A faint extended cluster in the outskirts of NGC 5128: evidence of a low mass accretion

We report the discovery of an extended globular cluster in a halo field in Centaurus A (NGC 5128), situated \sim 38\kpc from the centre of that galaxy, imaged with the Advanced Camera for Surveys on board the Hubble Space Telescope. At the distance of the galaxy, the half-light radius of the cluster is r_h ~ 17pc, placing it among the largest globular clusters known. The faint absolute magnitude of the star cluster, M_(V,o)=-5.2, and its large size render this object somewhat different from the population of extended globular clusters previously reported, making it the first firm detection in the outskirts of a giant galaxy of an analogue of the faint, diffuse globular clusters present in the outer halo of the Milky Way. The colour-magnitude diagram of the cluster, covering approximately the brightest four magnitudes of the red giant branch, is consistent with an ancient, i.e., older than ~8 Gyr, intermediate-metallicity, i.e., [M/H] ~-1.0 dex, stellar population. We also report the detection of a second, even fainter cluster candidate which would have r_h ~ 9pc, and M_(V,o)=-3.4 if it is at the distance of NGC 5128. The properties of the extended globular cluster and the diffuse stellar populations in its close vicinity suggest that they are part of a low mass accretion in the outer regions of NGC 5128.Comment: 9 pages, MNRAS, in pres

Ancient stars beyond the Local Group: RR Lyrae variables and Blue Horizontal Branch stars in Sculptor Group Dwarf Galaxies

We have used Hubble Space Telescope ACS images to generate color-magnitude diagrams that reach below the magnitude of the horizontal branch in the Sculptor Group dwarf galaxies ESO294-010 and ESO410-005. In both diagrams blue horizontal branch stars are unambiguously present, a signature of the existence of an ancient stellar population whose age is comparable to that of the Galactic halo globular clusters. The result is reinforced by the discovery of numerous RR Lyrae variables in both galaxies. The occurrence of these stars in the first direct confirmation of the existence of ancient stellar populations beyond the Local Group and indicates that star formation can occur at the earliest epochs even in low density environments.Comment: 11 pages, 2 figures, accepted for publication in Astrophysical Journal Letter

Visuo-spatial ability in colonoscopy simulator training

Visuo-spatial ability is associated with a quality of performance in a variety of surgical and medical skills. However, visuo-spatial ability is typically assessed using Visualization tests only, which led to an incomplete understanding of the involvement of visuo-spatial ability in these skills. To remedy this situation, the current study investigated the role of a broad range of visuo-spatial factors in colonoscopy simulator training. Fifteen medical trainees (no clinical experience in colonoscopy) participated in two psycho-metric test sessions to assess four visuo-spatial ability factors. Next, participants trained flexible endoscope manipulation, and navigation to the cecum on the GI Mentor II simulator, for four sessions within 1 week. Visualization, and to a lesser degree Spatial relations were the only visuo-spatial ability factors to correlate with colonoscopy simulator performance. Visualization additionally covaried with learning rate for time on task on both simulator tasks. High Visualization ability indicated faster exercise completion. Similar to other endoscopic procedures, performance in colonoscopy is positively associated with Visualization, a visuo-spatial ability factor characterized by the ability to mentally manipulate complex visuo-spatial stimuli. The complexity of the visuo-spatial mental transformations required to successfully perform colonoscopy is likely responsible for the challenging nature of this technique, and should inform training- and assessment design. Long term training studies, as well as studies investigating the nature of visuo-spatial complexity in this domain are needed to better understand the role of visuo-spatial ability in colonoscopy, and other endoscopic techniques

Transiting extrasolar planetary candidates in the Galactic bulge

More than 200 extrasolar planets have been discovered around relatively nearby stars, primarily through the Doppler line shifts owing to the reflex motions of their host stars, and more recently through transits of some planets across the face of the host stars. The detection of planets with the shortest known periods, 1.2 to 2.5 days, has mainly resulted from transit surveys which have generally targeted stars more massive than 0.75 M_sun. Here we report the results from a planetary transit search performed in a rich stellar field towards the Galactic bulge. We discovered 16 candidates with orbital periods between 0.4 and 4.2 days, five of which orbit stars of 0.44 to 0.75 M_sun. In two cases, radial-velocity measurements support the planetary nature of the companions. Five candidates have orbital periods below 1.0 day, constituting a new class of ultra-short-period planets (USPPs), which occur only around stars of less than 0.88 M_sun. This indicates that those orbiting very close to more luminous stars might be evaporatively destroyed, or that jovian planets around lower-mass stars might migrate to smaller radii.Comment: To appear in October 5, 2006 issue of Natur

