8,603 research outputs found
The clumped (13C-18O) isotope composition of echinoid calcite: further evidence for “vital effects” in the clumped isotope proxy
Carbonate clumped isotope thermometry is based on the thermodynamically dependent relative abundance of 13C-18O bonds (quantified as Δ47) within the carbonate crystal lattice. The clumping of 13C-18O in carbonates is based on a self-reaction of isotope exchange that occurs rapidly at near neutral pH. Similar Δ47-temperature relationships between biogenic and inorganically precipitated carbonate in initial studies led to the promise of a proxy free of biologically driven disequilibrium effects, commonly referred to as "vital effects". This has been largely the case for most organisms investigated. Biologically mediated disequilibrium precipitation has however been reported in corals and cephalopods and brachiopod molluscs. Echinoderms, despite their complex inter-cellular bio-mineralization strategy, large inter-skeletal fractionation of δ18O, δ13C and rapid calcite precipitation have however not been previously investigated with regards to their clumped isotope composition. We present clumped isotopic composition (Δ47) of 25 inter-skeletal elements of 5 echinoid species with varying growth temperatures. We found no statistically significant inter-skeletal variation in Δ47 in all echinoid species measured, a surprising find given the inter-skeletal variability reported for δ13C and δ18O. Our echinoid Δ47-temperature calibration however shows a statistically significant positive offset from Δ47-temperature calibration for inorganic calcite of 0.015‰. The pattern of isotopic fractionation in δ18O and Δ47 of echinoderms is not consistent with CO2 hydration or hydroxylation, diffusion or high-Mg composition of echinoid calcite. Positive offsets in the Δ47 of echinoid calcite may however relate to deviations in the pH of the calcifying fluid from the pH at which equilibrium calcite is precipitated
Management of everolimus-associated adverse events in patients with tuberous sclerosis complex: a practical guide
Tuberous sclerosis complex (TSC) is a genetic disorder characterised by highly variable comorbid dysfunction and subsequent morbidity. The mTOR inhibitor everolimus is indicated for the treatment of adult TSC patients with renal angiomyolipomas (AMLs) and for subependymal giant astrocytoma (SEGA) in both adults and children, based on data from the EXIST-1 and EXIST-2 trials. However, due to the historical predominance of everolimus in the oncology setting, some physicians who treat TSC patients may be unfamiliar with everolimus-associated adverse events (AEs) and appropriate management strategies. This article aims to serve as a resource for specialists including nephrologists, paediatricians, neurologists and geneticists who require practical guidance on the management of events such as non-infectious pneumonitis, rash, stomatitis, infections, and renal AEs. Additional consideration is given to drug interactions, hepatic impairment, fertility, and sexual maturation. Since patients with TSC receive clinical benefit from continued therapy, it is important that everolimus-related events are dealt with appropriately through strategies such as dose modification, interruption, the provision of supportive care, regular monitoring, and patient education
Cross-Bedded Woody Debris From A Pliocene Forested River System In the High Arctic: Beaufort Formation, Meighen Island, Canada
Abstract: Cross-bedding, the inclined internal stratification that records the migration of certain transverse sedimentary bedforms, is nearly ubiquitous in current-transported bedload sediments. Although examples of the structure are known from inorganic clastic sediments and sedimentary rocks from practically all depositional environments and intervals of geologic history, here we report cross-bedded lenses that are composed wholly or significantly of woody debris, in Pliocene alluvium of the Beaufort Formation in the Canadian High Arctic. The uniqueness of cross-bedded woody debris has hitherto been overlooked, but we demonstrate that, in the entire Phanerozoic record, it is apparently restricted to alluvium deposited during a warm climatic interval that permitted the growth of boreal-type forests within 10° latitude of the North Pole. The marked spatiotemporal restriction of cross-bedded woody debris implies that there may be environmental factors, unique to polar forests, which promote the subaqueous transport of large amounts of fine woody debris as fluvial bedload. We propose a non-uniformitarian conceptual model for the formation of cross-bedded woody debris in forested polar rivers whereby an exceptional abundance of woody debris could accumulate, and become saturated and denser than water, due to reduced decomposition on forest floors that were subject to prolonged periods of darkness and subzero temperatures
The origin of switching noise in GaAs/AlGaAs lateral gated devices
We have studied the origin of switching (telegraph) noise at low temperature
in lateral quantum structures defined electrostatically in GaAs/AlGaAs
heterostructures by surface gates. The noise was measured by monitoring the
conductance fluctuations around on the first step of a quantum point
contact at around 1.2 K. Cooling with a positive bias on the gates dramatically
reduces this noise, while an asymmetric bias exacerbates it. We propose a model
in which the noise originates from a leakage current of electrons that tunnel
through the Schottky barrier under the gate into the doped layer. The key to
reducing noise is to keep this barrier opaque under experimental conditions.
