Osteoimmunology: from mice to humans

The immune system has been recognized as one of the most important regulators of bone turnover and its deregulation is implicated in several bone diseases such as postmenopausal osteoporosis and inflammatory bone loss; recently it has been suggested that the gut microbiota may influence bone turnover by modulation of the immune system. The study of the relationship between the immune system and bone metabolism is generally indicated under the term ‘osteoimmunology'. The vast majority of these studies have been performed in animal models; however, several data have been confirmed in humans as well: this review summarizes recent data on the relationship between the immune system and bone with particular regard to the data confirmed in humans

The supramedullary cells of the teleost Coris julis (L.): A noradrenergic neuronal system

This study, carried out on Coris julis (Labridae), is a contribution to the immunocytochemical characterization of fish supramedullary neurons. The significance of these giant cells has been debated since the beginning of the twentieth century. Our research provides the first evidence for a noradrenergic feature of this neuronal system. The possible role of supramedullary neurons as components of the autonomic nervous system is discussed. Moreover, the present results, taken together with our previous studies, surmise that this the first known case of co-localization of a neuropeptide (gastrin/CCK-like) and noradrenaline in the nervous system of teleosts

Population density and photosynthetic pigment content in symbiotic dinoflagellates in the Brazilian scleractinian coral Montastrea cavernosa (Linnaeus, 1767)

A dinâmica sazonal na densidade de células e na concentração de pigmentos fotossintetizantes das zooxantelas de Montastrea cavernosa foram analisados no período setembro/1999 a setembro/2000 nos Recifes do Picãozinho (06º42'05"/07º07'30" S e 34º48'37"/34º50'00" W), Nordeste do Brasil. Verificou-se que existe um padrão distinto entre estes parâmetros, com maior quantidade de células no período chuvoso e maior concentração de pigmentos fotossintetizantes na época de estiagem. Ambos os parâmetros apresentaram, no entanto, uma nítida redução em seus valores nos meses de maiores índices pluviométricos (junho e julho /1999). Especulamos que tal fato deve estar relacionado com o regime de chuvas que pode variar em magnitude e freqüência, afetando a qualidade ótica da água e o estado fisiológico das células.The seasonal dynamics of cell density and photosynthetic pigment contents of the zooxanthellae hosted by Montastrea cavernosa were investigated on coastal reefs off Picãozinho (06º42'05"/07º07'30"S and 34º48'37"/34º50'00" W), Northeast Brazil between September 1999 and 2000. A distinct pattern of these parameters was found: cell numbers were greater during the rainy season (autumn/winter) while photosynthetic pigments were greater during the dry season (summer). Both parameters showed drastic reductions during heavy rains (June and July 1999). We speculate that this pattern is largely influenced by the rain cycles which, owing to their magnitude and frequency, affect the water clarity and the seasonal physiological condition of the cells

Active stability observer using artificial neural network for intuitive physical human–robot interaction

Physical human-robot interaction may present an obstacle to transparency and operations’ intuitiveness. This barrier could occur due to the vibrations caused by a stiff environment interacting with the robotic mechanisms. In this regard, this paper aims to deal with the aforementioned issues while using an observer and an adaptive gain controller. The adaptation of the gain loop should be performed in all circumstances in order to maintain operators’ safety and operations’ intuitiveness. Hence, two approaches for detecting and then reducing vibrations will be introduced in this study as follows: 1) a statistical analysis of a sensor signal (force and velocity) and 2) a multilayer perceptron artificial neural network capable of compensating the first approach for ensuring vibrations identification in real time. Simulations and experimental results are then conducted and compared in order to evaluate the validity of the suggested approaches in minimizing vibrations

Musculoskeletal Diseases Role in the Frailty Syndrome: A Case-Control Study.

Frailty syndrome severely burdens older age, and musculoskeletal diseases are of paramount importance in its development. The aim of this study is to unravel the contribution of musculoskeletal diseases to frailty syndrome. This is a case-control study, and we enrolled 55 robust community-dwelling age- and gender-matched patients, with 58 frail and pre-frail subjects. Frailty was diagnosed according to the Fried criteria (FP), and the Fragility Index (FI) was calculated. In all the subjects, a comprehensive geriatric assessment was carried out. Their nutritional status was evaluated by the Mini Nutritional Assessment and Bioelectrical Impedance Analyses. Their bone density (BMD), bone turnover, muscle mass, strength and performance were evaluated. Here, we show that the prevalence of frailty varies according to the diagnostic criteria used and that FP and FI showed a moderate to good agreement. Despite age and gender matching, frail subjects had lower muscle strength, performance and BMD. Their quality of life and cognitive performance were reduced in the frail subjects compared to the robust ones. Muscular strength and performance, together with mood, significantly predicted the diagnosis of frailty, whereas BMD and bone turnover did not. In conclusion, we show that sarcopenia plays a pivotal role in predicting the diagnosis of frailty, whereas osteoporosis does not

Fatores associados à utilização de serviços ambulatoriais: estudo de base populacional

OBJECTIVE: To identify factors that lead people to visit a doctor in Brazil and assess differences between socioeconomic groups. METHODS: A cross-sectional study comprising 1,260 subjects aged 15 or more was carried out in southern Brazil. Demographic, socioeconomic, health needs and regular source of care data were analyzed concerning visits to a doctor within two months from the interview. Adjusted prevalence ratios and 95% confidence intervals were calculated using Poisson regression. RESULTS: Adjusted PR showed that women having stressful life events, health insurance, and a regular doctor increased the outcome. A dose-related response was found with self-reported health, and the probability of visiting a doctor increased with health needs. Analysis in the chronic disease group revealed that uneducated lower income subjects had a 62% reduction in the chance of visiting a doctor compared to uneducated higher income ones. However, as it was seen a significant interaction between income and education, years of schooling increased utilization in this group. CONCLUSIONS: Results suggest the existence of health inequity in the poorest group that could be overcome with education. Specific measures reinforcing the importance of having a regular doctor may also improve access in the underserved group.OBJETIVO: Identificar os fatores que levam uma pessoa a consultar o médico no Brasil e avaliar as diferenças entre grupos socioeconômicos. MÉTODOS: Foi realizado um estudo transversal com 1.260 pessoas de 15 anos ou mais no sul do Brasil. Foram analisados dados demográficos, socioeconômicos, de necessidade em saúde e de fonte definida para consulta quanto a visita ao médico nos últimos dois meses. Foram calculadas as razões ajustadas de prevalência (RP) e os Intervalos de Confiança de 95% (IC 95%), utilizando a regressão de Poisson. RESULTADOS: As RP ajustadas mostraram que mulher, eventos estressantes, seguro de saúde e médico de referência aumentaram a probabilidade do desfecho. Foi encontrada uma relação de tipo dose-resposta com auto-avaliação do estado de saúde, e a probabilidade de consultar aumentou a medida que a necessidade em saúde também aumentou. A análise no grupo com doença crônica evidenciou que o grupo de menor renda e sem escolaridade teve uma redução de 62% na probabilidade de visitar o médico em comparação com o grupo de maior renda e sem estudo. Contudo, como ocorreu interação significativa entre renda e educação, o tempo de estudo melhorou a utilização nesse grupo. CONCLUSÕES: Os resultados sugerem a existência de iniqüidade no grupo mais pobre que pode ser modificada pela educação. Medidas específicas reforçando a importância de ter um médico de referência podem também melhorar o acesso dos mais pobres