57 research outputs found
TO SHOVE ON PEDESTRIAN RECITAL ON SIDE WALKS
- Publication venue
- International Journal of Innovative Technology and Research
- Publication date
- 20/04/2018
- Field of study
It gives a sidewalk pavement width design technique for making extra pedestrian quality and walk-inspiring sidewalk pavements in the urban location. Instead of using the current sidewalk pavement width format preferred that commonly results in having minimal values, these studies investigated pedestrians’ alternatives on the tiers of provider, surveyed actual footpath trajectories inside the sidewalk pavements, and located pedestrian movement characteristics inside the streets. Pedestrian crucial diagrams and pedestrian traits depend upon gender of the pedestrian, age of pedestrian and type of centres. “Pedestrian traits, crucial diagrams for unidirectional waft in addition to bi-directional go together with the drift, evaluation of pedestrian critical diagrams between unidirectional and bi-directional waft, capability and stage of provider for above three sections” have become done in this test. Hypothesis trying out come to be performed for evaluating the pedestrian pace among one-of-a-kind sections and special mixtures had been completed on this examine
Comparative analysis of Klebsiella pneumoniae genomes identifies a phospholipase D family protein as a novel virulence factor
- Author
- A Iwobi
- A Mey
- AB Russell
- AG Torres
- AH Li
- AM Simoons-Smit
- Ana S Almeida
- Anna Tomas
- AS Shon
- B Hochhut
- B Wu
- BW Wortham
- C Fevre
- CP Fung
- CP Ponting
- CR Hsu
- D Balestrino
- D Decre
- D Moranta
- DL Baldi
- DR Flower
- E Llobet
- EG Bligh
- F Boyer
- FF Buettner
- H Tsugawa
- HA Choy
- HF Lavender
- HJ Newton
- HL Tang
- I Shibuya
- J Hinnebusch
- J Hytonen
- J Putze
- JH Yoon
- JM Warszawska
- José A Bengoechea
- K Agladze
- K Beiter
- K Kuhle
- K Mizuta
- K Suzuki
- KM Wu
- KM Yeh
- L Frangeul
- L Izquierdo
- Letícia MS Lery
- Lionel Frangeul
- LK Siu
- M Regue
- M Schlame
- M Teplitski
- MA Bachman
- MA Campos
- MA Khan
- MC Wu
- MM Castiblanco-Valencia
- MS Lawlor
- N Nagarajan
- NB Ray
- O Gal-Mor
- P Di Martino
- P Shah
- P Ye
- PF Sarris
- Philippe Sansonetti
- PJ McNamara
- R Conde-Alvarez
- R Mercado-Lubo
- R Podschun
- R Wacharotayankun
- RC Moellering Jr
- RK Aziz
- Régis Tournebize
- S Bialek-Davenet
- S Brisse
- S Brisse
- S Shrivastava
- SA Shelburne 3rd
- SC Lopes
- SC McKean
- SC McKean
- SC Su
- SF Altschul
- SL Murdoch
- ST Miyata
- Suzanne Bialek-Davenet
- Sylvain Brisse
- T Whitworth
- TL Lin
- V Mohan Das
- Valérie Barbe
- Virginie Passet
- X Nassif
- X Nassif
- X Nassif
- Y Keynan
- YL Chen
- Z Ge
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Candida glabrata : a review of its features and resistance
- Author
- A Chakrabarti
- A Chakrabarti
- A Kalkanci
- A Kramer
- A Peñas De Las
- A Roetzer
- A Roetzer
- A Roetzer
- A Roetzer