Bias cooling reduces the density of ionized donors, which builds in an
effective negative gate voltage. A smaller negative bias is therefore needed to
reach the desired operating point. This suppresses tunnelling from the gate and
hence the noise. The reduction in the density of ionized donors also
strengthens the barrier to tunneling at a given applied voltage. Support for
the model comes from our direct observation of the leakage current into a
closed quantum dot, around for this device. The current
was detected by a neighboring quantum point contact, which showed monotonic
steps in time associated with the tunneling of single electrons into the dot.
If asymmetric gate voltages are applied, our model suggests that the noise will
increase as a consequence of the more negative gate voltage applied to one of
the gates to maintain the same device conductance. We observe exactly this
behaviour in our experiments.Comment: 8 pages, 7 figure
J.S. Bell's Concept of Local Causality
John Stewart Bell's famous 1964 theorem is widely regarded as one of the most
important developments in the foundations of physics. It has even been
described as "the most profound discovery of science." Yet even as we approach
the 50th anniversary of Bell's discovery, its meaning and implications remain
controversial. Many textbooks and commentators report that Bell's theorem
refutes the possibility (suggested especially by Einstein, Podolsky, and Rosen
in 1935) of supplementing ordinary quantum theory with additional ("hidden")
variables that might restore determinism and/or some notion of an
observer-independent reality. On this view, Bell's theorem supports the
orthodox Copenhagen interpretation. Bell's own view of his theorem, however,
was quite different. He instead took the theorem as establishing an "essential
conflict" between the now well-tested empirical predictions of quantum theory
and relativistic \emph{local causality}. The goal of the present paper is, in
general, to make Bell's own views more widely known and, in particular, to
explain in detail Bell's little-known mathematical formulation of the concept
of relativistic local causality on which his theorem rests. We thus collect and
organize many of Bell's crucial statements on these topics, which are scattered
throughout his writings, into a self-contained, pedagogical discussion
including elaborations of the concepts "beable", "completeness", and
"causality" which figure in the formulation. We also show how local causality
(as formulated by Bell) can be used to derive an empirically testable Bell-type
inequality, and how it can be used to recapitulate the EPR argument.Comment: 19 pages, 4 figure
The C-Band All-Sky Survey: Instrument design, status, and first-look data
The C-Band All-Sky Survey (C-BASS) aims to produce sensitive, all-sky maps of
diffuse Galactic emission at 5 GHz in total intensity and linear polarization.
