744 research outputs found
History of depression and survival after acute myocardial infarction
Objective: To compare survival in post-myocardial (MI) participants from the Enhancing Recovery In Coronary Heart Disease (ENRICHD) clinical trial with a first episode of major depression (MD) and those with recurrent MID, which is a risk factor for mortality after acute MI. Recent reports suggest that the level of risk may depend on whether the comorbid MD is a first or a recurrent episode. Methods: Survival was compared over a median of 29 months in 370 patients with an initial episode of MD, 550 with recurrent MD, and 408 who were free of depression. Results: After adjusting for an all-cause mortality risk score, initial Beck Depression Inventory score, and the use of selective serotonin reuptake inhibitor antidepressants, patients with a first episode of MD had poorer survival (18.4% all-cause mortality) than those with recurrent MD (11.8%) (hazard ratio (HR)=1.4; 95% Confidence Interval (CI)=1.0-2.0; p=.05). Both first depression (HR=3.1; 95% CI=1.6-6.1; p=.001) and recurrent MD (HR=2.2; 95% CI=1.1-4.4; p=.03) had significantly poorer survival than did the nondepressed patients (3.4%). A secondary analysis of deaths classified as probably due to a cardiovascular cause resulted in similar HRs, but the difference between depression groups was not significant. Conclusions: Both initial and recurrent episodes of MD predict shorter survival after acute MI, but initial MD episodes are more strongly predictive than recurrent episodes. Exploratory analyses suggest that this cannot be explained by more severe heart disease at index, poorer response to depression treatment, or a higher risk of cerebrovascular disease in patients with initial MD episodes
Gauged Dimension Bubbles
Some of the peculiar electrodynamical effects associated with gauged
``dimension bubbles'' are presented. Such bubbles, which effectively enclose a
region of 5d spacetime, can arise from a 5d theory with a compact extra
dimension. Bubbles with thin domain walls can be stabilized against total
collapse by the entrapment of light charged scalar bosons inside the bubble,
extending the idea of a neutral dimension bubble to accommodate the case of a
gauged U(1) symmetry. Using a dielectric approach to the 4d dilaton-Maxwell
theory, it is seen that the bubble wall is almost totally opaque to photons,
leading to a new stabilization mechanism due to trapped photons. Photon
dominated bubbles very slowly shrink, resulting in a temperature increase
inside the bubble. At some critical temperature, however, these bubbles
explode, with a release of radiation.Comment: 14 pages, no figures; to appear in Phys.Rev.
Family Unification with SO(10)
Unification based on the group SO(10)^3 \times S_3 is studied. Each family
has its own SO(10) group, and the S_3 permutes the three families and SO(10)
factors. This is the maximal local symmetry for the known fermions. Family
unification is achieved in the sense that all known fermions are in a single
irreducible multiplet of the symmetry. The symmetry suppresses SUSY flavor
changing effects by making all squarks and sleptons degenerate in the symmetry
limit. Doublet-triplet splitting can arise simply, and non-trivial structure of
the quark and lepton masses emerges from the gauge symmetry, including the
"doubly lopsided" form.Comment: 11 pages, references adde
TeV scale resonant leptogenesis from supersymmetry breaking
We propose a model of TeV-scale resonant leptogenesis based upon recent
models of the generation of light neutrino masses from supersymmetry-breaking
effects with TeV-scale right-handed (rhd) neutrinos, . The model leads to
naturally large cosmological lepton asymmetries via the resonant behaviour of
the one-loop self-energy contribution to decay. Our model addresses the
primary problems of previous phenomenological studies of low-energy
leptogenesis: a rational for TeV-scale rhd neutrinos with small Yukawa
couplings so that the out-of equilibrium condition for decay is
satisfied; the origin of the tiny, but non-zero mass splitting required between
at least two masses; and the necessary non-trivial breaking of flavour
symmetries in the rhd neutrino sector. The low mass-scale of the rhd neutrinos
and their superpartners, and the TeV-scale -terms automatically contained
within the model offer opportunities for partial direct experimental tests of
this leptogenesis mechanism at future colliders.Comment: 10 Pages latex, version for JHE
