n.1/4(1921)

A.1,n.1(1921): Arnone N., Origine e avvenire della Società di Storia Patria per la Provincia di Salerno, P.3-6 ; Bilotti P.E., I doveri della nostra Società di Storia, P.7-28; Sinno A., Determinazione della sede della Scuola Medica di Salerno, P.29-61; Mazziotti M., L'insurrezione salernitana nel 1860 (parte I), P.62-70; De Angelis M., Lucerna fittile salernitana del III-IV secolo, P.71-73; Carucci C., Gli Ebrei in Salerno nei secoli 11. e 12., P.74-79; Martini E. M., Intorno a Pietro Capuano cardinale scrittore (sec. 12. e 13.) (parte 1.), P.80-90; Carucci P., La grotta dell'Angelo di Pertosa e la sua completa esplorazione speleologica, P.91-105; Torraca F., Per Giacinto Romano. Discorso commemorativo, P.106-117. -A.1,n.2/3(1921): Mazziotti M., L'insurrezione salernitana nel 1860 (parte II e ultima), P. 121-144; Solimena G., Origini, armi feudali e Giuspatronati dei Solimena di Salerno, P.145-151; Carucci C., L'ultimo cancelliere normanno: Matteo d'Aiello salernitano, P.152-186; Arnone N., Matteo Ripa e l'Istituto Orientale di Napoli, P.187-210; Sinno A., Diplomi di laurea dell'Almo Collegio Salernitano, P. 211-251; Martini E. M., Intorno a Pietro Capuano cardinale scrittore (sec. 12.e 13.) (parte 2.) P.252-257; Conforti R., Un patriottico articolo di . . ., P. 258-265; D'Alessio G., Un'epigrafe funeraria in Nocera Inferiore, P. 266-267; De Crescenzo A., Un'urna discoperta ed un sarcofago da scoprire, P. 267-269. -A.1,n.4(1921): Mazziotti M., La rivoluzione del 1820 in Provincia di Salerno (parte 1.), P.273-294; Martini E. M., Intorno a Pietro Capuano cardinale scrittore (sec. 12.-13.) (parte 3. ed ultima), P.295-311; Ravello (trad. di M. Zoccoletti), P.312-334 ; Carucci C., Le preoccupazioni di Carlo d'Angiò per Salerno dopo la battaglia di Tagliacozzo in tre documenti del tempo, P.335-339; De Crescenzo A., Il sepolcro dei due Romualdo, P.339-342; Salerno nella poesia inglese (R. Browning, C. Pearce Cranch, J.E. Reade), P.342- 348

The ESA Hera Mission : Detailed Characterization of the DART Impact Outcome and of the Binary Asteroid (65803) Didymos

