A chemical sensor based on a photonic-crystal L3 nanocavity defined in a silicon-nitride membrane

The application of a silicon-nitride based L3 optical nanocavity as a chemical sensor is explored. It is shown that by adjusting the thickness of an ultra-thin Lumogen Red film deposited onto the nanocavity surface, the fundamental optical mode undergoes a progressive red-shift as the layer-thickness increases, with the cavity being able to detect the presence of a single molecular monolayer. The optical properties of a nanocavity whose surface is coated with a thin layer of a porphyrin-based polymer are also explored. On exposure of the cavity to an acidic-vapour, it is shown that changes in the optical properties of the porphyrin-film (thickness and refractive index) can be detected through a reversible shift in the cavity mode wavelength. Such effects are described using a finite difference time-domain model

Wind tunnel results of the low-speed NLF(1)-0414F airfoil

The large performance gains predicted for the Natural Laminar Flow (NLF)(1)-0414F airfoil were demonstrated in two-dimensional airfoil tests and in wind tunnel tests conducted with a full scale modified Cessna 210. The performance gains result from maintaining extensive areas of natural laminar flow, and were verified by flight tests conducted with the modified Cessna. The lift, stability, and control characteristics of the Cessna were found to be essentially unchanged when boundary layer transition was fixed near the wing leading edge. These characteristics are very desirable from a safety and certification view where premature boundary layer transition (due to insect contamination, etc.) must be considered. The leading edge modifications were found to enhance the roll damping of the Cessna at the stall, and were therefore considered effective in improving the stall/departure resistance. Also, the modifications were found to be responsible for only minor performance penalties

Nutrition Knowledge of Amateur Bicyclists in South Florida, USA

Nutrition is an important component in chronic disease prevention. Diet plays an important role in the athletic performance and the overall health of the amateur bicyclists; yet information concerning diet and amateur bicyclists is lacking. This was a cross-sectional, convenience sample of 125 amateur bicyclists ages 18-65 years from South Florida who consented to SurveyMonkey, web-designed survey on nutrition knowledge. The survey was validated for endurance runners. Less than one-quarter of the participants had adequate nutrition knowledge (score of 75% or higher). Female bicyclists scored higher on nutrition knowledge as compared to males. There were no differences in nutrition knowledge by race, marital status, education or income. Accessibility to nutrition information is abundant, yet the validity of this information is questionable. Amateur bicyclist may not have access to the health professionals available to professional athletes. There is a need for nutrition counseling targeting amateur athletes

Starter Motor Sizing For Large Gas Turbine (Single-Shaft) Driven LNG Strings.

LecturePg. 7-16The purpose of this paper is to describe how computer simulation was used to size the main starter motors for single shaft gas turbine driven compressor strings used in a large LNG plant. The paper describes how the components of the system were modelled and discusses assumptions used in the calculations. The paper presents the actual computer output plots showing the predicted torque loading on the motor and the contributions of each of the components in the string to this predicted loading. The simulation program was also used to predict the loading of the motor during a full load test at the compressor vendor's facility. A torquemeter was used to measure the output of the motor during the string acceleration. The paper presents the results of the simulation prediction for the test runs and correlates the actual test measurements to the prediction

Coronae as Consequence of Large Scale Magnetic Fields in Turbulent Accretion Disks

Non-thermal X-ray emission in compact accretion engines can be interpreted to result from magnetic dissipation in an optically thin magnetized corona above an optically thick accretion disk. If coronal magnetic field originates in the disk and the disk is turbulent, then only magnetic structures large enough for their turbulent shredding time to exceed their buoyant rise time survive the journey to the corona. We use this concept and a physical model to constrain the minimum fraction of magnetic energy above the critical scale for buoyancy as a function of the observed coronal to bolometric emission. Our results suggest that a significant fraction of the magnetic energy in accretion disks resides in large scale fields, which in turn provides circumstantial evidence for significant non-local transport phenomena and the need for large scale magnetic field generation. For the example of Seyfert AGN, for which of order 30 per cent of the bolometric flux is in the X-ray band, we find that more than 20 per cent of the magnetic energy must be of large enough scale to rise and dissipate in the corona.Comment: submitted to ApJL, 2 fig

Extended quantum conditional entropy and quantum uncertainty inequalities

Quantum states can be subjected to classical measurements, whose incompatibility, or uncertainty, can be quantified by a comparison of certain entropies. There is a long history of such entropy inequalities between position and momentum. Recently these inequalities have been generalized to the tensor product of several Hilbert spaces and we show here how their derivations can be shortened to a few lines and how they can be generalized. All the recently derived uncertainty relations utilize the strong subadditivity (SSA) theorem; our contribution relies on directly utilizing the proof technique of the original derivation of SSA.Comment: 4 page

Retrograde semaphorin-plexin signalling drives homeostatic synaptic plasticity.

