Mecanismos alternativos de solución de controversias en el contrato estatal la amigable composición

Con este documento se pretende adentrarse mucho más en el estudio de los mecanismos alternativos de solución de controversias que puedan surgir dentro del desarrollo del contrato estatal y en especial el mecanismo denominado como la Amigable Composición de muy poca utilización entre las partes en conflicto pese a tener muchas ventajas en lo que tiene que ver con el procedimiento establecido para llevarla a cabo, efectos legales luego de su realización y la posibilidad de intervención de un tercero imparcial. Se entrara a manejar el tema desde las definiciones de cada uno de los mecanismos alternativos de solución de controversias consagrado para dirimir los conflictos que puedan surgir con ocasión de la celebración de un contrato estatal, hasta llegar a la comparación de cada uno de estos métodos con la Amigable Composición, estableciendo similitudes y diferencias para que el lector tenga los criterios suficientes para emitir una opinión en lo que tiene que ver con la mayor idoneidad de uno u otro mecanismo alternativo de solución de controversias

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population

The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

International audienceSignificance There is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population