Comparison of basic neurocognitive violations in patients with residual schizophrenia with and without history of ischemic stroke

Relevance. The cognitive symptoms associated with schizophrenia have been a subject of controversy and are often viewed through a dualistic lens. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), these cognitive symptoms can be further elucidated within specific neurocognitive domains. Many of the symptoms of schizophrenia manifest behaviorally and can be challenging to differentiate from the consequences of organic brain impairment, especially when these symptoms involve the frontal and temporal cortex or have a diffuse presentation. Aim – to evaluate neurocognitive deficit in patients with residual schizophrenia with history of ischemic stroke. Materials and methods. A comprehensive study was conducted involving 100 patients diagnosed with recurrent schizophrenia (ICD-10: F20.5) at the Communal Non-Profit Enterprise "Regional Clinical Institution for the Provision of Psychiatric Care". We selected 59 patients: 32 patients with residual schizophrenia without history of stroke (Group 1, G1) and 27 patients with residual schizophrenia with history of stroke (Group 2, G2). Neuropsychological testing was used to evaluate neurocognitive violations. Due to massive distortions that brought to testing results by schizophrenia negative symptoms, only general evaluation was made to reflect critical or non-critical to no violations in separate functions. Statistical method of chi-square test was used to compare results in groups.  Study results. To compare neurocognitive violations in G1 and G2 we performed neuropsychological testing in basic neurocognitive domains. G2 patients, diagnosed with both schizophrenia and a stroke, generally exhibit heightened cognitive impairments compared to G1 patients with only schizophrenia. Notably, deficits in Sustained Attention, Divided Attention, Processing Speed, Working Memory, Mental Flexibility, immediate memory, implicit learning, and both expressive and receptive language are more pronounced in G2 patients. However, for functions like Selective Attention, Planning, Decision-Making, recent and very-long-term memory, and interpersonal understanding, the added influence of a stroke in G2 doesn't drastically differentiate them from G1. In essence, while schizophrenia inherently poses cognitive challenges, the co-occurrence of a stroke amplifies certain deficits but not others. This data suggests a complex interplay between schizophrenia and stroke in influencing cognitive function. Conclusions. The coexistence of schizophrenia and a history of stroke in G2 patients frequently exacerbates certain cognitive impairments when compared to those diagnosed solely with schizophrenia. This underlines the compounded cognitive challenges faced by patients with comorbid conditions. However, for some cognitive domains, the severity of impairments is primarily governed by schizophrenia, irrespective of the presence of an additional stroke history. This comprehensive analysis underscores the complex interplay of multiple conditions on cognitive function and emphasizes the importance of individualized care and intervention strategies tailored to the specific cognitive challenges faced by each patient group

Speckle Interferometry with CMOS Detector

In 2022 we carried out an upgrade of the speckle polarimeter (SPP) -- the facility instrument of the 2.5-m telescope of the Caucasian Observatory of the SAI MSU. During the overhaul, CMOS Hamamatsu ORCA-Quest qCMOS C15550-20UP was installed as the main detector, some drawback of the previous version of the instrument were eliminated. In this paper, we present a description of the instrument, as well as study some features of the CMOS detector and ways to take them into account in speckle interferometric processing. Quantitative comparison of CMOS and EMCCD in the context of speckle interferometry is performed using numerical simulation of the detection process. Speckle interferometric observations of 25 young variable stars are given as an example of astronomical result. It was found that BM And is a binary system with a separation of 273 mas. The variability of the system is dominated by the brightness variations of the main component. A binary system was also found in NSV 16694 (TYC 120-876-1). The separation of this system is 202 mas.Comment: 24 pages, 27 figures. Minor style differences with respect to version accepted to Astrophys. Bull. V. 78, no.

