47 research outputs found
Text Mining Improves Prediction of Protein Functional Sites
- Author
- A Koussounadis
- A Sokolov
- AG Murzin
- AR Atilgan
- AT Laurie
- BJ Grant
- CA Earhart
- CB Ahlers
- CJO Baker
- CM Nunn
- CT Porter
- D Ferrucci
- D Ming
- D Ming
- D Ming
- D Ming
- D Ming
- D Oliver
- D Zhou
- DS Greer
- F Horn
- F Leitner
- GL Card
- HJ Nam
- HM Berman
- I Bahar
- J Dundas
- J Laurila
- J Ory
- JD Cohn
- JG Caporaso
- JG Caporaso
- JK Hurley
- JM Jez
- Judith D. Cohn
- JY Choe
- K Hinsen
- K Nagel
- K Nagel
- K Nagel
- K Verspoor
- K Verspoor
- K Verspoor
- K Verspoor
- Karin M. Verspoor
- KB Cohen
- KE Ravikumar
- KL Damm
- Komandur E. Ravikumar
- L Hu
- L Xie
- LH Weaver
- LJ Jensen
- LL Huang
- M Ankerst
- M Krallinger
- M Krallinger
- ME Wall
- MF Sanner
- Michael E. Wall
- ML Benson
- ML Benson
- MM Tirion
- N Chim
- Neil R. Smalheiser
- PE Bourne
- R Gaizauskas
- R Witte
- RC Edgar
- S Perot
- TW Schwartz
- WA Baumgartner Jr
- Publication venue
- Public Library of Science
- Publication date
- 29/02/2012
- Field of study
We present an approach that integrates protein structure analysis and text mining for protein functional site prediction, called LEAP-FS (Literature Enhanced Automated Prediction of Functional Sites). The structure analysis was carried out using Dynamics Perturbation Analysis (DPA), which predicts functional sites at control points where interactions greatly perturb protein vibrations. The text mining extracts mentions of residues in the literature, and predicts that residues mentioned are functionally important. We assessed the significance of each of these methods by analyzing their performance in finding known functional sites (specifically, small-molecule binding sites and catalytic sites) in about 100,000 publicly available protein structures. The DPA predictions recapitulated many of the functional site annotations and preferentially recovered binding sites annotated as biologically relevant vs. those annotated as potentially spurious. The text-based predictions were also substantially supported by the functional site annotations: compared to other residues, residues mentioned in text were roughly six times more likely to be found in a functional site. The overlap of predictions with annotations improved when the text-based and structure-based methods agreed. Our analysis also yielded new high-quality predictions of many functional site residues that were not catalogued in the curated data sources we inspected. We conclude that both DPA and text mining independently provide valuable high-throughput protein functional site predictions, and that integrating the two methods using LEAP-FS further improves the quality of these predictions
The epidemiological impact of childhood influenza vaccination using live-attenuated influenza vaccine (LAIV) in Germany: predictions of a simulation study
- Author
- AE Fiore
- AS Monto
- AS Monto
- CJ Williams
- CS Ambrose
- DM Fleming
- E Savidan
- E Vynnycky
- F Carrat
- G Chowell
- G Fairbrother
- Hagen Krüger
- HS Izurieta