A close look at the Centaurus A group of galaxies: I. Metallicity distribution functions and population gradients in early-type dwarfs

We study dwarf galaxies in the Centaurus A group to investigate their metallicity and possible environmental effects. The Centaurus A group (at ~4 Mpc from the Milky Way) contains about 50 known dwarf companions of different morphologies and stellar contents, thus making it a very interesting target to study how these galaxies evolve. Here we present results for the early-type dwarf galaxy population in this group. We use archival HST/ACS data to study the resolved stellar content of 6 galaxies, together with isochrones from the Dartmouth stellar evolutionary models. We derive photometric metallicity distribution functions of stars on the upper red giant branch via isochrone interpolation. The 6 galaxies are moderately metal-poor (=-1.56 to -1.08), and metallicity spreads are observed (internal dispersions of sigma_[Fe/H]=0.10 to 0.41 dex). We also investigate the possible presence of intermediate-age stars, and discuss how these affect our results. The dwarfs exhibit flat to weak radial metallicity gradients. For the two most luminous, most metal-rich galaxies, we find statistically significant evidence for at least two stellar subpopulations: the more metal-rich stars are found in the center of the galaxies, while the metal-poor ones are more broadly distributed within the galaxies. We find no clear trend of the derived physical properties as a function of (present-day) galaxy position in the group, which may be due to the small sample we investigate. We compare our results to the early-type dwarf population of the Local Group, and find no outstanding differences, despite the fact that the Centaurus A group is a denser environment that is possibly in a more advanced dynamical stage.Comment: 21 pages, 12 figures, accepted for publication in Astronomy and Astrophysic

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice

Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death receptors’ such as Fas/APO-1; and the ‘intrinsic’ pathway, which is triggered by diverse cellular stresses, and is regulated by prosurvival and pro-apoptotic members of the Bcl-2 family of proteins. Pro-survival Mcl-1, which can block activation of the proapoptotic proteins, Bax and Bak, appears critical for the survival and maintenance of multiple haemopoietic cell types. To investigate the impact on haemopoiesis of simultaneously inhibiting both apoptosis pathways, we introduced the vavP-Mcl-1 transgene, which causes overexpression of Mcl-1 protein in all haemopoietic lineages, into Faslpr/lpr mice, which lack functional Fas and are prone to autoimmunity. The combined mutations had a modest impact on myelopoiesis, primarily an increase in the macrophage/monocyte population in Mcl-1tg/lpr mice compared with lpr or Mcl-1tg mice. The impact on lymphopoiesis was striking, with a marked elevation in all major lymphoid subsets, including the non-conventional double-negative (DN) T cells (TCRβ+ CD4– CD8– B220+ ) characteristic of Faslpr/lpr mice. Of note, the onset of autoimmunity was markedly accelerated in Mcl-1tg/lpr mice compared with lpr mice, and this was preceded by an increase in immunoglobulin (Ig)-producing cells and circulating autoantibodies. This degree of impact was surprising, given the relatively mild phenotype conferred by the vavP-Mcl-1 transgene by itself: a two- to threefold elevation of peripheral B and T cells, no significant increase in the non-conventional DN T-cell population and no autoimmune disease. Comparison of the phenotype with that of other susceptible mice suggests that the development of autoimmune disease in Mcl-1tg/lpr mice may be influenced not only by Ig-producing cells but also other haemopoietic cell types

The merger that led to the formation of the Milky Way's inner stellar halo and thick disk

The assembly process of our Galaxy can be retrieved using the motions and chemistry of individual stars. Chemo-dynamical studies of the nearby halo have long hinted at the presence of multiple components such as streams, clumps, duality and correlations between the stars' chemical abundances and orbital parameters. More recently, the analysis of two large stellar surveys have revealed the presence of a well-populated chemical elemental abundance sequence, of two distinct sequences in the colour-magnitude diagram, and of a prominent slightly retrograde kinematic structure all in the nearby halo, which may trace an important accretion event experienced by the Galaxy. Here report an analysis of the kinematics, chemistry, age and spatial distribution of stars in a relatively large volume around the Sun that are mainly linked to two major Galactic components, the thick disk and the stellar halo. We demonstrate that the inner halo is dominated by debris from an object which at infall was slightly more massive than the Small Magellanic Cloud, and which we refer to as Gaia-Enceladus. The stars originating in Gaia-Enceladus cover nearly the full sky, their motions reveal the presence of streams and slightly retrograde and elongated trajectories. Hundreds of RR Lyrae stars and thirteen globular clusters following a consistent age-metallicity relation can be associated to Gaia-Enceladus on the basis of their orbits. With an estimated 4:1 mass-ratio, the merger with Gaia-Enceladus must have led to the dynamical heating of the precursor of the Galactic thick disk and therefore contributed to the formation of this component approximately 10 Gyr ago. These findings are in line with simulations of galaxy formation, which predict that the inner stellar halo should be dominated by debris from just a few massive progenitors.Comment: 19 pages, 8 figures. Published in Nature in the issue of Nov. 1st, 2018. This is the authors' version before final edit

