4,110 research outputs found
First results of the ROSEBUD Dark Matter experiment
Rare Objects SEarch with Bolometers UndergrounD) is an experiment which
attempts to detect low mass Weak Interacting Massive Particles (WIMPs) through
their elastic scattering off Al and O nuclei. It consists of three small
sapphire bolometers (of a total mass of 100 g) with NTD-Ge sensors in a
dilution refrigerator operating at 20 mK in the Canfranc Underground
Laboratory. We report in this paper the results of several runs (of about 10
days each) with successively improved energy thresholds, and the progressive
background reduction obtained by improvement of the radiopurity of the
components and subsequent modifications in the experimental assembly, including
the addition of old lead shields. Mid-term plans and perspectives of the
experiment are also presented.Comment: 14 pages, 8 figures, submitted to Astroparticle Physic
Gauge Invariance in Chern-Simons Systems
We show explicitly that the question of gauge invariance of the effective
potential in standard scalar electrodynamics remains unchanged despite the
introduction of the Chern-Simons term. The result does not depend on the
presence of the Maxwell term in the Chern-Simons territory.Comment: 10 pages, Plain Tex, DF/UFPB-14/9
Calibration and First light of the Diabolo photometer at the Millimetre and Infrared Testa Grigia Observatory
We have designed and built a large-throughput dual channel photometer,
Diabolo. This photometer is dedicated to the observation of millimetre
continuum diffuse sources, and in particular, of the Sunyaev-Zel'dovich effect
and of anisotropies of the 3K background. We describe the optical layout and
filtering system of the instrument, which uses two bolometric detectors for
simultaneous observations in two frequency channels at 1.2 and 2.1 mm. The
bolometers are cooled to a working temperature of 0.1 K provided by a compact
dilution cryostat. The photometric and angular responses of the instrument are
measured in the laboratory. First astronomical light was detected in March 1995
at the focus of the new Millimetre and Infrared Testa Grigia Observatory (MITO)
Telescope. The established sensitivity of the system is of 7 mK_RJ s^1/2$. For
a typical map of at least 10 beams, with one hour of integration per beam, one
can achieve the rms values of y_SZ ~ 7 10^-5 and the 3K background anisotropy
Delta T/T ~ 7 10^-5, in winter conditions. We also report on a novel bolometer
AC readout circuit which allows for the first time total power measurements on
the sky. This technique alleviates (but does not forbid) the use of chopping
with a secondary mirror. This technique and the dilution fridge concept will be
used in future scan--modulated space instrument like the ESA Planck mission
project.Comment: 10 pages, LaTeX, 12 figures, accepted for publication in Astronomy
and Astrophysics Supplement Serie
Superfield Formulation for Non-Relativistic Chern-Simons-Matter Theory
We construct a superfield formulation for non-relativistic
Chern-Simons-Matter theories with manifest dynamical supersymmetry. By
eliminating all the auxiliary fields, we show that the simple action reduces to
the one obtained by taking non-relativistic limit from the relativistic
Chern-Simons-Matter theory proposed in the literature. As a further
application, we give a manifestly supersymmetric derivation of the
non-relativistic ABJM theory.Comment: 18 page
Impact of a probiotic fermented milk in the gut ecosystem and in the systemic immunity using a non-severe protein-energy-malnutrition model in mice
<p>Abstract</p> <p>Background</p> <p>Malnutrition affects the immune response, causing a decrease of defence mechanisms and making the host more susceptible to infections. Probiotics can reconstitute the intestinal mucosa and stimulate local and systemic immunity. The aim of this work was evaluate the effects of a probiotic fermented milk as a complement of a re-nutrition diet, on the recovery of the intestinal barrier, and mucosal and systemic immune functions in a murine model of non-severe protein-energy-malnutrition. Its potential protection against <it>Salmonella enterica </it>serovar Typhimurium (<it>S</it>. Typhimurium) infection was also analyzed.</p> <p>Methods</p> <p>Mice were undernourished and divided into 3 groups according to the dietary supplement received during re-nutrition (milk, probiotic fermented milk or its bacterial free supernatant) and compared to well-nourished and malnourished mice. They were sacrificed previous to the re-nutrition and 5 days post re-nutrition. The phagocytic activity of macrophages from spleen and peritoneum and the changes in the intestinal histology and microbiota were evaluated. Different immune cell populations and cytokine productions were analyzed in the small intestine tissues. The effect of the re-nutrition supplements on the systemic immunity using OVA antigen and against an infection with <it>S. </it>Typhimurium was also studied.</p> <p>Results</p> <p>Probiotic fermented milk was the most effective re-nutrition diet that improved the intestinal microbiota. Its administration also increased the number of IgA+ cells, macrophages and dendritic cells. The production of different cytokine (IFN-γ, TNF-α, IL-12) by these cells and the phagocytic activity in peritoneum and spleen was also increased. This re-nutrition diet also stimulated the systemic immune response against OVA antigen which was diminished after the malnutrition period and also improved the host response against <it>S. </it>Typhimurium, decreasing the spread of pathogenic bacteria to the liver and the spleen. The importance of the metabolites released during milk fermentation was also demonstrated through the analysis of the bacterial free supernatant obtained from the probiotic fermented milk, but the whole product showed the best effects in the parameters evaluated in this study.</p> <p>Conclusions</p> <p>The administration of probiotic fermented milk as a dietary supplement during the re-nutrition process in a murine immunodeficiency model by malnutrition could be a good adjuvant diet to improve the gut and systemic immune response for the protection against <it>Salmonella </it>infection.</p
Gauge Invariant Effective Potential for Abelian Maxwell-Chern-Simons Systems
We investigate the effective potential for Abelian Maxwell--Chern--Simons
systems. The calculations follow an alternate approach, recently proposed as a
gauge invariant formulation of the effective potential, constructed in terms of
a gauge invariant order parameter. We compare the results with another
investigation, obtained within a standard route of calculating the effective
potential.Comment: 10 pages. Revtex. To appear in Phys. Rev.
