New onshore insights into the role of structural inheritance during Mesozoic opening of the Inner Moray Firth Basin, Scotland

The Inner Moray Firth Basin (IMFB) forms the western arm of the North Sea trilete rift system that initiated mainly during the Late Jurassic–Early Cretaceous with the widespread development of major NE–SW-trending dip-slip growth faults. The IMFB is superimposed over the southern part of the older Devonian Orcadian Basin. The potential influence of older rift-related faults on the kinematics of later Mesozoic basin opening has received little attention, partly owing to the poor resolution of offshore seismic reflection data at depth. New field observations augmented by drone photography and photogrammetry, coupled with U–Pb geochronology, have been used to explore the kinematic history of faulting in onshore exposures along the southern IMFB margin. Dip-slip north–south- to NNE–SSW-striking Devonian growth faults are recognized that have undergone later dextral reactivation during NNW–SSE extension. The U–Pb calcite dating of a sample from the synkinematic calcite veins associated with this later episode shows that the age of fault reactivation is 130.99  ±  4.60 Ma (Hauterivian). The recognition of dextral-oblique Early Cretaceous reactivation of faults related to the underlying and older Orcadian Basin highlights the importance of structural inheritance in controlling basin- to sub-basin-scale architectures and how this influences the kinematics of IMFB rifting

New onshore insights into the role of structural inheritance during Mesozoic opening of the Inner Moray Firth Basin, Scotland

The Inner Moray Firth Basin (IMFB) forms the western arm of the North Sea trilete rift system that initiated mainly during the Late Jurassic–Early Cretaceous with the widespread development of major NE–SW-trending dip-slip growth faults. The IMFB is superimposed over the southern part of the older Devonian Orcadian Basin. The potential influence of older rift-related faults on the kinematics of later Mesozoic basin opening has received little attention, partly owing to the poor resolution of offshore seismic reflection data at depth. New field observations augmented by drone photography and photogrammetry, coupled with U–Pb geochronology, have been used to explore the kinematic history of faulting in onshore exposures along the southern IMFB margin. Dip-slip north–south- to NNE–SSW-striking Devonian growth faults are recognized that have undergone later dextral reactivation during NNW–SSE extension. The U–Pb calcite dating of a sample from the synkinematic calcite veins associated with this later episode shows that the age of fault reactivation is 130.99  ±  4.60 Ma (Hauterivian). The recognition of dextral-oblique Early Cretaceous reactivation of faults related to the underlying and older Orcadian Basin highlights the importance of structural inheritance in controlling basin- to sub-basin-scale architectures and how this influences the kinematics of IMFB rifting

Using UAV-Based Photogrammetry Coupled with In Situ Fieldwork and U-Pb Geochronology to Decipher Multi-Phase Deformation Processes: A Case Study from Sarclet, Inner Moray Firth Basin, UK

Constraining the age of formation and repeated movements along fault arrays in superimposed rift basins helps us to better unravel the kinematic history as well as the role of inherited structures in basin evolution. The Inner Moray Firth Basin (IMFB, western North Sea) overlies rocks of the Caledonian basement, the pre-existing Devonian–Carboniferous Orcadian Basin, and a regionally developed Permo–Triassic North Sea basin system. IMFB rifting occurred mainly in the Upper Jurassic–Lower Cretaceous. The rift basin then experienced further regional tilting, uplift and fault reactivation during the Cenozoic. The Devonian successions exposed onshore along the northwestern coast of IMFB and the southeastern onshore exposures of the Orcadian Basin at Sarclet preserve a variety of fault orientations and structures. Their timing and relationship to the structural development of the wider Orcadian and IMFB are poorly understood. In this study, drone airborne optical images are used to create high-resolution 3D digital outcrops. Analyses of these images are then coupled with detailed field observations and U-Pb geochronology of syn-faulting mineralised veins in order to constrain the orientations and absolute timing of fault populations and decipher the kinematic history of the area. In addition, the findings help to better identify deformation structures associated with earlier basin-forming events. This holistic approach helped identify and characterise multiple deformation events, including the Late Carboniferous inversion of Devonian rifting structures, Permian minor fracturing, Late Jurassic–Early Cretaceous rifting and Cenozoic reactivation and local inversion. We were also able to isolate characteristic structures, fault kinematics, fault rock developments and associated mineralisation types related to these event