- J Mossong
- J Rhorer
- JH Bueving
- Johannes G Liese
- Joint Committee on Vaccination and Immunisation
- JP Fox
- JS Tam
- KA Poehling
- KL Nichol
- KM Neuzil
- Markus A Rose
- Markus Knuf
- Markus Schwehm
- Martin Eichner
- MT Osterholm
- N Giglio
- NA Molinari
- Oliver Damm
- Peter Wutzler
- PL Fraaij
- PR Blank
- PR Blank
- RJ Pitman
- Robert Koch-Institut
- S Esposito
- SAGE Influenza Working Group
- Statistisches Bundesamt
- Statistisches Bundesamt
- T Jefferson
- T Jefferson
- T Vesikari
- Thomas F Kochmann
- Tom Schaberg
- Ulrich Wahn
- V Usonis
- WH Press
- Wolfgang Greiner
- WW Thompson
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cost-effectiveness of human papillomavirus vaccination in Germany
- Author
- A Lin
- A Luyten
- A Schneider
- A Schneider
- A Szarewski
- A Szarewski
- AA Deshmukh
- AE Grulich
- Alexander Krämer
- Andreas M. Kaufmann
- AR Giuliano
- AR Kreimer
- B Lu
- B Romanowski
- B Ultsch
- Bernhard Ultsch
- Bundesagentur für Arbeit
- C Dannecker
- C Fraser
- C Poethko-Müller
- C Remschmidt
- CE Greer
- D Schobert
- DR Brown
- EF Dunne
- EH Elbasha
- EH Elbasha
- FX Bosch
- G Sroczynski
- GM Clifford
- GM Clifford
- H Kerek-Bodden
- H Roggendorf
- I Zechmeister
- IMCM Kok de
- IMCM Kok de
- J Horn
- J Olsen
- J Paavonen
- J Peto
- JJ Carter
- JJ Kim
- JMG Schulenburg von der
- Johannes Horn
- JS Smith
- K Canfell
- KB Zarnke
- KU Petry
- M Brisson
- M Canvin
- M David
- M Kohli
- M Safaeian
- MBBH Yahia
- Mirjam E. E. Kretzschmar
- ML Gillison
- MR Gold
- MW Beckmann
- N Kash
- N Kotsopoulos
- N Muñoz
- O Damm
- Ole Wichmann
- Oliver Damm
- P Hillemanns
- P Hillemanns
- P Hillemanns
- P Soergel
- P Stöcker
- R Vincenzo de
- Rafael T. Mikolajczyk
- Robert Koch-Institut
- RP Insinga
- RP Insinga
- RT Mikolajczyk
- S Sanjosé de
- SE Forhan
- SJ Goldie
- SJ Klug
- SM Garland
- SRM Dobson
- Statistisches Bundesamt
- Ständige Impfkommission
- Ständige Impfkommission
- T Iftner
- T Rieck
- The FUTURE II Study Group
- Wolfgang Greiner
- X Castellsagué
- Y Deleré
- Y Deleré
- YH Choi
- Yvonne Deleré
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
- Abraham T.
- Abrams J.
- Abu H.
- Abu-Arafeh A.
- Acton C.
- Adam F.
- Adam M.
- Adams C.
- Adams C.
- Adams D.
- Adams L.
- Addo A.
- Adedeji O.
- Adegoke K.
- Adewunmi E.
- Adeyemo T.
- Agbeko R.
- Aggarwal S.
- Ahmad S.
- Ahmed A.
- Ahmed I.
- Ahmed M.
- Ahmed R.
- Ahmed R.
- Ainsworth M.
- Ajmi A.
- Akili S.
- Al Aaraj A.
- Al Balushi A.
- Al-Asadi A.
- Al-Khalil M.
- Al-Ramadhani B.
- Al-Saadi Z.
- Al-Shahi Salman R.
- Al-Sheklly B.
- Albert P.
- Alegria A.
- Alexander A.
- Alexander P.
- Alhabsha O.
- Ali M.
- Ali M.
- Aliberti E.
- Alin J.
- Aliyuda F.
- Alkhudhayri A.
- Allan N.
- Allanson A.
- Allen E.
- Allen L.
- Alshaer I.
- Altaf S.
- Amezaga M.
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- Woollen L.
- Wootton D.
- Worton S.
- Wren L.
- Wright F.
- Wright R.
- Wubetu J.
- Xavier B.
- Yaqoob N.
- Yasmin S.
- Yates B.
- Yates T.
- Yelnoorkar F.
- Yelnoorkar F.
- Yeoh A.
- Younes Ibrahim A.
- Young L.