Association of HLA types A1-B8-DR3 and B27 with rapid and slow progression of HIV disease
We examined how HLA types A1-B8-DR3 and B27 were related to progression of clinical disease and rate of loss of CD4 lymphocytes in the Edinburgh City Hospital cohort of HIV-positive patients, mainly injection drug users. Patients (n = 692) were prospectively followed from 1985 through March 1994. Accurately estimated seroconversion times were determined retrospectively for a subgroup of 313 (45%). Of 262 patients (39%) who were fully or partially HLA typed, 155 (50%) had known seroconversions. Of 34 patients typed positive for A1-B8-DR3, 29 progressed to CDC stage IV, 22 to AIDS and 20 died. Twelve patients were typed positive for B27; six of these progressed to CDC stage IV, one to AIDS and none died. In a proportional hazards analysis of the 313 patients with known seroconversions, A1-B8-DR3 was significantly associated with covariate-adjusted relative risks of 3.7 (95% CI 1.9-7.2), 3.1 (1.6-6.0) and 1.9 (1.1-3.2) for progression from seroconversion to death, AIDS and CDC stage IV, respectively. Events for B27 were too rare to include B27 in analyses to death and AIDS, but B27 was significantly associated with slower progression to CDC stage IV (0.3, CI 0.1-0.9). Random effects growth curve models were used to estimate individual rates of loss of square root CD4 count and loss of CD4 percentage, for 603 and 617 patients, respectively. A1-B8-DR3 was associated with rapid loss of both markers (p=0.02 and p = 0.01, respectively); B27 was associated with slow loss of both markers (p=0.04 and p<0.005
The Interplay Between the "Low" and "High" Energy CP-Violation in Leptogenesis
We analyse within the "flavoured" leptogenesis scenario of baryon asymmetry
generation, the interplay of the "low energy" CP-violation, originating from
the PMNS neutrino mixing matrix , and the "high energy" CP-violation which
can be present in the matrix of neutrino Yukawa couplings, , and can
manifest itself only in "high" energy scale processes. The type I see-saw model
with three heavy right-handed Majorana neutrinos having hierarchical spectrum
is considered. The "orthogonal" parametrisation of the matrix of neutrino
Yukawa couplings, which involves a complex orthogonal matrix , is employed.
In this approach the matrix is the source of "high energy" CP-violation.
Results for normal hierarchical (NH) and inverted hierarchical (IH) light
neutrino mass spectrum are derived in the case of decoupling of the heaviest RH
Majorana neutrino. It is shown that taking into account the contribution to
due to the CP-violating phases in the neutrino mixing matrix can
change drastically the predictions for , obtained assuming only "high
energy" CP-violation from the -matrix is operative in leptogenesis. In the
case of IH spectrum, in particular, there exist significant regions in the
corresponding parameter space where the purely "high energy" contribution in
plays a subdominant role in the production of baryon asymmetry compatible
with the observations.Comment: Results unchanged; comments and references added; version to be
puplished in Eur.Phys.J.
Can R-parity violation explain the LSND data as well?
The recent Super-Kamiokande data now admit only one type of mass hierarchy in
a framework with three active and one sterile neutrinos. We show that neutrino
masses and mixings generated by R-parity-violating couplings, with values
within their experimental upper limits, are capable of reproducing this
hierarchy, explaining all neutrino data particularly after including the LSND
results.Comment: 7 pages, Latex, 3 PS figures; in v2 a few clarifying remarks included
and two references added (to appear in Physical Review D
Remarks on the forces generated by two-neutrino exchange
A brief up-to-date review of the long range forces generated by two neutrino
exchange is presented. The potential due to exchange of a massive
neutrino-antineutrino pair between particles carrying weak charge might be
larger than expected if the neutrinos have not only masses but also magnetic
moments close to the present experimental bounds. It still remains too small to
be observable.Comment: 10 pages, 3 figures. One figure added. Accepted for publication in
EPJ
IMproving Preclinical Assessment of Cardioprotective Therapies (IMPACT) criteria : guidelines of the EU-CARDIOPROTECTION COST Action
