55 research outputs found
Size effects in indentation of hydrated biological tissues
- Publication venue
- 'Cambridge University Press (CUP)'
- Publication date
- 14/12/2011
- Field of study
Fluid flow in biological tissues is important in both mechanical and biological contexts. Given the hierarchical nature of tissues, there are varying length scales at which time-dependent mechanical behavior due to fluid flow may be exhibited. Here, spherical nanoindentation and microindentation testings are used for the characterization of length scale effects in the mechanical response of hydrated tissues. Although elastic properties were consistent across length scales, there was a substantial difference between the time-dependent mechanical responses for large and small contact radii in the same tissue specimens. This difference was far more obvious when poroelastic analysis was used instead of viscoelastic analysis. Overall, indentation testing is a fast and robust technique for characterizing the hierarchical structure of biological materials from nanometer to micrometer length scales and is capable of making quantitative material property measurements to do with fluid flow
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke
- Author
- A Gschwendtner
- Agnieszka Slowik
- Aiden Corvin
- Amy Strange
- Ananth C Viswanathan
- Andreas Gschwendtner
- Anna Helgadottir
- Anna Rautanen
- Annette I Burgess
- Anuj Goel
- Arne Lindgren
- Audrey Duncanson
- B Langley
- Bertram MĂŒller-Myhsok
- BF Voight
- BL Browning
- Bo Norrving
- Bradford B Worrall
- Braxton D Mitchell
- Brett Kissela
- C Bellenguez
- C Newton-Cheh
- Caroline A Jackson
- Cathie L M Sudlow
- Chris C A Spencer
- Chris Levi
- Christa Meisinger
- Christopher G Mathew
- Colin Freeman
- Colin N A Palmer
- Cordelia Langford
- CĂ©line Bellenguez
- Daniel Woo
- Deborah Poole
- DF Conrad
- DF Gudbjartsson
- Dorota Wloch-Kopec
- Elizabeth Holliday
- Elvira Bramon
- Emma Gray
- Eugenio A Parati
- Gavin Band
- Giorgio B Boncoraglio
- Gudmar Thorleifsson
- Helen Ross-Adams
- Helen Segal
- Hossein Delavaran
- HP Adams Jr.
- HS Markus
- Hugh S Markus
- James F Meschia
- Janusz Jankowski
- Jenefer M Blackwell
- Joanna Pera
- John Attia
- Jonathan Rosand
- Juan P Casas
- Julia Slark
- K Chen
- Karen Furie
- Kari Stefansson
- KB Glaser
- Lee Murphy
- Leena Peltonen
- Lynelle Cortellini
- M Dichgans
- M Haberland
- M Kubo
- MA Ikram
- Maria-Grazia Franzosi
- Martin Dichgans
- Martin Farrall
- Mary Joan Macleod
- Matthew A Brown
- Matthew Traylor
- Matthew Walters
- Matti Pirinen
- Michael A Nalls
- Nicholas W Wood
- P Jerrard-Dunne
- Pankaj Sharma
- Panos Deloukas
- Paul D Syme
- Peter Donnelly
- Peter M Rothwell
- R Lemmens
- Rainer Malik
- Renata Schanz
- Richard C Trembath
- RL Sacco
- Robert Plomin
- Robin Lemmens
- S Chang
- S Gretarsdottir
- S Olsson
- Sarah Edkins
- Sarah Hunt
- Serge Dronov
- Solveig Gretarsdottir
- Stephen J Sawcer
- Steve Bevan
- Steven Boonen
- Steven J Kittner
- T Kouzarides
- TM Teslovich
- Tom James
- Udo Seedorf
- Unnur Thorsteinsdottir
- Valerie Valant
- Vincent Thijs
- Yu-Ching Cheng
- YY Teo
- Z Su
- Zhan Su
- Publication venue
- NATURE PUBLISHING GROUP
- Publication date
- 01/01/2012
- Field of study
Genetic factors have been implicated in stroke risk but few replicated associations have been reported. We conducted a genome-wide association study (GWAS) in ischemic stroke and its subtypes in 3,548 cases and 5,972 controls, all of European ancestry. Replication of potential
signals was performed in 5,859 cases and 6,281 controls. We replicated reported associations between variants close to PITX2 and ZFHX3 with cardioembolic stroke, and a 9p21 locus with large vessel stroke. We identified a novel association for a SNP within the histone deacetylase 9(HDAC9) gene on chromosome 7p21.1 which was associated with large vessel stroke including additional replication in a further 735 cases and 28583 controls (rs11984041, combined P =
1.87Ă10â11, OR=1.42 (95% CI) 1.28-1.57). All four loci exhibit evidence for heterogeneity of effect across the stroke subtypes, with some, and possibly all, affecting risk for only one subtype. This suggests differing genetic architectures for different stroke subtypes
Use of anticoagulants and antiplatelet agents in stable outpatients with coronary artery disease and atrial fibrillation. International CLARIFY registry
- Author
- A. L. R. Ng
- Abardia Oliva F. J.
- Abdel Malak S.
- Abdel Wahab H.
- Abdul Kareem B. B.
- Abdul Manap H.
- Abdul Rahim A. A.
- Abdulkader F.
- Abdulla A. H. K.
- AbdulWahab M. Z.
- Abduvalieva V.
- Abele S.
- Aboyans V.
- Abreu P. E.
- Adam-Blanpain M.
- Adamaszek K.
- Adamczyk-Kot D.
- Adamkiewicz-Piejko A.
- Adda M.
- Aftab A.