- Yu C.
- Zaki K.
- Zammit-Mangion M.
- Zayed M.
- Zhu D.
- Zia M.
- Zitter L.
- Zuhra N.
- Zullo C.
- Publication venue
- Springer Science and Business Media LLC
- Publication date
- 31/01/2024
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease
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- Abdur Rahman M
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- Zhu Wangqin
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- Zoghbi J
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- Zuchelkowski A
- Zulauf N
- Ågårdh A
- Öner A
- Publication venue
- 'Massachusetts Medical Society'
- Publication date
- 01/01/2017
- Field of study
BACKGROUND:
Patients with atherosclerotic vascular disease remain at high risk for cardiovascular events despite effective statin-based treatment of low-density lipoprotein (LDL) cholesterol levels. The inhibition of cholesteryl ester transfer protein (CETP) by anacetrapib reduces LDL cholesterol levels and increases high-density lipoprotein (HDL) cholesterol levels. However, trials of other CETP inhibitors have shown neutral or adverse effects on cardiovascular outcomes.
METHODS:
We conducted a randomized, double-blind, placebo-controlled trial involving 30,449 adults with atherosclerotic vascular disease who were receiving intensive atorvastatin therapy and who had a mean LDL cholesterol level of 61 mg per deciliter (1.58 mmol per liter), a mean non-HDL cholesterol level of 92 mg per deciliter (2.38 mmol per liter), and a mean HDL cholesterol level of 40 mg per deciliter (1.03 mmol per liter). The patients were assigned to receive either 100 mg of anacetrapib once daily (15,225 patients) or matching placebo (15,224 patients). The primary outcome was the first major coronary event, a composite of coronary death, myocardial infarction, or coronary revascularization.
RESULTS:
During the median follow-up period of 4.1 years, the primary outcome occurred in significantly fewer patients in the anacetrapib group than in the placebo group (1640 of 15,225 patients [10.8%] vs. 1803 of 15,224 patients [11.8%]; rate ratio, 0.91; 95% confidence interval, 0.85 to 0.97; P=0.004). The relative difference in risk was similar across multiple prespecified subgroups. At the trial midpoint, the mean level of HDL cholesterol was higher by 43 mg per deciliter (1.12 mmol per liter) in the anacetrapib group than in the placebo group (a relative difference of 104%), and the mean level of non-HDL cholesterol was lower by 17 mg per deciliter (0.44 mmol per liter), a relative difference of -18%. There were no significant between-group differences in the risk of death, cancer, or other serious adverse events.
CONCLUSIONS:
Among patients with atherosclerotic vascular disease who were receiving intensive statin therapy, the use of anacetrapib resulted in a lower incidence of major coronary events than the use of placebo. (Funded by Merck and others; Current Controlled Trials number, ISRCTN48678192 ; ClinicalTrials.gov number, NCT01252953 ; and EudraCT number, 2010-023467-18 .)
