LATE DIAGNOSIS OF POST-PARTUM COLORECTAL CANCER IN A YOUNG KAZAKH WOMAN

Introduction: Colorectal cancer (CRC) is generally expected among population above 60 years of age and rarely occurs in younger age groups. Its occurrence in young individuals is sporadic and has poor prognosis.Presentation of the case: A 24-year old woman, previously healthy, delivered her first child and subsequently developed pelvic problems. Despite multiple surgeries and diagnostic work-up, which included cross-sectional imaging, the patient’s diagnosis remained unknown. At the time of diagnosis with a colonoscopic evaluation, the patient was in the late stage of disease and died few months later.Conclusion: CRC should be in the differentials list in all patient cases, when suggestive symptoms present, regardless of age and other factors. Its association with pregnancy may obscure symptoms and delay the diagnosis

Assessment of unmet needs and barriers to end-of-life care provision in Kazakhstan

Palliative care, a holistic multidisciplinary approach for those persons with terminal diseases, providing relief for physical, emotional, psychosocial and spiritual suffering of both the patients and their families and to support the dignity of all involved in the process of dying¹. Palliative care has developed recently, and an understanding of unmet needs and barriers, especially in Kazakhstan, can be addressed through innovative rigorous qualitative research methods covering all the stakeholders involved. Palliative care is an integral Nazarbayev University’s commitment to improving health services in Kazakhstan. The published literature shows a lack of palliative care providers in Kazakhstan and the few existing services are underdeveloped2,3. Our current will substantially characterize more in-depth and more broadly on opportunities and barriers for national expansion of quality palliative care in Kazakhstan

Late Diagnosis of Post-partum Colorectal Cancer in a Young Kazakh Woman

http://www.ivyunion.org/index.php/ajccr/article/view/1343Introduction: Colorectal cancer (CRC) is generally expected among population above 60 years of age and rarely occurs in younger age groups. Its occurrence in young individuals is sporadic and has poor prognosis. Presentation of the case: A 24-year old woman, previously healthy, delivered her first child and subsequently developed pelvic problems. Despite multiple surgeries and diagnostic work-up, which included cross-sectional imaging, the patient’s diagnosis remained unknown. At the time of diagnosis with a colonoscopic evaluation, the patient was in the late stage of disease and died few months later. Conclusion: CRC should be in the differentials list in all patient cases, when suggestive symptoms present, regardless of age and other factors. Its association with pregnancy may obscure symptoms and delay the diagnosis

Assessment of unmet needs and barriers to end-of-life care provision in Kazakhstan

Palliative care, a holistic multidisciplinary approach for those persons with terminal diseases, providing relief for physical, emotional, psychosocial and spiritual suffering of both the patients and their families and to support the dignity of all involved in the process of dying¹. Palliative care has developed recently, and an understanding of unmet needs and barriers, especially in Kazakhstan, can be addressed through innovative rigorous qualitative research methods covering all the stakeholders involved. Palliative care is an integral Nazarbayev University’s commitment to improving health services in Kazakhstan. The published literature shows a lack of palliative care providers in Kazakhstan and the few existing services are underdeveloped2,3. Our current will substantially characterize more in-depth and more broadly on opportunities and barriers for national expansion of quality palliative care in Kazakhstan

Additional file 5: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S3. General disease outcome and prognostic measures. (DOCX 38 kb

Additional file 6: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Figure S3. Expression levels of the top 500 most variable transcripts in CD4 and CD8 cells, shown for each of 135 samples. Sample groups are indicated by the orange (CD4) and blue (CD8) bars at the top of the heatmap. (DOCX 555 kb

Additional file 11: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S8. Significant CD8 genes shared by phenotypes at T1. (CSV 5 kb

Additional file 2: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Figure S1. Quality control metrics for stored specimens. Representative FACS analysis for FITC bound CD4 (A) and APC bound CD8 cells (B). Panel C displays the FACS confirmed purity of all specimens, with case and control samples represented by red and blue triangles respectively. (DOCX 100 kb

Additional file 10: of Longitudinal expression profiling of CD4+ and CD8+ cells in patients with active to quiescent giant cell arteritis

Table S7. Significant CD4 genes shared by phenotypes at T1. (CSV 4 kb