On the combination of omics data for prediction of binary outcomes
Enrichment of predictive models with new biomolecular markers is an important
task in high-dimensional omic applications. Increasingly, clinical studies
include several sets of such omics markers available for each patient,
measuring different levels of biological variation. As a result, one of the
main challenges in predictive research is the integration of different sources
of omic biomarkers for the prediction of health traits. We review several
approaches for the combination of omic markers in the context of binary outcome
prediction, all based on double cross-validation and regularized regression
models. We evaluate their performance in terms of calibration and
discrimination and we compare their performance with respect to single-omic
source predictions. We illustrate the methods through the analysis of two real
datasets. On the one hand, we consider the combination of two fractions of
proteomic mass spectrometry for the calibration of a diagnostic rule for the
detection of early-stage breast cancer. On the other hand, we consider
transcriptomics and metabolomics as predictors of obesity using data from the
Dietary, Lifestyle, and Genetic determinants of Obesity and Metabolic syndrome
(DILGOM) study, a population-based cohort, from Finland
Reproductive tract size and position score: Estimation of genetic parameters for a novel fertility trait in dairy cows.
The dairy industry is moving toward selecting animals with better fertility to decrease the economic losses linked to reproductive issues. The reproductive tract size and position score (SPS) was recently developed in physiological studies as an indicator of pregnancy rate and the number of services to conception. Cows are scored as SPS 1, 2, or 3 based on the size of their reproductive tract and its position in the pelvis, as determined by transrectal palpation. The objective of this study was to estimate genetic parameters for SPS to assess its potential as a novel fertility trait. Phenotypes were collected at the University of British Columbia's research herd from 2017 to 2020, consisting of 3,247 within- and across-lactation SPS records from 490 Holstein cows. A univariate animal model was used to estimate the variance components for SPS. Both threshold and linear models were fit under a Bayesian approach and the results were compared using the Spearman rank correlation (r) between the estimated breeding values. The 2 models ranked the animals very similarly (r = 0.99), and the linear model was selected for further analysis. Genetic correlations with other currently evaluated traits were estimated using a bivariate animal model. The posterior means (± posterior standard deviation) for heritability and repeatability within- and across-lactation were 0.113 (± 0.013), 0.242 (± 0.012), and 0.134 (± 0.014), respectively. The SPS showed null correlations with production traits and favorable correlations with traditional fertility traits, varying from -0.730 (nonreturn rate) to 0.931 (number of services). Although preliminary, these results are encouraging because SPS seems to be more heritable than and strongly genetically correlated with number of services, nonreturn rate, and first service to conception, indicating potential for effective indirect selection response on these traits from SPS genetic selection. Therefore, further studies with larger data sets to validate these findings are warranted
Application des recommandations dans la prise en charge du cancer de l’endomètre en pratique clinique. Étude rétrospective bretonne
National audienceObjective - To assess the use of French Cancer Institute recommendations for the diagnosis and treatment of endometrial cancer. Methods - Retrospective observational study involving 137Â patients with endometrial cancer between 2011 and 2013. Results - Both MRI and pathological assessment with correct report as recommended were used for 66.4% of patients with endometrial cancer. For patients with correct preoperative assessment, 44.9% of patients were uncorrectly classified and upgraded on final pathological analysis of hysterectomy concerning lymph node involvement risk. These patients did not have confident surgical assessment, according this risk. Conclusion - To improve relevance of preoperative assessment in endometrial cancer, radiological and pathological expertise is required. However, even performed optimally, preoperative assessment does not allow correct risk stratification of lymph node involvement in endometrial cancer. This ineffective stratification leads to propose sentinel lymph node biopsy with hysterectomy in case of preoperative low risk endometrial cancer assessment
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