- A Thierry
- AA Almeida de
- AL Colombo
- AM Calcagno
- AM Nicola
- AW Segal
- B Dujon
- B Guo
- B Klempp-Selb
- BB Magee
- BD Alexander
- BP Cormack
- C Lass-Flörl
- C Marcos-Arias
- C. F. Rodrigues
- CJ Seneviratne
- CS Kaufmann
- CS Lim
- CT Hittinger
- CY Lin
- D Dyk van
- D Wilson
- DA Stead
- DC Sheppard
- DJ Klionsky
- DJ Klionsky
- DM Kuhn
- DR Reagan
- EA Kraneveld
- EJ Helmerhorst
- EJ Helmerhorst
- EK Bethea
- EM Kojic
- F Bambeke Van
- F Barchiesi
- F Hasan
- FC Odds
- FG Oppenheim
- FG Oppenheim
- G Butler
- G Butler
- G Luo
- G Luo
- G Ramage
- G Ramage
- GM Cox
- GR Thompson 3rd
- H Muller
- H Tsai
- H Urk Van
- H Wisplinghoff
- HM Bandara
- HT Taff
- I Castaño
- I Iraqui
- J Chandra
- J Chandra
- J Kim
- J Lee
- JA Hagerty
- JA Jayatilake
- JA Noble
- JA Vazquez
- JA Vazquez
- JCO Sardi
- JE Bennett
- JH Shin
- JL Vincent
- JP Vermitsky
- JR Blankenship
- K Gulshan
- K Lewis
- K Lewis
- K Seider
- K Ueno
- KE Caudle
- KH Chen
- KH Wolfe
- KJ Verstrepen
- KW Henry
- L Vale-Silva
- LP Samaranayake
- LP Samaranayake
- M Bassetti
- M Edgerton
- M Negri
- M Niimi
- M Niimi
- M Riera
- M Sikora
- M Tscherner
- M. Henriques
- MA Al-Fattani
- MA Pfaller
- MA Pfaller
- MA Pfaller
- MC Arendrup
- MC Lorenz
- MD LaFleur
- MD Lafleur
- MN Rai
- N Berila
- NK Tamura
- O Bader
- P Gutiérrez-Escribano
- P Perumal
- P Shahi
- P Sundstrom
- P Uppuluri
- P Vandeputte
- P Vandeputte
- PL Fidel Jr
- PW Groot De
- R Domergue
- R Kaur
- R Kaur
- R Kaur
- R Rajendran
- RA Akins
- RA Calderone
- RD Cannon
- RK Shields
- S Brunke
- S Brunke
- S Farahyar
- S Ferrari
- S Ferrari
- S Hawser
- S Paul
- S Silva
- S Silva
- S Silva
- S Silva
- S Silva
- S. Silva
- SC Halliwell
- SP Hawser
- SY Ruan
- T Miyazaki
- T Saijo
- TFC Mah
- V Krcmery
- V Krcmery
- V Mohan das
- Y Nakagawa
- Z Jandric
- Z Xie
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Candida species belong to the normal microbiota of the oral cavity and gastrointestinal and vaginal tracts, and are responsible for several clinical manifestations, from mucocutaneous overgrowth to bloodstream infections. Once believed to be non-pathogenic, Candida glabrata was rapidly blamable for many human diseases. Year after year, these pathological circumstances are more recurrent and problematic to treat, especially when patients reveal any level of immunosuppression. These difficulties arise from the capacity of C. glabrata to form biofilms and also from its high resistance to traditional antifungal therapies. Thus, this review intends to present an excerpt of the biology, epidemiology, and pathology of C. glabrata, and detail an approach to its resistance mechanisms based on studies carried out up to the present.The authors are grateful to strategic project PTDC/SAU-MIC/119069/2010 for the financial support to the research center and for Celia F. Rodrigues' grant
Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.
