67 research outputs found
Re-orientation Transition in Molecular Thin Films: Potts Model with Dipolar Interaction
We study the low-temperature behavior and the phase transition of a thin film
by Monte Carlo simulation. The thin film has a simple cubic lattice structure
where each site is occupied by a Potts parameter which indicates the molecular
orientation of the site. We take only three molecular orientations in this
paper which correspond to the 3-state Potts model. The Hamiltonian of the
system includes: (i) the exchange interaction between nearest-neighbor
sites and (ii) the long-range dipolar interaction of amplitude
truncated at a cutoff distance (iii) a single-ion perpendicular
anisotropy of amplitude . We allow between surface spins, and
otherwise. We show that the ground state depends on the the ratio
and . For a single layer, for a given , there is a critical value
below (above) which the ground-state (GS) configuration of molecular axes
is perpendicular (parallel) to the film surface. When the temperature is
increased, a re-orientation transition occurs near : the low- in-plane
ordering undergoes a transition to the perpendicular ordering at a finite ,
below the transition to the paramagnetic phase. The same phenomenon is observed
in the case of a film with a thickness. We show that the surface phase
transition can occur below or above the bulk transition depending on the ratio
. Surface and bulk order parameters as well as other physical quantities
are shown and discussed.Comment: 7 pages, 11 figures, submitted for publicatio
One-Year Mortality after Contemporary Laparoscopic Bariatric Surgery: An Analysis of the Bariatric Outcomes Longitudinal Database.
BACKGROUND:Contemporary mortality after bariatric surgery is low and has been decreasing over the past 2 decades. Most studies have reported inpatient or 30-day mortality, which may not represent the true risk of bariatric surgery. The objective of this study was to examine 1-year mortality and factors predictive of 1-year mortality after contemporary laparoscopic bariatric surgery. STUDY DESIGN:Using the 2008 to 2012 Bariatric Outcomes Longitudinal Database (BOLD), data from 158,606 operations were analyzed, including 128,349 (80.9%) laparoscopic Roux-en-Y gastric bypass (LRYGB) and 30,257 (19.1%) laparoscopic sleeve gastrectomy (LSG) operations. Multivariate logistic regression was used to determine independent risk factors associated with 1-year mortality for each type of procedure. RESULTS:The 30-day and 1-year mortality rates for LRYGB were 0.13% and 0.23%, respectively, and for LSG were 0.06% and 0.11%, respectively. Risk factors for 1-year mortality included older age (LRYGB: adjusted odds ratio [AOR] 1.05 per year, p < 0.001; LSG: AOR 1.08 per year, p < 0.001); male sex (LRYGB: AOR 1.88, p < 0.001); higher BMI (LRYGB: AOR 1.04 per unit, p < 0.001; LSG: AOR 1.05 per unit, p = 0.009); and the presence of 30-day leak (LRYGB: AOR 25.4, p < 0.001; LSG: AOR 35.8, p < 0.001), 30-day pulmonary embolism (LRYGB: AOR 34.5, p < 0.001; LSG: AOR 252, p < 0.001), and 30-day hemorrhage (LRYGB: AOR 2.34, p = 0.001). CONCLUSIONS:Contemporary 1-year mortality after laparoscopic bariatric surgery is much lower than previously reported, at <0.25%. It is important to continually refine techniques and perioperative management in order to minimize leaks, hemorrhage, and pulmonary embolus after bariatric surgery because these complications contribute to a higher risk of mortality
Effect of Dipolar Interaction in Molecular Crystals
We investigate in this paper the ground state and the nature of the
transition from an orientational ordered phase at low temperature to the
disordered state at high temperature in a molecular crystal. Our model is a
Potts model which takes into account the exchange interaction between
nearest-neighbor molecules and a dipolar interaction between molecular axes in
three dimensions. The dipolar interaction is characterized by two parameters:
its amplitude and the cutoff distance . If the molecular axis at a
lattice site has three orientations, say the , or axes, then when
D=0, the system is equivalent to the 3-state Potts model: the transition to the
disordered phase is known to be of first order. When , the
ground-state configuration is shown to be composed of two independent
interpenetrating layered subsystems which form a sandwich whose periodicity
depends on and . We show by extensive Monte Carlo simulation with a
histogram method that the phase transition remains of first order at relatively
large values of .Comment: 6 pages, 7 figure
A Multivalent and Cross-Protective Vaccine Strategy against Arenaviruses Associated with Human Disease