- Agrawal A.
- Aguiar C.
- Ahuad Guerrero A.
- Ahuja R.
- Ai F.
- Aimouch N.
- Aiyegbayo O.
- Ajani A.
- Akbar M.
- Aksyutina N.
- Al Dhanki M.
- Al Ghool S.
- Al Kandari F.
- Al Lawati A.
- Al Mahmeed W.
- Al Radaideh G.
- Al Rashdan I.
- Al Sousi A.
- Al Suwaidi J.
- Al Tamimi F.
- Al Wahshi Y.
- Al Yazeedi J.
- Al Zaibag M.
- Al-Baker H.
- Al-Faleh H.
- Al-Hersi A.
- Al-Khalidi B.
- Al-Shamiri M.
- Al-Zaibag M.
- Alam A.
- Alanazy M.
- Alanbaei M.
- Albero Martinez V.
- Alberto Ramirez Reyes H.
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- Alekseenko V.
- Alekseeva T.
- Alexanderson E.
- Alexopoulos I.
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- Allcock A.
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- Altmann U.
- Alvarenga Recalde N.
- Alvarez Aunon A.
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- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2015
- Field of study
Pharmacogenetic meta-analysis of genome-wide association studies of LDL cholesterol response to statins
- Author
- Adrienne Cupples L.
- Ahlqvist Emma
- Arnold Alice M.
- Arsenault Benoit J.
- Avery Christy L.
- Ballantyne Christie M.
- Band Gavin
- Barnes Michael R.
- Barratt Bryan J.
- Barroso Ines
- Barroso Ines
- Bellenguez CĂ©line
- Betteridge John
- Bis Joshua C.
- Blackburn Hannah
- Blackwell Jenefer M.
- Blackwell Jenefer M.
- Boerwinkle Eric
- Bramon Elvira
- Brown Matthew A.
- Brown Matthew A.
- Buckley Brendan M.
- Bumpstead Suzannah J.
- Carr Fiona
- Casas Juan P.
- Caulfield Mark J.
- Chasman Daniel I.
- Chu Audrey Y.
- Colhoun Helen M.
- Corvin Aiden
- Corvin Aiden
- de Craen Anton J. M.
- de Keyser Catherine E.
- Deloukas Panos
- Deloukas Panos
- Denny Joshua C.
- Deshmukh Harshal A.
- Ding Jingzhong
- Doney Alex
- Donnelly Louise A.
- Donnelly Peter
- Donnelly Peter
- Dronov Serge
- Duncanson Audrey
- Durrington Paul N.
- Edkins Sarah
- Eiriksdottir Gudny
- Eline Slagboom P.
- Emilsson Valur
- Evans Daniel S.
- Feng QiPing
- Ford Ian
- Franco Oscar H.
- Freeman Colin
- Giannoulatou Eleni
- Gillman Matthew
- Giulianini Franco
- Gray Emma
- Griffin Paula
- Groop Leif
- Gudnason Vilmundur
- Guo Xiuqing
- Gwilliam Rhian
- Hammond Naomi
- Harris Tamara B.
- Heckbert Susan R
- Hellenthal Garrett
- Herrington David M.
- Hitman Graham
- Hofman Albert
- Hunt Sarah E.
- Ida Chen Y.-D.
- Jankowski Janusz
- Jayakumar Alagurevathi
- Johnson Andrew D.
- Kastelein John J. P.
- Kees Hovingh G.
- Krauss Ronald M.
- Kritchevsky Stephen B.
- Langford Cordelia
- Launer Leonore J.
- Li Guo
- Li Xiaohui
- Liddle Jennifer
- Liu Ching-Ti
- Liu Yongmei
- Lumley Thomas
- MacFadyen Jean G.
- Markus Hugh S.
- Mathew Christopher G.
- Mathew Christopher G.
- Matthijs Boekholdt S.
- McCann Owen T.
- McCarthy Mark I.
- McCarthy Mark I.
- McKeigue Paul M.
- Morris Andrew
- Munroe Patricia B.
- Neil Andrew
- Ngwa Julius S.
- Nickerson Deborah A.
- Nyberg Fredrik
- OâBrien Eoin
- OâDonnell Christopher J.
- Palmer Colin N. A.
- Palmer Colin N. A.
- Pearson Richard
- Pierre Dubé Marie
- Pirinen Matti
- Plomin Robert
- Post Wendy
- Postmus Iris
- Potter Simon C.
- Poulter Neil
- Psaty Bruce M.
- Rautanen Anna
- Ravindrarajah Radhi
- Rice Kenneth
- Ricketts Michelle
- Ridker Paul M.
- Rivadeneira Fernando
- Rotter Jerome I.
- Sattar Naveed
- Sawcer Stephen J.
- Sever Peter
- Shaw-Hawkins Sue
- Shields Denis C.
- Smith Albert V.
- Smith Joshua D.
- Smith Nicholas L.
- Sotoodehnia Nona
- Spencer Chris C. A.
- Spencer Chris C. A.
- Stafford Jeanette M.
- Stanton Alice
- Stott David J.
- Strange Amy
- Stricker Bruno H.
- StĂŒrmer Til
- Su Zhan
- Sun Fangui
- Tardif Jean-Claude
- Taylor Kent D.
- Trembath Richard C.
- Trompet Stella
- Uitterlinden André G.
- Vasan Ramachandran S.
- Viswanathan Ananth C.
- Vukcevic Damjan
- Waller Matthew
- Warren Helen R.
- Wei Wei-Qi
- Westendorp Rudi G. J.
