Vacuum field energy and spontaneous emission in anomalously dispersive cavities

Anomalously dispersive cavities, particularly white light cavities, may have larger bandwidth to finesse ratios than their normally dispersive counterparts. Partly for this reason, their use has been proposed for use in LIGO-like gravity wave detectors and in ring-laser gyroscopes. In this paper we analyze the quantum noise associated with anomalously dispersive cavity modes. The vacuum field energy associated with a particular cavity mode is proportional to the cavity-averaged group velocity of that mode. For anomalously dispersive cavities with group index values between 1 and 0, this means that the total vacuum field energy associated with a particular cavity mode must exceed $\hbar \omega/2$. For white light cavities in particular, the group index approaches zero and the vacuum field energy of a particular spatial mode may be significantly enhanced. We predict enhanced spontaneous emission rates into anomalously dispersive cavity modes and broadened laser linewidths when the linewidth of intracavity emitters is broader than the cavity linewidth.Comment: 9 pages, 4 figure

Socio-economic predictors of environmental performance among African nations

Socio-economic changes in Africa have increased pressure on the continent's ecosystems. Most research investigating environmental change has focused on the changing status of specific species or communities and protected areas, but has largely neglected the broad-scale socio-economic conditions underlying environmental degradation. We tested national-scale hypotheses regarding the socioeconomic predictors of ecosystem change and degradation across Africa, hypothesizing that human density and economic development increase the likelihood of cumulative environmental damage. Our combined environmental performance rank includes national ecological footprint, proportional species threat, recent deforestation, freshwater removal, livestock density, cropland coverage, and per capita emissions. Countries like Central African Republic, Botswana, Namibia, and Congo have the best relative environmental performance overall. Structural equation models indicate that increasing population density and overall economic activity (per capita gross domestic product corrected for purchasing-power parity) are the most strongly correlated with greater environmental degradation, while greater wealth inequality (Gini index) correlates with better environmental performance. This represents the first Africa-scale assessment of the socio-economic correlates of environmental degradation, and suggests that dedicated family planning to reduce population growth, and economic development that limits agricultural expansion (cf. intensification) are needed to support environmental sustainability.Peer reviewe

Motivations for personal financial management: A Self-Determination Theory perspective

Financial knowledge and sound financial decision making are now broadly recognized to be important determinants of both personal and societal prosperity, but research has yet to examine how distinct qualities of motivation may be associated with the way people manage their money. In two studies we applied the framework of Self-Determination Theory (SDT) to examine people's autonomous (volitional) and controlled (pressured) motivation for understanding and managing their finances, as well as their amotivation (lack of motivation) for doing so, and the differential associations these motives have with financial knowledge and financial well-being. American participants (Study 1, N = 516; Study 2, N = 534) completed detailed demographic surveys and questionnaires assessing the financial variables of interest. As hypothesized, SDT's motivational constructs were associated with financial outcomes over and above participants' age, gender, income, household wealth, and educational attainment. Autonomous motivation was positively associated with a host of positive financial behaviors and characteristics (e.g., saving/investing and financial self-efficacy, well-being, and self-awareness). Controlled motivation was negatively associated with financial well-being. Amotivation was positively associated with overspending and negatively associated with financial self-efficacy and well-being. These findings support the relevance of SDT's framework in this domain and suggest that interventions aimed at promoting financial knowledge and wellness may benefit by adopting evidence-supported strategies for optimizing more autonomous motivations and addressing amotivations

Biodistribution and inflammatory profiles of novel penton and hexon double-mutant serotype 5 adenoviruses

The use of adenovirus serotype 5 (Ad5) vectors in the clinical setting is severely hampered by the profound liver tropism observed after intravascular delivery coupled with the pronounced inflammatory and innate immune response elicited by these vectors. Liver transduction by circulating Ad5 virions is mediated by a high-affinity interaction between the capsid hexon protein and blood coagulation factor X (FX), whilst penton-α(v)integrin interactions are thought to contribute to the induction of anti-Ad5 inflammatory and innate immune responses. To overcome these limitations, we sought to develop and characterise for the first time novel Ad5 vectors possessing mutations ablating both hexon:FX and penton:integrin interactions. As expected, intravascular administration of the FX binding-ablated Ad5HVR5*HVR7*E451Q vector (AdT*) resulted in significantly reduced liver transduction in vivo compared to Ad5. In macrophage-depleted mice, increased spleen uptake of AdT* was accompanied by an elevation in the levels of several inflammatory mediators. However ablation of the penton RGD motif in the AdT* vector background (AdT*RGE) resulted in a significant 5-fold reduction in spleen uptake and attenuated the antiviral inflammatory response. A reduction in spleen uptake and inflammatory activation was also observed in animals after intravascular administration of Ad5RGE compared to the parental Ad5 vector, with reduced co-localisation of the viral beta-galactosidase transgene with MAdCAM-1+ sinus-lining endothelial cells. Our detailed assessment of these novel adenoviruses indicates that penton base RGE mutation in combination with FX binding-ablation may be a viable strategy to attenuate the undesired liver uptake and pro-inflammatory responses to Ad5 vectors after intravascular deliver

