15 research outputs found
第702回千葉医学会例会・第1内科教室同門会例会 17.
Description of patients included at each time point in each of the development and validation samples. (DOC 37 kb
第673回千葉医学会整形外科例会 28.
Description of patients included at each time point in each of the development and validation samples. (DOC 37 kb
Additional file 1: of Cost-effectiveness of a cardiac output-guided haemodynamic therapy algorithm in high-risk patients undergoing major gastrointestinal surgery
Supplementary data describing costs and the findings of sub-group analyses and sensitivity analyses. The additional file 1 includes supplementary information on unit costs of resources, 6 months results (hospital costs, sub-group results, cost-effectiveness acceptability curves), Kaplan-Meier survival curves and parametric extrapolation of survival beyond trial period, results of sensitivity analysis and populationexpected value of perfect information
Additional file 3: of Dynamic modulation of phosphoprotein expression in ovarian cancer xenograft models
Differential protein expression. Log fold changes of differentially expressed proteins over 14Â days are shown in 4 worksheets, each for a xenograft-treatment condition: carboplatin treated OV1002; carboplatin treated HOX424; carboplatin-paclitaxel treated OV1002; carboplatin-paclitaxel treated HOX424. (XLS 57 kb
Additional file 2: of FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care
Figure S2. Study algorithm for the management of patients randomised to continuous positive airway pressure. (PDF 156 kb
Additional file 4: of FIRST-line support for Assistance in Breathing in Children (FIRST-ABC): a multicentre pilot randomised controlled trial of high-flow nasal cannula therapy versus continuous positive airway pressure in paediatric critical care
Figure S3. Crossover and escalation to invasive ventilation within 72Â h of starting the randomised treatment by treatment group. (PDF 50 kb
Additional file 5: Table S4. of Predicting invasive fungal disease due to Candida species in non-neutropenic, critically ill, adult patients in United Kingdom critical care units
Final risk models at admission, 24Â h and end of calendar day 3. (DOC 44 kb
Irish National ICU Audit Annual Report 2017
By the end of 2017, the Irish National Intensive Care Unit Audit (INICUA) run by the National Office of Clinical Audit (NOCA) covered 58% of Intensive Care Unit (ICU) activity in adult Health Service Executive (HSE) funded hospitals (12 Units in nine hospitals) and all ICU activity in both specialist paediatric hospitals in the Republic of Ireland (ROI).</div
Additional file 1: Table S1. of Predicting invasive fungal disease due to Candida species in non-neutropenic, critically ill, adult patients in United Kingdom critical care units
Site of Candida invasive fungal disease (Nâ=â359). (DOC 31 kb
1,2,4-Triazolo-[1,5‑<i>a</i>]pyridine HIF Prolylhydroxylase Domain‑1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction
Herein
we describe the identification of 4-{[1,2,4]triazolo[1,5-<i>a</i>]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible
factor prolylhydroxylase domain-1 (PHD-1) enzyme. These inhibitors
were shown to possess a novel binding mode by X-ray crystallography,
in which the triazolo N1 atom coordinates in a hitherto unreported
monodentate interaction with the active site Fe<sup>2+</sup> ion,
while the benzonitrile group accepts a hydrogen-bonding interaction
from the side chain residue of Asn315. Further optimization led to
potent PHD-1 inhibitors with good physicochemical and pharmacokinetic
properties