2,933 research outputs found
Heavy-flavor dynamics in nucleus-nucleus collisions: from RHIC to LHC
The stochastic dynamics of c and b quarks in the fireball created in
nucleus-nucleus collisions at RHIC and LHC is studied employing a relativistic
Langevin equation, based on a picture of multiple uncorrelated random
collisions with the medium. Heavy-quark transport coefficients are evaluated
within a pQCD approach, with a proper HTL resummation of medium effects for
soft scatterings. The Langevin equation is embedded in a multi-step setup
developed to study heavy-flavor observables in pp and AA collisions, starting
from a NLO pQCD calculation of initial heavy-quark yields, complemented in the
nuclear case by shadowing corrections, k_T-broadening and nuclear geometry
effects. Then, only for AA collisions, the Langevin equation is solved
numerically in a background medium described by relativistic hydrodynamics.
Finally, the propagated heavy quarks are made hadronize and decay into
electrons. Results for the nuclear modification factor R_AA of heavy-flavor
hadrons and electrons from their semi-leptonic decays are provided, both for
RHIC and LHC beam energies.Comment: 4 pages, 2 figures (3 eps files); submitted for publication in the
proceedings of "Quark Matter 2011", 23-28 May 2011, Annecy (France
The role of homophilic binding in anti-tumor antibody R24 recognition of molecular surfaces. Demonstration of an intermolecular beta-sheet interaction between vh domains.
The murine antibody R24 and mouse-human Fv-IgG1(kappa) chimeric antibody chR24 are specific for the cell-surface tumor antigen disialoganglioside GD3. X-ray diffraction and surface plasmon resonance experiments have been employed to study the mechanism of "homophilic binding," in which molecules of R24 recognize and bind to other molecules of R24 though their heavy chain variable domains. R24 exhibits strong binding to liposomes containing disialoganglioside GD3; however, the kinetics are unusual in that saturation of binding is not observed. The binding of chR24 to GD3-bearing liposomes is significantly weaker, suggesting that cooperative interactions involving antibody constant regions contribute to R24 binding of membrane-bound GD3. The crystal structures of the Fabs from R24 and chR24 reveal the mechanism for homophilic binding and confirm that the homophilic and antigen-binding idiotopes are distinct. The homophilic binding idiotope is formed largely by an anti-parallel beta-sheet dimerization between the H2 complementarity determining region (CDR) loops of two Fabs, while the antigen-binding idiotope is a pocket formed by the three CDR loops on the heavy chain. The formation of homophilic dimers requires the presence of a canonical conformation for the H2 CDR in conjunction with participation of side chains. The relative positions of the homophilic and antigen-binding sites allows for a lattice of GD3-specific antibodies to be constructed, which is stabilized by the presence of the cell membrane. This model provides for the selective recognition by R24 of cells that overexpress GD3 on the cell surface
The response of perennial and temporary headwater stream invertebrate communities to hydrological extremes
The headwaters of karst rivers experience considerable hydrological variability, including spates and streambed drying. Extreme summer flooding on the River Lathkill (Derbyshire, UK) provided the opportunity to examine the invertebrate community response to unseasonal spate flows, flow recession and, at temporary sites, streambed drying. Invertebrates were sampled at sites with differing flow permanence regimes during and after the spates. Following streambed drying at temporary sites, dewatered surface sediments were investigated as a refugium for aquatic invertebrates. Experimental rehydration of these dewatered sediments was conducted to promote development of desiccation-tolerant life stages. At perennial sites, spate flows reduced invertebrate abundance and diversity, whilst at temporary sites, flow reactivation facilitated rapid colonisation of the surface channel by a limited number of invertebrate taxa. Following streambed drying, 38 taxa were recorded from the dewatered and rehydrated sediments, with Oligochaeta being the most abundant taxon and Chironomidae (Diptera) the most diverse. Experimental rehydration of dewatered sediments revealed the presence of additional taxa, including Stenophylax sp. (Trichoptera: Limnephilidae) and Nemoura sp. (Plecoptera: Nemouridae). The influence of flow permanence on invertebrate community composition was apparent despite the aseasonal high-magnitude flood events
High-pT pi^zero Production with Respect to the Reaction Plane in Au + Au Collisions at sqrt(s_NN) = 200 GeV
Measurements of the azimuthal anisotropy of high-\pT neutral pion neutral
pion production in Au+Au collisions at sqrt(s_NN) = 200 GeV by the PHENIX
experiment are presented. The data included in this paper were collected during
the 2004 RHIC running period and represent approximately an order of magnitude
increase in the number of analyzed events relative to previously published
results. Azimuthal angle distributions of pi^0s detected in the PHENIX
electromagnetic calorimeters are measured relative to the reaction plane
determined event-by-event using the forward and backward beam-beam counters.
