Pisces IV submersible observations in the epicentral region of the 1929 Grand Banks earthquake

The PISCES IVsubmersible was used to investigate the upper continental slope around 44 ON, 56 W, near the epicentre of the 1929 Grand Banks earthquake. Four dives in water depths of 800-2000 m were undertaken to observe speci3c features identijied with the SeaMARC I sidescan system in 1983. Two dives were made in the head of Eastern Valley where pebbly mudstones ofprobable Pleistocene age were recognized outcropping on the seafloor. Constructional features of cobbles and boulders, derived by exhumation and reworking of the pebbly mudstone, were also observed. These include gravel/sand bedforms (transverse waves) on the valley floor. Slope failure features in semiconsolidated mudstone were recognized on two dives onto the St. Pierre slope. Exposures in these mudstones are rapidly eroded by intense burrowing by benthic organisms

Single-cell western blotting.

To measure cell-to-cell variation in protein-mediated functions, we developed an approach to conduct ∼10(3) concurrent single-cell western blots (scWesterns) in ∼4 h. A microscope slide supporting a 30-μm-thick photoactive polyacrylamide gel enables western blotting: settling of single cells into microwells, lysis in situ, gel electrophoresis, photoinitiated blotting to immobilize proteins and antibody probing. We applied this scWestern method to monitor single-cell differentiation of rat neural stem cells and responses to mitogen stimulation. The scWestern quantified target proteins even with off-target antibody binding, multiplexed to 11 protein targets per single cell with detection thresholds of <30,000 molecules, and supported analyses of low starting cell numbers (∼200) when integrated with FACS. The scWestern overcomes limitations of antibody fidelity and sensitivity in other single-cell protein analysis methods and constitutes a versatile tool for the study of complex cell populations at single-cell resolution

Arraché au feu : le sauvetage du patrimoine culturel juif de Wilna

L’article de David Fishman, d’abord paru en 1996 dans une version bilingue yiddish-anglais sous les auspices du YIVO, a été ensuite traduit du yiddish et publié en allemand dans une édition bilingue par Maria Kühn- Ludewig pour le périodique professionnel indépendant Laurentius. (« Dem Feuer entrissen : die Rettung jüdischer Kulturschätze in Wilna », David E. Fishman. Hannover, Laurentius, 1998. 50 p. ISBN 3-931614-97-2). Son auteur est chercheur associé au YIVO de New York et au Jewish Theological Seminary of America . Il a publié Russia first modern Jews : the Jews of Shklov (New York University Press, 1996. ISBN 0814726607), une histoire de la communauté de Shklov (aujourd’hui en Biélorussie). Après le témoignage de Dina Abramowicz sur la bibliothèque du ghetto de Wilna publié dans le numéro 4 (octobre 2002) de BIBLIOthèque(s) et l’article de Kornelia Richter sur la lecture à Terezin publié dans le numéro 5/6, cette étude sur la tentative de sauvegarde du patrimoine juif de Wilna clôt la série d’articles consacrée aux bibliothèques et à la lecture dans les camps et dans les ghettos. La suite et fin du texte de David Fishman paraîtra dans le numéro 8 d’avril 2003. L’étude montre un autre aspect de l’extrême valorisation de la lecture et de l’écrit dans la société juive d’Europe orientale au début du XXe siècle, celui de la constitution et de la préservation du patrimoine, et éclaire dans le détail la dimension culturelle de la spoliation systématique opérée par les Allemands

Incidence, outcomes, and risk factors of pleural effusion in patients receiving dasatinib therapy for Philadelphia chromosome-positive leukemia.