Full list of the EU-CARDIOPROTECTION COST Action CA16225 Working group members is provided at the end of the article in Acknowledgements section. Funding Information: This article is based on the work from COST Action EU-CARDIOPROTECTION CA16225 supported by COST (European Cooperation in Science and Technology). DJH is supported by the Duke-National University Singapore Medical School, Singapore Ministry of Health’s National Medical Research Council under its Clinician Scientist-Senior Investigator scheme (NMRC/CSA-SI/0011/2017) and Collaborative Centre Grant scheme (NMRC/CGAug16C006). SL is supported by grants from the South African Department of Science and Technology and the South African National Research Foundation. SMD is supported by grants from the British Heart Foundation (PG/19/51/34493 and PG/16/85/32471). GH is supported by the German Research Foundation (SFB 1116 B8). MRM is supported by the Spanish Institute of Health Carlos III (FIS PI19/01196 and CIBER-CV). RS is supported by Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [Project number 268555672—SFB 1213, Project B05]. PF is supported by the National Research, Development and Innovation Office of Hungary (Research Excellence Program—TKP, National Heart Program NVKP 16-1-2016-0017) and by the Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the Therapeutic Development thematic program of the Semmelweis University. Funding Information: The IMPACT criteria were presented for approval to the Management Committee of the EU-CARDIOPROTECTION COST Action CA16225: Pavle Adamovski, Ioanna Andreadou, Saime Batirel, Monika Bartekov?, Luc Bertrand, Christophe Beauloye, David Biedermann, Vilmante Borutaite, Hans Erik Botker, Stefan Chlopicki, Maija Dambrova, Sean Davidson, Yvan Devaux, Fabio Di Lisa, Dragan Djuric, David Erlinge, Ines Falcao-Pires, P?ter Ferdinandy, Eleftheria Galatou, Alfonso Garcia-Sosa, Henrique Girao, Zoltan Giricz, Mariann Gyongyosi, Derek J Hausenloy, Donagh Healy, Gerd Heusch, Vladimir Jakovljevic, Jelena Jovanic, George Kararigas, Risto Kerkal, Frantisek Kolar, Brenda Kwak, Przemys?aw Leszek, Edgars Liepinsh , Jacob Lonborg, Sarah Longnus, Jasna Marinovic, Danina Mirela Muntean, Lana Nezic, Michel Ovize, Pasquale Pagliaro, Clarissa Pedrosa Da Costa Gomes, John Pernow, Andreas Persidis, S?ren Erik Pischke, Bruno Podesser, Ines Poto?njak, Fabrice Prunier, Tanya Ravingerova, Marisol Ruiz-Meana, Alina Serban, Katrine Slagsvold, Rainer Schulz, Niels van Royen, Belma Turan, Marko Vendelin, Stewart Walsh, Nace Zidar, Coert Zuurbier, Derek Yellon. Publisher Copyright: © 2021, The Author(s).Acute myocardial infarction (AMI) and the heart failure (HF) which may follow are among the leading causes of death and disability worldwide. As such, new therapeutic interventions are still needed to protect the heart against acute ischemia/reperfusion injury to reduce myocardial infarct size and prevent the onset of HF in patients presenting with AMI. However, the clinical translation of cardioprotective interventions that have proven to be beneficial in preclinical animal studies, has been challenging. One likely major reason for this failure to translate cardioprotection into patient benefit is the lack of rigorous and systematic in vivo preclinical assessment of the efficacy of promising cardioprotective interventions prior to their clinical evaluation. To address this, we propose an in vivo set of step-by-step criteria for IMproving Preclinical Assessment of Cardioprotective Therapies (‘IMPACT’), for investigators to consider adopting before embarking on clinical studies, the aim of which is to improve the likelihood of translating novel cardioprotective interventions into the clinical setting for patient benefit.publishersversionPeer reviewe
TeV-scale seesaw from a multi-Higgs model
We suggest new simple model of generating tiny neutrino masses through a
TeV-scale seesaw mechanism without requiring tiny Yukawa couplings. This model
is a simple extension of the standard model by introducing extra one Higgs
singlet, and one Higgs doublet with a tiny vacuum expectation value.
Experimental constraints, electroweak precision data and no large flavor
changing neutral currents, are satisfied since the extra doublet only has a
Yukawa interaction with lepton doublets and right-handed neutrinos, and their
masses are heavy of order a TeV-scale. Since active light neutrinos are
Majorana particles, this model predicts a neutrinoless double beta decay.Comment: 21 pages, 8 figure
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