- Weston Paul
- Whitsel Eric A.
- Whittaker Pamela
- Widaa Sara
- Wiggins Kerri L.
- Wilke Russell A.
- Wood Nicholas W.
- Wouter Jukema J
- Zhou Kaixin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising signals in a further 22,318 statin recipients and identify two loci, SORT1/CELSR2/PSRC1 and SLCO1B1, not previously identified in GWAS. Moreover, we confirm the previously described associations with APOE and LPA. Our findings advance the understanding of the pharmacogenetic architecture of statin response
Evaluation of appendicitis risk prediction models in adults with suspected appendicitis
- Author
- Abbas Sh
- Abbas Sh
- Abbassi Oa
- Abbott T
- Abdelgadir Am
- Abdelrahman A
- Abdelrahman M
- Abdelrahman M
- Abdelwahed A
- Abellan M
- AbellĂĄn Am
- AbellĂĄn Am
- Abulafi M
- Acharya A
- Acosta A
- Adam Me
- Adams Re
- Adegbola So
- Adegbola So
- Adimonye A
- Adnan M
- Afshar S
- Agresta F
- Agua Ia
- Aguayo Jl
- Agudo Ar
- Ahad A
- Ahel J
- Ahern Dp
- Ahmad A
- Ahmed B
- Ahmed G
- Ahmed Os
- Ahmed Os
- Ahmed S
- Ainsworth P
- Ais G
- Ais G
- Aisoni F
- Akbari K
- Akhtar K
- Akinsola O
- Akram F
- Al-Faham Z
- Al-Khafaji N
- Al-Khyatt W
- Al-Musawi S
- Al-Sarireh B
- Al-Sheikh M
- Alagna V
- Alani M
- Alberca-Paramo A
- Aldrey I
- Alexander R
- Alhammali T
- Alhammali T
- Ali M
- Aljorfi A
- Allen M
- Allington J
- Alonzo A
- Alshafei A
- Altomare Ma
- Alvarez Cm
- Alvarez E
- Alvarez-Gallego M
- Amaducci E
- Amarasinghe R
- Amayo A
- Ambrona-Zafra D
- Amin V
- Ammendola M
- Amtul N
- Amtul N
- Amuthalingam T
- Anandan L
- Anania G
- Anania M
- Anderson Dj
- Anderson O
- Andolfi E
- Andreani Sm
- Andreani Sm
- Andrews B
- Ang A
- Ang A
- Angelieri D
- Angelini M
- Angrisani M
- Anguita F
- Ansaloni L
- Ansari A
- Aravind B
- Archer Je
- Arcuri Ga
- Arcuri Ga
- Aremu Ma
- Arenal-Vera Jj
- Aresu S
- Aresu S
- Argenio G
- Argenti F
- Armellini A
- Arnau M
- Arredondo J
- Arroyo A
- Arshad F
- Arunachalam S
- Arunachalam S
- Arunachalam S
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- Berry B
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- Bhangu A. Nepogodiev D
- Bhangu A
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- Bolton W
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- Brennan S
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- Brewer H
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- Brews R
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- Bronder C
- Brown A
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- Brown Ce
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- Brown M
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- Brown Od
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- Brunelli Db
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- Bull C
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- Byrne Be
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- Caballero A
- Caldeira Ab
- Caldwell M
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- Cameron Fc
- Campagnaro T
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- Campbell U
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- Carrano Fm
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- Cartwright H
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- Castagnoli G
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- Caula C
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- Cavallo D
- Cavero A
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- CerdĂĄn-Santacruz C
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- Charalambous Mp
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- Chatzikonstantinou M
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- Chessa A
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- Chetta G
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- Chillitupa Cz
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- Choong Jh
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- Collier-Wakefield O
- Colombo F
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- Compagnoni B
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- Contine Ac
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- Cynthia G
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- De Freitas S
- De Luca E
- De Marchi F
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- De Prizio M
- De-La-Herranz-Guerrero P
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- De-Marchi Ja
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- Delgado-Plasencia Lj
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- Depalma N
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- GarcĂa-Granero A
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- GarcĂa-Gutierrez C
- GarcĂa-Novoa A
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- GarcĂa-Rivera Co
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- Nelli T
- Neophytou Gi
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- Newton Rc
- Newton Rc
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- Ng M
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- Okorocha E
- Olagbaiye O
- Oliva I
- Olivares-Oliver C
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- Olivier Jb
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- Pais M
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- Palani-Velu Lk
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- Pan Y
- Panagiotopoulos Sp
- Panda N
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- Panda N
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- Pandya D
- Pandya R
- Paniagua M
- Pankin Gp
- Papandrea M
- ParajĂł Ae
- Paramasevon Kr
- Pareja-CiurĂł F
- Parisi A
- Park Jh
- Park Jh
- Parkola Mj
- Parra Jm
- Parwaiz I
- Pascua-Sole M
- Pascual-Miguelañez I
- Pasquali S
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F
- Pata F.
