The relationship between the CEFI, as a measure for executive function, and the BASC-3, as a measure of externalizing behavior, on school problems for children receiving special education services

This study examined the relationship between executive function and externalizing behaviors within a student population that was assessed for special education services. Executive function was measured by using the Comprehensive Executive Function Inventory (CEFI). Externalizing behaviors and school problems was measured using the Behavior Assessment System for Children, Third Edition (BASC-3). Four separate structural equation models were produced and analyzed to examine this relationship. The results from this study indicate that there is a significant direct effect from executive function on externalizing behaviors and school problems, such that higher scores in executive function yielded lower externalizing behavior and school problems scores. Differences in average full scale CEFI scores were noted between types of special education placements and between various groupings of students in regards to what category they qualified in. The data indicates programs that facilitated more environmental supports and services had students with lower full scale CEFI scores, while students that qualified under Other Health Impairment and Emotional Disturbance shared comorbid features with other distinct processing deficits

Addressing the IS Enrollment Crisis: A 12-step Program to Bring about Change through the Introductory IS Course

An enrollment crisis continues to plague the Information Systems (IS) discipline. Although recent studies have begun to offer several potentially profitable strategies to reverse plummeting student enrollments, little evidence has been put forth to document comprehensive intervention initiatives aimed at attracting students in higher education institutions. To this end, this study describes a 12-step program targeted at the introductory IS course at one such institution. Developed based on empirical evidence from the literature, discussions with our IS colleagues, and best practices at other institutions, the 12-step program covers all aspects of the course including faculty assignment, tenor and approaches used in class, and innovative ways to tell the IS story. As a result of implementing the program, enrollments in core upper-division IS courses at the institution doubled. This paper presents a powerful, integrated program that is replicable and can be used by other IS departments to address the enrollment crisis at their institutions

TCR Convergence in Individuals Treated With Immune Checkpoint Inhibition for Cancer.

Tumor antigen-driven selection may expand T cells having T cell receptors (TCRs) of shared antigen specificity but different amino acid or nucleotide sequence in a process known as TCR convergence. Substitution sequencing errors introduced by TCRβ (TCRB) repertoire sequencing may create artifacts resembling TCR convergence. Given the anticipated differences in substitution error rates across different next-generation sequencing platforms, the choice of platform could be consequential. To test this, we performed TCRB sequencing on the same peripheral blood mononuclear cells (PBMC) from individuals with cancer receiving anti-CTLA-4 or anti-PD-1 using an Illumina-based approach (Sequenta) and an Ion Torrent-based approach (Oncomine TCRB-LR). While both approaches found similar TCR diversity, clonality, and clonal overlap, we found that Illumina-based sequencing resulted in higher TCR convergence than with the Ion Torrent approach. To build upon this initial observation we conducted a systematic comparison of Illumina-based TCRB sequencing assays, including those employing molecular barcodes, with the Oncomine assay, revealing differences in the frequency of convergent events, purportedly artifactual rearrangements, and sensitivity of detection. Finally, we applied the Ion Torrent-based approach to evaluate clonality and convergence in a cohort of individuals receiving anti-CTLA-4 blockade for cancer. We found that clonality and convergence independently predicted response and could be combined to improve the accuracy of a logistic regression classifier. These results demonstrate the importance of the sequencing platform in assessing TCRB convergence

Rapid Effective Trace-Back Capability Value in Reducing the Cost of a Foot and Mouth Disease Event

This study evaluates how the availability of animal tracing affects the cost of a hypothetical Foot and Mouth Disease (FMD) outbreak in the Texas High Plains using alternative tracing scenarios. To accomplish this objective, the AusSpread epidemic disease spread model (Ward et al., 2006) is used to simulate a High Plains FMD outbreak under different animal tracing possibilities. A simple economic costing module (Elbakidze, 2008) is used to determine the savings in terms of animal disease mitigation costs from rapid, effective trace-back. The savings from increased traceability are then be compared to the cost of a functional National Animal Identification System (NAIS). Initial results indicate that rapid, effective tracing reduces the overall cost of disease outbreaks and that the benefits per animal in terms of reduced cost of an outbreak more than outweigh the annualized cost per animal of implementing a NAIS. A value of time related to controlling an outbreak is estimated to have increased benefits from an identification system that incorporates a rapid response capability. We also find the level of benefits vary depending on the location of initial infection and whether or not welfare slaughter occurs.Traceability, Foot and Mouth Disease, Economics, Agricultural and Food Policy, Livestock Production/Industries,

Sawflies (Hymenoptera, Symphyta) Newly Recorded from Washington State

Examination of museum specimens, unpublished collection data, and field surveys conducted between 2010 and 2014 resulted in records for 22 species of sawflies new to Washington State, seven of which are likely to be pest problems in ornamental landscapes. These data highlight the continued range expansion of exotic species across North America. These new records also indicate that our collective knowledge of Pacific Northwest arthropod biodiversity and biogeography is underdeveloped, even for a relatively well known and species-poor group of insects. Notable gaps in the knowledge of Washington State’s Symphyta remain for the Olympic Peninsula, the Cascade Mountain Range, and the arid interior of the state. Washington’s shrub-steppe appears to be particularly poorly surveyed for sawflies

Sawflies (Hymenoptera, Symphyta) Newly Recorded from Washington State

Examination of museum specimens, unpublished collection data, and field surveys conducted between 2010 and 2014 resulted in records for 22 species of sawflies new to Washington State, seven of which are likely to be pest problems in ornamental landscapes. These data highlight the continued range expansion of exotic species across North America. These new records also indicate that our collective knowledge of Pacific Northwest arthropod biodiversity and biogeography is underdeveloped, even for a relatively well known and species-poor group of insects. Notable gaps in the knowledge of Washington State’s Symphyta remain for the Olympic Peninsula, the Cascade Mountain Range, and the arid interior of the state. Washington’s shrub-steppe appears to be particularly poorly surveyed for sawflies

Clinical depression and punishment sensitivity on the BART

Depression is associated with altered sensitivity to reward and punishment, which can influence complex decision-making. We examined punishment sensitivity in the performance of participants with major depressive disorder (MDD) with that of a comparison group on the automatic Balloon Analogue Risk Task (BART), which is a direct measure of risk taking. The present study examined the BART performance of 30 individuals with MDD and 30 matched comparison individuals. The comparison group (M = 63.25) entered a significantly (p < 0.001; d = 1.1) higher number of pumps on the BART than the MDD group (M = 50.83). Higher levels of depression symptoms were significantly correlated (r = -0.40, p < 0.05) with entering a lower number of pumps in the MDD group. MDD patients showed an increased sensitivity to punishment on the BART: after a loss, the MDD group decreased (M = 13.7) the number of subsequent pumps they entered by a significantly (p < 0.001, d = 0.81) greater amount than the comparison group (M = 4.35). This difference applied to losses only: no difference was found between the groups regarding the magnitude of change in pumps selected after a win. Findings suggest the presence of elevated punishment sensitivity among individuals with MDD, which may contribute to the maintenance of depressive symptoms