Dasatinib, a second-generation BCR-ABL1 tyrosine kinase inhibitor, is approved for the treatment of chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia, both as first-line therapy and after imatinib intolerance or resistance. While generally well tolerated, dasatinib has been associated with a higher risk for pleural effusions. Frequency, risk factors, and outcomes associated with pleural effusion were assessed in two phase 3 trials (DASISION and 034/Dose-optimization) and a pooled population of 11 trials that evaluated patients with chronic myeloid leukemia and Philadelphia chromosome-positive acute lymphoblastic leukemia treated with dasatinib (including DASISION and 034/Dose-optimization). In this largest assessment of patients across the dasatinib clinical trial program (N=2712), pleural effusion developed in 6-9% of patients at risk annually in DASISION, and in 5-15% of patients at risk annually in 034/Dose-optimization. With a minimum follow up of 5 and 7 years, drug-related pleural effusion occurred in 28% of patients in DASISION and in 33% of patients in 034/Dose-optimization, respectively. A significant risk factor identified for developing pleural effusion by a multivariate analysis was age. We found that overall responses to dasatinib, progression-free survival, and overall survival were similar in patients who developed pleural effusion and in patients who did not. clinicaltrials.gov identifier 00481247; 00123474

The Structure of Screening in QED

The possibility of constructing charged particles in gauge theories has long been the subject of debate. In the context of QED we have shown how to construct operators which have a particle description. In this paper we further support this programme by showing how the screening interactions arise between these charges. Unexpectedly we see that there are two different gauge invariant contributions with opposite signs. Their difference gives the expected result.Comment: 8 pages, LaTe

3D geological models and their hydrogeological applications : supporting urban development : a case study in Glasgow-Clyde, UK

Urban planners and developers in some parts of the United Kingdom can now access geodata in an easy-to-retrieve and understandable format. 3D attributed geological framework models and associated GIS outputs, developed by the British Geological Survey (BGS), provide a predictive tool for planning site investigations for some of the UK's largest regeneration projects in the Thames and Clyde River catchments. Using the 3D models, planners can get a 3D preview of properties of the subsurface using virtual cross-section and borehole tools in visualisation software, allowing critical decisions to be made before any expensive site investigation takes place, and potentially saving time and money. 3D models can integrate artificial and superficial deposits and bedrock geology, and can be used for recognition of major resources (such as water, thermal and sand and gravel), for example in buried valleys, groundwater modelling and assessing impacts of underground mining. A preliminary groundwater recharge and flow model for a pilot area in Glasgow has been developed using the 3D geological models as a framework. This paper focuses on the River Clyde and the Glasgow conurbation, and the BGS's Clyde Urban Super-Project (CUSP) in particular, which supports major regeneration projects in and around the City of Glasgow in the West of Scotland

Double-impulse magnetic focusing of launched cold atoms.

We have theoretically investigated three-dimensional focusing of a launched cloud of cold atoms using a pair of magnetic lens pulses (the alternate-gradient method). Individual lenses focus radially and defocus axially or vice versa. The performance of the two possible pulse sequences are compared and found to be ideal for loading both 'pancake' and 'sausage' shaped magnetic/optical microtraps. It is shown that focusing aberrations are considerably smaller for double-impulse magnetic lenses compared to single-impulse magnetic lenses. An analysis of clouds focused by the double-impulse technique is presented

Generating summary documents for a variable-quality PDF document collection

The Cochrane Schizophrenia Group’s Register of studies details all aspects of the effects of treating people with schizophrenia. It has been gathered over the last 20 years and consists of around 20,000 documents, overwhelmingly in PDF. Document collections of this sort – on a given theme but gathered from a wide range of sources – will generally have huge variability in the quality of the PDF, particularly with respect to the key property of text searchability. Summarising the results from the best of these papers, to allow evidence-based health care decision making, has so far been done by manually creating a summary document, starting from a visual inspection of the relevant PDF file. This labour-intensive process has resulted, to date, in only 4,000 of the papers being summarised – with enormous duplication of effort and with many issues around the validity and reliability of the data extraction. This paper describes a pilot project to provide a computer-assisted framework in which any of the PDF documents could be searched for the occurrence of some 8,000 keywords and key phrases.Once keyword tagging has been completed the framework assists in the generation of a standard summary document, thereby greatly speeding up the production of these summaries. Early examples of the framework are described and its capabilities illustrated