Redefine statistical significance

We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries

Dendroglaciological Dating of a Little Ice Age Glacial Advance at Moving Glacier, Vancouver Island, British Columbia

Dendrochronological investigations at Moving Glacier provide the first calendar-dating of a Little Ice Age glacier advance on Vancouver Island. In 1931, Moving Glacier was within 30 to 50 m of a distinct trimline and terminal moraine marking its maximum Little Ice Age extent. A reconnaissance of the site in 1993 revealed the presence of sheared in situ stumps and detrital trunks inside the 1931 ice limit. Sampling in 1994 showed the site was covered by a mature subalpine forest prior to the glacial advance which overrode the site after 1718 A.D. Following this period of expansion, which saw Moving Glacier expand to its maximum Little Ice Age position after 1818 A.D., the glacier apparently experienced only minimal retreat prior to first being photographed in 1931.Des recherches en dendrochronologie menées sur le glacier Moving ont permis de dater l'évolution d'un glacier au Petit Âge glaciaire. En 1931, Le glacier Moving était situé entre 30 et 50 m d'un épaulement et d'une moraine frontale correspondant à sa limite d'expansion maximale au Petit Âge glaciaire. L'exploration du site en 1993 a permis de découvrir des souches et des débris de bois in situ à l'intérieur de la limite glaciaire de 1931. Un échantillonnage effectué en 1994 a montré que le site était recouvert d'une forêt subalpine mûre avant l'avancée glaciaire qui a bouleversé le site après 1718 ap. J.-C. Après la période d'expansion, qui a permis au glacier d'atteindre sa limite maximale après 1818 ap. J.-C, le glacier a connu un recul minimal avant d'être photographié en 1931.Dendrochnronologische Forschungen am Moving-Gletscher ergeben die erste Kalenderdatierung eines GletschervorstoBes wâhrend der kleinen Eiszeit auf der Insel Vancouver. 1931 befand sich der Moving-Gletscher innerhalb der 30 bis 50 m einer klaren Abflachung und der Endmorâne, was seiner maximalen Ausdehnung in der kleinen Eiszeit entsprach. 1993 fand man bei der Erkundung des Platzes in situ abgescherte Baumstùmpfe und Trùmmer von Baumstâmmen innerhalb der Eisgrenze von 1931. 1994 zeigte eine Probenentnahme, daf3 der Platz mit einem ausgewachsenen subalpinen WaId bewachsen war, bevor der glaziale VorstoB den Platz nach 1718 u.Z. verwandelte. Nach dieser Ausdehnungs-periode, in welcher der Moving-Gletscher nach 1818 u.Z. seine maximale Position in der kleinen Eiszeit erreichte, hat der Gletscher offenbar nur einen minimalen Rùckzug vollzogen, bevor er 1931 zum 1. Mal photographiert wurde

The equilibrium model for the effect of temperature on enzymes: Insights and implications

A new, experimentally-validated “Equilibrium Model” describes the effect of temperature on enzymes, and provides a new mechanism for the reversible loss of enzyme activity with temperature. It incorporates two new, fundamental parameters that allow a complete description of the effect of temperature on enzyme activity: ΔHeq and Teq. ΔHeq emerges as an intrinsic and quantitative measure of enzyme eurythermal adaptation, while Teq, the equilibrium temperature, has fundamental and technological significance for our understanding of the effect of temperature on enzymatic reactions. For biotechnological purposes, these parameters need to be considered when enzymes are applied or engineered for activity at high temperatures

Design and Implementation of a Digital Controller for a Vibration Isolation and Vernier Pointing System

This paper discusses the recommissioning of the Annular Suspension and Pointing System (ASPS), originally developed in the mid 1970's for pointing and vibration isolation of space experiments. The hardware was developed for NASA Langley Research Center by Sperry Flight Systems (now Honeywell Satellite Systems), was delivered to NASA in 1983. Recently, the hardware was loaned to Old Dominion University (ODU). The ASPS includes coarse gimbal assemblies and a Vernier Pointing Assembly (VPA) that utilize magnetic suspension to provide noncontacting vibration isolation and vernier pointing of the payload. The VPA is the main focus of this research. At ODU, the system has been modified such that it can now be operated in a l-g environment without a gravity offload. Suspension of the annular iron rotor in five degrees-of-freedom has been achieved with the use of modern switching power amplifiers and a digital controller implemented on a 486-class PC