Arenaviruses are the causative pathogens of severe hemorrhagic fever and aseptic meningitis in humans, for which no licensed vaccines are currently available. Pathogen heterogeneity within the Arenaviridae family poses a significant challenge for vaccine development. The main hypothesis we tested in the present study was whether it is possible to design a universal vaccine strategy capable of inducing simultaneous HLA-restricted CD8+ T cell responses against 7 pathogenic arenaviruses (including the lymphocytic choriomeningitis, Lassa, Guanarito, Junin, Machupo, Sabia, and Whitewater Arroyo viruses), either through the identification of widely conserved epitopes, or by the identification of a collection of epitopes derived from multiple arenavirus species. By inoculating HLA transgenic mice with a panel of recombinant vaccinia viruses (rVACVs) expressing the different arenavirus proteins, we identified 10 HLA-A02 and 10 HLA-A03-restricted epitopes that are naturally processed in human antigen-presenting cells. For some of these epitopes we were able to demonstrate cross-reactive CD8+ T cell responses, further increasing the coverage afforded by the epitope set against each different arenavirus species. Importantly, we showed that immunization of HLA transgenic mice with an epitope cocktail generated simultaneous CD8+ T cell responses against all 7 arenaviruses, and protected mice against challenge with rVACVs expressing either Old or New World arenavirus glycoproteins. In conclusion, the set of identified epitopes allows broad, non-ethnically biased coverage of all 7 viral species targeted by our studies
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US Renal Data System 2018 Annual Data Report: Epidemiology of Kidney Disease in the United States.
The influence of human genetic variation on early transcriptional responses and protective immunity following immunization with Rotarix vaccine in infants in Ho Chi Minh City in Vietnam : a study protocol for an open single-arm interventional trial [awaiting peer review]
Background: Rotavirus (RoV) remains the leading cause of acute gastroenteritis in infants and children aged under five years in both high- and low-middle-income countries (LMICs). In LMICs, RoV infections are associated with substantial mortality. Two RoV vaccines (Rotarix and Rotateq) are widely available for use in infants, both of which have been shown to be highly efficacious in Europe and North America. However, for unknown reasons, these RoV vaccines have markedly lower efficacy in LMICs. We hypothesize that poor RoV vaccine efficacy across in certain regions may be associated with genetic heritability or gene expression in the human host.
Methods/design: We designed an open-label single-arm interventional trial with the Rotarix RoV vaccine to identify genetic and transcriptomic markers associated with generating a protective immune response against RoV. Overall, 1,000 infants will be recruited prior to Expanded Program on Immunization (EPI) vaccinations at two months of age and vaccinated with oral Rotarix vaccine at two and three months, after which the infants will be followed-up for diarrheal disease until 18 months of age. Blood sampling for genetics, transcriptomics, and immunological analysis will be conducted before each Rotarix vaccination, 2-3 days post-vaccination, and at each follow-up visit (i.e. 6, 12 and 18 months of age). Stool samples will be collected during each diarrheal episode to identify RoV infection. The primary outcome will be Rotarix vaccine failure events (i.e. symptomatic RoV infection despite vaccination), secondary outcomes will be antibody responses and genotypic characterization of the infection virus in Rotarix failure events.
Discussion: This study will be the largest and best powered study of its kind to be conducted to date in infants, and will be critical for our understanding of RoV immunity, human genetics in the Vietnam population, and mechanisms determining RoV vaccine-mediated protection.
Registration: ClinicalTrials.gov, ID: NCT03587389. Registered on 16 July 2018
Theory and Simulation of Magnetic Materials: Physics at Phase Frontiers
Abstract. The combination of theory and simulation is necessary in the investigation of properties of complex systems where each method alone cannot do the task properly. Theory needs simulation to test ideas and to check approximations. Simulation needs theory for modeling and for understanding results coming out from computers. In this review, we give recent examples to illustrate this necessary combination in a few domains of interest such as frustrated spin systems, surface magnetism, spintransport andmelting. Frustratedspin systems have been intensively studied for more than 30 years. Surface effects in magnetic materials have been widely investigated also in the last three decades. These fields are closely related to each other and their spectacular development is due to numerous applications. We confine ourselves to theoretical developments and numerical simulations on these subjects with emphasis on spectacular effects occurring at frontiers of different phases. 1
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