- Author
- Aamir A
- Abbas J
- Abbas N
- Abbott TEF
- Abdalla M
- Abdikadir H
- Abuhussein N
- Acquaah F
- Adamson R
- Adeleye O
- Adeogun A
- Adlan A
- Aftab R
- Afzal Z
- Agarwal M
- Aglan H
- Agnew CJF
- Agrawal R
- Ahern D
- Ahluwalia J
- Ahluwalia V
- Ahmad A
- Ahmad K
- Ahmed H
- Ahmed I
- Ahmed L
- Ahmed N
- Ahmed P
- Ainger E
- Ainsworth P
- Aishwarya G
- Ajibola-Taylor O
- Akhbari M
- Akhtar A
- Akhtar R
- Akpenyi O
- Al-Ausi M
- Al-Huneidi R
- Al-Khudairi R
- Al-Masri S
- Al-Mousawi A
- Al-Saadi N
- Alagappan A
- Alberts J
- Alfa-Wali M
- Ali A
- Ali B
- Ali I
- Ali M
- Ali Q
- Ali S
- Alturki N
- Alwandi A
- Amani L
- Amarnath T
- Amer M
- Amin H
- Amin MN
- Amoah R
- Amoah-Arko A
- Anandarajah C
- Ananthavarathan P
- Andah EJE
- Andrew K
- Andrews H
- Ang A
- Ang HL
- Ang JJ
- Ani C
- Anilkumar A
- Anto N
- Anwar S
- Apperley H
- Appleton S
- Aquilina T
- Archer M
- Arif T
- Arneill M
- Arnell S
- Arnold TJ
- Arshad A
- Arthur J
- Arulkumaran N
- Arya J
- Asad M
- Asemota N
- Ashaye T
- Ashdown T
- Ashour R
- Ashraf MR
- Ashwood J
- Asif U
- Atkin G
- Atkins B
- Attalla M
- Aubrey-Jones D
- Auckburally S
- Auld F
- Auluck I
- Azam S
- Aziz R
- Azizi A
- Azmi F
- Babatunde F
- Babu VS
- Bachi A
- Bagga R
- Bains H
- Bajwa DS
- Baker A
- Baker C
- Balai E
- Balian V
- Ball M
- Bamford M
- Bana R
- Banfield DA
- Bannard-Smith J
- Barai I
- Barclay J
- Barfi L
- Barker C
- Barker M
- Barmayehvar B
- Barnfield J
- Barnor-Ahiaku E
- Baron C
- Barr CJ
- Barraclough J
- Baryan HK
- Basra M
- Bassam N
- Bath MF
- Battle J
- Beasley W
- Beattie G
- Beattie S
- Beatty M
- Beghal G
- Begum F
- Behranwala K
- Belchos J
- Belgaid DR
- Belgaumkar A
- Bell S
- Ben-Gal O
- Benchetrit S
- Bennett M
- Benons N
- Bernal TL
- Bertelli M
- Berthaume-Hawkins SD
- Best R
- Betts A
- Bevan K
- Bews-Hair M
- Bhambra R
- Bhamra N
- Bhangu A
- Bhatte S
- Bhatti A
- Bhide I
- Bhome R
- Bhudia R
- Bhullar S
- Bienias A
- Billyard C
- Bird C
- Birkinshaw F
- Black J
- Blake E
- Blazeby JM
- Bleakley A
- Bloom I
- Bogle R
- Bolton W
- Borakati A
- Boraluwe-Rallage H
- Borg CM
- Botha A
- Boualbanat Y
- Boulton APR
- Bountra K
- Bowley D
- Boyd G
- Boyles L
- Bradley P
- Brannick S
- Brayley J
- Brecher J
- Breen H
- Bristow S
- Britton N
- Broad J
- Brobbey P
- Brock E
- Brooke M
- Brown A
- Brown B
- Brown F
- Brown FS
- Brown H
- Brown K
- Brown LR
- Brown M
- Brown N
- Brown R
- Brown S
- Brown T
- Bruce C
- Bruce P
- Budd E
- Bull K
- Burgin A
- Burke D
- Burke J
- Burnage S
- Burns N
- Burrows A
- Busti S
- Butler A
- Cabdi NMO
- Cadden F
- Cairns C
- Calabria C
- Calciu A
- Campbell A
- Campbell B
- Campbell G
- Campbell HS
- Cannon SP
- Cant M
- Capella S
- Cardus C
- Cardwell A
- Cargill Z
- Caroll P
- Carr G
- Carr R
- Carr W
- Carse S
- Carter N
- Carter R
- Castle A
- Cato L
- Cave D
- Cecil E
- Chadwick H
- Chadwick M
- Chan F
- Chan L
- Chan M
- Chan SSN
- Chan-lam N
- Chandler E
- Chandler S
- Chandramoorthy L
- Chandramoorthy S
- Chang A
- Chang LH
- Chang M
- Chappelow I
- Chapple K
- Charnley R
- Chaudhry A
- Chaudhry S
- Chauhan P
- Chavan A
- Chean CS
- Chen L
- Chen Y
- Chenciner L
- Cheng J
- Chesner R
- Cheung W
- Chin YR
- China Z
- Chitsabesan P
- Chohan K
- Choi JE
- Chong A
- Chong P
- Choo S
- Chopada A
- Chouari T
- Choudhary Y
- Choudhry M
- Choy CH
- Christie S
- Christopher E
- Chudek D
- Chui J
- Church M
- Church R
- Cipparrone M
- Claireaux HA
- Clark K
- Clarke B
- Clement KD
