Topological insight into the non-Arrhenius mode hopping of semiconductor ring lasers

We investigate both theoretically and experimentally the stochastic switching between two counter-propagating lasing modes of a semiconductor ring laser. Experimentally, the residence time distribution cannot be described by a simple one parameter Arrhenius exponential law and reveals the presence of two different mode-hop scenarios with distinct time scales. In order to elucidate the origin of these two time scales, we propose a topological approach based on a two-dimensional dynamical system.Comment: 4 pages, 3 figure

Regimes of operations of semiconductor ring lasers under optical injection and applications to optical signal processing

We present a detailed characterization of the semiconductor ring-laser operating regimes with special emphasis on the response to optical injection. Applications to an optical set/reset bistable memory and four-wave-mixing tunable THz signals generation are demonstrated.</p

Dynamical instabilities of dissipative solitons in nonlinear optical cavities with nonlocal materials

In this work we characterize the dynamical instabilities of localized structures exhibited by a recently introduced Gelens et al., Phys. Rev. A 75, 063812 2007 generalization of the Lugiato-Lefever model that includes a weakly nonlocal response of an intracavity metamaterial. A rich scenario, in which the localized structures exhibit different types of oscillatory instabilities, tristability, and excitability, including a regime of conditional excitability in which the system is bistable, is presented and discussed. Finally, it is shown that the scenario is organized by a pair of Takens-Bogdanov codimension-2 points.Comment: 8 pages, 9 figure

Power and Authority in Eastern Christian Experience: Papers of the Sophia Institute Academic Conference New York, December 2010

The essays in this volume were delivered at the Third Annual Conference of the Sophia Institute in December 2010 at Union Theological Seminary in New York City. The theme of that conference, “Power and Authority in Eastern Christian Experience,” brought forth a diverse group of scholars who contributed their perspectives on the ways the Eastern Orthodox Church, in its broadest sense, has negotiated the notions of power, authority, (dis)obedience, and resistance over time and space. These insightful essays promise to draw the Orthodox world into a dynamic and productive discourse

On N = 2 Truncations of IIB on T^{1,1}

We study the N=4 gauged supergravity theory which arises from the consistent truncation of IIB supergravity on the coset T^{1,1}. We analyze three N=2 subsectors and in particular we clarify the relationship between true superpotentials for gauged supergravity and certain fake superpotentials which have been widely used in the literature. We derive a superpotential for the general reduction of type I supergravity on T^{1,1} and this together with a certain solution generating symmetry is tantamount to a superpotential for the baryonic branch of the Klebanov-Strassler solution.Comment: 32 pages, v2:references adde

Type IIA orientifold compactification on SU(2)-structure manifolds

We investigate the effective theory of type IIA string theory on six-dimensional orientifold backgrounds with SU(2)-structure. We focus on the case of orientifolds with O6-planes, for which we compute the bosonic effective action in the supergravity approximation. For a generic SU(2)-structure background, we find that the low-energy effective theory is a gauged N=2 supergravity where moduli in both vector and hypermultiplets are charged. Since all these supergravities descend from a corresponding N=4 background, their scalar target space is always a quotient of a SU(1,1)/U(1) x SO(6,n)/SO(6)xSO(n) coset, and is therefore also very constrained.Comment: 31 pages; v2: local report number adde

Moduli Stabilization and Cosmology of Type IIB on SU(2)-Structure Orientifolds

We consider type IIB flux compactifications on six-dimensional SU(2)-structure manifolds with O5- and O7-planes. These six-dimensional spaces allow not only for F_3 and H_3 fluxes but also for F_1 and F_5 fluxes. We derive the four-dimensional N=1 scalar potential for such compactifications and present one explicit example of a fully stabilized AdS vacuum with large volume and small string coupling. We then discuss cosmological aspects of these compactifications and derive several no-go theorems that forbid dS vacua and slow-roll inflation under certain conditions. We also study concrete examples of cosets and twisted tori and find that our no-go theorems forbid dS vacua and slow-roll inflation in all but one of them. For the latter we find a dS critical point with \epsilon numerically zero. However, the point has two tachyons and eta-parameter \eta \approx -3.1.Comment: 35 pages + appendices, LaTeX2e; v2: numerical dS extremum added, typos corrected, references adde

CNTN6 mutations are risk factors for abnormal auditory sensory perception in autism spectrum disorders

Contactin genes CNTN5 and CNTN6 code for neuronal cell adhesion molecules that promote neurite outgrowth in sensory-motor neuronal pathways. Mutations of CNTN5 and CNTN6 have previously been reported in individuals with autism spectrum disorders (ASDs), but very little is known on their prevalence and clinical impact. In this study, we identified CNTN5 and CNTN6 deleterious variants in individuals with ASD. Among the carriers, a girl with ASD and attention-deficit/hyperactivity disorder was carrying five copies of CNTN5. For CNTN6, both deletions (6/1534 ASD vs 1/8936 controls; P=0.00006) and private coding sequence variants (18/501 ASD vs 535/33480 controls; P=0.0005) were enriched in individuals with ASD. Among the rare CNTN6 variants, two deletions were transmitted by fathers diagnosed with ASD, one stop mutation CNTN6W923X was transmitted by a mother to her two sons with ASD and one variant CNTN6P770L was found de novo in a boy with ASD. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway. These results reinforce the hypothesis of abnormal neuronal connectivity in the pathophysiology of ASD and shed new light on the genes that increase risk for abnormal sensory perception in ASD

A multiresolution approach to automated classification of protein subcellular location images

<p>Abstract</p> <p>Background</p> <p>Fluorescence microscopy is widely used to determine the subcellular location of proteins. Efforts to determine location on a proteome-wide basis create a need for automated methods to analyze the resulting images. Over the past ten years, the feasibility of using machine learning methods to recognize all major subcellular location patterns has been convincingly demonstrated, using diverse feature sets and classifiers. On a well-studied data set of 2D HeLa single-cell images, the best performance to date, 91.5%, was obtained by including a set of multiresolution features. This demonstrates the value of multiresolution approaches to this important problem.</p> <p>Results</p> <p>We report here a novel approach for the classification of subcellular location patterns by classifying in multiresolution subspaces. Our system is able to work with any feature set and any classifier. It consists of multiresolution (MR) decomposition, followed by feature computation and classification in each MR subspace, yielding local decisions that are then combined into a global decision. With 26 texture features alone and a neural network classifier, we obtained an increase in accuracy on the 2D HeLa data set to 95.3%.</p> <p>Conclusion</p> <p>We demonstrate that the space-frequency localized information in the multiresolution subspaces adds significantly to the discriminative power of the system. Moreover, we show that a vastly reduced set of features is sufficient, consisting of our novel modified Haralick texture features. Our proposed system is general, allowing for any combinations of sets of features and any combination of classifiers.</p