Homeostatic signalling systems ensure stable but flexible neural activity and animal behaviour. Presynaptic homeostatic plasticity is a conserved form of neuronal homeostatic signalling that is observed in organisms ranging from Drosophila to human. Defining the underlying molecular mechanisms of neuronal homeostatic signalling will be essential in order to establish clear connections to the causes and progression of neurological disease. During neural development, semaphorin-plexin signalling instructs axon guidance and neuronal morphogenesis. However, semaphorins and plexins are also expressed in the adult brain. Here we show that semaphorin 2b (Sema2b) is a target-derived signal that acts upon presynaptic plexin B (PlexB) receptors to mediate the retrograde, homeostatic control of presynaptic neurotransmitter release at the neuromuscular junction in Drosophila. Further, we show that Sema2b-PlexB signalling regulates presynaptic homeostatic plasticity through the cytoplasmic protein Mical and the oxoreductase-dependent control of presynaptic actin. We propose that semaphorin-plexin signalling is an essential platform for the stabilization of synaptic transmission throughout the developing and mature nervous system. These findings may be relevant to the aetiology and treatment of diverse neurological and psychiatric diseases that are characterized by altered or inappropriate neural function and behaviour

Nitric oxide precursors and congenital heart surgery: A randomized controlled trial of oral citrulline

ObjectiveThe study sought to determine whether citrulline supplementation, a precursor to nitric oxide synthesis, is safe and efficacious in increasing plasma citrulline concentrations and decreasing the risk of postoperative pulmonary hypertension.Study DesignForty children, undergoing cardiopulmonary bypass and at risk for pulmonary hypertension, were randomized to receive 5 perioperative doses (1.9 g/m2 per dose) of either oral citrulline or placebo. Plasma citrulline and arginine concentrations were measured at 5 time points. Measurements of systemic blood pressure and presence of pulmonary hypertension were collected.ResultsMedian citrulline concentrations were significantly higher in the citrulline group versus the placebo group immediately postoperatively (36 μmol/L vs 26 μmol/L, P = .012) and at 12 hours postoperatively (37 μmol/L vs 20 μmol/L, P = .015). Mean plasma arginine concentrations were significantly higher in the citrulline group versus the placebo group by 12 hours postoperatively (36 μmol/L vs 23 μmol/L, P = .037). Mean systemic blood pressure did not differ between groups (P = .53). Postoperative pulmonary hypertension developed in 9 patients, 6 of 20 (30%) in the placebo group and 3 of 20 (15%) in the citrulline group (P = .451), all of whom had plasma citrulline concentrations less than age-specific norms. Postoperative pulmonary hypertension did not develop in patients who demonstrated plasma citrulline concentrations in excess of 37 μmol/L (P = .036).ConclusionsOral citrulline supplementation safely increased plasma citrulline and arginine concentrations compared with placebo after cardiopulmonary bypass. Postoperative pulmonary hypertension did not occur in children with naturally elevated citrulline levels or elevations through supplementation. Oral citrulline supplementation may be effective in reducing postoperative pulmonary hypertension

Landau-De Gennes theory of nematic liquid\ud crystals: the Oseen-Frank limit and beyond

We study global minimizers of a continuum Landau-De Gennes energy functional for nematic liquid crystals, in three-dimensional domains, subject to uniaxial boundary conditions. We analyze the physically relevant limit of small elastic constant and show that global minimizers converge strongly, in W 1,2 , to a global minimizer predicted by the Oseen-Frank theory for uniaxial nematic liquid crystals with constant order parameter. Moreover, the convergence is uniform in the interior of the domain, away from the singularities of the limiting Oseen-Frank global minimizer. We obtain results on the rate of convergence of the eigenvalues and the regularity of the eigenvectors of the Landau-De Gennes global minimizer.\ud \ud \ud We also study the interplay between biaxiality and uniaxiality in Landau-De Gennes global energy minimizers and obtain estimates for various related quantities such as the biaxiality parameter and the size of admissible strongly biaxial regions

The origin of variability of the intermediate-mass black-hole ULX system HLX-1 in ESO 243-49

The ultra-luminous intermediate-mass black-hole system HLX-1 in the ESO 243-49 galaxy exhibits variability with a possible recurrence time of a few hundred days. Finding the origin of this variability would constrain the still largely unknown properties of this extraordinary object. Since it exhibits an intensity-hardness behavior characteristic of black-hole X-ray transients, we have analyzed the variability of HLX-1 in the framework of the disk instability model that explains outbursts of such systems. We find that the long-term variability of HLX-1 is unlikely to be explained by a model in which outbursts are triggered by thermal-viscous instabilities in an accretion disc. Possible alternatives include the instability in a radiation-pressure dominated disk but we argue that a more likely explanation is a modulated mass-transfer due to tidal stripping of a star on an eccentric orbit around the intermediate-mass black hole. We consider an evolutionary scenario leading to the creation of such a system and estimate the probability of its observation. We conclude, using a simplified dynamical model of the post-collapse cluster, that no more than 1/100 to 1/10 of Mbh < 10^4 Msun IMBHs - formed by run-away stellar mergers in the dense collapsed cores of young clusters - could have a few times 1 Msun Main-Sequence star evolve to an AGB on an orbit eccentric enough for mass transfer at periapse, while avoiding collisional destruction or being scattered into the IMBH by 2-body encounters. The finite but low probability of this configuration is consistent with the uniqueness of HLX-1. We note, however, that the actual response of a standard accretion disk to bursts of mass transfer may be too slow to explain the observations unless the orbit is close to parabolic (and hence even rarer) and/or additional heating, presumably linked to the highly time-dependent gravitational potential, are invoked.Comment: 8 pages, 2 figures. Additional figure, extended discussion. To be published in ApJ, June 10, 2011, v734 -