The demand for crop genetic resources: international use of the U.S. National Plant Germplasm System

In contrast to a perception that ex situ collections of germplasm are rarely used, this empirical case study reveals large quantities of germplasm samples distributed by the U.S. National Germplasm System to many types of scientific institutions located in numerous countries around the world. Distributions favor developing countries in several ways including the numbers of samples shipped, utilization rates in crop breeding programs, and the secondary benefits brought about through sharing this germplasm with other scientists. Expected future demand is also greater among scientists in developing countries. These findings underscore the importance to global science and technology of retaining such resources in the public domain.Germplasm resources, Plant Research., Germplasm conservation., Germplasm resources, Plant International cooperation. ,

Routine Outcomes Monitoring to Support Improving Care for Schizophrenia: Report from the VA Mental Health QUERI

In schizophrenia, treatments that improve outcomes have not been reliably disseminated. A major barrier to improving care has been a lack of routinely collected outcomes data that identify patients who are failing to improve or not receiving effective treatments. To support high quality care, the VA Mental Health QUERI used literature review, expert interviews, and a national panel process to increase consensus regarding outcomes monitoring instruments and strategies that support quality improvement. There was very good consensus in the domains of psychotic symptoms, side-effects, drugs and alcohol, depression, caregivers, vocational functioning, and community tenure. There are validated instruments and assessment strategies that are feasible for quality improvement in routine practice

Relative Burden of Large CNVs on a Range of Neurodevelopmental Phenotypes

While numerous studies have implicated copy number variants (CNVs) in a range of neurological phenotypes, the impact relative to disease severity has been difficult to ascertain due to small sample sizes, lack of phenotypic details, and heterogeneity in platforms used for discovery. Using a customized microarray enriched for genomic hotspots, we assayed for large CNVs among 1,227 individuals with various neurological deficits including dyslexia (376), sporadic autism (350), and intellectual disability (ID) (501), as well as 337 controls. We show that the frequency of large CNVs (>1 Mbp) is significantly greater for ID–associated phenotypes compared to autism (p = 9.58×10−11, odds ratio = 4.59), dyslexia (p = 3.81×10−18, odds ratio = 14.45), or controls (p = 2.75×10−17, odds ratio = 13.71). There is a striking difference in the frequency of rare CNVs (>50 kbp) in autism (10%, p = 2.4×10−6, odds ratio = 6) or ID (16%, p = 3.55×10−12, odds ratio = 10) compared to dyslexia (2%) with essentially no difference in large CNV burden among dyslexia patients compared to controls. Rare CNVs were more likely to arise de novo (64%) in ID when compared to autism (40%) or dyslexia (0%). We observed a significantly increased large CNV burden in individuals with ID and multiple congenital anomalies (MCA) compared to ID alone (p = 0.001, odds ratio = 2.54). Our data suggest that large CNV burden positively correlates with the severity of childhood disability: ID with MCA being most severely affected and dyslexics being indistinguishable from controls. When autism without ID was considered separately, the increase in CNV burden was modest compared to controls (p = 0.07, odds ratio = 2.33)

ACKNOWLEDGMENTS

In contrast to a perception that ex situ collections of germplasm are rarely used, this empirical case study reveals large quantities of germplasm samples distributed by the U.S. National Germplasm System to many types of scientific institutions located in numerous countries around the world. Distributions favor developing countries in several ways including the numbers of samples shipped, utilization rates in crop breeding programs, and the secondary benefits brought about through sharing this germplasm with other scientists. Expected future demand is also greater among scientists in developing countries. These findings underscore the importance to global science and technology of retaining such resources in the public domain. KEYWORDS: developing countries, crop genetic resources, plant breeding, germplasm collection ii ACKNOWLEDGMENTS Authors acknowledge the generous assistance of staff from the U.S. National Germplasm Resources Laboratory, staff of the International Plant Genetic Resources Institute, and financial support from the U.S. Agency for International Development. This study was conducted by the International Plant Genetic Resources Institute in partnership with the U.S. Department of Agriculture. iii TABLE OF CONTENTS 1. The Global Role of Germplasm Collections.................................................................. 1 2. The U.S. National Germplasm Collection..................................................................... 3 3. Data Sources .................................................................................................................. 5 4. Findings.......................................................................................................................... 7 5. Conclusions .......................................

Reporting of complex interventions in clinical trials : development of a taxonomy to classify and describe fall-prevention interventions

Background: Interventions for preventing falls in older people often involve several components, multidisciplinary teams, and implementation in a variety of settings. We have developed a classification system (taxonomy) to describe interventions used to prevent falls in older people, with the aim of improving the design and reporting of clinical trials of fall-prevention interventions, and synthesis of evidence from these trials. Methods: Thirty three international experts in falls prevention and health services research participated in a series of meetings to develop consensus. Robust techniques were used including literature reviews, expert presentations, and structured consensus workshops moderated by experienced facilitators. The taxonomy was refined using an international test panel of five health care practitioners. We assessed the chance corrected agreement of the final version by comparing taxonomy completion for 10 randomly selected published papers describing a variety of fall prevention interventions. Results: The taxonomy consists of four domains, summarized as the “Approach”, “Base”, “Components” and “Descriptors” of an intervention. Sub-domains include; where participants are identified; the theoretical approach of the intervention; clinical targeting criteria; details on assessments; descriptions of the nature and intensity of interventions. Chance corrected agreement of the final version of the taxonomy was good to excellent for all items. Further independent evaluation of the taxonomy is required. Conclusions: The taxonomy is a useful instrument for characterizing a broad range of interventions used in falls prevention. Investigators are encouraged to use the taxonomy to report their interventions