Methods for Health Economic Evaluation of Vaccines and Immunization Decision Frameworks: A Consensus Framework from a European Vaccine Economics Community
- Author
- A Brennan
- A Farrant
- A Takla
- A Tasset
- A Williams
- AF Dempsey
- AH Briggs
- AJ Hall
- AJ Hoek van
- AJ Hoek van
- Alexander Kuhlmann
- Andreas Gerber-Grote
- AR McLean
- AT Newall
- B Piso
- B Piso
- B Standaert
- B Ultsch
- Bernd Brüggenjürgen
- Bernhard Ultsch
- CH Jackson
- CH Jackson
- CH Jackson
- CJE Metcalf
- CT Bauch
- D Debicki
- Daniel Levy-Bruhl
- DC Taylor
- DC Taylor
- DG Walker
- DM Eddy
- F Ahmed
- F Weidemann
- Germaine Hanquet
- GL Freed
- GW Ricciardi
- H Christensen
- H Houweling
- H Nohynek
- HE Burchett
- Heini Salo
- J Bilcke
- J Caro
- J Hornberger
- J Mauskopf
- J Skoupá
- JA Nelder
- JF O’Mahony
- JJ Kim
- JJ Kim
- JM Bos
- Joke Bilcke
- Jürgen Wasem
- K Seto
- KA Phillips
- L Annemans
- L Fumanelli
- L Willem
- LJ Erickson
- M Baguelin
- M Brisson
- M Brisson
- M Brisson
- M Brisson
- M Brisson
- M Bryson
- M Bryson
- M Drummond
- M Drummond
- M Goetghebeur
- M Jit
- M Jit
- M Krol
- Maarten Postma
- Mark Jit
- Matthias Perleth
- MB Rothberg
- MC Weinstein
- MC Weinstein
- ME Halloran
- Mirjam Knol
- MJ Postma
- MJ Postma
- N Velde Van de
- NE Basta
- NK Stout
- O Damm
- O Ethgen
- Ole Wichmann
- Oliver Damm
- P Beutels
- P Beutels
- P Beutels
- P Jacobs
- P Poletti
- P Thokala
- Philippe Beutels
- R Pitman
- R Pradas-Velasco
- R V Barnabas
- R Welte
- Raymond Hutubessy
- RJ Duintjer Tebbens
- RM Klock
- RR West
- Rüdiger von Kries
- S Black
- SJ Ismail
- SY Kim
- T Vanni
- T Weinke
- TA Westra
- TD Szucs
- TD Szucs
- TG Kimman
- TL Kauf
- U Siebert
- Uwe Siebert
- VM Spicher
- WJ Edmunds
- Wolfgang Greiner
- Z Philips
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Dimethyl fumarate in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial
- Author
- Abbas M.
- Abdul Rasheed A.
- Abdul A.
- Abdul-Kadir R.
- Abdusamad K.
- Abernethy K.
- Aboelela H.
- Abouzaid M.
- Abraham M.
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- Al-Saadi Z.
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- Central Coordinating Office (for the RECOVERY Collaborative Group)
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- Data Monitoring Committee of the RECOVERY Collaborative Group
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- Publication date
- Field of study
Dimethyl fumarate (DMF) inhibits inflammasome-mediated inflammation and has been proposed as a treatment for patients hospitalised with COVID-19. This randomised, controlled, open-label platform trial (Randomised Evaluation of COVID-19 Therapy [RECOVERY]), is assessing multiple treatments in patients hospitalised for COVID-19 (NCT04381936, ISRCTN50189673). In this assessment of DMF performed at 27 UK hospitals, adults were randomly allocated (1:1) to either usual standard of care alone or usual standard of care plus DMF. The primary outcome was clinical status on day 5 measured on a seven-point ordinal scale. Secondary outcomes were time to sustained improvement in clinical status, time to discharge, day 5 peripheral blood oxygenation, day 5 C-reactive protein, and improvement in day 10 clinical status. Between 2 March 2021 and 18 November 2021, 713 patients were enroled in the DMF evaluation, of whom 356 were randomly allocated to receive usual care plus DMF, and 357 to usual care alone. 95% of patients received corticosteroids as part of routine care. There was no evidence of a beneficial effect of DMF on clinical status at day 5 (common odds ratio of unfavourable outcome 1.12; 95% CI 0.86-1.47; p = 0.40). There was no significant effect of DMF on any secondary outcome
Abstracts from the 3rd International Genomic Medicine Conference (3rd IGMC 2015)
- Author
- Aadil Hussain
- Abbes Salem
- Abdelbaset Buhmaida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbaset Buhmeida
- Abdelbasit Buhmeida
- Abdelbasit Buhmeida
- Abdellatif Bouazzaoui
- Abdelwahab Noorwali
- Abdulah E. A. Mathkoor
- Abdulazeez Sayyed
