Dynamic acoustic field activated cell separation (DAFACS)

Advances in diagnostics, cell and stem cell technologies drive the development of application-specific tools for cell and particle separation. Acoustic micro-particle separation offers a promising avenue for highthroughput, label-free, high recovery, cell and particle separation and isolation in regenerative medicine. Here, we demonstrate a novel approach utilizing a dynamic acoustic field that is capable of separating an arbitrary size range of cells. We first demonstrate the method for the separation of particles with different diameters between 6 and 45 μm and secondly particles of different densities in a heterogeneous medium. The dynamic acoustic field is then used to separate dorsal root ganglion cells. The shearless, label-free and low damage characteristics make this method of manipulation particularly suited for biological applications. Advantages of using a dynamic acoustic field for the separation of cells include its inherent safety and biocompatibility, the possibility to operate over large distances (centimetres), high purity (ratio of particle population, up to 100%), and high efficiency (ratio of separated particles over total number of particles to separate, up to 100%)

Interactive manipulation of microparticles in an octagonal sonotweezer

An ultrasonic device for micro-patterning and precision manipulation of micrometre-scale particles is demonstrated. The device is formed using eight piezoelectric transducers shaped into an octagonal cavity. By exciting combinations of transducers simultaneously, with a controlled phase delay between them, different acoustic landscapes can be created, patterning micro-particles into lines, squares, and more complex shapes. When operated with all eight transducers the device can, with appropriate phase control, manipulate the two dimensional acoustic pressure gradient; it thus has the ability to position and translate a single tweezing zone to different locations on a surface in a precise and programmable manner

Monolithic Implementation of a Planar Gunn Diode and a pHEMT

No abstract available

Mitigation of Moral Hazard and Adverse Selection in Venture Capital Financing: The Influence of the Country’s Institutional Setting

A venture capitalist (VC) needs to trade off benefits and costs when attempting to mitigate agency problems in their investor-investee relationship. We argue that signals of ventures complement the VC’s capacity to screen and conduct a due diligence during the pre-investment phase, but its attractiveness may diminish in institutional settings supporting greater transparency. Similarly, whereas a VC may opt for contractual covenants to curb potential opportunism by ventures in the post-investment phase, this may only be effective in settings supportive of shareholder rights enforcement. Using an international sample of VC contracts, our study finds broad support for these conjectures. It delineates theoretical and practical implications for how investors can best deploy their capital in different institutional settings whilst nurturing their relationships with entrepreneurs

MOSAIC: A Scalable reconfigurable 2D array system for NDT

This paper documents the development of a scalable 2D array system, or Mosaic that can be targeted at a wide range of NDT applications by way of a reconfigurable tile that can be tessellated to form arrays of any size and shape. Close coupling permits utilization of excitation voltages as low as +/-3.3V with insertion loss of 48dB on reflection from an aluminum back wall at 73mm achieved using 2D arrays without decoding

A Search for Pulsed and Bursty Radio Emission from X-ray Dim Isolated Neutron Stars

We have carried out a search for radio emission from six X-ray dim isolated neutron stars (XDINSs) observed with the Robert C. Byrd Green Bank Radio Telescope (GBT) at 820 MHz. No bursty or pulsed radio emission was found down to a 4sigma significance level. The corresponding flux limit is 0.01-0.04 mJy depending on the integration time for the particular source and pulse duty cycle of 2%. These are the most sensitive limits yet on radio emission from these objects.Comment: 3 pages, 3 figures, to be appeared in the Proceedings of the conference "40 Years of Pulsars: Millisecond Pulsars, Magnetars, and More" held on August 12-17, 2007, McGill University, Montreal, Canad

Micro-cooler Enhancements by Barrier Interface Analysis

Peer reviewedPublisher PD

Impact ionisation electroluminescence in planar GaAs-based heterostructure Gunn diodes:Spatial distribution and impact of doping nonuniformities

When biased in the negative differential resistance regime, electroluminescence (EL) is emitted from planar GaAs heterostructure Gunn diodes. This EL is due to the recombination of electrons in the device channel with holes that are generated by impact ionisation when the Gunn domains reach the anode edge. The EL forms non-uniform patterns whose intensity shows short-range intensity variations in the direction parallel to the contacts and decreases along the device channel towards the cathode. This paper employs Monte Carlo models, in conjunction with the experimental data, to analyse these non-uniform EL patterns and to study the carrier dynamics responsible for them. It is found that the short-range lateral (i.e., parallel to the device contacts) EL patterns are probably due to non-uniformities in the doping of the anode contact, illustrating the usefulness of EL analysis on the detection of such inhomogeneities. The overall decreasing EL intensity towards the anode is also discussed in terms of the interaction of holes with the time-dependent electric field due to the transit of the Gunn domains. Due to their lower relative mobility and the low electric field outside of the Gunn domain, freshly generated holes remain close to the anode until the arrival of a new domain accelerates them towards the cathode. When the average over the transit of several Gunn domains is considered, this results in a higher hole density, and hence a higher EL intensity, next to the anode

Investigation of mechanical losses of thin silicon flexures at low temperatures

The investigation of the mechanical loss of different silicon flexures in a temperature region from 5 to 300 K is presented. The flexures have been prepared by different fabrication techniques. A lowest mechanical loss of $3\times10^{-8}$ was observed for a 130 $\mu$m thick flexure at around 10 K. While the mechanical loss follows the thermoelastic predictions down to 50 K a difference can be observed at lower temperatures for different surface treatments. This surface loss will be limiting for all applications using silicon based oscillators at low temperatures. The extraction of a surface loss parameter using different results from our measurements and other references is presented. We focused on structures that are relevant for gravitational wave detectors. The surface loss parameter $\alpha_s$ = 0.5 pm was obtained. This reveals that the surface loss of silicon is significantly lower than the surface loss of fused silica.Comment: 16 pages, 7 figure

The first Suzaku observation of SGR 1806-20

The soft gamma-ray repeater SGR 1806-20 has been attracting a lot of attention owing to the fact that in December 2004 it emitted the most powerful giant flare ever observed. Here we present the results of the first Suzaku observation of SGR 1806-20, that seems to have reached a state characterized by a flux close to the pre-flare level and by a relatively soft spectrum. Despite this, the source remained quite active, as testified by several short bursts observed by Suzaku. We discuss the broadband spectral properties of SGR 1806-20 in the context of the magnetar model, considering its recent theoretical developments.Comment: 3 pages, 1 figure. Proceedings of the conference "40 Years of Pulsars, Millisecond Pulsars, Magnetars and More", Montreal, August 12-17 2007. AIP, in pres