Plastic pre-compression and creep damage effects on the fracture toughness behaviour of Type 316H stainless steel

The influence of inelastic damage in the form of plastic pre-strain and creep damage, on fracture toughness of Type 316H stainless steel has been examined. Creep damage has been introduced into the 8% pre-compressed material by interrupting creep crack growth tests. Comparisons have been made between the fracture toughness test results from the as-received, pre-compressed and creep damaged materials. Furthermore, the effects of creep crack discontinuities on the crack tip strain fields have been examined by digital image correlation measurements. Inelastic damage was found to reduce the fracture toughness of the material, with creep damage having more severe effects than pre-strain

Over-expression of BCL2 rescues muscle weakness in a mouse model of oculopharyngeal muscular dystrophy

Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscular dystrophy caused by a polyalanine expansion mutation in the coding region of the poly-(A) binding protein nuclear 1 (PABPN1) gene. In unaffected individuals, (GCG)6 encodes the first 6 alanines in a homopolymeric stretch of 10 alanines. In most patients, this (GCG)6 repeat is expanded to (GCG)8–13, leading to a stretch of 12–17 alanines in mutant PABPN1, which is thought to confer a toxic gain of function. Thus, OPMD has been modelled by expressing mutant PABPN1 transgenes in the presence of endogenous copies of the gene in cells and mice. In these models, increased apoptosis is seen, but it is unclear whether this process mediates OPMD. The role of apoptosis in the pathogenesis of different muscular dystrophies is unclear. Blocking apoptosis ameliorates muscle disease in some mouse models of muscular dystrophy such as laminin α-2-deficient mice, but not in others such as dystrophin-deficient (mdx) mice. Here we demonstrate that apoptosis is not only involved in the pathology of OPMD but also is a major contributor to the muscle weakness and dysfunction in this disease. Genetically blocking apoptosis by over-expressing BCL2 ameliorates muscle weakness in our mouse model of OPMD (A17 mice). The effect of BCL2 co-expression on muscle weakness is transient, since muscle weakness is apparent in mice expressing both A17 and BCL2 transgenes at late time points. Thus, while apoptosis is a major pathway that causes muscle weakness in OPMD, other cell death pathways may also contribute to the disease when apoptosis is inhibited

Nonlinear optics of III-V semiconductors in the terahertz regime: an ab-initio study

We compute from first principles the infrared dispersion of the nonlinear susceptibility $\chi^{(2)}$ in zincblende semiconductors. At terahertz frequencies the nonlinear susceptibility depends not only on the purely electronic response $\chi^{(2)}_{\infty}$, but also on three other parameters $C_1$, $C_2$ and $C_3$ describing the contributions from ionic motion. They relate to the TO Raman polarizability, the second-order displacement-induced dielectric polarization, and the third-order lattice potential. Contrary to previous theory, we find that mechanical anharmonicity ($C_3$) dominates over electrical anharmonicity ($C_2$), which is consistent with recent experiments on GaAs. We predict that the sharp minimum in the intensity of second-harmonic generation recently observed for GaAs between $\omega_{\rm TO}/2$ and $\omega_{\rm TO}$ does not occur for several other III-V compounds.Comment: 9 pages, 3 figures; updated bibliograph

The ubiquitin proteasome system in Huntington's disease and the spinocerebellar ataxias

Huntington's disease and several of the spinocerebellar ataxias are caused by the abnormal expansion of a CAG repeat within the coding region of the disease gene. This results in the production of a mutant protein with an abnormally expanded polyglutamine tract. Although these disorders have a clear monogenic cause, each polyglutamine expansion mutation is likely to cause the dysfunction of many pathways and processes within the cell. It has been proposed that the ubiquitin proteasome system is impaired in polyglutamine expansion disorders and that this contributes to pathology. However, this is controversial with some groups demonstrating decreased proteasome activity in polyglutamine expansion disorders, some showing no change in activity and others demonstrating an increase in proteasome activity. It remains unknown whether the ubiquitin proteasome system is a feasible therapeutic target in these disorders. Here we review the conflicting results obtained from different assays performed in a variety of different systems

Mineral status in canine medial coronoid process disease: a cohort study using analysis of hair by mass spectrometry

In several species, developmental skeletal diseases involving abnormal endochondral ossification have been associated with imbalanced mineral intake. Hair analysis reflects long-term mineral status. To determine the mineral content of hair from dogs with or without medial coronoid process disease (MCPD). Dogs with MCPD have a different profile of minerals known to influence metalloenzymes involved in endochondral ossification. After cleansing, chelation and acid digestion of hair samples (n=79 in total: control dogs, n=70 v MCPD, n=9), mineral profile (7 major and 25 trace elements) was determined by inductively coupled plasma-mass spectrometry. Dogs were of similar age (control, 4.05 [1.85-7.70] v MCPD, 4.30 [3.25-6.53] median (IQR) years; P=0.78) and gender (control, n=43/27 v MCPD, n=4/5 males/females). 28/70 (40 per cent) of control and 8/9 (88 per cent) of MCPD dogs were neutered, respectively. Hair from dogs with MCPD contained significantly lower amounts (µg/g/DM) of copper, sulphur and zinc (all at P<0.001). Age, sex and neutered status had no effect on hair mineral status. Based on hair analysis, a role for mineral imbalance including copper, sulphur and zinc in the aetiopathogenesis of canine MCPD is suggested. Hair mineral analysis may prove useful as a biomarker for susceptible puppies