- Pata G
- Pata G
- Pata G
- Patel As
- Patel By
- Patel By
- Patel C
- Patel H
- Patel Mm
- Patel N
- Patel Pk
- Patel Rt
- Patil Sd
- Patti S
- Pau R
- Payne Cj
- Payne Re
- PayĂĄ-Llorente C
- PayĂĄ-Llorente C
- Peacock M
- Pearce J
- Pearce J
- Pearce L
- Pearce L
- Pearson R
- Pedder A
- Peirce Cb
- Peiris Gb
- Peixoto R
- Peleki A
- Peleki A
- Pellegrino L
- PellicanĂČ Ga
- Pellicer-Franco E
- Pellino G
- Pento V
- Pento V
- Peponis C
- Peprah D
- Pereira A
- Pereira Am
- Pereira J
- Pereira-Mosquera E
- Perera Mi
- Perez-Calvo J
- Perin A
- Pertile D
- Pertile D
- Peña-Barturen C
- Phelan L
- Photiou D
- Pierre R
- Pietrabissa A
- Pigem A
- Pila U
- Pilkington Jp
- Pineño-Flores C
- Pinillos-Somalo A
- Pinkney Td
- Pinkney Td
- Pinkney Td
- Pinna E
- Pino-Perez O
- Pirari Pf
- Pisanu A
- Piu F
- Planellas P
- Plua-Muniz Kt
- Poacher A
- Podda F
- Podda M
- Podda M
- Podda M
- Poillucci G
- Pollard H
- Ponchietti L
- Popova D
- Poudevigne M
- Prats Ma
- Prideaux A
- Prieto-Nieto Mi
- Primo Jc
- Pronin S
- Provenza G
- Puerta E
- Pulighe F
- Pullabatla-Venkata Up
- Punj S
- PĂ©rez-Sanchez Le
- Quddus A
- Quill S
- Quinn Em
- Quinn Hc
- Rabie M
- Rabie Ma
- Rabie Mr
- Radwan Rw
- Radwan Rw
- Rahim A
- Rahman M
- Rahmani Ls
- Rajagopal S
- Rajaram R
- Rajaretnam N
- Rajjoub Y
- Rallage H
- Ramcharan S
- Ramirez L
- Ramirez-Redondo Aa
- Ramos Xh
- Ramos-Bernado Mi
- RamĂrez-Faraco M
- Ranathunga S
- Rangarajan K
- Rao M
- Rao V
- Raofi A
- Rashid M
- Rate A
- Ravindran R
- Raymond M
- Raza Ss
- Recreo Ac
- Reddy A
- Reddy A
- Redmond Ae
- Redondo E
- Redondo E
- Redondo-Calvo Fj
- Reese G
- Regina G
- Rehman S
- Rehman S
- Rekhraj S
- Ren Kz
- Renshaw S
- Renshaw S
- Renzi Cr
- Resende Fm
- Rezacova M
- Rezvani S
- Riaz W
- Riba-Combatti L
- Ribaudo M
- Ribeiro B
- Rich Je
- Richardson Td
- Ridaura N
- Riera E
- Rigby S
- Rigney B
- Rinkoff S
- Ripoli Mc
- Robb Hd
- Robertson C
- Robinson A
- Robinson A
- Robinson D
- Robinson D
- Rocha R
- Rodger V
- Rodicio-Miravalles Jl
- Rodriguez L
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- Rodriguez-Lopez M
- RodrĂguez Ec
- Rojo Ja
- RoldĂĄn-Ortiz S
- Rolph R
- Romano J
- Romano R
- Romario Uf
- Romoli L
- Roncero Ls
- Ronda Rn
- Roomi S
- Rosa Mj
- Rosat A
- Roscio F
- Roscio F
- Roscio F
- Rossi C
- Rossi D
- Rossi Gm
- Roth N
- Rothnie K
- Roxburgh C
- Roy C
- Ruano A
- Rubbini M
- Rudland I
- Ruffolo C
- Rufo E
- Ruggiu Gv
- Ruiz-MarĂn M
- Ruiz-MarĂn M
- Rupani S
- Rupasinghe Sn
- Rupasinghe Sn
- Rutherford Dg
- Ruzvidzo F
- Ruzzenente A
- Saad M
- Saad M
- Saavedra-ChacĂłn M
- Saba A
- Sabia D
- Sacco R
- Sacks R
- Sadek S
- Saghir N
- Sagnotta A
- Sagnotta A
- Saha A
- Sahay Sj
- Sahnan K
- Sahnan K
- Sainz B
- Sainz B
- Sajid Ms
- Salama Y
- Salamone G
- Salamone G
- Salamone G
- Salamone G
- Salandini Mc
- Salem A
- Salim S
- Salva Ab
- Salvador H
- Samartin C
- Sammarco G
- Sammarco G
- Samuel M
- Sana S
- Sanchez Er
- Sanchez Er
- Sanchez L
- Sanchez-Garcia S
- Sanchez-Guillen L
- Sanchez-Guillen L
- Sanchez-Martinez A
- Sancho-Muriel J
- Sandu L
- Sanna S
- Santamaria C
- SantamarĂa Pc
- Santarrufina-MartĂnez S
- Santos Sc
- Santurro L
- Sanz-Navarro S
- Sarmah P
- Sarmah P
- Sarmah P
- Sarveswaran J
- Sasia D
- Sasia D
- Saunders S
- Savill A
- Savino G
- Savino G
- Savioli F
- Scabini S
- Scabini S
- Scabini S
- Scandroglio Is
- Scanlon K
- Scatizzi M
- Scialandrone G
- Scricciolo M
- Sebastian Jf
- SebastiĂĄn-TomĂĄs Jc
- Seddon Tc
- Segalini E
- Segura-Sampedro Jj
- Sena G
- Sena-Ruiz F
- Seneviratne N
- Sepe C
- Serventi F
- Serventi F
- Seth M
- Setshwaelo T
- Sezen E
- Sgardelis P
- SgrĂČ A
- SgrĂČ A
- SgrĂČ A
- Shah J
- Shah K
- Shah Sm
- Shah Sm
- Shaikh Ia
- Shakoor Z
- Shanmuganathan V
- Shanmugarajah K
- Sharma A
- Sharma A
- Sharma P
- Sharp Ol
- Sharp Ol
- Shaw Av
- Shepherd Ja
- Sherif Ma
- Shet S
- Shetty Vd
- Shingler G
- Shiwani Mh
- Shrestha D
- Shurlock J
- Sian T
- Siaw O
- Siddique K
- Siddiqui Mn
- Siddiqui Za
- Sierra-Grañón Je
- Siggens Kl
- Sihra N
- Silva A
- Silva I
- Silvestri V
- Simioni A
- Simmonds L
- Simmonds L
- Simo V
- Simoes J
- Simpson Dj
- Singh A
- Singh J
- Singh P
- Singh S
- Singhal T
- Singhal T
- Sivaloganathan P
- Skalamera I
- Skerritt C
- Slezak I
- Smallcombe N
- Smart Cj
- Smart Cj
- Smart Nj
- Smart Nj
- Smoker H
- Soares A. S.