- Clements B
- Clements SE
- Cobley H
- Coe P
- Cohen J
- Coldicutt O
- Cole A
- Coleman M
- Collaborative S
- Collins J
- Collishaw A
- Common M
- Concannon K
- Conchie H
- Connelly A
- Connor M
- Cookson P
- Cope EA
- Cope T
- Copeland M
- Copley HC
- Coppel J
- Corbridge O
- Cotter M
- Courquin GR
- Court J
- Cox L
- Craig ARJ
- Craig N
- Crane E
- Cremen S
- Cresswell B
- Crewe A
- Crilly C
- Crilly L
- Croghan N
- Croitoru C
- Cromwell D
- Cronbach P
- Crook H
- Crozier L
- Cruddas L
- Cullum R
- Cumber E
- Cumming S
- Cummings D
- Cunliffe L
- Cunningham L
- Curtis A
- Curtis J
- D'Auria M
- D'Souza F
- Dada J
- Dalal F
- Dalrymple J
- Daly D
- Daniels J
- Das E
- Das K
- Datta U
- Davies E
- Davies G
- Davies J
- Davies P
- Davis H
- Davison C
- Dawe V
- Dawood S
- Day L
- De Cates C
- De Freitas M
- Dean S
- Debnath D
- Deekonda P
- Deepak S
- Deery L
- Delvi A
- Denley S
- Dennahy IS
- Dennis R
- Dennis Y
- Desai H
- Desai K
- Devalia S
- Dhaliwal R
- Dhillon AK
- Dhillon P
- Dhir T
- Dhuna S
- Diamond J
- Dib NP
- Dickson G
- Dietrich A
- Dindyal S
- Dixon O
- Do V
- Dobrzynska M
- Doherty C
- Donaldson G
- Donohoe C
- Doshi A
- Doull C
- Downes C
- Doyle C
- Drake TM
- Draper A
- Dudley B
- Duff F
- Duffield J
- Duggal A
- Dumann E
- Dunleavy K
- Dunne E
- Dupaguntla YS
- Durand C
- Durbacz M
- Durham-Hall A
- Durno J
- Durrigan T
- Duthie F
- Dutta A
- Dyal A
- Dynes K
- Easby S
- Easdon S
- Eastwood M
- Ebhogiaye O
- Eccles L
- Ecclestone T
- Eddama M
- Edgerton K
- Edozie F
- Edwin C
- Egan E
- Eiben I
- Eiben P
- Eilon T
- El Matary R
- El Tokhy O
- El-Sawy D
- El-Taji O
- Elangovan S
- Elbuzidi M
- Elder P
- Elias J
- Ellerby N
- Elliot J
- Elliott J
- Elsaddig M
- Elseedawy E
- Emberton J
- En BNW
- Engledow A
- English W
- Epanomeritakis E
- Episkopos C
- Epstein J
- Esmail R
- Evans D
- Evans E
- Evans L
- Evans R
- Ezzat A
- Fafemi O
- Falamarzi A
- Fam M
- Faraj A
- Farhan-Alanie MMH
- Farmer N
- Farooq M
- Farooqi M
- Farrar E
- Farwana M
- Faulkner S
- Fawole A
- Fearnhead N
- Feldman M
- Fenton K
- Ferris B
- Filipescu T
- Finch E
- Fitzgerald I
- Fitzgerald JE
- Fitzpatrick H
- Flack V
- Flamini T
- Fletcher D
- Foley MP
- Fong J
- Fowler AJ
- Fox H
- Fozard T
- France B
- Francis N
- Francis S
- Francois V
- Francombe J
- Freeman SK
- Frere M
- Frew K
- Friend C
- Froggatt P
- Frost A
- Frost J
- Fung H
- Gabriel R
- Gaddah M
- Gadsby C
- Gaffing S
- Galea M
- Gallogly P
- Galloway F
- Gammeri E
- Gani A
- Ganyani R
- Gao C
- Gardner I
- Gardner S
- Gardner T
- Garner C
- Garsaa T
- Gaukroger A
- Ge Y
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- George A
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- Gerard L
- Ghaffar A
- Ghag S
- Ghailan N
- Gharatya A
- Gibbons D
- Gibson W
- Gidwani A
- Gil H
- Gilbert A
- Gill A
- Gill K
- Gillespie H
- Gimson A
- Girdlestone T
- Given A
- Glace S
- Glasbey J
- Glasbey JC
- Glen P
- Glover M
- Gnanappiragasam D
- Goaman A
- Goergen N
- Goh C
- Goh ET
- Gohil J
- Gokani S
- Golding D
- Gomaa A
- Gonzalez-Ciscar A
- Goodson R
- Gopfert A
- Gordon J
- Gorman D
- Gower T
- Grace R
- Graham CJ
- Graham S
- Grant A
- Grant M
- Gravell R
- Green B
- Green S
- Greenan E
- Greenhalgh S
- Gregoriou K
- Gregory C
- Gresly J
- Grey A
- Gribbon C
- Griffith J
- Griffiths B
- Griffiths H
- Griffiths N
- Gruhn A
- Guevel B
- Guillotte C
- Gulzar I
- Gundogan B
- Gunwa T
- Gupta A
- Gupta R
- Gurjar S
- Gurung E
- Guy C
