An Exploration of Home Attachment Representations using an Adaptation of Adult Attachment Interview: Preliminary Data on the Home Attachment Interview

Background: In analysing the literature on household as a physical structure strongly linked to cultural and affective aspects, as well as to universal central psychological needs, a universe of meanings was found. The household, conceptualised as home and safe shelter that contains and protects, but also as a favourite place where the most important relationships of each human being unfold, suggests to use attachment theory perspective as a potentially useful framework to conceptualize the construct of home attachment. However, this perspective needs to be further investigated in order to understand its complex nature. Therefore, this pilot study aims to investigate how individuals represent their own homes according to their feelings and emotions related to their household.Methods: A qualitative-quantitative survey has been carried out with 50 adults (50% females) divided into five different age groups (from late adolescence to old age). An adapted version of the Adult Attachment Interview, the Home Attachment Interview, was administered.Results: Analysis identified the relevant aspects that distinguish the "house" as a physical structure, and the "home", that symbolically encloses emotional and affective experiences suggesting a perception of the "house" as "home", being a special place characterised by a strong attachment relationship connoted symbolically and affectively.Conclusions: Attachment theoretical and methodological tools used in the study appear especially useful to investigate and understand the construct of home attachment

EuCARE-hospitalised study protocol: a cohort study of patients hospitalised with COVID-19 in the EuCARE project

Background: Severe acute respiratory syndrome coronavirus 2 (SARS CoV-2), the virus responsible for coronavirus disease 2019 (COVID-19), can lead to hospitalisation, particularly in elderly, immunocompromised, and non-vaccinated or partially vaccinated individuals. Although vaccination provides protection, the duration of this protection wanes over time. Additional doses can restore immunity, but the influence of viral variants, specific sequences, and vaccine-induced immune responses on disease severity remains unclear. Moreover, the efficacy of therapeutic interventions during hospitalisation requires further investigation. The study aims to analyse the clinical course of COVID-19 in hospitalised patients, taking into account SARS-CoV-2 variants, viral sequences, and the impact of different vaccines. The primary outcome is all-cause in-hospital mortality, while secondary outcomes include admission to intensive care unit and length of stay, duration of hospitalisation, and the level of respiratory support required. Methods: This ongoing multicentre study observes hospitalised adult patients with confirmed SARS-CoV-2 infection, utilising a combination of retrospective and prospective data collection. It aims to gather clinical and laboratory variables from around 35,000 patients, with potential for a larger sample size. Data analysis will involve biostatistical and machine-learning techniques. Selected patients will provide biological material. The study started on October 14, 2021 and is scheduled to end on October 13, 2026. Discussion: The analysis of a large sample of retrospective and prospective data about the acute phase of SARS CoV-2 infection in hospitalised patients, viral variants and vaccination in several European and non-European countries will help us to better understand risk factors for disease severity and the interplay between SARS CoV-2 variants, immune responses and vaccine efficacy. The main strengths of this study are the large sample size, the long study duration covering different waves of COVID-19 and the collection of biological samples that allows future research. Trial registration: The trial has been registered on ClinicalTrials.gov. The unique identifier assigned to this trial is NCT05463380

Synthesis and evaluation of the antiplasmodial activity of novel indeno[2,1-c]quinoline derivatives

With the aim to explore the potentiality of new chemical scaffolds for the design of new antimalarials, a set of new indeno[2,1-c]quinolines bearing different basic heads has been synthesized and tested in vitro against chloroquine sensitive (CQ-S) and chloroquine resistant (CQ-R) strains of Plasmodium falciparum. Most of the synthesized compounds exhibited a moderate antiplasmodial activity, inhibiting the growth of both CQ-S and CQ-R strains of P. falciparum with IC50 ranging from 0.24 to 6.9\u3bcM and with a very low resistance index. The most potent compounds (1.2-1.3-fold the CQ on the W-2 strain) can be considered as promising 'lead compounds' to be further optimized to improve efficacy and selectivity against Plasmodia