Rainfall but not selective logging affect changes in abundance of tropical forest butterfly in Sabah, Borneo

We investigated the effects of rainfall on the distribution and abundance of the satyrine butterfly Ragadia makuta in selectively logged and unlogged forest on Borneo. In 1997-98, there was a severe El Nino-Southern Oscillation (ENSO) drought, and annual surveys over a 4-y period showed that abundance of R. makuta was greatly reduced during the drought, but that populations quickly recovered after it. Monthly surveys over a 12-mo period of typical rainfall showed that high rainfall in the month preceding surveys significantly reduced butterfly abundance. Butterfly abundance and distribution did not differ between selectively logged and unlogged areas in either monthly or annual surveys and there was no difference between selectively logged and unlogged areas in the pattern of post-drought recovery. These results indicate that the abundance of R. makuta was significantly reduced both after high rainfall and during severe drought, but that these impacts were short-lived and were not affected by habitat disturbance. ENSO droughts on Borneo naturally often lead to widespread forest fires and thus impacts of ENSO events for butterflies are more likely to be due to indirect effects of habitat loss, rather than direct effects of drought on butterfly population dynamics

Analysis and Design of a Box Culvert Using Bentley Culvert Master Software: Qoshtapa Culvert as a Case Study

Box culverts are utilized in situations where natural stream flow intersects with roads and railway lines. This research utilizes a digital elevation model and the water Modeling System software to assess the catchment area of the primary valley and identify the factors contributing to flooding in Qoshtapa City. The study involves an analysis of the existing culvert and generated the necessary data for the design of a new culvert. Despite the presence of the existing culvert, floodwater levels rose to over 1 m above the roadway elevation of Erbil-Kirkuk during the last flood event in 2021–2022. The research collected hydrological and climatic data for the study area, conducted soil type analysis using the Harmonized World Soil Database software, and performed hydraulic calculations to estimate the maximum flood discharge of the valley using the Hydrological Engineering Center-Hydrological Modeling System software for flood return periods of 50, 100, and 200 years, for design, to select the best economic alternative. The new culvert design was executed using Bentley Culvert Master software to ensure that floodwaters can flow through the culvert without rising to street level. The results indicated that the new culvert design surpasses the capacity of the existing one. The results show that the best economic alternative hydraulic design is the first alternative capacity of 201 m3/s of a 100-year return period; the new design cross-section area of the culvert is 52.5 m2

Resistance to Direct-Acting Antiviral Agents in Treatment of Hepatitis C Virus Infections

Compounds targeting nonstructural (NS) proteins of hepatitis C virus (HCV) demonstrate clinical promise, suggesting that NS3/NS4a, NS5A, or NS5B inhibitors are potential components in direct-acting antiviral (DAA) combination therapies. In vitro studies revealed dramatic inhibition of viral replication or alteration in subcellular localization of NS proteins. DAAs bind either to catalytic sites (NS3 and NS5B) or to domain-1 of NS5A. Although >90% of the patients clear HCV RNA from their sera, a significant portion of cirrhotic patients suffer from resistance or virological relapse. Mutations in specific residues (Q80K) in NS3 (M28, A30, L31, and Y93 in genotypes 1a and 1b or L28, L30, M31, and Y93 in genotype 4) in NS5A and A282T in NS5B are associated with resistance to DAA [resistance-associated variants (RAVs)]. Current knowledge on the NS functions, mode of action of DAAs, and impacts of RAVs on treatment response are discussed. Not only mutations affecting the binding of DAAs to target proteins but also substitutions affecting the replication fitness of mutant quasispecies are major determinants of treatment failures. These resistance-associated substitutions (RASs) are now considered the major viral mutants that influence the virological outcome after DAA treatment

Flood Modeling on Koya Catchment Area Using Hyfran, Web Map Service, and HEC-RAS Software

In this research, The boundaries of the Koya catchment area have been delineated, and valley paths in the region were drawn by using the Water Modeling System (WMS) software, Analysis of the morphometric information indicated that the morphometric characteristics of watersheds contribute to the floods. The average surface runoff depth depends on the curve number values that are determined based on the types of soil cover and soil class according to Harmonized World Soil Database HWSD software that indicates the soil class in the study area are Group B silt loam,  The results obtained also show that the potential for surface runoff varies with land use and soil characteristics. Also, the value of the curve number (CN) was determined to be 71. The hydrological modeling was performed by the HEC-HMS program that simulates the process of rainfall to runoff using the SCS curve number model. A flood hydrograph was constructed at the catchment area outlet and the floodplain delineation was verified by the HEC-RAS software. The results indicated that the 100-year return period flood could Reach critical areas such as the urban area, agricultural area, residential areas. the results of this study indicate that there are suitable sites in the catchment areas for constructing small dams and ponds for water harvesting.&nbsp