516 research outputs found

    A System for In-Flight Determination of Lunar Orbit Injection Conditions

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    This paper is based on vork accomplished by the Douglas Missile and Space Systems Division under Contracts NAS7-380 and NAST-53T for the Goddard Space Flight Center, National Aeronautics and Space Administration, Greenbelt, Maryland

    Impact and Casualty Prediction for Malfunctioning Multi-Stage Vehicles

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    Presented is a rather general explanation of an automated method for determining, by Monte Carlo techniques, the probabilities of impacting populated land masses and causing a casualty when a malfunctioning multi-stage vehicle deviates from its normal instantaneous earth impact pattern. The generation of this data is explained through the use of illustrative material which describes the necessary flow of information and computational operations. The economic advantages of the method discussed are compared, in terms of manpower, computer time, and total elapsed time requirements,with those of a forerunning method used to generate such data

    Lessons Learned from Positon-Electron Project Low Level RF and Longitudinal Feedback

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    The PEP-II B-Factory collider ended the final phase of operation at nearly twice the design current and 4X the design luminosity. To highlight the evolution from the original conceptual design through to the 1.2E34 final machine we choose one example each from the broadband feedback and from the LLRF system. They illustrate the original design estimation missed some very significant details, and how in the course of PEP-II operation unexpected difficulties led to significant insights and new approaches which allowed higher machine performance. We present valuable ”lessons learned” which are of interest to designers of next generation feedback and impedance controlled LLRF systems

    Substantial increases in healthcare students’ state empathy scores owing to participation in a single improvisation session

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    Purpose: To determine whether the 12-item state empathy scale could be modified reliably to measure empathy in healthcare professions students and to detect changes in their empathy owing to a single improvisation (improv) session. Methods: Three cohorts of students from two healthcare professions programs (total = 165 students) participated in an improv session. During the session, one of the researchers (BS) tasked the students with several improv activities. Participants’ self-reported state empathy scores were assessed at three time points (pre-improv, post-improv, and end of semester) using revised, in-class paper versions of the State Empathy Scale. Results: The exploratory factor analysis revealed a single factor solution for the revised scale, justifying the creation of an overall state empathy score from the questionnaire. Cronbach’s alpha reliability values averaged 0.87. Students’ mean empathy scores were higher directly after the improv session than directly prior to the session (p \u3c 0.0001; effect size = r = 0.67, 0.55, and 0.79 for cohorts 1, 2, and 3, respectively). Conclusions: These findings show that a single one- or two-hour improv session can foster substantial increases in healthcare professional students’ state empathy for one another. Greater healthcare professional empathy and compassion foster better healthcare team cooperation and patient outcomes, so healthcare professionals and their students should engage in such empathy-enhancing activities at regular intervals throughout their training and careers

    Short versus long silver nanowires: a comparison of in vivo pulmonary effects post instillation.

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    BackgroundSilver nanowires (Ag NWs) are increasingly being used to produce touchscreens for smart phones and computers. When applied in a thin film over a plastic substrate, Ag NWs create a transparent, highly-conductive network of fibers enabling the touch interface between consumers and their electronics. Large-scale application methods utilize techniques whereby Ag NW suspensions are deposited onto substrates via droplets. Aerosolized droplets increase risk of occupational Ag NW exposure. Currently, there are few published studies on Ag NW exposure-related health effects. Concerns have risen about the potential for greater toxicity from exposure to high-aspect ratio nanomaterials compared to their non-fibrous counterparts. This study examines whether Ag NWs of varying lengths affect biological responses and silver distribution within the lungs at different time-points.MethodsTwo different sizes of Ag NWs (2 ÎĽm [S-Ag NWs] and 20 ÎĽm [L-Ag NWs]) were tested. Male, Sprague-Dawley rats were intratracheally instilled with Ag NWs (0, 0.1, 0.5, or 1.0 mg/kg). Broncho-alveolar lavage fluid (BALF) and lung tissues were obtained at 1, 7, and 21 days post exposure for analysis of BAL total cells, cell differentials, and total protein as well as tissue pathology and silver distribution.Results and conclusionsThe two highest doses produced significant increases in BAL endpoints. At Day 1, Ag NWs increased total cells, inflammatory polymorphonuclear cells (PMNs), and total protein. PMNs persisted for both Ag NW types at Day 7, though not significantly so, and by Day 21, PMNs appeared in line with sham control values. Striking histopathological features associated with Ag NWs included 1) a strong influx of eosinophils at Days 1 and 7; and 2) formation of Langhans and foreign body giant cells at Days 7 and 21. Epithelial sloughing in the terminal bronchioles (TB) and cellular exudate in alveolar regions were also common. By Day 21, Ag NWs were primarily enclosed in granulomas or surrounded by numerous macrophages in the TB-alveolar duct junction. These findings suggest short and long Ag NWs produce pulmonary toxicity; thus, further research into exposure-related health effects and possible exposure scenarios are necessary to ensure human safety as Ag NW demand increases
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