- Abdulla A. Alharthi
- Abdullah Al-Harbi
- Abdullah Alashwal
- Abdullah M. Gari
- Abdullraheem Rozi
- Abdulmonem Al-Mutawa
- Abdulmonem Al-Mutawa
- Abdulrahman M. S. Sibiani
- Abeer A. Al-refai
- Abid Qureshi
- Abrar Al Qahtani
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chaudhary
- Adeel G. Chudhary
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- Adel Abuzenada
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Abuzenadah
- Adel Al-Ammari
- Adel Al-Ammari
- Adel Al-Johari
- Adel Al-Johari
- Adel E. El-Tarras
- Adel Galal Ahmed El-Shemi
- Adel Galal Ahmed El-Shemi
- Adel Galal El-Shemi
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- Adel M. Abuzenadah
- Adel M. Abuzenadah
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- Adel M. Abuzenadah
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- Adel M. Abuzenadah
- Adel Mohammed Abuzenadah
- Adil Jamal
- Adnan Merdad
- Adnan Merdad
- Afnan Bahamaid
- Afnan Bandah
- Afnan Bandah
- Afnan Bandah
- Afnan O. Bahmaid
- Ahmad A. T. Naqvi
- Ahmad Ashshi
- Ahmad Ashshi
- Ahmad J. Al Sayyad
- Ahmad J. Al Sayyad
- Ahmed Al-Sayyad
- Ahmed Al-Sayyad
- Ahmed Ateya
- Ahmed M. Ashshi
- Ahmed M. Isa
- Ahmed M. Z. Darwish
- Ahmed Rebai
- Ahmed Rebai
- Ahmed Rebai
- Ahmed S. Masmoudi
- Aisha A. Alyamani
- Aisha Alyamani
- Aisha Hassan Elaimi
- Alaa A. Albogmi
- Alaa A. Albogmi
- Alaa A. Alboogmi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
- Alaa Al-Ahmadi
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- Mohamad I. Lone
- Mohamad Saka
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- Mohamed M. M. Ibrahim
- Mohamed Nabil Alama
- Mohammad A. Al Karaawi
- Mohammad A. Alzohairy
- Mohammad A. Aziz
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Jafri
- Mohammad A. Kamal
- Mohammad A. Kamal
- Mohammad Al-Qahtani
- Mohammad Al-Qahtani
- Mohammad Al-Qahtani
- Mohammad Athar
- Mohammad H. Al Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad H. Al-Qahtani
- Mohammad I. Lone
- Mohammad Khalid Alwasiyah
- Mohammad Khalid Alwasiyah
- Mohammad Khalid Alwasiyah
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- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
- Mohammad S. Jamal
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
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- Mohammed Al-Qahtani
- Mohammed Al-Qahtani
- Mohammed Aldress
- Mohammed Alqahtani
- Mohammed Bangash
- Mohammed Bangash
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- Mohammed Basalamah
- Mohammed Basalamah
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- Mohammed F. Elshal
- Mohammed H. Al Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Al-Qahtani
- Mohammed H. Alkaf
- Mohammed H. Alkaf
- Mohammed H. Alkaf
- Mohammed H. Alqahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed H. AlQahtani
- Mohammed Imran Nasser
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. Abbas
- Mohammed M. F. Al-Halbosiy
- Mohammed M. Jan
- Mohammed Sarwar Jamal
- Mohd A. Beg
- Mohd A. Beg
- Mohd A. Beg
- Mohd A. Beg
- Mohd Rehan
- Mohd Suhail
- Mohiuddin K. Warsi
- Mohiuddin K. Warsi
- Mohiuddin M. Taher
- Mohmmad Shoab Mansuri
- Mohmmed H. Alkaff
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- Mona Al-Sharif
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- Mourad Assidi
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- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
- Mourad Assidi
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- Mourad Assidi
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- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
- Muhammad Abu-Elmagd
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- Roaa Kadam
- Roaa Kadam
- Roaa Kadam
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- Rukhsana Satar
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- Sahar A. F. Hammoudah
- Sahar Hakamy
- Sahar Hakamy
- Sahar Hakamy
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- Saif Ahmad
- Sajid Mehmood
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- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