These maps will be used (with other surveys) to separate the several
astrophysical components contributing to microwave emission, and in particular
will allow an accurate map of synchrotron emission to be produced for the
subtraction of foregrounds from measurements of the polarized Cosmic Microwave
Background. We describe the design of the analog instrument, the optics of our
6.1 m dish at the Owens Valley Radio Observatory, the status of observations,
and first-look data.Comment: 10 pages, 11 figures, published in Proceedings of SPIE MIllimeter,
Submillimeter, and Far-Infrared Detectors and Instrumentation for Astronomy V
(2010), Vol. 7741, 77411I-1 - 77411I-1
Evolving the service model for child and adolescent mental health services
A new model for a community mental health service for children and young people aged 0-18 years is described. This has been formulated after multi-level consultation including extensive user/carer involvement. The proposed model is multidisciplinary and integrated with multiagency provision, with smooth access onto and through care pathways. This model brings voluntary and statutory agencies into an integrated collaboration. It reinforces that social and emotional development and psychological functioning is everybody’s business and creates conditions where a child’s needs can be addressed on a day-to-day basis rather than through a “clinic-based model”.</jats:p
Scaling of the B and D meson spectrum in lattice QCD
We give results for the and the meson spectrum using NRQCD on the
lattice in the quenched approximation. The masses of radially and orbitally
excited states are calculated as well as -wave hyperfine and -wave fine
structure. Radially excited -states are observed for the first time. Radial
and orbital excitation energies match well to experiment, as does the
strange-non-strange -wave splitting. We compare the light and heavy quark
mass dependence of various splittings to experiment. Our -results cover a
range in lattice spacings of more than a factor of two. Our -results are
from a single lattice spacing and we compare them to numbers in the literature
from finer lattices using other methods. We see no significant dependence of
physical results on the lattice spacing.
PACS: 11.15.Ha 12.38.Gc 14.40.Lb 14.40.NdComment: 78 pages, 29 tables, 30 figures Revised version. Minor corrections to
spelling and wordin
Metasomatism in the Ultrahigh-pressure Svartberget Garnet-peridotite (Western Gneiss Region, Norway): Implications for the Transport of Crust-derived Fluids within the Mantle
Garnet-peridotites often contain veins or layers of pyroxenite and eclogite of uncertain origin. We investigate the Svartberget garnet-peridotite from the northernmost ultrahigh-pressure domain in the Western Gneiss Region (WGR) in Norway and show that the observed layering represents a sequence of metasomatic reaction zones developed along a fracture system. From the garnet-peridotite wall-rock to the fractures the following sequential reaction zones are recognized: clinohumite bearing garnet-peridotite, olivine-garnet-websterite, garnet-websterite, orthopyroxene-phlogopite-garnet-websterite, coarse-grained phlogopite-garnet-websterite, phlogopite-garnet-websterite, phlogopite-free garnet-websterite, inclusion-rich garnetite, garnetite, eclogite, retrograde omphacitite and felsic amphibole-pegmatite. The MgO, FeO and CaO contents generally decrease from the pristine peridotite towards the most metasomatized samples, with an associated increase in SiO2 and Al2O3. Concentrations of fluid-mobile elements increase from the most pristine peridotite towards the garnetite, whereas Ni and Cr decrease from ∼700 to ∼10 ppm and ∼2600 to ∼25 ppm, respectively. Changes in mineral mode are accompanied by changes in mineral chemistry. All minerals display decreasing Mg# and Cr content with degree of metasomatism, whereas Na2O concentrations in amphibole, and most notably in clinopyroxene, increase from 0·2 to 3·0 and from 0·2 to 8 wt %, respectively. The trivalent ions Cr and Al display complex intra-granular vein-like or patchy zoning in garnet and pyroxenes that may be characteristic of metasomatized peridotites. Dating by the U-Pb method suggests metamorphic growth of zircon in the garnetite at 397·2 ± 1·2 Ma, formation of leucosomes in host-rock gneiss at 391·2 ± 0·8 Ma, and amphibole-pegmatite in the core of a garnetite vein at 390·1 ± 0·9 Ma. Initial 87Sr/86Sr values calculated at 397 Ma are elevated (∼0·723) in the most pristine peridotites and increase to ∼0·743 in the most metasomatized samples. The initial 87Sr/86Sr values of both the host gneiss and its leucosomes are also elevated (0·734-0·776), which suggests that the leucosomes found in the gneisses are the most likely, now solidified, remnants of the reactive agent that metasomatized the Svartberget peridotite. A scenario is envisaged in which material derived from the country rock gneiss was the source of the metasomatic addition of elements to the peridotites and the gneisses acted as the host for all elements removed from the peridotite. The Svartberget peridotite may provide an important analogue of how felsic, slab-derived material interacts with the overlying mantle wedge peridotite in regions of arc magma generatio
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