- Soares As
- Soares As
- Soares As
- Soares As
- Soares As
- Soh B
- Solaini L
- Solar-GarcĂa L
- Soliani P
- Solinas L
- Sooriyamoorthy T
- Soria-Aledo V
- Soria-Aledo V
- Soriano Jt
- Sorrentino L
- Sousa Hs
- Souter J
- Sparta C
- Spaziani A
- Speake D
- Speake D
- Springate El
- Sreedharan L
- Sreedharan L
- Staderini F
- Stecca T
- Stella M
- Stephens Gf
- Stephens Gf
- Stevenson R
- Stewart Dj
- Stoica I
- Storey R
- Stoyanov Ti
- Strachan E
- Strange Ja
- Stubbs Bm
- Stupalkowska W
- Stupalkowska W
- Suarez-Cabrera A
- Suero Ca
- Sultana A
- Summerfield L
- Sunter H
- Surg Pt
- Suriyakumar S
- SuĂĄrez-SĂĄnchez A
- Swords C
- Symons N
- Szentpali K
- Szucs A
- Szucs A
- SĂĄnchez-Cifuentes A
- SĂĄnchez-Fuentes Mn
- SĂĄnchez-Rubio M
- Tabain V
- Taglietti L
- Tague Le
- Tahir W
- Tailor K
- Tallon-Aguilar L
- Tallon-Aguilar L
- Tamayo-LĂłpez Mj
- Tamborska A
- Tamini N
- Tamini N
- Tamini N
- Tan Cy
- Tan Cy
- Tan E
- Tan Hl
- Tan S
- Tang Am
- Tapiolas I
- Tarazi M
- Tatulli F
- Tay Yh
- Tayeh S
- Taylor M
- Taylor Ns
- Taylor Ns
- Taze D
- Tee A
- Tejero-Pintor Fj
- Tenconi Sm
- Tezas S
- Thaha Ma
- Thakral N
- Thakur D
- Thava B
- Thavanesan N
- Thavanesan N
- Thaventhiran Aj
- Theodoropoulou K
- Thomas At
- Thomas L
- Thompson C
- Thompson Db
- Thompson Db
- Thompson R
- Thompson R
- Thoukididou Sn
- Tiedt La
- Tiedt La
- Ting N
- Tinoco-GonzĂĄlez J
- Tinsley Bj
- Tognarelli Jm
- Tojal A
- Tokidis E
- Tomasoni M
- Tonini V
- Toomey D
- Toomey Db
- Torkington J
- Torkington J
- Torrado Aa
- Torrance A
- Torrance A
- Townsend Dc
- Townsend Dc
- Tozer Pj
- Trail M
- Trail M
- Trastulli S
- Trew F
- Trostchansky I
- Trujillo-Diaz Jj
- Tsang B
- Tudyka V
- Tudyka V
- Turnbull A
- Turner Ej
- Tutino R
- Twum-Barima Cs
- Twum-Barima Cs
- Tyler R
- Tyler R
- Ugarte-Sierra B
- Vacca A
- Vaccari S
- Vakis S
- Valente Pm
- Valiani Sv
- Vallejo-Bernad C
- Vallve-Bernal M
- Van Boxel Gi
- Vance-Daniel J
- Vannucchi A
- Varcada M
- Vargas-Pierola Hj
- Vaughan Em
- Vaughan Em
- Vazquez-Fernandez Ap
- Vega L
- Velchuru Vr
- Velho R
- Venkata Up
- Venkatasubramaniam Ak
- Venn Ml
- Venn Ml
- Venugopal R
- Verea S
- Veres T
- Veres T
- Verroiotou M
- Vescio G
- Vettoretto N
- Vigorita V
- Vijay V
- Vila-Zarate C
- Villarejo-Campos P
- Vinnicombe Z
- Viscosi F
- Vitish-Sharma P
- Viviani E
- Viñas Nl
- Vohra R
- Vohra R
- Vulcano I
- Waite K
- Walji Hd
- Walsh E
- Walsh Tn
- Walters Kj
- Walters U
- Wardle Bg
- Wardle Bg
- Wardle Sd
- Warren O
- Warren Oj
- Warusavitarne J
- Watfah J
- Watson N
- Wauchope J
- Weatherburn Lw
- Weaver J
- Weegenaar Cr
- Weegenaar Cr
- Welsh S
- Wensley F
- West H
- West H
- Wheatstone S
- Wheeler C
- Whewell He
- White F
- Whitehorn Se
- Whitehorn Se
- Whitehouse P
- Whiteman E
- Whittaker L
- Wiggill S
- Wijesundera K
- Wilcox G
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R
- Wilkin R. J. W.