The Metallicity Distribution Functions of SEGUE G and K dwarfs: Constraints for Disk Chemical Evolution and Formation

We present the metallicity distribution function (MDF) for 24,270 G and 16,847 K dwarfs at distances from 0.2 to 2.3 kpc from the Galactic plane, based on spectroscopy from the Sloan Extension for Galactic Understanding and Exploration (SEGUE) survey. This stellar sample is significantly larger in both number and volume than previous spectroscopic analyses, which were limited to the solar vicinity, making it ideal for comparison with local volume-limited samples and Galactic models. For the first time, we have corrected the MDF for the various observational biases introduced by the SEGUE target selection strategy. The SEGUE sample is particularly notable for K dwarfs, which are too faint to examine spectroscopically far from the solar neighborhood. The MDF of both spectral types becomes more metal-poor with increasing |Z|, which reflects the transition from a sample with small [alpha/Fe] values at small heights to one with enhanced [alpha/Fe] above 1 kpc. Comparison of our SEGUE distributions to those of two different Milky Way models reveals that both are more metal-rich than our observed distributions at all heights above the plane. Our unbiased observations of G and K dwarfs provide valuable constraints over the |Z|-height range of the Milky Way disk for chemical and dynamical Galaxy evolution models, previously only calibrated to the solar neighborhood, with particular utility for thin- and thick-disk formation models.Comment: 70 pages, 25 figures, 7 tables. Accepted by The Astrophysical Journa

Stellar evolution and modelling stars

In this chapter I give an overall description of the structure and evolution of stars of different masses, and review the main ingredients included in state-of-the-art calculations aiming at reproducing observational features. I give particular emphasis to processes where large uncertainties still exist as they have strong impact on stellar properties derived from large compilations of tracks and isochrones, and are therefore of fundamental importance in many fields of astrophysics.Comment: Lecture presented at the IVth Azores International Advanced School in Space Sciences on "Asteroseismology and Exoplanets: Listening to the Stars and Searching for New Worlds" (arXiv:1709.00645), which took place in Horta, Azores Islands, Portugal in July 201

Abundances in giant stars of the globular cluster NGC 6752

Recent theoretical yields and chemical evolution models demonstrate that intermediate-mass AGB stars cannot reproduce the observed abundance distributions of O, Na, Mg, and Al. As a further observational test of this finding, we present elemental abundance ratios [X/Fe] for 20 elements in 38 bright giants of the globular cluster NGC 6752. Our mean abundance ratios [X/Fe] are in good agreement with previous studies of this cluster and are also consistent with other globular clusters and field stars at the same metallicity. The mean abundance ratios [Ba/Eu] and [La/Eu] exhibit values, in agreement with field stars at the same metallicity, that lie approximately midway between the pure r-process and the solar (s-process + r-process) mix, indicating that AGB stars have played a role in the chemical evolution of the proto-cluster gas. For the first time, we find possible evidence for an abundance variation for elements heavier than Al in this cluster. We find a correlation between [Si/Fe] and [Al/Fe] which is consistent with the abundance anomalies being synthesized via proton captures at high temperatures. Leakage from the Mg-Al chain into 28Si may explain the Si excess in stars with the highest [Al/Fe]. We identify correlations between [Y/Fe] and [Al/Fe], [Zr/Fe] and [Al/Fe], and [Ba/Fe] and [Al/Fe] suggesting that Y, Zr, and Ba abundances may increase by about 0.1 dex as Al increases by about 1.3 dex. While the correlations are statistically significant, the amplitudes of the variations are small. If the small variations in Y, Zr, and Ba are indeed real, then the synthesis of the Al anomalies must have taken place within an unknown class of stars that also ran the s-process. [Abridged]Comment: Accepted for publication in A&