1,101 research outputs found
Role of Arctic Sea Ice Variability in Climate Models
Arctic sea ice plays an important role in climate by influencing surface heat fluxes and albedo, so must be accurately represented in climate models. This study finds that the fully coupled ice-ocean-atmosphere-land Community Climate System Model (CCSM3.0) underestimates day-to-day ice variability compared to observations and employs the Community Atmosphere Model (CAM3.0) to investigate the atmospheric sensitivity to sea ice variability. Three 100-ensemble experiments are forced with climatological, daily-varying, and smoothly-varying sea ice conditions from an anomalously low ice period (September 2006-February 2007). Daily ice variability has a large local impact on the atmosphere when ice undergoes rapid changes, leading to local cooling and subsequent circulation changes. The most notable example of a large-scale atmospheric response occurs over Northern Europe during fall where daily ice variability forces reductions in the number and strength of cyclones, leading to positive sea level pressure anomalies, surface warming, and reduced cloud cover.Signature Page...i Title Page...ii Abstract...iii Table of Contents...iv List of Figures...vi List of Tables...x List of Appendices...xi 1 Introduction...14 1.1 Introduction – Arctic Sea Ice Evolution...14 1.2 Introduction – Impact of Sea Ice on Atmosphere...17 1.3 Model Versus Observed Arctic Sea Ice...21 1.3.1 Data Properties...21 1.3.2 Mean Ice Conditions...22 1.3.3 Standard Deviation...24 1.3.4 Day-to-day Change of Ice Concentration...27 Model, Data and Methods...30 2.1 Model Description...30 2.2 Observations...31 2.2.1 Data Used as Boundary Conditions in CTRL, DAILY and SMTH Experiments...32 2.3 Methods...41 2.3.1 Number of Ensembles...41 2.3.2 Storm Track Algorithm...42 2.3.3 Bandpassed Filtering...43 2 3 4 5 v Results and Discussion...44 3.1 Fall (September – October) Response...44 3.2 Winter (November – February) Response...55 3.3 Stormtrack Response in the Midlatitudes and the Arctic...59 3.4 Ensemble Analysis...62 Summary and Conclusions...65 References...6
Impact of Daily Arctic Sea Ice Variability in CAM3.0 during Fall and Winter
Climate projections suggest that an ice-free summer Arctic Ocean is possible within several decades and with this comes the prospect of increased ship traffic and safety concerns. The daily sea ice concentration tendency in five Coupled Model Intercomparison Project phase 5 (CMIP5) simulations is compared with observations to reveal that many models underestimate this quantity that describes high-frequency ice movements, particularly in the marginal ice zone. To investigate whether high-frequency ice variability impacts the atmosphere, the Community Atmosphere Model, version 3.0 (CAM3.0), is forced by sea ice with and without daily fluctuations. Two 100-member ensemble experiments with daily varying (DAILY) and smoothly varying (SMTH) sea ice are conducted, along with a climatological control, for an anoma- lously low ice period (August 2006–November 2007). Results are presented for three periods: September 2006, October 2006, and December–February (DJF) 2006/07. The atmospheric response differs between DAILY and SMTH. In September, sea ice differences lead to an anomalous high and weaker storm activity over northern Europe. During October, the ice expands equatorward faster in DAILY than SMTH in the Siberian seas and leads to a local response of near-surface cooling. In DJF, there is a 1.5-hPa positive sea level pressure anomaly over North America, leading to anomalous northerly flow and anomalously cool continental U.S. temperatures. While the atmospheric responses are modest, the differences arising from high temporal frequency ice variability cannot be ignored. Increasing the accuracy of coupled model sea ice variations on short time scales is needed to improve short-term coupled model forecasts
Wie und wo arbeiten Bielefelder Soziologen?