- Williams Gl
- Williams M
- Williams R
- Williams S
- Wilson Ej
- Wilson M
- Winter Dc
- Winter Dc
- Wolff J
- Wong A
- Wong C
- Wong J
- Wong J
- Wong Ml
- Wong Sy
- Woo R
- Wood Cs
- Woodrow C
- Woodward A
- Woodward B
- Woodward B
- Worku D
- Worku D
- Wright E
- Wright Hl
- Wu F
- Xidas A
- Yalamarthi S
- Yang P
- Yanni F
- Yardimci E
- Yasin T
- Yen Sk
- Yeung K
- Yeung K
- Yoganathan S
- Yoong S
- Youssef H
- Yow L
- Yow L
- Zaborowski A
- Zadi Az
- Zalla T
- Zarka Za
- Zarka Za
- Zarog Ma
- Zelazek M
- Zerpa C
- Zhang Ay
- Zhou S
- Zorrilla L
- Zuin M
- Zurleni Tz
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2019
- Field of study
Background
Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis.
Methods
A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16â45âyears presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis).
Results
Some 5345 patients across 154 UK hospitals were identified, of which twoâthirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; Pâ<â0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cutâoff score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cutâoff score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent).
Conclusion
Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decisionâmaking by identifying adults in the UK at low risk of appendicitis were identified
α-Synuclein vaccination modulates regulatory T cell activation and microglia in the absence of brain pathology
- Author
- A Flores-Langarica
- A Malmberg
- A Prigione
- A Prigione
- A Reboldi
- A Ulusoy
- AD Reynolds
- AD Reynolds
- AD Reynolds
- AH Haas de
- AN Barclay
- B Mollenhauer
- B Saha
- C Battisti
- C Laurie
- C Prado
- C Sarkar
- C Sarkar
- CF Orr
- CH Stevens
- D Beraud
- D Besong-Agbo
- D Franz
- Daniel E. Otzen
- E Masliah
- E Masliah
- EC Shin
- EJ Benner
- EL Smith
- F Simonetta
- G Huang
- GA Seventer Van
- H Gonzalez
- H Zhang
- HJ Lee
- I Comerford
- J Bas
- J Kipnis
- J Wu
- J Yong
- Josefine R. Christiansen
- K Baruch
- K Kretschmer
- K Nakano
- K Nakano
- K Nakaso
- KA Conway
- KC Luk
- KJ Doorn
- KK Papachroni
- M Beyer
- M Calopa
- M Cosentino
- M Kleinewietfeld
- M Levite
- M Levite
- M Lochner
- M Romero-Ramos
- MA Gruden
- Mads N. Olesen
- Marina Romero-Ramos
- MB Watson
- MC Ghosh
- MJ Besser
- MN Hedrick
- MT Armentero
- O Annacker
- O Tavassoly
- P Desplats
- P Garcia-Esparcia
- PG Strange
- PH Lee
- R Barbour
- R Cappai
- R Pacheco
- R Pacheco
- RB Tinsley
- RE Smith
- S Kim
- S Mitra
- S Paillusson
- SB Nielsen
- SJ Gardai
- SJ Lee
- SL Leong
- T Alberio
- T Yamazaki
- TB Ferreira
- TF Outeiro
- UK Hanisch
- UK Hanisch
- V Brochard
- V Caro Di
- V Sanchez-Guajardo
- V Sanchez-Guajardo
- Vanesa Sanchez-Guajardo
- VH Perry
- W Maetzler
- Y Baba
- Y Couch
- Y Ha
- Y Nagai
- YY Wan
- Z Allakhverdi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes
- Author
- Adolfsson Rolf
- Agartz Ingrid
- Agerbo Esben
- Akil Huda
- Albani Diego
- Albus Margot
- Alda Martin
- Alexander Madeline
- Alliey-Rodriguez Ney
- Als Thomas D
- Amin Farooq
- Andreassen Ole A
- Anjorin Adebayo
- Arranz Maria J
- Awasthi Swapnil
- Bacanu Silviu A
- Badner Judith A
- Baekvad-Hansen Marie
- Bakker Steven
- Band Gavin
- Barchas Jack D
- Barroso Ines
- Bass Nicholas
- Bauer Michael
- Baune Bernhard T
- Begemann Martin
- Bellenguez Celine
- Bellivier Frank
- Bender Stephan
- Bene Judit
- Bergen Sarah E
- Berrettini Wade H
- Bevilacqua Elizabeth
- Biernacka Joanna M
- Bigdeli Tim B
- Black Donald W
- Blackburn Hannah
- Blackwell Jenefer M
- Blackwood Douglas HR
- Boehnke Michael
- Boks Marco
- Boocock James
- Borglum Anders D
- Bramon Elvira
- Breen Gerome
- Brown Matthew A
- Bruggeman Richard
- Buccola Nancy G
- Buckner Randy L
- Budde Monika
- Bulik-Sullivan Brendan
- Bumpstead Suzannah J
- Bunney William
- Burmeister Margit
- Buxbaum Joseph D
- Bybjerg-Grauholm Jonas
- Byerley William
- Cahn Wiepke
- Cai Guiqing
- Cairns Murray J
- Campion Dominique
- Cantor Rita M
- Carr Vaughan J
- Carrera Noa
- Casas Juan P
- Casas Miquel
- Case-Control Wellcome Trust
- Catts Stanley V
- Cervantes Pablo
- Chambert Kimberley D
- Chan Raymond CK
- Charney Alexander W
- Chen Eric YH
- Chen Ronald YL
- Cheng Wei
- Cheung Eric FC
- Chong Siow Ann
- Cichon Sven
- Clarke Toni-Kim
- Cloninger C Robert
- Cohen David
- Cohen Nadine
- Coleman Jonathan RI
- Collier David A
- Consortium Psychiat Genomics
