Relative Histories

Relative Histories focuses on the Asian American memoir that specifically recounts the story of at least three generations of the same family. This form of auto/biography concentrates as much on other members of one’s family as on oneself, generally collapses the boundaries conventionally established between biography and autobiography, and in many cases—as Rocío G. Davis proposes for the auto/biographies of ethnic writers—crosses the frontier into history, promoting collective memory. Davis centers on how Asian American family memoirs expand the limits and function of life writing by reclaiming history and promoting community cohesion. She argues that identity is shaped by not only the stories we have been told, but also the stories we tell, making these narratives important examples of the ways we remember our family’s past and tell our community’s story. In the context of auto/biographical writing or filmmaking that explores specific ethnic experiences of diaspora, assimilation, and integration, this work considers two important aspects: These texts re-imagine the past by creating a work that exists both in history and as a historical document, making the creative process a form of re-enactment of the past itself. Each chapter centers on a thematic concern germane to the Asian American experience: the narrative of twentieth-century Asian wars and revolutions, which has become the subtext of a significant number of Asian American family memoirs (Pang-Mei Natasha Chang’s Bound Feet and Western Dress, May-lee and Winberg Chai’s The Girl from Purple Mountain, K. Connie Kang’s Home Was The Land of Morning Calm, Doung Van Mai Elliott’s The Sacred Willow); family experiences of travel and displacement within Asia in the nineteenth and early twentieth centuries, which unveil a history of multiple diasporas that are often elided after families immigrate to the United States (Helie Lee’s Still Life With Rice, Jael Silliman’s Jewish Portraits, Indian Frames, Mira Kamdar’s Motiba’s Tattoos); and the development of Chinatowns as family spaces (Maxine Hong Kingston’s China Men, Lisa See’s On Gold Mountain, Bruce Edward Hall’s Tea that Burns). The final chapter analyzes the discursive possibilities of the filmed family memoir (“family portrait documentary”), examining Lise Yasui’s A Family Gathering, Ruth Ozeki Lounsbury’s Halving the Bones, and Ann Marie Fleming’s The Magical Life of Long Tack Sam. Davis concludes the work with a metaliterary engagement with the history of her own Asian diasporic family as she demonstrates the profound interconnection between forms of life writing

"Sigrid Nunez's a Feather on the Breath of God" : visions of the ethnic self in a chinese american short story cycle

Este artículo analiza el "short story cycle" (ciclo de relatos) como un género literario particularmente apropiado para reflejar el drama de identidad étnica que viven los inmigrantes en Estados Unidos. A través de una discusión de las características específicas de esta forma híbrida, en donde los relatos independientes están interrelacionados para formar un conjunto, se comprende su adaptabilidad a los temas propios de la literatura de inmigrantes, en particular la búsqueda de una identidad. El análisis del ciclo de Sigrid Nunez titulado A Feather on the Breath of God demuestra claramente cómo esta forma literaria, con raíces en la tradición literaria norteamericana y manifestaciones concretas en la china-americana, sirve para presentar la situación de diáspora y la fragmentación experimentadas por muchas inmigrantes. La narradora de los cuatro relatos busca, en cada relato, un punto de partida para la creación de su peculiar identidad personal y étnica. Su tragedia será no hallar lo que necesita para su autoafirmación, el reconocimiento de su valor como persona, y su lugar dentro de la cultura de sus padres o la del país donde vive. El papel de la propia etnia, la importancia del lenguaje y las relaciones interpersonales son otras de los temas recurrentes que unen los diversos relatos y dan coherencia a este ciclo sobre el enigma de la etnicidad

"Sigrid Nunez's a Feather on the Breath of God" : visions of the ethnic self in a chinese american short story cycle

Este artículo analiza el "short story cycle" (ciclo de relatos) como un género literario particularmente apropiado para reflejar el drama de identidad étnica que viven los inmigrantes en Estados Unidos. A través de una discusión de las características específicas de esta forma híbrida, en donde los relatos independientes están interrelacionados para formar un conjunto, se comprende su adaptabilidad a los temas propios de la literatura de inmigrantes, en particular la búsqueda de una identidad. El análisis del ciclo de Sigrid Nunez titulado A Feather on the Breath of God demuestra claramente cómo esta forma literaria, con raíces en la tradición literaria norteamericana y manifestaciones concretas en la china-americana, sirve para presentar la situación de diáspora y la fragmentación experimentadas por muchas inmigrantes. La narradora de los cuatro relatos busca, en cada relato, un punto de partida para la creación de su peculiar identidad personal y étnica. Su tragedia será no hallar lo que necesita para su autoafirmación, el reconocimiento de su valor como persona, y su lugar dentro de la cultura de sus padres o la del país donde vive. El papel de la propia etnia, la importancia del lenguaje y las relaciones interpersonales son otras de los temas recurrentes que unen los diversos relatos y dan coherencia a este ciclo sobre el enigma de la etnicidad