In dem Beitrag wird der berufliche Verbleib der Bielefelder Soziologen untersucht. Ausgewertet werden Telefoninterviews der Absolventen, die zwischen 1970 und 1991 ihr Soziologiestudium abgeschlossen haben. Gefragt wird nach dem Beschäftigungsverhältnis. Neben dem Öffentlichen Dienst und der Forschung wird der Bildungsbereich als das absorptionsfähigste Feld für Soziologen ermittelt. Es wird beschrieben, in welchen anderen Organisationen als gesellschaftliche Funktionssysteme Soziologen arbeiten. Die Erhebung zeigt, daß neben die klassischen Berufe für Soziologinnen und Soziologen eine ganze Reihe von neuen getreten sind: im Bereich von Geschäftsführung, Beratung, Marketing, Marktforschung und EDV. Auch nimmt die Wirtschaft als Arbeitgeber einen immer größeren Stellenwert ein. (ICA
First observations of sea ice flexural–gravity waves with ground-based radar interferometry in Utqiaġvik, Alaska
We investigate the application of ground-based radar
interferometry for measuring flexural–gravity waves in sea ice. We deployed
a GAMMA Portable Radar Interferometer (GPRI) on top of a grounded iceberg
surrounded by landfast sea ice near Utqiaġvik, Alaska. The GPRI
collected 238 acquisitions in stare mode during a period of moderate lateral
ice motion during 23–24 April 2021. Individual 30 s interferograms
exhibit ∼ 20–50 s periodic motion indicative of propagating
infragravity waves with ∼ 1 mm amplitudes. Results include
examples of onshore wave propagation at the speed predicted by the water
depth and a possible edge wave along an ice discontinuity. Findings are
supported through comparison with on-ice Ice Wave Rider (IWR) accelerometers
and modeled wave propagation. These results suggest that the GPRI can be a
valuable tool to track wave propagation through sea ice and possibly detect
changes in such properties across variable ice conditions.</p
Cerebral palsy and placental infection: a case-cohort study
BACKGROUND: The association between cerebral palsy in very preterm infants and clinical, histopathologic and microbiological indicators of chorioamnionitis, including the identification of specific micro-organisms in the placenta, was evaluated in a case-cohort study. METHODS: Children with a diagnosis of cerebral palsy at five years of age were identified from amongst participants in a long-term follow-up program of preterm infants. The comparison group was a subcohort of infants randomly selected from all infants enrolled in the program. The placentas were examined histopathologically for chorioamnionitis and funisitis, and the chorioamnionic interface was aseptically swabbed and comprehensively cultured for aerobic and anaerobic bacteria, yeast and genital mycoplasmas. Associations between obstetric and demographic variables, indicators of chorioamnionitis and cerebral palsy status were examined by univariate analysis. RESULTS: Eighty-two infants with cerebral palsy were compared with the subcohort of 207 infants. Threatened preterm labor was nearly twice as common among the cases as in the subcohort (p < 0.01). Recorded clinical choroamnionitis was similar in the two groups and there was no difference in histopathologic evidence of infection between the two groups. E. coli was cultured from the placenta in 6/30 (20%) of cases as compared with 4/85 (5%) of subcohort (p = 0.01). Group B Streptococcus was more frequent among the cases, but the difference was not statistically significant. CONCLUSIONS: The association between E. coli in the chorioamnion and cerebral palsy in preterm infants identified in this study requires confirmation in larger multicenter studies which include microbiological study of placentas
Neuroinflammation and structural injury of the fetal ovine brain following intra-amniotic Candida albicans exposure.
BackgroundIntra-amniotic Candida albicans (C. Albicans) infection is associated with preterm birth and high morbidity and mortality rates. Survivors are prone to adverse neurodevelopmental outcomes. The mechanisms leading to these adverse neonatal brain outcomes remain largely unknown. To better understand the mechanisms underlying C. albicans-induced fetal brain injury, we studied immunological responses and structural changes of the fetal brain in a well-established translational ovine model of intra-amniotic C. albicans infection. In addition, we tested whether these potential adverse outcomes of the fetal brain were improved in utero by antifungal treatment with fluconazole.MethodsPregnant ewes received an intra-amniotic injection of 10(7) colony-forming units C. albicans or saline (controls) at 3 or 5 days before preterm delivery at 0.8 of gestation (term ~ 150 days). Fetal intra-amniotic/intra-peritoneal injections of fluconazole or saline (controls) were administered 2 days after C. albicans exposure. Post mortem analyses for fungal burden, peripheral immune activation, neuroinflammation, and white matter/neuronal injury were performed to determine the effects of intra-amniotic C. albicans and fluconazole treatment.ResultsIntra-amniotic exposure to C. albicans caused a severe systemic inflammatory response, illustrated by a robust increase of plasma interleukin-6 concentrations. Cerebrospinal fluid cultures were positive for C. albicans in the majority of the 3-day C. albicans-exposed animals whereas no positive cultures were present in the 5-day C. albicans-exposed and fluconazole-treated animals. Although C. albicans was not detected in the brain parenchyma, a neuroinflammatory response in the hippocampus and white matter was seen which was characterized by increased microglial and astrocyte activation. These neuroinflammatory changes were accompanied by structural white matter injury. Intra-amniotic fluconazole reduced fetal mortality but did not attenuate neuroinflammation and white matter injury.ConclusionsIntra-amniotic C. albicans exposure provoked acute systemic and neuroinflammatory responses with concomitant white matter injury. Fluconazole treatment prevented systemic inflammation without attenuating cerebral inflammation and injury
Validation of Tuba1a as appropriate internal control for normalization of gene expression analysis during mouse lung development
© 2015 by the authors; licensee MDPI, Basel, Switzerland. The expression ratio between the analysed gene and an internal control gene is the most widely used normalization method for quantitative RT-PCR (qRT-PCR) expression analysis. The ideal reference gene for a specific experiment is the one whose expression is not affected by the different experimental conditions tested. In this study, we validate the applicability of five commonly used reference genes during different stages of mouse lung development. The stability of expression of five different reference genes (Tuba1a, Actb Gapdh, Rn18S and Hist4h4) was calculated within five experimental groups using the statistical algorithm of geNorm software. Overall, Tuba1a showed the least variability in expression among the different stages of lung development, while Hist4h4 and Rn18S showed the maximum variability in their expression. Expression analysis of two lung specific markers, surfactant protein C (SftpC) and Clara cell-specific 10 kDA protein (Scgb1a1), normalized to each of the five reference genes tested here, confirmed our results and showed that incorrect reference gene choice can lead to artefacts. Moreover, a combination of two internal controls for normalization of expression analysis during lung development will increase the accuracy and reliability of results
Instantaneous sea ice drift speed from TanDEM-X interferometry
The drift of sea ice is an important geophysical process with
widespread implications for the ocean energy budget and ecosystems. Drifting
sea ice can also threaten marine operations and present a hazard for ocean
vessels and installations. Here, we evaluate single-pass along-track
synthetic aperture radar (SAR) interferometry (S-ATI) as a tool to assess
ice drift while discussing possible applications and inherent limitations.