- Consortium Psychiat Genomics
- Cormican Paul
- Corvin Aiden
- Coryell William
- Craddock Nicholas
- Craig David W
- Crespo-Facorro Benedicto
- Crowley James J
- Cruceanu Cristiana
- Cuellar-Barboza Alfredo B
- Curtis David
- Czerski Piotr M
- Dale Anders M
- Daly Mark J
- Dannlowski Udo
- Darvasi Ariel
- Davidson Michael
- Davis Kenneth L
- de Haan Lieuwe
- de Leeuw Christiaan A
- Degenhardt Franziska
- Del Favero Jurgen
- DeLisi Lynn E
- Deloukas Panos
- Demontis Ditte
- DePaulo J Raymond
- Di Florio Arianna
- di Forti Marta
- Dikeos Dimitris
- Dinan Timothy
- Djurovic Srdjan
- Dobbyn Amanda L
- Domenici Enrico
- Donnelly Peter
- Donohoe Gary
- Drapeau Elodie
- Dronov Serge
- Duan Jubao
- Dudbridge Frank
- Duncanson Audrey
- Edenberg Howard
- Edkins Sarah
- Ehrenreich Hannelore
- Eichhammer Peter
- Elvsashagen Torbjorn
- Eriksson Johan
- Escott-Price Valentina
- Esko Tonu
- Essioux Laurent
- Etain Bruno
- Fan Chun Chieh
- Fanous Ayman H
- Farh Kai-How
- Farrell Martilias S
- Flickinger Matthew
- Foroud Tatiana M
- Forstner Andreas J
- Forty Liz
- Frank Josef
- Franke Lude
- Fraser Christine
- Freedman Robert
- Freeman Colin
- Freimer Nelson B
- Friedman Joseph I
- Fromer Menachem
- Frye Mark A
- Fullerton Janice M
- Gade Katrin
- Garnham Julie
- Gaspar Helena A
- Gejman Pablo V
- Genovese Giulio
- Georgieva Lyudmila
- Gershon Elliot S
- Giambartolomei Claudia
- Giannoulatou Eleni
- Giegling Ina
- Gill Michael
- Gillman Matthew
- Giusti-Rodriguez Paola
- Godard Stephanie
- Goes Fernando
- Goldstein Jacqueline I
- Gopal Srihari
- Gordon Scott D
- Gordon-Smith Katherine
- Gratten Jacob
- Gray Emma
- Green Elaine K
- Green Melissa J
- Greenwood Tiffany A
- Grigoroiu-Serbanescu Maria
- Grove Jakob
- Guan Weihua
- Gurling Hugh
- Gwilliam Rhian
- Hall Jeremy
- Hall Mei-Hua
- Hammer Christian
- Hammond Naomi
- Hamshere Marian L
- Hansen Christine Soholm
- Hansen Mark
- Hansen Thomas
- Haroutunian Vahram
- Hartmann Annette M
- Hauser Joanna
- Hautzinger Martin
- Heilbronner Urs
- Hellenthal Garrett
- Henskens Frans A
- Herms Stefan
- Hipolito Maria
- Hirschhorn Joel N
- Hoffmann Per
- Hollegaard Mads V
- Holmans Peter A
- Hougaard David M
- Huang Hailiang
- Huckins Laura
- Hultman Christina M
- Hunt Sarah E
- Ikeda Masashi
- Inter Psychosis Endophenotypes
- Iwata Nakao
- Iyegbe Conrad
- Jablensky Assen V
- Jamain Stephane
- Jankowski Janusz
- Jayakumar Alagurevathi
- Joa Inge
- Jones Ian
- Jones Lisa A
- Jonsson Erik G
- Jr Belliveau Richard A
- Jr Macek Milan
- Julia Antonio
- Jureus Anders
- Kahler Anna K
- Kahn Rene S
- Kalaydjieva Luba
- Kalman Janos L
- Kandaswamy Radhika
- Karachanak-Yankova Sena
- Karjalainen Juha
- Karlsson Robert
- Kavanagh David
- Keller Matthew C
- Kelly Brian J
- Kelsoe John
- Kendler Kenneth S
- Kennedy James L
- Keong Jimmy Lee Chee
- Khrunin Andrey
- Kim Yunjung
- Kirov George
- Kittel-Schneider Sarah
- Klovins Janis
- Knight Jo
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- Knowles James A
- Kogevinas Manolis
- Konte Bettina
- Kravariti Eugenia
- Kucinskas Vaidutis
- Kucinskiene Zita Ausrele
- Kupka Ralph
- Kuzelova-Ptackova Hana
- Landen Mikael
- Langford Cordelia
- Laurent Claudine
- Lawrence Jacob
- Lawrie Stephen
- Lawson William B
- Leber Markus
- Leboyer Marion
- Lee Phil H
- Lee S Hong
- Legge Sophie E
- Lencz Todd
- Lerer Bernard
- Levinson Douglas F
- Levy Shawn E
- Lewis Cathryn M
- Li Jun Z
- Li Miaoxin
- Li Qingqin S
- Li Tao
- Liang Kung-Yee
- Liddle Jennifer
- Lieberman Jeffrey
- Limborska Svetlana
- Lin Kuang
- Linszen Don H
- Lissowska Jolanta
- Liu Chunyu
- Liu Jianjun
- Lonnqvist Jouko
- Loohuis Loes M Olde
- Loughland Carmel M
- Lubinski Jan
- Lucae Susanne
- MacIntyre Donald J
- Magnusson Patrik KE
- Maher Brion S
- Mahon Pamela B
- Maier Wolfgang
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- Mallet Jacques
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- Markus Hugh S
- Marsal Sara
- Martin Nicholas G
- Mata Ignacio
- Mathew Christopher G
- Mattheisen Manuel
- Mattingsdal Morten
- Mayoral Fermin
- McCann Owen T
- McCarley Robert W
- McCarroll Steven A
- McCarthy Mark I
- McDonald Colm
- McElroy Susan L
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- Mckay James D
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- Medeiros Helena
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- Meier Sandra