The role of anatomy demonstrators: surgical trainees’ perspective

ABSTRACT Core Surgical Trainees (CST) in the London (UK) Postgraduate School of Surgery receive clinical anatomy teaching in their first year of training, and, in their second year, give thirty sessions of anatomy teaching to medical and other students. This study set out to investigate the role of demonstrators from the perspective of the trainees. A focus group was convened to ascertain trainees’ perspectives on demonstrating anatomy and to identify problems and improvement strategies to optimise their ability to enhance students’ learning. A questionnaire was formulated and all second-year CST (n=186 – from two cohorts) in the London Postgraduate School of Surgery were invited. A total of 109 out of 186 trainees completed the questionnaire. A high percentage (98%) of trainees that completed the questionnaire responded that demonstrating was an invaluable part of their training. Sixty-two per cent responded that anatomy teaching they received in their first year of core surgical training helped them in their teaching role and 80% responded that it helped them prepare for surgical training. The study also revealed the need for improved communication between trainees and the London Postgraduate School of Surgery / Medical Schools / National Health Service Trusts to address issues such as trainees’ perceived difficulty in fulfilling their teaching session requirement. The stakeholders have acknowledged and addressed the outcomes to improve the experience for both surgical trainees and students. The results indicate that anatomy demonstrating delivers important benefits to early surgical trainees, in addition to those received by the students that they teach

Five rules for managing large, complex projects

Large-scale, long-term projects are notoriously difficult to manage. But recent research on megaprojects — defined as projects costing more than $1 billion — reveals five lessons that can help executives manage any big, complex project more effectively

Effects of plastic pre-straining level on the creep deformation, crack initiation and growth behaviour of 316H stainless steel

The effects of the material pre-straining level, in the form of plastic pre-compression at room temperature, on the tensile, creep deformation, creep crack initiation and growth behaviour of 316H stainless steel have been examined at 550 °C. Experiments have been performed on the 4%, 8% and 12% pre-compressed specimens and the results are compared with existing data on the pre-compressed material to investigate the change in mechanical response, creep failure, creep crack initiation and growth behaviour of 316H over a range of plastic pre-straining levels. Comparisons are also made to short term and long term test data on the as-received material. It has been found that creep ductility and rupture times decreased with an increase in pre-strain levels considered. The test results obtained from different material states are discussed in terms of the influence of material pre-straining level on the microstructural deformation, mechanical response, creep deformation and crack growth behaviour of the material

Self-defining memories predict engagement in structured activity in First Episode Psychosis, independent of neurocognition and metacognition

Background: Self-defining memories (SDM) are vivid personal memories, related to narrative identity. Individuals with schizophrenia report less specific, more negative, and extract less meaning from these memories compared to control groups. Self-defining memories have been shown to be predicted by neurocognition, associated with metacognition, and linked to goal outcomes in healthy controls. As neurocognition and metacognition are known predictors of poor functioning in psychosis, self-defining memories may also be a predictor. No study has assessed the relationship to functioning or pattern of SDMs in First Episode Psychosis. Methods: This was a cross-sectional study involving 71 individuals with First Episode Psychosis (FEP) and 57 healthy controls who completed a self-defining memories questionnaire. FEP participants completed measures of neurocognition, metacognition (Metacognitive Assessment Interview), functional capacity (The UCSD Performance-Based Skills Assessment) and functional outcome (Time-Use Survey). Results: Self-defining memories reported by individuals with FEP were less integrated compared to healthy controls. Within the FEP sample, holding less specific memories was associated with engagement in significantly fewer hours of structured activity per week and specificity of SDMs mediated the relationship between neurocognition and functional outcome, independent of metacognition. Conclusion: This is the first study to assess SDMs in FEP and to explore the important role of SDMs on clinical outcomes, compared to healthy controls. This study suggests that elaborating on specific self-defining memories is a valid therapeutic target and may be considered a tool to improve daily functioning in FEP

RXJ0142.0+2131: I. The galaxy content of an X-ray-luminous galaxy cluster at z=0.28

We present a photometric and spectroscopic study of stellar populations in the X-ray-luminous cluster of galaxies RXJ0142.0+2131 at z=0.280. This paper analyses the results of high signal-to-noise spectroscopy, as well as g'-, r'-, and i'-band imaging, using the Gemini Multi-Object Spectrograph on Gemini North. Of 43 spectroscopic targets, we find 30 cluster members over a range in color. Central velocity dispersions and absorption-line strengths for lines in the range 3700A < lambda_rest < 5800A are derived for cluster members, and are compared with a low-redshift sample of cluster galaxies, and single stellar population (SSP) models. We use a combination of these indicators to estimate luminosity-weighted mean ages, metallicities ([M/H]), and alpha-element abundance ratios ([alpha/Fe]). RXJ0142.0+2131 is a relatively poor cluster and lacks galaxies with high central velocity dispersions. Although the red sequence and the Faber-Jackson relation are consistent with pure passive evolution of the early-type population with a formation redshift of z_form = 2, the strengths of the 4000A break and scaling relations between metal line indices and velocity dispersion reject this model with high significance. By inverting SSP models for the Hbeta_G, Mgb, and line indices, we calculate that, at a given velocity dispersion and metallicity, galaxies in RXJ0142.0+2131 have luminosity-weighted mean ages 0.14 +- 0.07 dex older than the low-redshift sample. We also find that [alpha/Fe] in stellar populations in RXJ0142.0+2131 is 0.14 +- 0.03 greater than at low redshift. All scaling relations are consistent with these estimated offsets. (abridged)Comment: AJ, accepted. 31 pages, 13 figures, uses emulateapj.cls. High-resolution figures available on request from first autho