Scrutinizing the Components of Mindfulness: Insights from Current, Past, and Non-meditators

The factor structure of the Five Facets Mindfulness Questionnaire (FFMQ) seems to vary across samples depending on whether meditators or non-meditators are studied and whether a sample is analyzed before or after mindfulness-based cognitive therapy. The current study illustrates the inconsistencies typically found (e.g., whether all five facets can load on an overall construct of mindfulness), as well as provides and tests alternative explanations in three samples with different levels of meditation experience (i.e., current meditators, past meditators, and non-meditators). Altogether, 2247 German-speaking volunteers completed the FFMQ and reported their meditation experiences online. Results showed that the scaling of three facets of the FFMQ (i.e., observing, describing, and non-judging) were constrained in all samples. The past meditators revealed unique features in terms of their mindfulness level: (1) stopping practicing meditation reduced their levels of mindfulness in facets of awareness, non-judging, and non-reacting, yet observing and describing seemed to remain and (2) those past meditators with intensive trainings scored higher in all five facets than those past meditators who practiced less. The CFA yielded a good fit in all three samples. A hierarchical factor analysis showed how the factors unfolded from level to level and demonstrated that in particular the observing facet loaded on the overall construct of mindfulness differently across the three samples. The empirical results confirmed the alternative interpretations on why the discrepancy regarding the loading of the “observing” facet on an overall mindfulness construct occurs, but future studies might think of investigating each hypothesis specifically

miRNA-378 reverses chemoresistance to cisplatin in lung adenocarcinoma cells by targeting secreted clusterin

Cisplatin resistance is a major obstacle in the treatment of NSCLC, and its mechanism has not been fully elucidated. The objectives of the study were to determine the role of miR-378 in the sensitivity of lung adenocarcinoma cells to cisplatin (cDDP) and its working mechanism. With TargetScan and luciferase assay, miR-378 was found to directly target sCLU. miR-378 and sCLU were regulated in A549/cDDP and Anip973/cDDP cells to investigate the effect of miR-378 on the sensitivity and apoptotic effects of cDDP. The effect of miR-378 upregulation on tumor growth was analyzed in a nude mouse xenograft model. The correlation between miR-378 and chemoresistance was tested in patient samples. We found that upregulation of miR-378 in A549/cDDP and Anip973/cDDP cells significantly down-regulated sCLU expression, and sensitized these cells to cDDP. miR-378 overexpression inhibited tumor growth and sCLU expression in a xenograft animal model. Analysis of human lung adenocarcinoma tissues revealed that the cDDP sensitive group expressed higher levels of miR-378 and lower levels of sCLU. miR-378 and sCLU were negatively correlated. To conclude, we identified sCLU as a novel miR-378 target, and we showed that targeting sCLU via miR-378 may help disable the chemoresistance against cisplatin in lung adenocarcinoma cells

Recent Advances on Cellulosic Emulsions for Encapsulation of Bioactive Substances

Protection, dispersion and delivery of the functional components can implement in the emulsion-encapsulating systems. Among the stabilizers of the emulsion, specific structure of the cellulose may improve the stability of the system, and supplying the utilization of the bioactive substances on encapsulation and release. Therefore, the recent advances on stabilizing mechanism, cellulosic materials, properties of bioactive substances and factors affecting on the release of cellulosic emulsion-encapsulating systems are summarized in this review. In addition, the paper focuses on the release process and regulated mechanism of cellulose, which shows high length-diameter ratio and mechanical strength in the emulsion-delivery system of bioactive substances, and providing reference for the development of the food-grade delivery system. Studies indicates that cellulose-stabilized emulsion can improve the dispersion and oxidation stability of the bioactive substances, while controlling the release and improving the bioavailability of the functional factors. However, there is still vast research space for its safety evaluation in the food system, and related toxicological experiments urgently need to be carried out

System engineering and key technologies research and practice of smart mine

In order to overcome the problems existed in the construction process of complex giant system of smart mine, the overall technical framework of smart mine construction was proposed, and a detailed description was made from the aspects of smart mine system model construction, underground space reconstruction and model dynamic update, machine vision measurement technology, radio frequency explosion-proof test method of gas environment, mine safety closed-loop control system, smart mine standard system, etc. The smart mine was divided into information sensing support layer, edge computing layer, cloud data center, multi-type network, intelligent mine production management and control platform, intelligent mine production system and intelligent mine operation and maintenance management system. The smart mine technology architecture based on the deep integration of multiple systems was built. Based on the knowledge map and information extraction of smart mine, a smart mine system model driven by data innovation, based on communication network and centered on data computing power was constructed. A 3D visual space model based on machine vision perception information and supplemented by other perception information was constructed, and a 3D vision and spatial reconstruction framework of mine underground scene was proposed to realize the reconstruction and dynamic update of the 3D space of underground mine. Based on machine vision technology, the identification algorithm of downhole equipment position and coal-rock interface was developed to realize the simultaneous aerial measurement of fully mechanized mining equipment group and coal-rock interface. The limitations and shortcomings of the current explosion-proof standards on the power of 5G base stations in the underground gas environment were discussed, and a special test device for radio-frequency electromagnetic energy explosion-proof was designed and developed, which provides a method for reference to improve the power threshold of underground 5G base stations. The technical framework of mine disaster closed-loop management and control system, which integrates comprehensive perception of disaster information, independent decision-making of prevention and control plan, and coordinated control of prevention and control equipment, was proposed to realize advanced prediction and early warning and coordinated prevention and control of underground disasters. The framework of intelligent coal mine standard system was constructed, the typical cases of intelligent construction of coal mine and metal mine in China were analyzed, and the development trend and suggestions of intelligent mine construction were put forward

