Distributed Model Predictive Control for Heterogeneous Vehicle Platoon with Inter-Vehicular Spacing Constraints

This paper proposes a distributed control scheme for a platoon of heterogeneous vehicles based on the mechanism of model predictive control (MPC). The platoon composes of a group of vehicles interacting with each other via inter-vehicular spacing constraints, to avoid collision and reduce communication latency, and aims to make multiple vehicles driving on the same lane safely with a close range and the same velocity. Each vehicle is subject to both state constraints and input constraints, communicates only with neighboring vehicles, and may not know a priori desired setpoint. We divide the computation of control inputs into several local optimization problems based on each vehicle’s local information. To compute the control input of each vehicle based on local information, a distributed computing method must be adopted and thus the coupled constraint is required to be decoupled. This is achieved by introducing the reference state trajectories from neighboring vehicles for each vehicle and by employing the interactive structure of computing local problems of vehicles with odd indices and even indices. It is shown that the feasibility of MPC optimization problems is achieved at all time steps based on tailored terminal inequality constraints, and the asymptotic stability of each vehicle to the desired trajectory is guaranteed even under a single iteration between vehicles at each time. Finally, a comparison simulation is conducted to demonstrate the effectiveness of the proposed distributed MPC method for heterogeneous vehicle control with respect to normal and extreme scenarios

Workflow-based Fast Data-driven Predictive Control with Disturbance Observer in Cloud-edge Collaborative Architecture

Data-driven predictive control (DPC) has been studied and used in various scenarios, since it could generate the predicted control sequence only relying on the historical input and output data. Recently, based on cloud computing, data-driven predictive cloud control system (DPCCS) has been proposed with the advantage of sufficient computational resources. However, the existing computation mode of DPCCS is centralized. This computation mode could not utilize fully the computing power of cloud computing, of which the structure is distributed. Thus, the computation delay could not been reduced and still affects the control quality. In this paper, a novel cloud-edge collaborative containerised workflow-based DPC system with disturbance observer (DOB) is proposed, to improve the computation efficiency and guarantee the control accuracy. First, a construction method for the DPC workflow is designed, to match the distributed processing environment of cloud computing. But the non-computation overheads of the workflow tasks are relatively high. Therefore, a cloud-edge collaborative control scheme with DOB is designed. The low-weight data could be truncated to reduce the non-computation overheads. Meanwhile, we design an edge DOB to estimate and compensate the uncertainty in cloud workflow processing, and obtain the composite control variable. The UUB stability of the DOB is also proved. Third, to execute the workflow-based DPC controller and evaluate the proposed cloud-edge collaborative control scheme with DOB in the real cloud environment, we design and implement a practical workflow-based cloud control experimental system based on container technology. Finally, a series of evaluations show that, the computation times are decreased by 45.19% and 74.35% for two real-time control examples, respectively, and by at most 85.10% for a high-dimension control example.Comment: 58 pages and 23 figure

Acute rejection is associated with antibodies to non-Gal antigens in baboons using Gal-knockout pig kidneys

We transplanted kidneys from α1,3-galactosyltransferase knockout (GalT-KO) pigs into six baboons using two different immunosuppressive regimens, but most of the baboons died from severe acute humoral xenograft rejection. Circulating induced antibodies to non-Gal antigens were markedly elevated at rejection, which mediated strong complement-dependent cytotoxicity against GalT-KO porcine target cells. These data suggest that antibodies to non-Gal antigens will present an additional barrier to transplantation of organs from GalT-KO pigs to humans. © 2005 Nature Publishing Group

Ultrastructural insights into cellular organization, energy storage and ribosomal dynamics of an ammonia-oxidizing archaeon from oligotrophic oceans

IntroductionNitrososphaeria, formerly known as Thaumarchaeota, constitute a diverse and widespread group of ammonia-oxidizing archaea (AOA) inhabiting ubiquitously in marine and terrestrial environments, playing a pivotal role in global nitrogen cycling. Despite their importance in Earth’s ecosystems, the cellular organization of AOA remains largely unexplored, leading to a significant unanswered question of how the machinery of these organisms underpins metabolic functions.MethodsIn this study, we combined spherical-chromatic-aberration-corrected cryo-electron tomography (cryo-ET), scanning transmission electron microscopy (STEM), and energy dispersive X-ray spectroscopy (EDS) to unveil the cellular organization and elemental composition of Nitrosopumilus maritimus SCM1, a representative member of marine Nitrososphaeria.Results and DiscussionOur tomograms show the native ultrastructural morphology of SCM1 and one to several dense storage granules in the cytoplasm. STEM-EDS analysis identifies two types of storage granules: one type is possibly composed of polyphosphate and the other polyhydroxyalkanoate. With precise measurements using cryo-ET, we observed low quantity and density of ribosomes in SCM1 cells, which are in alignment with the documented slow growth of AOA in laboratory cultures. Collectively, these findings provide visual evidence supporting the resilience of AOA in the vast oligotrophic marine environment

Large-scale association analysis identifies new lung cancer susceptibility loci and heterogeneity in genetic susceptibility across histological subtypes.

Although several lung cancer susceptibility loci have been identified, much of the heritability for lung cancer remains unexplained. Here 14,803 cases and 12,262 controls of European descent were genotyped on the OncoArray and combined with existing data for an aggregated genome-wide association study (GWAS) analysis of lung cancer in 29,266 cases and 56,450 controls. We identified 18 susceptibility loci achieving genome-wide significance, including 10 new loci. The new loci highlight the striking heterogeneity in genetic susceptibility across the histological subtypes of lung cancer, with four loci associated with lung cancer overall and six loci associated with lung adenocarcinoma. Gene expression quantitative trait locus (eQTL) analysis in 1,425 normal lung tissue samples highlights RNASET2, SECISBP2L and NRG1 as candidate genes. Other loci include genes such as a cholinergic nicotinic receptor, CHRNA2, and the telomere-related genes OFBC1 and RTEL1. Further exploration of the target genes will continue to provide new insights into the etiology of lung cancer

EFFECTS OF TEMPERATURE ON THE SPECTRAL EMISSIVITY OF C/SiC COMPOSITES

The effect of temperature on the infrared spectral emissivity of C/SiC composites as a thermal protection material has been studied, using a measurement system based on a FT-IR spectrometer. The spectral emissivity of C/SiC composites in the wavelength range 3-20 μm and in the temperature range from 1000 K to over 2000 K was measured. Based on the analysis of the measured spectral emissivity, variations of the spectral emissivity with temperature were studied. The relationship between emissivity and temperature in some certain wavelength was found