Semilinear problems for the fractional laplacian with a singular nonlinearity

The aim of this paper is to study the solvability of the problem (-Δ)s u = F(x,u) := λ f(x)/uγ + Mup in ω u > 0 in ω, u = 0 in RN \ ω, where Ω is a bounded smooth domain of RN, N > 2s, M ε {0, 1}, 0 0, λ > 0, p > 1 and f is a nonnegative function. We distinguish two cases: - For M = 0, we prove the existence of a solution for every γ > 0 and λ > 0. A1 - For M = 1, we consider f ≡ 1 and we find a threshold ∧ such that there exists a solution for every 0 ∧Work partially supported by project MTM2013-40846-P MINECO. The third author is also supported for the grant BES-2011-044216 associated to MTM2010-1812

MatLab Toolbox for the numerical solution of linear Volterra integral equations arising in metastatic tumor growth models

This paper introduces VIE Toolbox composed by fourteen MatLab functions used for the numerical resolution of Volterra Integral Equations (VIEs) of the second kind on infinite intervals. An application to metastatic tumor growth models is also considered, assuming five different tumor growth laws, e.g. exponential, power-law, Gompertz, generalized logistic and von Bertalanffy-West laws, for lung and breast tumors data

Evaluation of the Iatrogenic Sciatic Nerve Injury following Double Pelvic Osteotomy Performed with Piezoelectric Cutting Tool in Dogs

(1) Background: The double pelvic osteotomy (DPO) is a prophylactic surgical procedure associated with 0.4% incidence of sciatic nerve injury. The piezoelectric cutting tool is a surgical device able to involve only mineralized tissue avoiding neurovascular tissue and other soft tissue. This study aimed to evaluate the sciatic nerve injury observed in dogs underwent iliac osteotomy performed using the piezoelectric cutting tool. (2) Methods: Dogs underwent DPO performed with piezoelectric cutting tool were included. Neurological assessment was performed 6 and 24 h after surgery and then repeated 12 days, 4 and 8 weeks after surgery. Temporary and or permanent sciatic nerve injury were recorded. (3) Results: 84 DPOs performed in fifty dogs were included. No temporary/permanent neurological disease associated with iatrogenic damage of the sciatic nerve were observed. (4) Conclusions: The iliac osteotomy performed with piezoelectric cutting tool was not associated to iatrogenic sciatic nerve injury

Use of Transversus Abdominis Plane and Intercostal Blocks in Bitches Undergoing Laparoscopic Ovariectomy: A Randomized Controlled Trial

In humans and dogs, loco-regional anesthesia is associated with lower peri-operative opioid consumption and less related side effects. The combination of transversus abdominis plane (TAP) and intercostal blocks can be used to desensitize the entire abdominal wall in dogs. The aim of this study was to evaluate the effectiveness of TAP and intercostal blocks in bitches undergoing laparoscopic ovariectomy. Twenty client-owned bitches were enrolled in this double-blinded randomized controlled trial. After premedication with dexmedetomidine, methadone and ketamine, the animals were randomized into two groups. Dogs in the TAP group received intercostal blocks from T8 to T10 and a TAP block with ropivacaine. Dogs in the FEN group received a fentanyl bolus and a constant rate infusion for the entire duration of the procedure. Intra-operative cardiovascular stability, post-operative pain scores, rescue opioid requirement, dysphoria during recovery, time to attain sternal recumbency and interest in food at 6 h post-extubation were compared. Bitches in the TAP group received a statistically significant lower amount of rescue fentanyl intra-operatively and methadone post-operatively. Pain scores were lower in the TAP group until 6 h post-extubation. No difference was found for dysphoric recoveries, time to attain sternal recumbency and appetite at 6 h post-extubation. No adverse event was recorded for any of the dogs. The combination of TAP and intercostal blocks can be part of an effective multi-modal analgesic strategy in bitches undergoing laparoscopic ovariectomy

A compact array calibrator to study the feasibility of acoustic neutrino detection

