Catecholamine-cAMP induces arrhythmias in the infarcting pig heart

[No abstract available

4-Nitrobenzyl 5-oxo-2-(2-oxopiperidin-1-yl)-tetrahydrofuran-2-carboxylate

The title compound, C17H18N2O7, is a synthetic racemic analogue of lactivicin, a natural product antibiotic that targets penicillin-binding proteins. There are two almost identical molecules in the asymmetric uni

Modelling the checkpoint response to telomere uncapping in budding yeast

One of the DNA damage-response mechanisms in budding yeast is temporary cell-cycle arrest while DNA repair takes place. The DNA damage response requires the coordinated interaction between DNA repair and checkpoint pathways. Telomeres of budding yeast are capped by the Cdc13 complex. In the temperature-sensitive cdc13-1 strain, telomeres are unprotected over a specific temperature range leading to activation of the DNA damage response and subsequently cell-cycle arrest. Inactivation of cdc13-1 results in the generation of long regions of single-stranded DNA (ssDNA) and is affected by the activity of various checkpoint proteins and nucleases