- Gwilym B
- Gwozdz AM
- Hack J
- Hackney E
- Haddad S
- Hague M
- Hair J
- Hall M
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- Hallan R
- Hamdan K
- Hamid H
- Hammad A
- Hanson M
- Haq T
- Haque A
- Haray P
- Hare L
- Harinath G
- Harlinska A
- Harris A
- Harris C
- Harris L
- Harris R
- Harris S
- Harrison E
- Harrison EM
- Harrison P
- Harrogate S
- Hart SJ
- Harte J
- Hartley J
- Hartley M
- Harty M
- Hashemi R
- Hassanin K
- Hathaway C
- Haughey B
- Hawthorne T
- Hayashi E
- Hayat A
- Hayat F
- Hayes JDB
- Haynes K
- Haynes S
- Hayward J
- Haywood E
- Hazeldine P
- He YY
- Hedley C
- Helliwell R
- Heng S
- Henry J
- Henshaw V
- Herman A
- Hernon J
- Heywood E
- Hickland P
- Hill N
- Hilton J
- Hitchen C
- Ho B
- Ho C
- Ho M
- Ho W
- Hodgson B
- Hodgson S
- Hogg G
- Holdsworth R
- Hole J
- Hollington D
- Holmes D
- Holt F
- Hopkins M
- Horne L
- Horseman C
- Hosamuddin H
- Hoskins T
- Hossain M
- Hossain S
- Hough A
- Houghton C
- Houlton J
- Howlader M
- Hrvacic N
- Hubert J
- Hudson S
- Hudson-Peacock N
- Hughes B
- Hughes EJ
- Hughes J
- Hughes K
- Huisman L
- Hull K
- Hung YMA
- Hungwe C
- Hunt C
- Huppatz IW
- Huq T
- Hurst P
- Hussain A
- Hussain M
- Hussain SF
- Hussain ST
- Hussein N
- Hutchinson S
- Ibrahim B
- Ibrahim I
- Ijeomah A
- Ikogho O
- Ikram B
- Ilenkovan N
- Imam SZ
- Imran H
- Ingleton R
- Ingram H
- Innes R
- Iqbal F
- Iqbal S
- Iroegbu U
- Ishaq H
- Islam Y
- Ismail O
- Ito G
- Ivo T
- Jackman T
- Jackson CES
- Jacob-Ramsdale B
- Jain D
- Jain P
- Jamal S
- James F
- Javaid NR
- Jawad L
- Jawad ZAR
- Jebakumar R
- Jeffreys N
- Jeyabaladevan S
- Ji C
- Jiang J
- Jiao LR
- John I
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- Jones A
- Jones C
- Jones D
- Jones E
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- Jones M
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- Jong B
- Jordan P
- Joseph R
- Joyce H
- Joyner C
- Jull P
- Kale A
- Kamarajah S
- Kambasha C
- Kaminski F
- Kanabar S
- Kanapeckaite L
- Kandage D
- Kandhari N
- Kandiah K
- Kane D
- Kane L
- Kapp J
- Kaptanis S
- Karaj J
- Karam E
- Karbowiak M
- Karim MA
- Karim MJ
- Karmarkar A
- Karsan RB
- Karunatilleke AS
- Katira A
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- Kaur G
- Kausar A
- Kazmi Z
- Keane K
- Kee JY
- Keelan G
- Kelkar A
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- Kelly M
- Kenefick N
- Kennedy ED
- Keogh C
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- Kerrigan K
- Kersey T
- Kershaw S
- Keshvala C
- Kethees A
- Keyte A
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- Khalil M
- Khaliq M
- Khan A
- Khan H
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- Khatri C
- Khaw J
- Khawaja H
- Khawar H
- Khawari S
- Khodatars K
- Khoo E
- Kiandee M
- Kidanu D
- Kiely A
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- Kim P
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- King J
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- Kinnersley H
- Kirby S
- Kirk S
- Kishore A
- Klimach S
- Knight C
- Knight JS
- Kokayi A
- Komolafe O
- Komoriyama A
- Kong C
- Kong CH
- Kong JTH
- Koo PY
- Kopczynska M
- Koshy R
- Kossoff J
- Kremel D
- Krishna K
- Krysztopik R
- Kukran S
- Kumar AP
- Kumar KM
- Kumar R
- Lacy-Colson J
- Ladha D
- Lagzouli N
- Laing C
- Lake C
- Lakin F
- Lal K
- Lalor P
- Lam J
- Lambotharan S
- Lamptey E
- Lang-Orsini M
- Langasco N
- Latter J
- Lau J
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- Lawday S