[EN] Underwater acoustic detection of ultra-high-energy neutrinos was proposed already in 1950s: when a neutrino interacts with a nucleus in water, the resulting particle cascade produces a pressure pulse that has a bipolar temporal structure and propagates within a flat disk-like volume. A telescope that consists of thousands of acoustic sensors deployed in the deep sea can monitor hundreds of cubic kilometres of water looking for these signals and discriminating them from acoustic noise. To study the feasibility of the technique it is critical to have a calibrator able to mimic the neutrino signature that can be operated from a vessel. Due to the axial-symmetry of the signal, their very directive short bipolar shape and the constraints of operating at sea, the development of such a calibrator is very challenging. Once the possibility of using the acoustic parametric technique for this aim was validated with the first compact array calibrator prototype, in this paper we describe the new design for such a calibrator composed of an array of piezo ceramic tube transducers emitting in axial direction.We acknowledge the financial support of the Spanish Ministerio de Economía y Competitividad, Grants FPA2012-37528-C02-02, and Consolider MultiDark CSD2009-00064, of the Generalitat Valenciana, Grants ACOMP/2015/175 PrometeoII/2014/079 and of the European FEDER funds.Ardid Ramírez, M.; Camarena Femenia, F.; Felis-Enguix, I.; Herrero Debón, A.; Llorens Alvarez, CD.; Martínez Mora, JA.; Saldaña-Coscollar, M. (2016). A compact array calibrator to study the feasibility of acoustic neutrino detection. EPJ Web of Conferences. 116(03001):1-4. https://doi.org/10.1051/epjconf/201611603001S141160300

Indirect detection of Dark Matter with the ANTARES Neutrino Telescope

[EN] One of the main objectives of the ANTARES neutrino telescope is the search for neutrinos produced in self-annihilation of Dark Matter (DM) particles. The analysis for different sources of DM (Sun, Galactic Center, Earth, ...) or DM models (SUSY, Secluded) will be described and the results presented. The specific advantages of neutrino telescopes in general and of ANTARES in particular will be explained. As an example, the indirect search for DM towards the Sun performed by neutrino telescopes currently leads to more stringent limits on the spin-dependent WIMP-nucleon cross section with respect to existing direct detection experiments.We acknowledge the financial support of the Spanish Ministerio de Economía y Competitividad, Grants FPA2012-37528-C02-02, and Consolider MultiDark CSD2009-00064, of the Generalitat Valenciana, Grants ACOMP/2015/175 PrometeoII/2014/079 and of the European FEDER funds.Ardid Ramírez, M. (2016). Indirect detection of Dark Matter with the ANTARES Neutrino Telescope. EPJ Web of Conferences. 116:1-5. https://doi.org/10.1051/epjconf/201611604002S1511

Five-Year Outcome After Continuous Flow LVAD With Full-Magnetic (HeartMate 3) Versus Hybrid Levitation System (HeartWare): A Propensity-Score Matched Study From an All-Comers Multicentre Registry

Despite the withdrawal of the HeartWare Ventricular Assist Device (HVAD), hundreds of patients are still supported with this continuous-flow pump, and the long-term management of these patients is still under debate. This study aims to analyse 5 years survival and freedom from major adverse events in patients supported by HVAD and HeartMate3 (HM3). From 2010 to 2022, the MIRAMACS Italian Registry enrolled all-comer patients receiving a LVAD support at seven Cardiac Surgery Centres. Out of 447 LVAD implantation, 214 (47.9%) received HM3 and 233 (52.1%) received HVAD. Cox-regression analysis adjusted for major confounders showed an increased risk for mortality (HR 1.5 [1.2–1.9]; p = 0.031), for both ischemic stroke (HR 2.08 [1.06–4.08]; p = 0.033) and haemorrhagic stroke (HR 2.6 [1.3–4.9]; p = 0.005), and for pump thrombosis (HR 25.7 [3.5–188.9]; p < 0.001) in HVAD patients. The propensity-score matching analysis (130 pairs of HVAD vs. HM3) confirmed a significantly lower 5 years survival (81.25% vs. 64.1%; p 0.02), freedom from haemorrhagic stroke (90.5% vs. 70.1%; p < 0.001) and from pump thrombosis (98.5% vs. 74.7%; p < 0.001) in HVAD cohort. Although similar perioperative outcome, patients implanted with HVAD developed a higher risk for mortality, haemorrhagic stroke and thrombosis during 5 years of follow-up compared to HM3 patients