Untersuchungen uber das Schicksal der in rohes und gekochtes Brunnenwasser gemischten pathogenen Bakterien

Der Verfasser hat Untersuchungen uber die Lebensdauer von pathogenen Darmbakterien, die in rohes und gekochtes Brunnenwasser gemischt wurden, durchgefuhrt. Er hat 5 Brunnenwasser untersucht mit B. typhosus, B. paratyphosus A u. B, B. dysenteriae Komagome A u. B, B. dysenteriae Shiga; die Stamme erhielt Verf. aus dem Staatlichen Institut fur Infektionskrankheiten und aus dem bakteriologischen Institut zu Chiba. Die Ergebnisse sind folgende: 1) war die Menge der verwandten Bakterien klein (ca. 1/3000 Ose in 10 cc.), lebten alle Bakterien in rohem Wasser langer als in gekochtem Wasser. 2) war die Bakterienmenge relativ gross (1 Ose in 10 cc.), lebten die Bakterien zwar langer als bei geringer Menge, verschwanden aber in rohem Wasser schneller als in gekochtem. 3) Unter beiden Versuchsanordnungen lebten die Bakterien im Brunnenwasser langer als in Aq. dest. oder in physiologischer Kochsalzlosung. 4) Die Tabellen zeigen kurz die Ergebnisse: (Autoreferat

Systematic identification and characterization of chicken (Gallus gallus) ncRNAs

Recent studies have demonstrated that non-coding RNAs (ncRNAs) play important roles during development and evolution. Chicken, the first genome-sequenced non-mammalian amniote, possesses unique features for developmental and evolutionary studies. However, apart from microRNAs, information on chicken ncRNAs has mainly been obtained from computational predictions without experimental validation. In the present study, we performed a systematic identification of intermediate size ncRNAs (50–500 nt) by ncRNA library construction and identified 125 chicken ncRNAs. Importantly, through the bioinformatics and expression analysis, we found the chicken ncRNAs has several novel features: (i) comparative genomic analysis against 18 sequenced vertebrate genomes revealed that the majority of the newly identified ncRNA candidates is not conserved and most are potentially bird/chicken specific, suggesting that ncRNAs play roles in lineage/species specification during evolution. (ii) The expression pattern analysis of intronic snoRNAs and their host genes suggested the coordinated expression between snoRNAs and their host genes. (iii) Several spatio-temporal specific expression patterns suggest involvement of ncRNAs in tissue development. Together, these findings provide new clues for future functional study of ncRNAs during development and evolution

Troponin Is Unrelated to Outcomes in Heart Failure Patients Discharged From the Emergency Department

Background: Prior data has demonstrated increased mortality in hospitalized patients with acute heart failure (AHF) and troponin elevation. No data has specifically examined the prognostic significance of troponin elevation in patients with AHF discharged after emergency department (ED) management. Objective: Evaluate the relationship between troponin elevation and outcomes in patients with AHF who are treated and released from the ED. Methods: This was a secondary analysis of the Get with the Guidelines to Reduce Disparities in AHF Patients Discharged from the ED (GUIDED-HF) trial, a randomized, controlled trial of ED patients with AHF who were discharged. Patients with elevated conventional troponin not due to acute coronary syndrome (ACS) were included. Our primary outcome was a composite endpoint: time to 30-day cardiovascular death and/or heart failure-related events. Results: Of the 491 subjects included in the GUIDED-HF trial, 418 had troponin measured during the ED evaluation and 66 (16%) had troponin values above the 99th percentile. Median age was 63 years (interquartile range, 54-70), 62% (n = 261) were male, 63% (n = 265) were Black, and 16% (n = 67) experienced our primary outcome. There were no differences in our primary outcome between those with and without troponin elevation (12/66, 18.1% vs 55/352, 15.6%; P = 0.60). This effect was maintained regardless of assignment to usual care or the intervention arm. In multivariable regression analysis, there was no association between our primary outcome and elevated troponin (hazard ratio, 1.00; 95% confidence interval, 0.49-2.01, P = 0.994). Conclusion: If confirmed in a larger cohort, these findings may facilitate safe ED discharge for a group of patients with AHF without ACS when an elevated troponin is the primary reason for admission

Scrutinizing the components of Mindfulness: Insights from current, past and non-meditators

The factor structure of the Five Facets Mindfulness Questionnaire (FFMQ) seems to vary across samples depending on whether meditators or non-meditators are studied and whether a sample is analyzed before or after mindfulness-based cognitive therapy. The current study illustrates the inconsistencies typically found (e.g., whether all five facets can load on an overall construct of mindfulness), as well as provides and tests alternative explanations in three samples with different levels of meditation experience (i.e., current meditators, past meditators, and non-meditators). Altogether, 2247 German-speaking volunteers completed the FFMQ and reported their meditation experiences online. Results showed that the scaling of three facets of the FFMQ (i.e., observing, describing, and non-judging) were constrained in all samples. The past meditators revealed unique features in terms of their mindfulness level: (1) stopping practicing meditation reduced their levels of mindfulness in facets of awareness, non-judging, and non-reacting, yet observing and describing seemed to remain and (2) those past meditators with intensive trainings scored higher in all five facets than those past meditators who practiced less. The CFA yielded a good fit in all three samples. A hierarchical factor analysis showed how the factors unfolded from level to level and demonstrated that in particular the observing facet loaded on the overall construct of mindfulness differently across the three samples. The empirical results confirmed the alternative interpretations on why the discrepancy regarding the loading of the “observing” facet on an overall mindfulness construct occurs, but future studies might think of investigating each hypothesis specifically