New insights into crustal structure, Cenozoic magmatism, CO2 degassing and seismogenesis in the southern Apennines and Irpinia region from local earthquake tomography

We present high-resolution Vp and Vp/Vs models of the southern Apennines (Italy) computed using local earthquakes recorded from 2006 to 2011 with a graded inversion scheme that progressively resolves the crustal structure, from the large scale of the Apennines belt to the local scale of the normal-fault system. High-Vp bodies defined in the upper and mid crust under the external Apennines are interpreted as extensive mafic intrusions revealing anorogenic magmatism episodes that broadened on the Adriatic domain during Paleogene. Under the mountain belt, a low-Vp region, annular to the Neapolitan volcanic district, indicates the existence of a thermal/fluid anomaly in the mid crust, coinciding with a shallow Moho and diffuse degassing of deeply derived CO2. In the belt axial zone, low Vp/Vs gas-pressurized rock volumes under the Apulian carbonates correlate to high heat flow, strong CO2-dominated gas emissions of mantle origin and shallow carbonate reservoirs with pressurized CO2 gas caps. We hypothesize that the pressurized fluid volumes located at the base of the active fault system influence the rupture process of large normal-faulting earthquakes, like the 1980 Mw6.9 Irpinia event, and that major asperities are confined within the high-Vp Apulian carbonates. This study confirms once more that pre-existing structures of the Pliocene Apulian belt controlled the rupture propagation during the Irpinia earthquake. The main shock broke a 30 km long, NE-dipping seismogenic structure, whereas delayed ruptures (both the 20 s and the 40 s sub-events) developed on antithetic faults, reactivating thrust faults located at the eastern edge of the Apulian belt

The 2013–2018 matese and beneventano seismic sequences (Central–Southern apennines). New constraints on the hypocentral depth determination

The Matese and Beneventano areas coincide with the transition from the central to the southern Apennines and are characterized by both SW-and NE-dipping normal faulting seismogenic structures, responsible for the large historical earthquakes. We studied the Matese and Beneventano seismicity by means of high-precision locations of earthquakes spanning from 29 December 2013 to 4 September 2018. Events were located by using all of the available data from temporary and permanent stations in the area and a 1D computed velocity model, inverting the dataset with the Velest code. For events M > 2.8 we used P-and S-waves arrival times of the strong motion stations located in the study area. A constant value of 1.83 for Vp/Vs was computed with a modified Wadati method. The dataset consists of 2378 earthquakes, 18,715 P-and 12,295 S-wave arrival times. We computed 55 new fault plane solutions. The mechanisms show predominantly normal fault movements, with T-axis trends oriented NE–SW. Only relatively small E–W trending clusters in the eastern peripheral zones of the Apenninic belt show right-lateral strike-slip kinematics similar to that observed in the Potenza (1990–1991) and Molise (2002 and 2018) sequences. These belong to transfer zones associated with differential slab retreat of the Adriatic plate subduction beneath the Apennines. The Matese sequence (December 2013–February 2014; main shock Mw 5.0) is the most relevant part of our dataset. Hypocentral depths along the axis of the Apenninic belt are in agreement with previous seismological studies that place most of the earthquakes in the brittle upper crust. We confirm a general deepening of seismicity moving from west to the east along the Apennines. Seismicity depth is controlled by heat-flow, which is lower in the eastern side, thus causing a deeper brittle–ductile transition

Heterogeneities along the 2009 L’Aquila normal fault inferred by the b-value distribution

In this study we map the distribution of the b-value of the Gutenberg-Richter law—as well as complementary seismicity parameters—along the fault responsible for the 2009 MW 6.1 L'Aquila earthquake. We perform the calculations for two independent aftershock sub-catalogs, before and after a stable magnitude of completeness is reached. We find a substantial spatial variability of the b-values, which range from 0.6 to 1.3 over the fault plane. The comparison between the spatial distribution of the b-values and the main-shock slip pattern shows that the largest slip occurs in normal-to-high b-values portion of the fault plane, while low b-value is observed close to the main-shock nucleation. No substantial differences are found in the b-value computed before and after the main-shock struck in the small region of the fault plane populated by foreshocks

Receiver Function Analysis at Stromboli Volcano (Italy)

This study focuses on constraining the crust and upper mantle discontinuities at Stromboli volcano by applying the receiver function (RF) analysis. This technique utilizes the waveforms of P-SV conversions generated by discontinuities to infer the structure beneath the seismic stations. RFs have been obtained by deconvolving the vertical component of teleseismic P-wave records from the corresponding rotate horizontal components applying the Multi-Taper Spectral Correlation technique. For this study the seismograms of about 125 teleseismic earthquakes (M greater than 6.0), recorded between 2004 and 2006 at 13 broad-band seismic stations deployed by the INGV, have been considered. A preliminar characterization of the structure beneath the stations has been inferred from the stacking of teleseismic Ps converted waves and multiply converted waves at the seismic interface. The analysis, at frequency of 1 and 2 Hz, show a horizontal seismic discontinuity at an average depth of about 17 km and a Vp/Vs ratio lower than 1.73. This discontinuity explains the positive pulses about 1.9 s and 7.5 s after the direct P arrival. These pulses can be interpreted as Ps and PpPs converted phases, respectively. The depth of this discontinuity is in agreement with the Moho-depth obtained in independent studies

Transmural gradient of glycogen metabolism in the normal rat left ventricle.