Funding Information: To achieve these objectives, Milani is carrying two scientific payloads, the ASPECT visual and near-infrared (Vis-NIR) imaging spectrometer and the VISTA thermogravimeter aimed at collecting and characterizing volatiles and dust particles below 10 μm. Additionally, navigation payloads include a visible navigation camera and lidar. The Milani consortium is composed of entities and institutions from Italy, the Czech Republic, and Finland. The consortium Prime is Tyvak International, responsible for the whole program management and platform design, development, integration, testing, and final delivery to the customer. Politecnico di Torino is tasked with defining requirements and performing thermal, radiation, and debris analysis. Politecnico di Milano is responsible for mission analysis and GNC. Altec will support the Ground Segment architecture and interface definition. Centro Italiano per la Ricerca Aerospaziale (CIRA) is responsible for the execution of the vehicle environmental campaign. HULD contributes to developing the mission-specific software. VTT is the main payload (ASPECT hyperspectral imager) provider and is supported by the following entities dealing with ASPECT-related development: University of Helsinki (ASPECT calibration); Reaktor Space Lab (ASPECT Data Processing Unit development), Institute of Geology of the Czech Academy of Sciences (ASPECT scientific algorithms requirements and testing); and Brno University of Technology (ASPECT scientific algorithms development). INAF-IAPS is the secondary Payload (VISTA, dust detector) provider. Funding Information: The Mission PI is appointed by ESA and is the primary interface to ESA. The Hera SMB consists of the ESA Hera Project Scientist (ESA PS), the Mission PI, and the Hera Advisory Board, consisting of four mission advisors. The Mission PI chairs the HIT and is supported by the Hera Advisory Board. The tasks of the Hera SMB are 1. advising the Hera mission project team on all aspects related to the Hera mission objectives; 2. ensuring that the WGs’ activities cover the needs of the Hera mission; 3. providing recommendations to ESA concerning the membership in the HIT; and 4. implementing the Publication Policy. Funding Information: Hera is the ESA contribution to the AIDA collaboration. Hera, Juventas, Milani, and their instruments are developed under ESA contract supported by national agencies. This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement No. 870377 (project NEO-MAPP), the CNRS through the MITI interdisciplinary programs, ASI, CNES, JAXA, the Academy of Finland project no. 335595, and was conducted with institutional support RVO 67985831 of the Institute of Geology of the Czech Academy of Sciences. M.L., E.P., P.T .and E.D. are grateful to the Italian Space Agency (ASI) for financial support through Agreement No. 2022-8-HH.0 in the context of ESA’s Hera mission. We are grateful to the whole Hera team, including Working Group core members and other contributors for their continuous efforts and support. Their names can be found on the following website: https:// www.heramission.space/team. Publisher Copyright: © 2022. The Author(s). Published by the American Astronomical Society.Hera is a planetary defense mission under development in the Space Safety and Security Program of the European Space Agency for launch in 2024 October. It will rendezvous in late 2026 December with the binary asteroid (65803) Didymos and in particular its moon, Dimorphos, which will be impacted by NASA’s DART spacecraft on 2022 September 26 as the first asteroid deflection test. The main goals of Hera are the detailed characterization of the physical properties of Didymos and Dimorphos and of the crater made by the DART mission, as well as measurement of the momentum transfer efficiency resulting from DART’s impact. The data from the Hera spacecraft and its two CubeSats will also provide significant insights into asteroid science and the evolutionary history of our solar system. Hera will perform the first rendezvous with a binary asteroid and provide new measurements, such as radar sounding of an asteroid interior, which will allow models in planetary science to be tested. Hera will thus provide a crucial element in the global effort to avert future asteroid impacts at the same time as providing world-leading science.Peer reviewe

Toxin Levels and Profiles in Microalgae from the North-Western Adriatic Sea—15 Years of Studies on Cultured Species

The Northern Adriatic Sea is the area of the Mediterranean Sea where eutrophication and episodes related to harmful algae have occurred most frequently since the 1970s. In this area, which is highly exploited for mollusk farming, the first occurrence of human intoxication due to shellfish consumption occurred in 1989, nearly 10 years later than other countries in Europe and worldwide that had faced similar problems. Until 1997, Adriatic mollusks had been found to be contaminated mostly by diarrhetic shellfish poisoning toxins (i.e., okadaic acid and dinophysistoxins) that, along with paralytic shellfish poisoning toxins (i.e., saxitoxins), constitute the most common marine biotoxins. Only once, in 1994, a toxic outbreak was related to the occurrence of paralytic shellfish poisoning toxins in the Adriatic coastal waters. Moreover, in the past 15 years, the Adriatic Sea has been characterized by the presence of toxic or potentially toxic algae, not highly widespread outside Europe, such as species producing yessotoxins (i.e., Protoceratium reticulatum, Gonyaulax spinifera and Lingulodinium polyedrum), recurrent blooms of the potentially ichthyotoxic species Fibrocapsa japonica and, recently, by blooms of palytoxin-like producing species of the Ostreopsis genus. This review is aimed at integrating monitoring data on toxin spectra and levels in mussels farmed along the coast of the Emilia-Romagna region with laboratory studies performed on the species involved in the production of those toxins; toxicity studies on toxic or potentially toxic species that have recently appeared in this area are also reviewed. Overall, reviewed data are related to: (i) the yessotoxins producing species P. reticulatum, G. spinifera and L. polyedrum, highlighting genetic and toxic characteristics; (ii) Adriatic strains of Alexandrium minutum, Alexandrium ostenfeldii and Prorocentrum lima whose toxic profiles are compared with those of strains of different geographic origins; (iii) F. japonica and Ostreopsis cf. ovata toxicity. Moreover, new data concerning domoic acid production by a Pseudo-nitzschia multistriata strain, toxicity investigations on a Prorocentrum cf. levis, and on presumably ichthyotoxic species, Heterosigma akashiwo and Chattonella cf. subsalsa, are also reported