2011 Report of NSF Workshop Series on Scientific Software Security Innovation Institute

Over the period of 2010-2011, a series of two workshops were held in response to NSF Dear Colleague Letter NSF 10-050 calling for exploratory workshops to consider requirements for Scientific Software Innovation Institutes (S2I2s). The specific topic of the workshop series was the potential benefits of a security-focused software institute that would serve the entire NSF research and development community. The first workshop was held on August 6th, 2010 in Arlington, VA and represented an initial exploration of the topic. The second workshop was held on October 26th, 2011 in Chicago, IL and its goals were to 1) Extend our understanding of relevant needs of MREFC and large NSF Projects, 2) refine outcome from first workshop with broader community input, and 3) vet concepts for a trusted cyberinfrastructure institute. Towards those goals, the participants other 2011workshop included greater representation from MREFC and large NSF projects, and, for the most part, did not overlap with the participants from the 2010 workshop. A highlight of the second workshop was, at the invitation of the organizers, a presentation by Scott Koranda of the LIGO project on the history of LIGO’s identity management activities and how those could have benefited from a security institute. A key analysis he presented is that, by his estimation, LIGO could have saved 2 senior FTE-years of effort by following suitable expert guidance had it existed. The overarching finding from the workshops is that security is a critical crosscutting issue for the NSF software infrastructure and recommended a security focused activity to address this issue broadly, for example a security software institute (S2I2) under the SI2 program. Additionally, the 2010 workshop participants agreed to 15 key additional findings, which the 2011 workshop confirmed, with some refinement as discussed in this report.NSF Grant # 1043843Ope

Multicolour Single Molecule Imaging in Cells with Near Infra-Red Dyes

Background: The autofluorescence background of biological samples impedes the detection of single molecules when imaging. The most common method of reducing the background is to use evanescent field excitation, which is incompatible with imaging beyond the surface of biological samples. An alternative would be to use probes that can be excited in the near infra-red region of the spectrum, where autofluorescence is low. Such probes could also increase the number of labels that can be imaged in multicolour single molecule microscopes. Despite being widely used in ensemble imaging, there is a currently a shortage of information available for selecting appropriate commercial near infra-red dyes for single molecule work. It is therefore important to characterise available near infra-red dyes relevant to multicolour single molecule imaging. Methodology/Principal Findings: A range of commercially available near infra-red dyes compatible with multi-colour imaging was screened to find the brightest and most photostable candidates. Image series of immobilised samples of the brightest dyes (Alexa 700, IRDye 700DX, Alexa 790 and IRDye 800CW) were analysed to obtain the mean intensity of single dye molecules, their photobleaching rates and long period blinking kinetics. Using the optimum dye pair, we have demonstrated for the first time widefield, multi-colour, near infra-red single molecule imaging using a supercontinuum light source in MCF-7 cells

Global patient outcomes after elective surgery: prospective cohort study in 27 low-, middle- and high-income countries.

