Managing highly innovative projects: the influence of design characteristics on project valuation

The climate change debate and economic recovery strategies in various industries demand highly innovative projects featuring stretched performance goals for developing clean technology. These projects face multiple sources of uncertainty in high risk situations, and require specialized know-how and longer periods for revenue growth than their counterparts in other industries. We use data from 207 clean technology projects funded by the U.S. Advanced Research Projects Agency-Energy to conduct a comparative study of how operations design can hedge risk and enhance project valuation in technology development and deployment stages. We find that deployment feasibility is significantly and positively related to project valuation. On the other hand, stretched technical performance goals, development feasibility and market growth targets are associated with lower valuation. We also find some significant differences for these results across institution types: mature firms, start-ups, universities, and research centers. We examine the risk profile of these projects by technology and institution type, and discuss the managerial and policy implications for these findings

Nilpotent normal form for divergence-free vector fields and volume-preserving maps

We study the normal forms for incompressible flows and maps in the neighborhood of an equilibrium or fixed point with a triple eigenvalue. We prove that when a divergence free vector field in $\mathbb{R}^3$ has nilpotent linearization with maximal Jordan block then, to arbitrary degree, coordinates can be chosen so that the nonlinear terms occur as a single function of two variables in the third component. The analogue for volume-preserving diffeomorphisms gives an optimal normal form in which the truncation of the normal form at any degree gives an exactly volume-preserving map whose inverse is also polynomial inverse with the same degree.Comment: laTeX, 20 pages, 1 figur

Far-field engineering of metal -metal terahertz quantum cascade lasers with integrated horn antennas

The far-field of metal-metal terahertz quantum cascade lasers is greatly improved through integrated and stable planar horn antennas on top of the QCL ridge. The antenna structures introduce a gradual change in the high modal confinement of metal-metal waveguides and permit an improved far-field, showing a five times increase in the emitted output power. The two dimensional far-field patterns are measured at 77K and compared to electromagnetic simulations. The influence of parasitic high order transverse modes are restricted through the engineering of antenna structure (ridge and antenna width) to couple out the fundamental mode only

Nonlinear frequency mixing in quantum cascade lasers: Towards broadband wavelength shifting and THz up-conversion

Terahertz (THz) sideband generation on a near-infrared (NIR) carrier has been recently demonstrated using quantum cascade lasers (QCL), with potential applications in wavelength shifting and THz up-conversion. However, the NIR wavelength range and nonlinear efficiency were severely limited by absorption. Here we overcome this drawback through a novel reflection geometry, whilst preserving a large interaction area. As well as insights into the nonlinear mechanism, this allows a much large range of NIR pump energies, relaxing the criteria of using particular excitation wavelengths

Monolithic echo-less photoconductive switches for high-resolution terahertz time-domain spectroscopy

Interdigitated photoconductive (IPC) switches are convenient sources and detectors for terahertz (THz) time domain spectroscopy. However, reflection of the emitted or detected radiation within the device substrate can lead to echoes that inherently limits the spectroscopic resolution achievable. In this work, we design and realize low-temperature-grown-GaAs (LT-GaAs) IPC switches for THz pulse generation and detection that suppresses such unwanted echoes. This is realized through a monolithic geometry of an IPC switch with a metal plane buried at a subwavelength depth below the LT-GaAs surface. Using this device as a detector, and coupling it to an echo-less IPC source, enables echo-free THz-TDS and high-resolution spectroscopy, with a resolution limited only by the temporal length of the measurement governed by the mechanical delay line used

Optical sideband generation up to room temperature with mid-infrared quantum cascade lasers

Room temperature sideband generation on an optical carrier is demonstrated using midinfrared quantum cascade lasers. This is achieved via an enhancement of the nonlinear susceptibility via resonant interband and intersubband excitations, compensating the large phase-mismatch

Introduction

The concept of Responsible Research and Innovation (RRI) originates in discourses on emerging technologies and research ethics in contested innovative fields, such as nanotechnologies or geo-engineering, and has been predominantly driven by European research and innovation policy over the past 10 years. The concept was initially developed and introduced by policy makers and social scientists, but recent studies have aimed to shed light on the implementation of responsible research and innovation practices in business. The contributions collected in this book are a result of work conducted by seven partner organisations in the European funded Horizon 2020 project "COMPASS – Evidence and opportunities for responsible innovation in SMEs". In combination, they illustrate that responsible innovation (RI) has been emerging as a new field in the ongoing discourse on the role and responsibility of business in society

Optimising use of electronic health records to describe the presentation of rheumatoid arthritis in primary care: a strategy for developing code lists

Background Research using electronic health records (EHRs) relies heavily on coded clinical data. Due to variation in coding practices, it can be difficult to aggregate the codes for a condition in order to define cases. This paper describes a methodology to develop ‘indicator markers’ found in patients with early rheumatoid arthritis (RA); these are a broader range of codes which may allow a probabilistic case definition to use in cases where no diagnostic code is yet recorded. Methods We examined EHRs of 5,843 patients in the General Practice Research Database, aged ≥30y, with a first coded diagnosis of RA between 2005 and 2008. Lists of indicator markers for RA were developed initially by panels of clinicians drawing up code-lists and then modified based on scrutiny of available data. The prevalence of indicator markers, and their temporal relationship to RA codes, was examined in patients from 3y before to 14d after recorded RA diagnosis. Findings Indicator markers were common throughout EHRs of RA patients, with 83.5% having 2 or more markers. 34% of patients received a disease-specific prescription before RA was coded; 42% had a referral to rheumatology, and 63% had a test for rheumatoid factor. 65% had at least one joint symptom or sign recorded and in 44% this was at least 6-months before recorded RA diagnosis. Conclusion Indicator markers of RA may be valuable for case definition in cases which do not yet have a diagnostic code. The clinical diagnosis of RA is likely to occur some months before it is coded, shown by markers frequently occurring ≥6 months before recorded diagnosis. It is difficult to differentiate delay in diagnosis from delay in recording. Information concealed in free text may be required for the accurate identification of patients and to assess the quality of care in general practice

Constraining globular cluster formation through studies of young massive clusters - V. ALMA observations of clusters in the Antennae

Some formation scenarios that have been put forward to explain multiple populations within Globular Clusters (GCs) require that the young massive cluster have large reservoirs of cold gas within them, which is necessary to form future generations of stars. In this paper we use deep observations taken with Atacama Large Millimeter/sub-millimeter Array (ALMA) to assess the amount of molecular gas within 3 young (50-200 Myr) massive (~10^6 Msun) clusters in the Antennae galaxies. No significant CO(3--2) emission was found associated with any of the three clusters. We place upper limits for the molecular gas within these clusters of ~1x10^5 Msun (or <9 % of the current stellar mass). We briefly review different scenarios that propose multiple episodes of star formation and discuss some of their assumptions and implications. Our results are in tension with the predictions of GC formation scenarios that expect large reservoirs of cool gas within young massive clusters at these ages