Amplitudes of the second Fourier component (v_2) of the angular distributions
are presented as a function of pi^0 transverse momentum p_T for different bins
in collision centrality. Measured reaction plane dependent pi^0 yields are used
to determine the azimuthal dependence of the pi^0 suppression as a function of
p_T, R_AA (Delta phi,p_T). A jet-quenching motivated geometric analysis is
presented that attempts to simultaneously describe the centrality dependence
and reaction plane angle dependence of the pi^0 suppression in terms of the
path lengths of hypothetical parent partons in the medium. This set of results
allows for a detailed examination of the influence of geometry in the collision
region, and of the interplay between collective flow and jet-quenching effects
along the azimuthal axis.Comment: 344 authors, 35 pages text, RevTeX-4, 24 figures, 8 tables. Submitted
to Physical Review
Transverse-energy distributions at midrapidity in , Au, and AuAu collisions at --200~GeV and implications for particle-production models
Measurements of the midrapidity transverse energy distribution, d\Et/d\eta,
are presented for , Au, and AuAu collisions at
GeV and additionally for AuAu collisions at
and 130 GeV. The d\Et/d\eta distributions are first
compared with the number of nucleon participants , number of
binary collisions , and number of constituent-quark participants
calculated from a Glauber model based on the nuclear geometry. For
AuAu, \mean{d\Et/d\eta}/N_{\rm part} increases with , while
\mean{d\Et/d\eta}/N_{qp} is approximately constant for all three energies.
This indicates that the two component ansatz, , which has been used to represent
distributions, is simply a proxy for , and that the term
does not represent a hard-scattering component in distributions. The
distributions of AuAu and Au are then calculated from
the measured distribution using two models that both reproduce
the AuAu data. However, while the number-of-constituent-quark-participant
model agrees well with the Au data, the additive-quark model does not.Comment: 391 authors, 24 pages, 19 figures, and 15 Tables. Submitted to Phys.
Rev. C. Plain text data tables for the points plotted in figures for this and
previous PHENIX publications are publicly available at
http://www.phenix.bnl.gov/papers.htm
Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV
A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay
channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7
TeV is presented. The data were collected at the LHC, with the CMS detector,
and correspond to an integrated luminosity of 4.6 inverse femtobarns. No
significant excess is observed above the background expectation, and upper
limits are set on the Higgs boson production cross section. The presence of the
standard model Higgs boson with a mass in the 270-440 GeV range is excluded at
95% confidence level.Comment: Submitted to JHE
Transverse momentum and centrality dependence of dihadron correlations in Au+Au collisions at sqrt(s_NN)=200 GeV: Jet-quenching and the response of partonic matter
Azimuthal angle \Delta\phi correlations are presented for charged hadrons
from dijets for 0.4 < p_T < 10 GeV/c in Au+Au collisions at sqrt(s_NN) = 200
GeV. With increasing p_T, the away-side distribution evolves from a broad to a
concave shape, then to a convex shape. Comparisons to p+p data suggest that the
away-side can be divided into a partially suppressed "head" region centered at
Delta\phi ~ \pi, and an enhanced "shoulder" region centered at Delta\phi ~ \pi
+/- 1.1. The p_T spectrum for the "head" region softens toward central
collisions, consistent with the onset of jet quenching. The spectral slope for
the "shoulder" region is independent of centrality and trigger p_T, which
offers constraints on energy transport mechanisms and suggests that the
"shoulder" region contains the medium response to energetic jets.Comment: 420 authors from 58 institutions, 6 pages, 4 figures. Submitted to
Physical Review Letters. Plain text data tables for the points plotted in
figures for this and previous PHENIX publications are (or will be) publicly
available at http://www.phenix.bnl.gov/papers.htm
Systematic study of charged-pion and kaon femtoscopy in AuAu collisions at =200 GeV
We present a systematic study of charged pion and kaon interferometry in
AuAu collisions at =200 GeV. The kaon mean source radii
are found to be larger than pion radii in the outward and longitudinal
directions for the same transverse mass; this difference increases for more
central collisions. The azimuthal-angle dependence of the radii was measured
with respect to the second-order event plane and similar oscillations of the
source radii were found for pions and kaons. Hydrodynamic models qualitatively
describe the similar oscillations of the mean source radii for pions and kaons,
but they do not fully describe the transverse-mass dependence of the
oscillations.Comment: 499 authors, 27 pages, 13 figures, and 11 tables. v2 is the version
accepted for publication in Phys. Rev. C. Plain text data tables for the
points plotted in figures for this and previous PHENIX publications are (or
will be) publicly available at http://www.phenix.bnl.gov/papers.htm
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