Initial validation shows that TanDEM-X phase-derived drift speed corresponds
well with drift products from a ground-based radar at Utqiaġvik, Alaska.
Joint analysis of TanDEM-X and Sentinel-1 data covering the Fram Strait
demonstrates that S-ATI can help quantify the opening/closing rate of leads
with possible applications for navigation. S-ATI enables an instantaneous
assessment of ice drift and dynamic processes that are otherwise difficult
to observe. For instance, by evaluating sea ice drift through the Vilkitsky
Strait, Russia, we identified short-lived transient convergence patterns. We
conclude that S-ATI enables the identification and analysis of potentially
important dynamic processes (e.g., drift, rafting, and ridging). However,
current limitations of S-ATI are significant (e.g., data availability and
they presently only provide the cross-track vector component of the ice drift
field) but may be significantly reduced with future SAR systems.</p
Nonequilibrium relaxation of the two-dimensional Ising model: Series-expansion and Monte Carlo studies
We study the critical relaxation of the two-dimensional Ising model from a
fully ordered configuration by series expansion in time t and by Monte Carlo
simulation. Both the magnetization (m) and energy series are obtained up to
12-th order. An accurate estimate from series analysis for the dynamical
critical exponent z is difficult but compatible with 2.2. We also use Monte
Carlo simulation to determine an effective exponent, z_eff(t) = - {1/8} d ln t
/d ln m, directly from a ratio of three-spin correlation to m. Extrapolation to
t = infinity leads to an estimate z = 2.169 +/- 0.003.Comment: 9 pages including 2 figure
MRC ORACLE Children Study. Long term outcomes following prescription of antibiotics to pregnant women with either spontaneous preterm labour or preterm rupture of the membranes
BACKGROUND: The Medical Research Council (MRC) ORACLE trial evaluated the use of co-amoxiclav 375 mg and/or erythromycin 250 mg in women presenting with preterm rupture of membranes (PROM) ORACLE I or in spontaneous preterm labour (SPL) ORACLE II using a factorial design. The results showed that for women with a singleton baby with PROM the prescription of erythromycin is associated with improvements in short term neonatal outcomes, although co-amoxiclav is associated with prolongation of pregnancy, a significantly higher rate of neonatal necrotising enterocolitis was found in these babies. Prescription of erythromycin is now established practice for women with PROM. For women with SPL antibiotics demonstrated no improvements in short term neonatal outcomes and are not recommended treatment. There is evidence that both these conditions are associated with subclinical infection so perinatal antibiotic administration may reduce the risk of later disabilities, including cerebral palsy, although the risk may be increased through exposure to inflammatory cytokines, so assessment of longer term functional and educational outcomes is appropriate. METHODS: The MRC ORACLE Children's Study will follow up UK children at age 7 years born to 4809 women with PROM and the 4266 women with SPL enrolled in the earlier ORACLE trials. We will use a parental questionnaire including validated tools to assess disability and behaviour. We will collect the frequency of specific medical conditions: cerebral palsy, epilepsy, respiratory illness including asthma, diabetes, admission to hospital in last year and other diseases, as reported by parents. National standard test results will be collected to assess educational attainment at Key Stage 1 for children in England. DISCUSSION: This study is designed to investigate whether or not peripartum antibiotics improve health and disability for children at 7 years of age. TRIAL REGISTRATION: The ORACLE Trial and Children Study is registered in the Current Controlled Trials registry. ISCRTN 52995660
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