- Laws J
- Lazarou A
- Leadholm N
- Lee A
- Lee G
- Lee J
- Lee S
- Leer M
- Leinhardt D
- Leong A
- Leong K
- Leong S
- Leong SH
- Leptidis I
- Leung E
- Lewis N
- Lex J
- Li H
- Liew I
- Lim D
- Lim H
- Lim S
- Lim SW
- Lim ZC
- Lim ZH
- Limb C
- Lingam G
- Linley-Adams L
- Linn T
- Liu H
- Livesey C
- Livie J
- Livie V
- Lloyd J
- Lobo L
- Lock L
- Logan AE
- Logan P
- Loh SY
- Loizidou A
- Loka T
- Long M
- Long S
- Loo F
- Looi WL
- Love E
- Lovett B
- Lowe C
- Lowe-Zinola JD
- Luk J
- Luk YL
- Lund J
- Lunt AJ
- Luo C
- Luo RS
- Lyell I
- Macdonald B
- Macdonald C
- MacDonald E
- Mackay K
- Mackey R
- Mackinnon S
- Mackrell T
- MacLeod CS
- Magalhaes J
- Mah T
- Mahalingam P
- Mahankali-Rao P
- Mahfooz M
- Mahir G
- Mahmood F
- Mahmood R
- Mahmood S
- Mahmood W
- Majkowski L
- Makanji D
- Makwana S
- Malik Q
- Malik TAM
- Malla S
- Malone N
- Mandishona T
- Manikavasagar V
- Manimaran M
- Manivannan S
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- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators
- STARSurg Collaborative Writing Committee, Data analysis, Steering committee, Advisory group, Regional leads, Collaborators and validators, Nepogodiev, D
- Stechman M
- Stewart D
- Stewart E
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- Stewart R
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- Stoddart MT
- Stokes E
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- Stringfellow TD
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- Sulaiman SK
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- Suresh S
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- Yahaya AA
- Yalamarthi S
- Yang DD
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- Yarham E
- Yasin IH
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- Youssef H
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- Zanichelli D
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- Zheleniakova T
- Zhu Y
- Zornoza A
- Zubikarai G
- Zulkifli A
- Zuzarte L
- Publication venue
- 'Wiley'
- Publication date
- 18/05/2018
- Field of study
Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
- Author
- A Abbott
- A Abou-Raya
- A Aljandali
- A Ambesi-Impiombato
- A Aydin
- A Balcerczyk
- A Besarab
- A Brzezinski
- A Campbell
- A Carrillo-Vico
- A Cavalli
- A Chattopadhyay
- A Chattopadhyay
- A Cherubini
- A Dey
- A Doms
- A Donovan
- A Donovan
- A Dávalos
- A Gaeta
- A Garny
- A Gnjec
- A Gomes
- A Gopalakrishnan
- A Hald
- A Henney
- A Hirayama
- A Hoffmann
- A Huber
- A Hugman
- A Iannetti
- A Ide-Ektessabi
- A Jacobs
- A Jeyabalan
- A Kahvejian
- A Karrar
- A Kasztler
- A Kibel
- A Kocyigit
- A Kotha
- A Kumral
- A Lass
- A Lecube
- A Lewén
- A Lotery
- A Maggio
- A Malek
- A Malik
- A Mantovani
- A Matsuzawa
- A Mitra
- A Monge
- A Murakami
- A Murakami
- A Murakami
- A Murakami
- A Mutti
- A Nijnik
- A Nunomura
- A Nunomura
- A Patt
- A Persson
- A Pietrangelo
- A Piga
- A Pirat
- A Post
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- A Terman
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- ZZ Chong
- ZZ Chong
- Publication venue
- Publication date
- 09/08/2008
- Field of study
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
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- Chhor V
- Chiang CC
- Chiang CH
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- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
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- Cho Y