BACKGROUND: As global initiatives increase patient access to surgical treatments, there remains a need to understand the adverse effects of surgery and define appropriate levels of perioperative care. METHODS: We designed a prospective international 7-day cohort study of outcomes following elective adult inpatient surgery in 27 countries. The primary outcome was in-hospital complications. Secondary outcomes were death following a complication (failure to rescue) and death in hospital. Process measures were admission to critical care immediately after surgery or to treat a complication and duration of hospital stay. A single definition of critical care was used for all countries. RESULTS: A total of 474 hospitals in 19 high-, 7 middle- and 1 low-income country were included in the primary analysis. Data included 44 814 patients with a median hospital stay of 4 (range 2-7) days. A total of 7508 patients (16.8%) developed one or more postoperative complication and 207 died (0.5%). The overall mortality among patients who developed complications was 2.8%. Mortality following complications ranged from 2.4% for pulmonary embolism to 43.9% for cardiac arrest. A total of 4360 (9.7%) patients were admitted to a critical care unit as routine immediately after surgery, of whom 2198 (50.4%) developed a complication, with 105 (2.4%) deaths. A total of 1233 patients (16.4%) were admitted to a critical care unit to treat complications, with 119 (9.7%) deaths. Despite lower baseline risk, outcomes were similar in low- and middle-income compared with high-income countries. CONCLUSIONS: Poor patient outcomes are common after inpatient surgery. Global initiatives to increase access to surgical treatments should also address the need for safe perioperative care. STUDY REGISTRATION: ISRCTN5181700

First Sagittarius A* Event Horizon Telescope results. II. EHT and multiwavelength observations, data processing, and calibration

We present Event Horizon Telescope (EHT) 1.3 mm measurements of the radio source located at the position of the supermassive black hole Sagittarius A* (Sgr A*), collected during the 2017 April 5–11 campaign. The observations were carried out with eight facilities at six locations across the globe. Novel calibration methods are employed to account for Sgr A*'s flux variability. The majority of the 1.3 mm emission arises from horizon scales, where intrinsic structural source variability is detected on timescales of minutes to hours. The effects of interstellar scattering on the image and its variability are found to be subdominant to intrinsic source structure. The calibrated visibility amplitudes, particularly the locations of the visibility minima, are broadly consistent with a blurred ring with a diameter of ∼50 μas, as determined in later works in this series. Contemporaneous multiwavelength monitoring of Sgr A* was performed at 22, 43, and 86 GHz and at near-infrared and X-ray wavelengths. Several X-ray flares from Sgr A* are detected by Chandra, one at low significance jointly with Swift on 2017 April 7 and the other at higher significance jointly with NuSTAR on 2017 April 11. The brighter April 11 flare is not observed simultaneously by the EHT but is followed by a significant increase in millimeter flux variability immediately after the X-ray outburst, indicating a likely connection in the emission physics near the event horizon. We compare Sgr A*'s broadband flux during the EHT campaign to its historical spectral energy distribution and find that both the quiescent emission and flare emission are consistent with its long-term behavior.http://iopscience.iop.org/2041-8205Physic

First Sagittarius A* Event Horizon Telescope Results. II. EHT and Multiwavelength Observations, Data Processing, and Calibration

We present Event Horizon Telescope (EHT) 1.3 mm measurements of the radio source located at the position of the supermassive black hole Sagittarius A* (Sgr A*), collected during the 2017 April 5–11 campaign. The observations were carried out with eight facilities at six locations across the globe. Novel calibration methods are employed to account for Sgr A*'s flux variability. The majority of the 1.3 mm emission arises from horizon scales, where intrinsic structural source variability is detected on timescales of minutes to hours. The effects of interstellar scattering on the image and its variability are found to be subdominant to intrinsic source structure. The calibrated visibility amplitudes, particularly the locations of the visibility minima, are broadly consistent with a blurred ring with a diameter of ∼50 μas, as determined in later works in this series. Contemporaneous multiwavelength monitoring of Sgr A* was performed at 22, 43, and 86 GHz and at near-infrared and X-ray wavelengths. Several X-ray flares from Sgr A* are detected by Chandra, one at low significance jointly with Swift on 2017 April 7 and the other at higher significance jointly with NuSTAR on 2017 April 11. The brighter April 11 flare is not observed simultaneously by the EHT but is followed by a significant increase in millimeter flux variability immediately after the X-ray outburst, indicating a likely connection in the emission physics near the event horizon. We compare Sgr A*’s broadband flux during the EHT campaign to its historical spectral energy distribution and find that both the quiescent emission and flare emission are consistent with its long-term behavior