Comparison of basic neurocognitive violations in patients with residual schizophrenia with and without history of ischemic stroke

Relevance. The cognitive symptoms associated with schizophrenia have been a subject of controversy and are often viewed through a dualistic lens. According to the Diagnostic and Statistical Manual of Mental Disorders, Fifth Edition (DSM-5), these cognitive symptoms can be further elucidated within specific neurocognitive domains. Many of the symptoms of schizophrenia manifest behaviorally and can be challenging to differentiate from the consequences of organic brain impairment, especially when these symptoms involve the frontal and temporal cortex or have a diffuse presentation. Aim – to evaluate neurocognitive deficit in patients with residual schizophrenia with history of ischemic stroke. Materials and methods. A comprehensive study was conducted involving 100 patients diagnosed with recurrent schizophrenia (ICD-10: F20.5) at the Communal Non-Profit Enterprise "Regional Clinical Institution for the Provision of Psychiatric Care". We selected 59 patients: 32 patients with residual schizophrenia without history of stroke (Group 1, G1) and 27 patients with residual schizophrenia with history of stroke (Group 2, G2). Neuropsychological testing was used to evaluate neurocognitive violations. Due to massive distortions that brought to testing results by schizophrenia negative symptoms, only general evaluation was made to reflect critical or non-critical to no violations in separate functions. Statistical method of chi-square test was used to compare results in groups.  Study results. To compare neurocognitive violations in G1 and G2 we performed neuropsychological testing in basic neurocognitive domains. G2 patients, diagnosed with both schizophrenia and a stroke, generally exhibit heightened cognitive impairments compared to G1 patients with only schizophrenia. Notably, deficits in Sustained Attention, Divided Attention, Processing Speed, Working Memory, Mental Flexibility, immediate memory, implicit learning, and both expressive and receptive language are more pronounced in G2 patients. However, for functions like Selective Attention, Planning, Decision-Making, recent and very-long-term memory, and interpersonal understanding, the added influence of a stroke in G2 doesn't drastically differentiate them from G1. In essence, while schizophrenia inherently poses cognitive challenges, the co-occurrence of a stroke amplifies certain deficits but not others. This data suggests a complex interplay between schizophrenia and stroke in influencing cognitive function. Conclusions. The coexistence of schizophrenia and a history of stroke in G2 patients frequently exacerbates certain cognitive impairments when compared to those diagnosed solely with schizophrenia. This underlines the compounded cognitive challenges faced by patients with comorbid conditions. However, for some cognitive domains, the severity of impairments is primarily governed by schizophrenia, irrespective of the presence of an additional stroke history. This comprehensive analysis underscores the complex interplay of multiple conditions on cognitive function and emphasizes the importance of individualized care and intervention strategies tailored to the specific cognitive challenges faced by each patient group

On Uniqueness of Boundary Blow-up Solutions of a Class of Nonlinear Elliptic Equations

We study boundary blow-up solutions of semilinear elliptic equations $Lu=u_+^p$ with $p>1$, or $Lu=e^{au}$ with $a>0$, where $L$ is a second order elliptic operator with measurable coefficients. Several uniqueness theorems and an existence theorem are obtained.Comment: To appear in Comm. Partial Differential Equations; 10 page

Shot Noise in Mesoscopic Transport Through Localised States

We show that shot noise can be used for studies of hopping and resonant tunnelling between localised electron states. In hopping via several states, shot noise is seen to be suppressed compared with its classical Poisson value $S_I=2eI$ ($I$ is the average current) and the suppression depends on the distribution of the barriers between the localised states. In resonant tunnelling through a single impurity an enhancement of shot noise is observed. It has been established, both theoretically and experimentally, that a considerable increase of noise occurs due to Coulomb interaction between two resonant tunnelling channels.Comment: 7 pages, 5 figures; Proceedings of the 10th Conference on Hopping and Related Phenomena (Trieste 2003); requires Wiley style files (included

Structure and Phase Composition of Zirconium Fuel Claddings in Initial State and after Creep Tests

The article's abstract is no available

Bose-Einstein condensation of magnons under incoherent pumping

Bose-Einstein condensation in a gas of magnons pumped by an incoherent pumping source is experimentally studied at room temperature. We demonstrate that the condensation can be achieved in a gas of bosons under conditions of incoherent pumping. Moreover, we show the critical transition point is almost independent of the frequency spectrum of the pumping source and is solely determined by the density of magnons. The electromagnetic power radiated by the magnon condensate was found to scale quadratically with the pumping power, which is in accordance with the theory of Bose-Einstein condensation in magnon gases