8 research outputs found
Copper(ii) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity And Their Interaction With Dna And Albumins
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)]center dot 0.5H(2)O and [CuCl(L2)(phen)]center dot 2H(2)O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)]center dot 0.5H(2)O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.2818797Fundacao de Amparo a Pesquisa do Estado de Minas Gerais (FAPEMIG)Fundacao Carlos Chagas Filho de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ)FIOCRUZConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq
Effect of whey protein concentrate on texture of fat-free desserts: sensory and instrumental measurements
Norfloxacin and N-Donor Mixed-Ligand Copper(II) Complexes: Synthesis, Albumin Interaction, and Anti-Trypanosoma cruzi Activity
Copper(II) complexes with the first-generation quinolone antibacterial agent norfloxacin containing a nitrogen donor heterocyclic ligand 2,2′-bipyridine (bipy) or 1,10-phenanthroline (phen) were prepared and characterized by IR, EPR spectra, molar conductivity, and elemental analyses. The experimental data suggest that norfloxacin was coordinated to copper(II) through the carboxylato and ketone oxygen atoms. The interaction of the copper(II) complexes with bovine serum albumin (BSA) and human serum albumin (HSA) was investigated using fluorescence quenching of the tryptophan residues and copper(II) EPR spectroscopy. The results of fluorescence titration revealed that copper(II) complexes have a moderate ability to quench the intrinsic fluorescence of the albumins through a static quenching mechanism. EPR experiments showed that BSA and HSA Cu(II) sites compete with NOR for Cu(II)-bipy and Cu(II)-phen to form protein mixed-ligand complexes. Copper(II) complexes, together with the corresponding ligands, were evaluated for their trypanocidal activity in vitro against Trypanosoma cruzi, the causative agent of Chagas disease. The tests performed using bloodstream trypomastigotes showed that the Cu(II)-N-donor precursors and the metal complexes were more active than the free fluoroquinolone
Evaluation of the contamination of the soil and water of an open dump in the Amazon Region, Brazil
Ministério de Sanidad, Consumo y Bienestar SocialFederal University of Pará. Graduate in Natural Sciences. Baião, PA, Brazil.Federal University of Pará. Coastal Studies Institute. Bragança, PA, Brazil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Toxicologia. Ananindeua, PA, Brasil.Ministério da Saúde. Secretaria de Vigilância em Saúde. Instituto Evandro Chagas. Laboratório de Toxicologia. Ananindeua, PA, Brasil.Federal University of Pará. Institute of Geosciences. Belém, PA, Brazil.Federal University of Pará. Institute of Geosciences. Belém, PA, Brazil.Federal University of Pará. Coastal Studies Institute. Bragança, PA, Brazil.Federal University of Pará. Coastal Studies Institute. Bragança, PA, Brazil.The emergence of cities and the ongoing growth of urban areas have contributed to an overwhelming increase in negative environmental impacts. A major concern is the impact caused by the inadequate disposal of municipal solid waste in open dumps without proper regulation or planning. The negative impacts caused by the inadequate disposal of solid waste include the contamination of groundwater and soils, the proliferation of disease vectors, and odoriferous and visual pollution. One specific problem generated by the disposal of solid waste is the decomposition of the organic matter found in this waste, which generates leachates. These highly soluble substances can percolate through the soil and penetrate bodies of superficial water or the water table. The present study was based on the integration of geophysical data with physicochemical, hydrochemical, and microbiological analyses, as well as the analysis of heavy metal concentrations in water and leachate samples. Contamination was confirmed and may be associated with the leachate produced by the solid waste deposited inadequately at the study site. The results provide insights into important public health and safety issues, and should alert local authorities with regard to the environmental impacts caused by underground contamination in the Amazon town of Mocajuba (Brazil)
Hydrophobic cellulose-based and non-woven fabrics coated with mesoporous TiO<sub>2</sub> and their virucidal properties under indoor light
Antiviral hydrophobic cellulose-based cotton or non-woven fabrics containing mesoporous TiO2 particles were developed for potential use in healthcare and in other contaminated environments. Hydrosols made with the sol-gel method using two different amounts of the Ti precursor were applied to cotton and non-woven fabrics and their virucidal effect on Murine Coronavirus (MHV-3) and Human Adenovirus (HAdV-5) was evaluated under indoor light irradiation. The results show 90% reduction of HAdV-5 and up to 99% of MHV-3 in non-woven fabric, and 90% reduction of MHV-3 and no reduction of HAdV-5 in cotton fabric. The antiviral activity was related to the properties of the TiO2 powders and coatings characterized by BET surface area, DRX, DLS, FTIR, DRS, SEM, TEM and water contact angle. The hydrophobic characteristic of the treated fabrics and the high surface area of the TiO2 particles favor interaction with the virus, especially MHV-3. These results demonstrate that non-woven fabric and cotton, coated with TiO2, can be highly effective in preventing contamination with MHV-3 and HAdV-5 viruses, particularly for applications in healthcare indoor environments.</p
REVIEW Open Access Individual and social vulnerabilities upon acquiring tuberculosis: a literature systematic review
Tuberculosis is a contagious infectious disease mainly caused by the bacteria Mycobacterium tuberculosis that still meets the priority criteria- high magnitude, transcendence and vulnerability- due to the threat it poses to public health. When taking into consideration the vulnerability conditions that favor the onset of the disease, this article aimed to investigate the implications originated from individual and social vulnerability conditions in which tuberculosis patients are inserted. Databases like MEDLINE, LILACS and SciELO were searched in Portuguese, Spanish and English using the descriptors tuberculosis and vulnerability, and 183 articles were found. After the selection criterion was applied, there were 22 publications left to be discussed. Some of the aspects that characterize the vulnerability to tuberculosis are: low-income and low-education families, age, poor living conditions, chemical dependency, pre-existing conditions/aggravations like diabetes mellitus and malnutrition, indigenous communities, variables related to health professionals, intense border crossings and migration, difficulty in accessing information and health services and lack of knowledge on tuberculosis. Much as such aspects are present and favor the onset of the disease, several reports show high incidence rates of tuberculosis in low vulnerability places, suggesting that some factors related to the disease are still unclear. In conclusion, health promotion is important in order to disfavor such conditions or factors of vulnerability to tuberculosis, making them a primary target in the public health planning process and disease control
Copper(II) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity and Their Interaction with DNA and Albumins
Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)].0.5H2O and [CuCl(L2)(phen)].2H2O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)].0.5H2O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins
Consórcio de milho com braquiária e guandu-anão em sistema de dessecação parcial
O objetivo deste trabalho foi avaliar a viabilidade do consórcio de milho (Zea mays) cv. BRS 1035 com braquiária (Urochloa brizantha) e guandu-anão (Cajanus cajan), no sistema de dessecação parcial. Os experimentos foram realizados na safra de verão de 2008/2009, em Santo Antônio de Goiás, GO e Ipameri, GO, em blocos completos ao acaso, com cinco repetições. Os tratamentos constituíram-se de cultivos de milho, em consórcio com braquiária e guandu-anão, com a aplicação de nitrogênio mineral em cobertura, à emergência da cultura ou aos 20 dias após esse evento, com ou sem aplicação de subdose de herbicida à braquiária não dessecada. A viabilidade do sistema de dessecação parcial é dependente do manejo da adubação nitrogenada do milho ou do controle do crescimento da braquiária nas faixas não dessecadas