Genotypic and allelic distribution of SNPs on <i>CYP2E1</i> and <i>GSTM1</i> genes among patients grouped according to clinical evolution.

*<p>¹p-value;</p>*<p>²OR-odds ratio, CI-confidence interval.</p

Combined and isolated genotypic distribution of <i>CYP2E1</i> gene (SNPs 1053T>C, 1293C>G and 7632T>A), and deletion (<i>GSTM1</i>^*<i>1/GSTM1</i>^*<i>0</i>) on gene <i>GSTM1</i> of patients classified accordingly to baciloscopic index BI (LBI and HBI).

*<p>¹p-value;</p>*<p>²OR-odds ratio, CI-confidence interval;</p>*<p>³Combined effect of mutant alleles of distinct genes.</p

Allele and genotype distributions of CYP2E1 and GSTM1 genes within two samples from leprosy patients and healthy individuals.

<p>Allele and genotype distributions of CYP2E1 and GSTM1 genes within two samples from leprosy patients and healthy individuals.</p

Demographic and clinical characteristic of the sample according with Baciloscopic Index.

a<p><i>t</i>-Test of Student;</p>b<p>Fisher’s Exact Test;</p>c<p>Baciloscopic Index (LBI  =  Baciloscopic Index Low; HBI  =  Baciloscopic Index High).</p

Logistic regression analysis of the association between genetic markers and LBI/HBI response in leprosy patients.

<p><b>β</b>, Coefficient Stimation; <b>S.E.</b>, Standard Error; <b>df</b>, Degrees of Freedom; <b><i>p</i></b>, p-value; <b>OR</b>, Odds Ratio; <b>CI</b>, Confident Interval.</p

Comparative population-based genetic analysis of the Amerindian with the populations in the HapMap database.

<p>The Amerindian sample (IND) was compared to 20 randomly selected samples from the following populations in the HapMap database: JPT (Japanese in Tokyo, Japan), CHD (Chinese in metropolitan Denver, Colorado, USA), CHB (Han Chinese in Beijing, China), CEU (residents of Utah, Nevada, USA with Northern and Western European ancestry from the CEPH collection), TSI (Tuscans in Italy), GIH (Gujarati Indians in Houston, Texas, USA), YRI (Yoruba in Ibadan, Nigeria), ASW (individuals with African ancestry in Southwest USA), LWK (Luhya in Webuye, Kenya), MKK (Maasai in Kinyawa, Kenya), and MEX (individuals with Mexican ancestry in Los Angeles, California, USA). The populations were clustered according to their geographic origin as follows: East-Asia (JPT, CHB, and CHD), Europe (CEU and TSI), South-West Asia (SWA, formed by the GIH population), Africa (YRI, ASW, LWK, and MKK) and North America (NA, formed by the MEX population). A) Diagram of the genetic contribution of the models for a value of K in the range of four to seven. The x-axis represents the different samples that were clustered according to the population and the geographic area of origin. B) Principal Component Analysis (PCA) of the Amerindian sample (indicated with the arrow) and the samples extracted from the HapMap database. The abscissa represents the 1^st component, and the ordinate represents the 2^nd component. C) Heat map of the FST index between the investigated populations and the Amerindian sample.</p

Population genetic structure analysis of 1,000 genomes project's, Aboriginal Australian and Native South American genotype dataset.

<p>The diagram of genetic contribution was obtained using Structure software for models of 4 to 6 subpopulations. The populations were grouped labeled as follow, according to their major continental ancestry: IND (Native South American individual, this work); ABO (Aboriginal Australian individual, Rasmussen et al. 2011); Eastern Asian (CHS, CHB and JPT); Europeans (CEU, IBS, TSI, FIN and GBR); African (ASW, LWK, MKK and YRI); and New Americans (CLM, PUR and MXL). The plot represents the rate of contribution from each subpopulation (colors) to the samples (x axis).</p

High-quality polymorphisms identified and not identified in the dbSNP build 135 database.

<p>*These percentages correspond to the column total.</p

Three-population admixture test <i>f₃</i>^*.

<p>*The <i>f₃</i> tests the hypothesis that the outgroup is result of admixture of two ingroups (see Material and Methods). The groups were identified as: IND - South Native American; ABO - Australian Aboriginal (Rasmussen et al. 2011); ASN - Asian populations (CHS, CHB and JPT); EUR - European populations (CEU, IBS, TSI, FIN and GBR); AFR - African populations (ASW, LWK, MKK and YRI); and AMR - American populations (CLM, PUR and MXL).</p

Correlation between the relative expression profiles of the antrum and cardia [11].

<p>For this analysis, all of the miRNAs with at least 10 reads in the antrum were used. The Pearson’s correlation value indicates that the expression profiles of the antrum and cardia tissues are significantly correlated (r = 0.73; p-value < 0.001).</p