Does Reverse Causality Underlie the Temporal Relationship between Depression and Crohn's Disease?

Background: Studies suggest that there is a temporal relationship between depression and Crohn's disease (CD) activity. However, these studies assumed a unidirectional relationship and did not examine the possibility of reverse causality and the risk of a spurious association due to the overlap of symptoms underlying the depression-CD relationship. We evaluated the existence of reverse causality reflected in a possible bidirectional relationship between patient-reported CD activity and an affective-cognitive dimension of depression. Methods: We studied 3307 adult volunteers with a self-reported diagnosis of CD who completed a baseline survey that included demographics, CD activity, and an affective-cognitive index of depression. Crohn's disease status and the affective-cognitive index of depression were also measured 6 and 12 months after the baseline evaluation. We used structural equation models to evaluate whether the effect of depression on future CD activity is stronger than the effect of CD activity on future depression. We calculated the likelihood that each of these hypotheses is supported by the data and calculated the likelihood ratio to provide a relative measure of which hypothesis best accounts for the data. Results: The results of the informative hypothesis testing showed the most support for the hypothesis stating that an affective-cognitive dimension of depression is a stronger predictor of patient-reported CD activity than the converse. Conclusions: The hypothesis that an affective-cognitive dimension of depression predicts patient-reported exacerbation of CD is 218 times more likely to account for the data than the converse

Toward an internally consistent astronomical distance scale

Accurate astronomical distance determination is crucial for all fields in astrophysics, from Galactic to cosmological scales. Despite, or perhaps because of, significant efforts to determine accurate distances, using a wide range of methods, tracers, and techniques, an internally consistent astronomical distance framework has not yet been established. We review current efforts to homogenize the Local Group's distance framework, with particular emphasis on the potential of RR Lyrae stars as distance indicators, and attempt to extend this in an internally consistent manner to cosmological distances. Calibration based on Type Ia supernovae and distance determinations based on gravitational lensing represent particularly promising approaches. We provide a positive outlook to improvements to the status quo expected from future surveys, missions, and facilities. Astronomical distance determination has clearly reached maturity and near-consistency.Comment: Review article, 59 pages (4 figures); Space Science Reviews, in press (chapter 8 of a special collection resulting from the May 2016 ISSI-BJ workshop on Astronomical Distance Determination in the Space Age

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Not AvailableOf late, intensive farming for higher food production is often associated with many negative implications for soil systems, such as decline of soil organic matter (SOM), increase in risks of soil erosion by wind and/or water, decline in soil biological diversity, increase in degradation of soil physical quality, lower nutrient-use efficiency, high risks of groundwater pollution, falling water tables, increasing salinization and waterlogging, in-field burning of crop residues, pollution of air and emission of greenhouse gases (GHG), leading to global warming, and decline in factor productivity. These negative implications necessitate an objective review of strategies to develop sustainable management practices, which could not only sustain soil health and ensure food security, but also enhance carbon sequestration, decrease GHG emissions, and offer clean and better ecosystem services. Conservation agriculture (CA), that includes reduced or no-till practices along with crop residue retention and mixed crop rotations, offers multiple benefits. Adoption of a system-based CA conserves water, improves and creates more efficient use of natural resources through the integrated management of available soil nutrients, water, and biological resources, and enhances use efficiency of external inputs. Due to apparent benefits of CA, it is increasingly being adopted and now covers about 180 million hectares (Mha) worldwide. However, in South Asia its spread is low (<5 Mha), mostly concentrated in the Indo-Gangetic Plains (IGP). In this region, one of the serious issues is “residue burning” with severe environmental impacts. A huge amount of crop residue left over after the combine harvest of rice has forced farmers to practice widespread residue burning (∼140 M tonnes) to cope with excessive stubble and also for timely planting/sowing of succeeding crops. In rice-wheat cropping systems, which cover more than 10 Mha in the IGP, CA practices are relatively more accepted by farmers. In these systems, any delay in sowing leads to yield penalty of 1–1.5% per day after the optimum sowing date of wheat. The strong adoption of CA practices in IGP is mainly to overcome delayed sowing due to the field preparation and control of weeds, timely planting, and also escape from terminal heat during the grain-filling stage. Major challenges to CA adoption in South Asia are small land holdings (<1 ha), low technological reach to farmers, nonavailability of suitable farm implements for small farm holders, and the staunch conventional farming mind-set. South Asia region consists of many countries of diverse agro-ecologies with contrasting farming systems and management. This region, recently known for rapid economic growth and increasing population, necessitates higher food production and also hot-spots for adoption of CA technologies. Therefore, in this review critically explores the possibility, extent of area, prospects, challenges, and benefits of CA in South Asia.Not Availabl

Home-based versus hospital-based rehabilitation after myocardial infarction: A randomized trial with preference arms - Cornwall Heart Attach Rehabilitation Management Study (CHARMS)

Background Home-based cardiac rehabilitation offers an alternative to traditional, hospital-based cardiac rehabilitation. Aim To compare the cost effectiveness of home-based cardiac rehabilitation and hospital-based cardiac rehabilitation. Methods 104 patients with an uncomplicated acute myocardial infarction and without major comorbidity were randomized to receive home-based rehabilitation (n = 60) i.e. nurse facilitated, self-help package of 6 weeks' duration (the Heart Manual) or hospital-based rehabilitation for 8–10 weeks (n = 44). Complete economic data were available in 80 patients (48 who received home-based rehabilitation and 32 who received hospital-based rehabilitation). Healthcare costs, patient costs, and quality of life (EQ-5D4.13) were assessed over the 9 months of the study. Results The cost of running the home-based rehabilitation programme was slightly lower than that of the hospital-based programme (mean (95% confidence interval) difference − £30 (− £45 to − £12) [− €44, − €67 to − €18] per patient. The cost difference was largely the result of reduced personnel costs. Over the 9 months of the study, no significant difference was seen between the two groups in overall healthcare costs (£78, − £1102 to £1191 [− €115, − €1631 to − €1763] per patient) or quality adjusted life-years (− 0.06 (− 0.15 to 0.02)). The lack of significant difference between home-based rehabilitation and hospital-based rehabilitation did not alter when different costs and different methods of analysis were used. Conclusions The health gain and total healthcare costs of the present hospital-based and home-based cardiac rehabilitation programmes for patients after myocardial infarction appear to be similar. These initial results require affirmation by further economic evaluations of cardiac rehabilitation in different settings

Personality at work

Studies of personality at work have made significant contributions to theory and applied practice in work and organizational settings. This review article proposes that there are also reciprocal influences between core personality science and research on personality in work and organizations, each drawing on insights from the other. Following this tradition, the objective of this article is to review key foundations of research in a way that informs and critically reflects on state-of-the-art evidence in four main themes: (1) conceptualization and structure of personality at work, (2) personality assessment in work settings, (3) personality processes and dynamics at work, and (4) impact of situations on personality at work. Critically reflections on key implications, and directions for future research are presented, anticipating how the field may adapt to the changing nature of work and society

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