The changes of glycogen metabolism with the location of tissue within the ventricle wall have been explored in the rat myocardium. The hearts were cut in 100 microns thick serial sections and all sections were analyzed for their content in glycogen, glucose-6-phosphate, UDPG and glycogen enzymes and for glucose incorporation into glycogen and for the 2-deoxyglucose uptake after the intravenous injection of the 14C-labelled sugars. The rate of glycogen turnover was significantly higher in the subendocardial myocardium (P less than 0.01) and the levels of glucose-6-phosphate and the total (i.e. a + b) activity of glycogen phosphorylase were significantly higher in the subepicardial tissue (P less than 0.01 in both instances). No significant transmural gradient of UDPG was found and transmural changes of total (i.e. I + D) synthase activity were barely significant. These changes in glycogen metabolism may be related to regional differences in the cardiac work load and to a differentiation of the subendocardial and subepicardial heart fibers

Flank sliding: A valve and a sentinel for paroxysmal eruptions and magma ascent at Mount Etna, Italy

Rising magma, dike intrusions, and flank collapse are observed at many volcanoes worldwide, but how they interact is still poorly documented. Extensive synthetic aperture radar interferometry and continuous global positioning system observations captured a sharp dike intrusion at Mount Etna, Italy, during the 2018 paroxysm that triggered a vigorous seaward sliding of the eastern flank connected with brittle failure and deep magmatic resourcing. We propose a feedback process between flank acceleration and magma intrusion that derives from the interaction between the long- and short-term deformation of the volcano. The flank sliding acts as a valve that modulates the emplacement and eruption of magma within the shallow system. Rapid flank acceleration could potentially evolve into sudden collapses and seismic release at shallow depth. In turn, flank slip events could act as a sentinel for changes in magma depth and paroxysmal eruptions at Mount Etna

From 3D to 4D passive seismic tomography: The sub-surface structure imaging of the Val d’Agri region, southern Italy

Local earthquakes (passive seismic) tomography (LET) is a well established tool for the imaging of the sub-surface structure. Alternative to active seismics, the main advantages of using natural sources are the better sounding in deeper portions of the upper crust, the relatively low cost, and the direct availability of S-waves. The main drawback is the achievable model resolution, which is limited by the density of the seismic network and the distribution of elastic sources, rather than the elastic wave frequency. Recently, 4D variations (in space and time) of velocity anomalies have been recognized in active volcanoes (Patanè et al., 2006) and normal faulting systems and ascribed to the medium response to transient geological processes, like dyke intrusions or fluid pressure increase on fault planes. In this paper we show how LET contributes to the imaging of the upper crust in a very attractive region like the Val d’Agri in southern Italy, which hosts both significant oil fields and seismogenic structures. We show that LET allows to improve the definition of the crust structure, at depths larger than those sampled by conventional seismic profiles, and detect the space-time dependency of elastic properties in response to local variations of fluid pressur

Automated detection of lung nodules in low-dose computed tomography

A computer-aided detection (CAD) system for the identification of pulmonary nodules in low-dose multi-detector computed-tomography (CT) images has been developed in the framework of the MAGIC-5 Italian project. One of the main goals of this project is to build a distributed database of lung CT scans in order to enable automated image analysis through a data and cpu GRID infrastructure. The basic modules of our lung-CAD system, consisting in a 3D dot-enhancement filter for nodule detection and a neural classifier for false-positive finding reduction, are described. The system was designed and tested for both internal and sub-pleural nodules. The database used in this study consists of 17 low-dose CT scans reconstructed with thin slice thickness (~300 slices/scan). The preliminary results are shown in terms of the FROC analysis reporting a good sensitivity (85% range) for both internal and sub-pleural nodules at an acceptable level of false positive findings (1-9 FP/scan); the sensitivity value remains very high (75% range) even at 1-6 FP/scanComment: 4 pages, 2 figures: Proceedings of the Computer Assisted Radiology and Surgery, 21th International Congress and Exhibition, Berlin, Volume 2, Supplement 1, June 2007, pp 357-35

Multi-scale analysis of lung computed tomography images

A computer-aided detection (CAD) system for the identification of lung internal nodules in low-dose multi-detector helical Computed Tomography (CT) images was developed in the framework of the MAGIC-5 project. The three modules of our lung CAD system, a segmentation algorithm for lung internal region identification, a multi-scale dot-enhancement filter for nodule candidate selection and a multi-scale neural technique for false positive finding reduction, are described. The results obtained on a dataset of low-dose and thin-slice CT scans are shown in terms of free response receiver operating characteristic (FROC) curves and discussed.Comment: 18 pages, 12 low-resolution figure

The role of erythropoietin stimulating agents in anemic patients with heart failure: solved and unresolved questions.

Anemia is a common finding in congestive heart failure (CHF) and is associated with an increased mortality and morbidity. Several conditions can cause depression of erythroid progenitor cells: reduction of iron absorption and reuptake, decreased bone marrow activity, reduced endogenous erythropoietin production, and chronic inflammatory state. Anemia's etiology in CHF is complex and partially understood; it involves several systems including impaired hemodynamic condition, reduced kidney and bone perfusion, increased inflammatory activity, and neurohormonal overdrive. The use of erythropoiesis stimulating agents (ESAs) such as erythropoietin and its derivatives is recently debated; the last interventional trial seems to demonstrate a neutral or negative effect in the active arm with darbepoetin treatment. The current data is opposite to many single blind studies and previous meta-analysis showing an improvement in quality of life, New York Heart Association class, and exercise tolerance using ESA therapy. These contrasting data raise several concerns regarding the target of hemoglobin levels needing intervention, the exact anemia classification and categorization, and the standardization of hematocrit cutoffs. Some cardiac and systemic conditions (ie, hypertension, atrial fibrillation, prothrombotic status) may predispose to adverse events, and ESA administration should be avoided. To prevent the negative effects, high-dosage and chronic administration should be avoided. Clarification of these items could probably identify patients that may benefit from additional iron or ESA treatment. In this review, we discuss the interventional trials made in anemic heart failure patients, the underlying mechanism of anemia in CHF, and the potential role of ESA in this setting