Relative Histories: Mediating History in Asian American Family Memoirs

Relative Histories focuses on the Asian American memoir that specifically recounts the story of at least three generations of the same family. This form of auto/biography concentrates as much on other members of one’s family as on oneself, generally collapses the boundaries conventionally established between biography and autobiography, and in many cases—as Rocío G. Davis proposes for the auto/biographies of ethnic writers—crosses the frontier into history, promoting collective memory. Davis centers on how Asian American family memoirs expand the limits and function of life writing by reclaiming history and promoting community cohesion. She argues that identity is shaped by not only the stories we have been told, but also the stories we tell, making these narratives important examples of the ways we remember our family’s past and tell our community’s story. In the context of auto/biographical writing or filmmaking that explores specific ethnic experiences of diaspora, assimilation, and integration, this work considers two important aspects: These texts re-imagine the past by creating a work that exists both in history and as a historical document, making the creative process a form of re-enactment of the past itself. Each chapter centers on a thematic concern germane to the Asian American experience: the narrative of twentieth-century Asian wars and revolutions, which has become the subtext of a significant number of Asian American family memoirs (Pang-Mei Natasha Chang’s Bound Feet and Western Dress, May-lee and Winberg Chai’s The Girl from Purple Mountain, K. Connie Kang’s Home Was The Land of Morning Calm, Doung Van Mai Elliott’s The Sacred Willow); family experiences of travel and displacement within Asia in the nineteenth and early twentieth centuries, which unveil a history of multiple diasporas that are often elided after families immigrate to the United States (Helie Lee’s Still Life With Rice, Jael Silliman’s Jewish Portraits, Indian Frames, Mira Kamdar’s Motiba’s Tattoos); and the development of Chinatowns as family spaces (Maxine Hong Kingston’s China Men, Lisa See’s On Gold Mountain, Bruce Edward Hall’s Tea that Burns). The final chapter analyzes the discursive possibilities of the filmed family memoir ("family portrait documentary"), examining Lise Yasui’s A Family Gathering, Ruth Ozeki Lounsbury’s Halving the Bones, and Ann Marie Fleming’s The Magical Life of Long Tack Sam. Davis concludes the work with a metaliterary engagement with the history of her own Asian diasporic family as she demonstrates the profound interconnection between forms of life writing

Identification and Pathway Analysis of microRNAs with No Previous Involvement in Breast Cancer

microRNA expression signatures can differentiate normal and breast cancer tissues and can define specific clinico-pathological phenotypes in breast tumors. In order to further evaluate the microRNA expression profile in breast cancer, we analyzed the expression of 667 microRNAs in 29 tumors and 21 adjacent normal tissues using TaqMan Low-density arrays. 130 miRNAs showed significant differential expression (adjusted P value = 0.05, Fold Change = 2) in breast tumors compared to the normal adjacent tissue. Importantly, the role of 43 of these microRNAs has not been previously reported in breast cancer, including several evolutionary conserved microRNA*, showing similar expression rates to that of their corresponding leading strand. The expression of 14 microRNAs was replicated in an independent set of 55 tumors. Bioinformatic analysis of mRNA targets of the altered miRNAs, identified oncogenes like ERBB2, YY1, several MAP kinases, and known tumor-suppressors like FOXA1 and SMAD4. Pathway analysis identified that some biological process which are important in breast carcinogenesis are affected by the altered microRNA expression, including signaling through MAP kinases and TP53 pathways, as well as biological processes like cell death and communication, focal adhesion and ERBB2-ERBB3 signaling. Our data identified the altered expression of several microRNAs whose aberrant expression might have an important impact on cancer-related cellular pathways and whose role in breast cancer has not been previously described

Evaluating the Effects of SARS-CoV-2 Spike Mutation D614G on Transmissibility and Pathogenicity.

Global dispersal and increasing frequency of the SARS-CoV-2 spike protein variant D614G are suggestive of a selective advantage but may also be due to a random founder effect. We investigate the hypothesis for positive selection of spike D614G in the United Kingdom using more than 25,000 whole genome SARS-CoV-2 sequences. Despite the availability of a large dataset, well represented by both spike 614 variants, not all approaches showed a conclusive signal of positive selection. Population genetic analysis indicates that 614G increases in frequency relative to 614D in a manner consistent with a selective advantage. We do not find any indication that patients infected with the spike 614G variant have higher COVID-19 mortality or clinical severity, but 614G is associated with higher viral load and younger age of patients. Significant differences in growth and size of 614G phylogenetic clusters indicate a need for continued study of this variant

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Reality beckons: metamodernist depthiness beyond panfictionality

It is often argued that postmodernism has been succeeded by a new dominant cultural logic. We conceive of this new logic as metamodernism. Whilst some twenty-first century texts still engage with and utilise postmodernist practices, they put these practices to new use. In this article, we investigate the metamodern usage of the typically postmodernist devices of metatextuality and ontological slippage in two genres: autofiction and true crime documentary. Specifically, we analyse Ruth Ozeki’s A Tale for the Time Being and the Netflix mini-series The Keepers, demonstrating that forms of fictionalisation, metafictionality and ontological blurring between fiction and reality have been repurposed. We argue that, rather than expand the scope of fiction, overriding reality, the metamodernist repurposing of postmodernist textual strategies generates a kind of ‘reality-effect’

Exponential growth, high prevalence of SARS-CoV-2, and vaccine effectiveness associated with the Delta variant

SARS-CoV-2 infections were rising during early summer 2021 in many countries associated with the Delta variant. We assessed RT-PCR swab-positivity in the REal-time Assessment of Community Transmission-1 (REACT-1) study in England. We observed sustained exponential growth with average doubling time (June-July 2021) of 25 days driven by complete replacement of Alpha variant by Delta, and by high prevalence at younger less-vaccinated ages. Unvaccinated people were three times more likely than double-vaccinated people to test positive. However, after adjusting for age and other variables, vaccine effectiveness for double-vaccinated people was estimated at between ~50% and ~60% during this period in England. Increased social mixing in the presence of Delta had the potential to generate sustained growth in infections, even at high levels of vaccination