Dismantling the poachernomics of the illegal wildlife trade

Persistent poaching fuelled by demand for elephant ivory and rhino horn continues to threaten these species. Despite international trade restrictions operating since the 1970s, limiting poaching has remained a substantial challenge over the last decade. The poaching economy of such storable goods is driven by a combination of persistent consumer demand and market speculation, and enabled by weak governance, lack of adequate resources for species protection, and alienation of local people who pay the costs of living alongside these species. We argue that restricting the legal supply of such wildlife products has created ideal conditions for the poaching economy - `poachernomics' - to thrive. Strategies that move toward empowering local communities with stronger property rights over wildlife and delivering more benefits to them, including via carefully regulated legal trade, are underused elements in the current fight against the onslaught of the international illegal wildlife trade.Peer reviewe

The X-ray spectral evolution of Cyg X-2 in the framework of bulk Comptonization

We used the newly developed thermal plus bulk Comptonization model comptb to investigate the spectral evolution of the neutron star LMXB Cyg X-2 along its Z-track. We selected a single source in order to trace in a quantitative way the evolution of the physical parameters of the model. We analyzed archival broad-band BeppoSAX spectra of Cyg X-2. Five broad-band spectra have been newly extracted according to the source position in the Z-track described in the colour-colour and colour-intensity diagrams. We have fitted the spectra of the source with two comptb components. The first one, with bulk parameter delta=0, dominates the overall source broad-band spectrum and its origin is related to thermal upscattering (Comptonization) of cold seed photons off warm electrons in high-opacity enviroment. We attribute the origin of these seed photons to the part of the disk which illuminates the outer coronal region (transition layer) located between the accretion disk itself and the neutron star surface. This thermal component is roughly constant with time and with inferred mass accretion rate. The second comptb model describes the overall Comptonization (thermal plus bulk, delta > 0) of hotter seed photons which come from both the inner transition layer and from the neutron star surface. The appearance of this component in the colour-colour or hardness-intensity diagram is more pronounced in the horizontal branch and is progressively disappearing towards the normal branch, where a pure blackbody spectrum is observed. The spectral evolution of Cyg X-2 is studied and interpreted in terms of changes in the innermost environmental conditions of the system, leading to a variable thermal-bulk Comptonization efficiency.Comment: 10 pages, 7 figures, accepted for publication in A&

REC drives recombination to repair double-strand breaks in animal mtDNA

Mechanisms that safeguard mitochondrial DNA (mtDNA) limit the accumulation of mutations linked to mitochondrial and age-related diseases. Yet, pathways that repair double-strand breaks (DSBs) in animal mitochondria are poorly understood. By performing a candidate screen for mtDNA repair proteins, we identify that REC—an MCM helicase that drives meiotic recombination in the nucleus—also localizes to mitochondria in Drosophila. We show that REC repairs mtDNA DSBs by homologous recombination in somatic and germline tissues. Moreover, REC prevents age-associated mtDNA mutations. We further show that MCM8, the human ortholog of REC, also localizes to mitochondria and limits the accumulation of mtDNA mutations. This study provides mechanistic insight into animal mtDNA recombination and demonstrates its importance in safeguarding mtDNA during ageing and evolution

Spectral evolution of bright NS LMXBs with INTEGRAL: an application of the thermal plus bulk Comptonization model

The aim of this work is to investigate in a physical and quantitative way the spectral evolution of bright Neutron Star Low-Mass X-ray Binaries (NS LMXBs), with special regard to the transient hard X-ray tails. We analyzed INTEGRAL data for five sources (GX 5-1, GX 349+2, GX 13+1, GX 3+1, GX 9+1) and built broad-band X-ray spectra from JEM-X1 and IBIS/ISGRI data. For each source, X-ray spectra from different states were fitted with the recently proposed model compTB. The spectra have been fit with a two-compTB model. In all cases the first compTB describes the dominant part of the spectrum that we interpret as thermal Comptonization of soft seed photons (< 1 keV), likely from the accretion disk, by a 3-5 keV corona. In all cases, this component does not evolve much in terms of Comptonization efficiency, with the system converging to thermal equilibrium for increasing accretion rate. The second compTB varies more dramatically spanning from bulk plus thermal Comptonization of blackbody seed photons to the blackbody emission alone. These seed photons (R < 12 km, kT_s > 1 keV), likely from the neutron star and the innermost part of the system, the Transition Layer, are Comptonized by matter in a converging flow. The presence and nature of this second compTB component (be it a pure blackbody or Comptonized) are related to the inner local accretion rate which can influence the transient behaviour of the hard tail: high values of accretion rates correspond to an efficient Bulk Comptonization process (bulk parameter delta > 0) while even higher values of accretion rates suppress the Comptonization, resulting in simple blackbody emission (delta=0).Comment: 12 pages, 10 figures, accepted for publication in A&

The broad band X-ray/hard X-ray spectra of accreting neutron stars

I review the energy spectra of low mass X-ray binaries (LMXBs) containing weakly magnetized accreting neutron stars (NS), emphasizing the most recent broad band (0.1-200 keV) spectral and timing observations performed by Beppo-SAX and RXTE. Drawing on the similarities between black hole candidate (BHC) and NS accretion, I discuss the accretion geometry and emission processes of NS LMXBs.Comment: 15 pages, 17 figures, Invited review at the 33rd COSPAR Scientific Assembly, Warsaw, Poland, July, 2000. Accepted for publication in Advances in Space Research. The paper is also available from http://www.cesr.fr/~barret