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- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
- Sajjad Karim
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- Samera F. AlBasri
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- Satoshi Serada
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- Shahida Khan
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- Shakeel A. Ansari
- Shakeel A. Ansari
- Shakeel A. Ansari
- Shakeel A. Ansari
- Shakeel Ansari
- Shereen A. Turkistany
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
- Shilu Mathew
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- Sudhir Kumar
- Sudhir Kumar
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- Sulman Basit
- Susan Walker
- Syed A. Hassan
- Syed A. Hassan
- Syed Asif Hassan
- Syed Hassan
- Syed K. Zaidi
- Syed Kashif Zaidi
- Syed Kashif Zaidi
- Taha A. Abdel-Meguid
- Taha Abduallah Kumosani
- Taha Abduallah Kumosani
- Taha Abdullah Kumosani
- Taha Abo Almagd
- Taha Kumosani
- Takahiko Nishigaki
- Takis Athanasopoulos
- Taoufik Nedjadi
- Taoufik Nedjadi
- Tatsuhiro Shibata
- Tej P. Singh
- Tetsuji Naka
- Toshirou Nishida
- Touhami Mahjoub
- Touhami Mahjoub
- Touhami Mahjoub
- Tsuyoshi Takahashi
- Vera Chayeb
- Vikram Gopalakrishna Pillai
- Vladimir B. Bajic
- Wafaey Gomaa
- Waseem Ahmad
- Waseem Ahmad
- Waseem Ahmad
- Waseem Ahmad
- Wassim Almawi
- Wassim Y. Almawi
- Wejdan Al-Qahtani
- Wejdan Al-Qahtani
- Wejdan Al-Qahtani
- Wided Malah
- Yogesh S. Marfatia
- Yosr Z. Haffani
- Yosr Z. Haffani
- Youjin Na
- Youjin Na
- Yousif A. Abutalib
- Youssri Ahmed
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- Zeenat Mirza
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- Zeyad Al Yousef
- Zhihong Cui
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Sperm competition leads to functional adaptations in avian testes to maximize sperm quantity and quality
- Publication venue
- 'Bioscientifica'
- Publication date
- 01/05/2011
- Field of study
The outcome of sperm competition (i.e. competition for fertilization between ejaculates from different males) is primarily determined by the relative number and quality of rival sperm. Therefore, the testes are under strong selection to maximize both sperm number and quality, which are likely to result in trade-offs in the process of spermatogenesis (e.g. between the rate of spermatogenesis and sperm length or sperm energetics). Comparative studies have shown positive associations between the level of sperm competition and both relative testis size and the proportion of seminiferous (sperm-producing) tissue within the testes. However, it is unknown how the seminiferous tissue itself or the process of spermatogenesis might evolve in response to sperm competition. Therefore, we quantified the different germ cell types and Sertoli cells (SC) in testes to assess the efficiency of sperm production and its associations with sperm length and mating system across 10 species of New World Blackbirds (Icteridae) that show marked variation in sperm length and sperm competition level. We found that species under strong sperm competition generate more round spermatids (RS)/spermatogonium and have SC that support a greater number of germ cells, both of which are likely to increase the maximum sperm output. However, fewer of the RS appeared to elongate to mature spermatozoa in these species, which might be the result of selection for discarding spermatids with undesirable characteristics as they develop. Our results suggest that, in addition to overall size and gross morphology, testes have also evolved functional adaptations to maximize sperm quantity and quality
Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2013
- Field of study
Siegeler K, Wistuba J, Damm OS, von Engelhardt N, Sachser N, Kaiser S. Early social instability affects plasma testosterone during adolescence but does not alter reproductive capacity or measures of stress later in life. Physiology & Behavior. 2013;120:143-149