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- Melegh Bela
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- Meng Fan
- Mesholam-Gately Raquelle I
- Metspalu Andres
- Michie Patricia T
- Milani Lili
- Milanova Vihra
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- Mokrab Younes
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- Moran Jennifer L
- Morken Gunnar
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- Nikitina-Zake Liene
- Nimgaonkar Vishwajit
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- Nordentoft Merete
- Nordin Annelie
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- Nurnberger John I
- Nwulia Evaristus A
- O'Callaghan Eadbhard
- O'Donovan Claire
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- Oedegaard Ketil J
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- Olincy Ann
- Olsen Line
- Ophoff Roel A
- Ori Anil PS
- Oruc Lilijana
- Owen Michael J
- Paciga Sara A
- Palmer Colin NA
- Palotie Aarno
- Pantelis Christos
- Papadimitriou George N
- Papiol Sergi
- Parkhomenko Elena
- Parra Jose Guzman
- Pato Carlos
- Pato Michele T
- Paunio Tiina
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- Pearson Richard
- Pedersen Carsten Bocker
- Pedersen Marianne Giortz
- Perkins Diana O
- Perlis Roy H
- Perry Amy
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- Petryshen Tracey L
- Pfennig Andrea
- Picchioni Marco
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- Ribases Marta
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- Ricketts Michelle
- Rietschel Marcella
- Riley Brien P
- Ripke Stephan
- Rivas Fabio
- Rivera Margarita
- Roffman Joshua L
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- Roussos Panos
- Ruderfer Douglas M
- Rujescu Dan
- Salomaa Veikko
- Sanchez-Mora Cristina
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- Schatzberg Alan F
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- Stefansson Hreinn
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- Steinberg Stacy
- Stogmann Elisabeth
- Stordal Eystein
- Strange Amy
- Straub Richard E
- Strauss John S
- Streit Fabian
- Strengman Eric
- Strohmaier Jana
- Stroup T Scott
- Su Zhan
- Subramaniam Mythily
- Sullivan Patrick F
- Suvisaari Jaana
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- Szatkiewicz Jin P
- Szelinger Szabolcs
- Tashakkori-Ghanbaria Avazeh
- Thirumalai Srinivas
- Thompson Robert C
- Thorgeirsson Thorgeir E
- Toncheva Draga
- Tooney Paul A
- Tosato Sarah
- Toulopoulou Timothea
- Trembath Richard C
- Treutlein Jens
- Trubetskoy Vassily
- Trubetskoy Vassily
- Turecki Gustavo
- Vaaler Arne E
- Van Os Jim
- Vedder Helmut
- Vieta Eduard
- Vincent John
- Visscher Peter M
- Viswanathan Ananth C
- Vukcevic Damjan
- Waddington John
- Waller Matthew
- Walsh Dermot
- Walshe Muriel
- Walters James TR
- Wang Dai
- Wang Qiang
- Wang Weiqing
- Wang Yunpeng
- Watson Stanley J
- Webb Brad-Ley T
- Weickert Cynthia Shannon
- Weickert Thomas W
- Weinberger Daniel R
- Weisbrod Matthias
- Weiser Mark
- Werge Thomas
- Weston Paul
- Whittaker Pamela
- Widaa Sara
- Wiersma Durk
- Wildenauer Dieter B
- Williams Nigel M
- Williams Stephanie
- Witt Stephanie H
- Wolen Aaron R
- Wong Emily HM
- Wood Nicholas W
- Wormley Brandon K
- Wray Naomi R
- Wu Jing Qin
- Xi Simon
- Xu Wei
- Young Allan H
- Zai Clement C
- Zandi Peter
- Zhang Peng
- Zheng Xuebin
- Zimprich Fritz
- Zollner Sebastian
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2018
- Field of study
publisher: Elsevier articletitle: Genomic Dissection of Bipolar Disorder and Schizophrenia, Including 28 Subphenotypes journaltitle: Cell articlelink: https://doi.org/10.1016/j.cell.2018.05.046 content_type: article copyright: © 2018 Elsevier Inc
Mechanical behaviour of electrospun fibre-reinforced hydrogels
- Publication venue
- 'Springer Science and Business Media LLC'
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- Field of study
Applications of V-Infinity Leveraging Maneuvers to Endgame Strategies for Planetary Moon Orbiters
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- Publication venue
- 'American Institute of Aeronautics and Astronautics (AIAA)'
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Erratum: Extracellular-matrix tethering regulates stem-cell fate
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
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