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- Chou W
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- Chouvarda I
- Christopher KB
- Chrétien JM
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- Chumaev A
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- Cinel I
- Cinnella G
- Citerio G
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- Colaprico A
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- Collange O
- Colombo A
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- Combes A
- Concha P
- Connolly B
- Constan A
- Constan A
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- Conti G
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- Cordero M
- Cordolcini V
- Cordovilla-Guardia S
- Cordón J
- Corona A
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- Corzo L
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- Cutuli SL
- Câmara M
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- Dalhuisen A
- Dalorzo M
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- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
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- Di Gravio V
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- Engelberts D
- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- Fleischmann E
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Kumari BK
- Kumbamu A
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- Nagib H
- Naito T
- Nakagawa S
- Nakao A
- Nakataki E
- Nakataki E
- Namiki M
- Namiki M
- Nandha R
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- Naz I
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- Neuville M
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- Noon A
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- Nosaka N
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- Nouris C
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- Nunes J
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- Nuvials X
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- Obukhova O
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- Ode S
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- Olaechea P
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- Pienovi R
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- Roesthuis L
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- Sales G
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- Sato K
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- Sawamura A
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- Scanziani E
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- Wray J
- Xie Z
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- Yamamoto H
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- Yan WW
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- Yilmazer F
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- Yonis H
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- You KM
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- Yuzawa J
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- Zepeda EM
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- Álvarez JT
- Álvarez-Lerma F
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- 'Springer Science and Business Media LLC'
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- 01/01/2016
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- 01/01/1988
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