The Engineers' Bookshelf

Our perception of an object’s size arises from the integration of multiple sources of visual information including retinal size, perceived distance and its size relative to other objects in the visual field. This constructive process is revealed through a number of classic size illusions such as the Delboeuf Illusion, the Ebbinghaus Illusion and others illustrating size constancy. Here we present a novel variant of the Delbouef and Ebbinghaus size illusions that we have named the Binding Ring Illusion. The illusion is such that the perceived size of a circular array of elements is underestimated when superimposed by a circular contour – a binding ring – and overestimated when the binding ring slightly exceeds the overall size of the array. Here we characterize the stimulus conditions that lead to the illusion, and the perceptual principles that underlie it. Our findings indicate that the perceived size of an array is susceptible to the assimilation of an explicitly defined superimposed contour. Our results also indicate that the assimilation process takes place at a relatively high level in the visual processing stream, after different spatial frequencies have been integrated and global shape has been constructed. We hypothesize that the Binding Ring Illusion arises due to the fact that the size of an array of elements is not explicitly defined and therefore can be influenced (through a process of assimilation) by the presence of a superimposed object that does have an explicit size

Towards predictive modelling of near-edge structures in electron energy loss spectra of AlN based ternary alloys

Although electron energy loss near edge structure analysis provides a tool for experimentally probing unoccupied density of states, a detailed comparison with simulations is necessary in order to understand the origin of individual peaks. This paper presents a density functional theory based technique for predicting the N K-edge for ternary (quasi-binary) nitrogen alloys by adopting a core hole approach, a methodology that has been successful for binary nitride compounds. It is demonstrated that using the spectra of binary compounds for optimising the core hole charge ($0.35\,\mathrm{e}$ for cubic Ti$_{1-x}$Al$_x$N and $0.45\,\mathrm{e}$ for wurtzite Al$_x$Ga$_{1-x}$N), the predicted spectra evolutions of the ternary alloys agree well with the experiments. The spectral features are subsequently discussed in terms of the electronic structure and bonding of the alloys.Comment: 11 pages, 9 figures, 1 tabl

Non-local nuclear spin quieting in quantum dot molecules: Optically-induced extended two-electron spin coherence time

We demonstrate the extension of coherence between all four two-electron spin ground states of an InAs quantum dot molecule (QDM) via non-local suppression of nuclear spin fluctuations in both constituent quantum dots (QDs), while optically addressing only the upper QD transitions. Long coherence times are revealed through dark-state spectroscopy as resulting from nuclear spin locking mediated by the exchange interaction between the QDs. Lineshape analysis provides the first measurement of the quieting of the Overhauser field distribution correlating with reduced nuclear spin fluctuations.Comment: Supplementary materials can be found on the publication page of our website. http://research.physics.lsa.umich.edu/dst/Publications.htm

Aortic calcification and femoral bone density are independently associated with left ventricular mass in patients with chronic kidney disease

Background Vascular calcification and reduced bone density are prevalent in chronic kidney disease and linked to increased cardiovascular risk. The mechanism is unknown. We assessed the relationship between vascular calcification, femoral bone density and left ventricular mass in patients with stage 3 non-diabetic chronic kidney disease in a cross-sectional observational study. Methodology and Principal Findings A total of 120 patients were recruited (54% male, mean age 55±14 years, mean glomerular filtration rate 50±13 ml/min/1.73 m2). Abdominal aortic calcification was assessed using lateral lumbar spine radiography and was present in 48%. Mean femoral Z-score measured using dual energy x-ray absorptiometry was 0.60±1.06. Cardiovascular magnetic resonance imaging was used to determine left ventricular mass. One patient had left ventricular hypertrophy. Subjects with aortic calcification had higher left ventricular mass compared to those without (56±16 vs. 48±12 g/m2, P = 0.002), as did patients with femoral Z-scores below zero (56±15 vs. 49±13 g/m2, P = 0.01). In univariate analysis presence of aortic calcification correlated with left ventricular mass (r = 0.32, P = 0.001); mean femoral Z-score inversely correlated with left ventricular mass (r = −0.28, P = 0.004). In a multivariate regression model that included presence of aortic calcification, mean femoral Z-score, gender and 24-hour systolic blood pressure, 46% of the variability in left ventricular mass was explained (P<0.001). Conclusions In patients with stage 3 non-diabetic chronic kidney disease, lower mean femoral Z-score and presence of aortic calcification are independently associated with increased left ventricular mass. Further research exploring the pathophysiology that underlies these relationships is warranted