Unplanned Category Purchase Incidence: Who Does It, How Often, and Why

Unplanned category purchase incidence is an important source of retailer volume and profits. We analyze this phenomenon in detail with a multi-level Poisson model calibrated on data from 434 households making over 18,000 purchases in 58 categories across 3,000 trips to 21 stores. We find that unplanned category purchase incidence is not proportional to the number of categories bought, and not a single shopping trip is completely unplanned. The majority of variation is across shoppers. Specifically, it is explained in part by demographic variables traditionally measured by marketers, but more by other traits that reflect long-run shopping habits such as level of planning and information gathering styles. Short term shopping goals (e.g., major trip, forgotten needs, etc.) also play an important role. We replicate classic results of time available (more unplanned purchasing) and high store knowledge (less unplanned purchasing); however we find that the overall occurrence of unplanned purchasing is significantly lower than that commonly reported

Profits in the pie of the beholder

Funding has been viewed in the literature as one of the main determinants of scientific activities. Also, at an individual level, securing funding is one of the most important factors for a researcher, enabling him/her to carry out research projects. However, not everyone is successful in obtaining the necessary funds. The main objective of this work is to measure the effect of several important factors such as past productivity, scientific collaboration or career age of researchers, on the amount of funding that is allocated to them. For this purpose, the paper estimates a temporal non-linear multiple regression model. According to the results, although past productivity of researchers positively affects the funding level, our findings highlight the significant role of networking and collaboration. It was observed that being a member of large scientific teams and getting connected to productive researchers who have also a good control over the collaboration network and the flow of information can increase the chances for securing more money. In fact, our results show that in the quest for the research money it is more important how researchers build their collaboration network than what publications they produce and whether they are cited

Structural Estimation of the Effect of Out-of-Stocks

We develop a structural demand model that endogenously captures the effect of out-of-stocks on customer choice by simulating a time-varying set of available alternatives. Our estimation method uses store-level data on sales and partial information on product availability. Our model allows for flexible substitution patterns, which are based on utility maximization principles and can accommodate categorical and continuous product characteristics. The methodology can be applied to data from multiple markets and in categories with a relatively large number of alternatives, slow-moving products, and frequent out-of-stocks (unlike many existing approaches). In addition, we illustrate how the model can be used to assist the decisions of a store manager in two ways. First, we show how to quantify the lost sales induced by out-of-stock products. Second, we provide insights on the financial consequences of out-of-stocks and suggest price promotion policies that can be used to help mitigate their negative economic impact, which run counter to simple commonly used heuristics

Peer-to-peer support: digital networking in aphasia to improve quality of life (PeerPAL)

BackgroundPeople with aphasia (PWA) often suffer from reduced participation and quality of life. Nevertheless, there are currently only a few specific interventions that respond to this problem. Participation and quality of life could be increased by interacting with peers who have similar experiences. Digital social networks could stimulate an autonomous interaction. However, digital social networks need to be adapted to the specific needs of PWA. Therefore, a participatory, agile process involving the target group should be chosen to develop such a solution, i.e., an app. The research project consists of a total of three phases. In the first phase—app development—the app was developed and programmed including the target group. In the second phase—app testing—the usability and user-friendliness of the app were evaluated with four PWA. In the third phase—feasibility and preliminary efficacy—that will be described in the article, the impact of the app on PWA will be evaluated.AimsThe overarching aim of our study is to provide preliminary efficacy of the intervention. Digital social interaction with other PWA can lead to increased social integration. In addition to digital interaction, personal encounters between PWA should be encouraged. As a result, we expect an improvement in quality of life of PWA. Additionally, we focus on identification of the most appropriate measurements to discover changes associated with the intervention.MethodsThe evaluation, which is described in this paper, takes place in a pre-test - post-test design with a total of n = 48 PWA. Participants will be recruited in regional clusters to facilitate face-to-face meetings. Half of the participants will be assigned to the delayed intervention group and the other half to the immediate intervention group. Participants in the delayed intervention group will go through a 3-month waiting period before using the app, while the participants of the immediate intervention group will start using the app for 3 months right away. Inclusion criteria are the presence of chronic aphasia (at least 6 months) and possession of a smartphone with internet access. Questionnaires on quality of life (SAQOL-39, GHQ-12), depression (GDS, DISCs), communicative participation (CPIB), and social support (F-SozU) will be conducted at inclusion (t0), after 3 months of app use (t1), and after another 3 months for follow-up (t2). Participants in the delayed intervention group will be assessed twice before the intervention, before the 3-month waiting period (t0a) and after the waiting period (t0b). In addition to the quantitative measures, interviews will take place with 6 to 8 selected participants after 3 months of app use. Responses will be analysed using Thematic Analysis.DiscussionThe app will be the first social network tool that is systematically developed with PWA. Initial indications from the first phases are that the app can be used by PWA, so that the evaluation of this app version can take place in the third phase. Results of this study can provide an initial indication of whether social network support is a suitable intervention. Findings will help provide information on the feasibility of digital connectivity for PWA. Preliminary findings on its impact on the participation and quality of life of PWA could be made available

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells

Glioblastoma multiforme (GBM) is an invariably fatal central nervous system tumor despite treatment with surgery, radiation, and chemotherapy. Further insights into the molecular and cellular mechanisms that drive GBM formation are required to improve patient outcome. MicroRNAs are emerging as important regulators of cellular differentiation and proliferation, and have been implicated in the etiology of a variety of cancers, yet the role of microRNAs in GBM remains poorly understood. In this study, we investigated the role of microRNAs in regulating the differentiation and proliferation of neural stem cells and glioblastoma-multiforme tumor cells.status: publishe