Aging predicts decline in explicit and implicit memory: a life-span study

Explicit memory declines with age, but age effects on implicit memory are debated. This issue is important because if implicit memory is age-invariant, it may support effective interventions in individuals experiencing memory decline. This study overcame several methodological issues in past research to clarify age effects on implicit memory (priming) and their relationship to explicit memory (recognition, source memory). It aimed to (1) recruit a large lifespan sample of participants (N=1072) during a residency at the Science Museum, London, (2) employ an implicit task that is unaffected by explicit contamination, and (3) systematically manipulate depth-of-processing and attention to assess their contribution to age effects. Participants witnessed a succession of overlapping colored objects, attending to one colour stream and ignoring the other, and at test identified masked objects before judging whether they were previously attended, unattended, or new. Age significantly predicted decline in both explicit and implicit memory for attended objects

First Results from the Large Area Lyman Alpha Survey

We report on a new survey for z=4.5 Lyman alpha sources, the Large Area Lyman Alpha (LALA) survey. Our survey achieves an unprecedented combination of volume and sensitivity by using narrow-band filters on the new 8192x8192 pixel CCD Mosaic Camera at the 4 meter Mayall telescope of Kitt Peak National Observatory. Well-detected sources with flux and equivalent width matching known high redshift Lyman alpha galaxies (i.e., observed equivalent width above 80 Angstroms and line+continuum flux between 2.6e-17 and 5.2e-17 erg/cm^2/sec in an 80 Angstrom filter) have an observed surface density corresponding to 11000 +- 700 per square degree per unit redshift at z=4.5. Spatial variation in this surface density is apparent on comparison between counts in 6561 and 6730 Angstrom filters. Early spectroscopic followup results from the Keck telescope included three sources meeting our criteria for good Lyman alpha candidates. Of these, one is confirmed as a z=4.52 source, while another remains consistent with either z=4.55 or z=0.81. We infer that 30 to 50% of our good candidates are bona fide Lyman alpha emitters, implying a net density of about 4000 Lyman alpha galaxies per square degree per unit redshift.Comment: 10 pages, 2 figures (3 .ps files), uses AASTeX 4. Submitted to The Astrophysical Journal Letter

Ultrasound in the study and monitoring of osteoarthritis

This review addresses the use of ultrasound (US) as an imaging technique for the evaluation and monitoring of the osteoarthritic joint. US complements both the clinical examination and radiological imaging by allowing the rheumatologist to recognize not only the bony profile but also to visualize the soft tissues. Systematic US scanning following established guidelines can demonstrate even minimal abnormalities of articular cartilage, bony cortex and synovial tissue. US is also extremely sensitive in the detection of soft tissue changes in the involved joints including the proliferation of the synovium and changes in the amount of fluid present within the joint. Monitoring the amount of fluid in the hip and knee joint with osteoarthritis may be a potentially useful finding in the selection of patients for clinical investigation and for assessing their response to therapeutic interventions. © 2008

The clock paradox in a static homogeneous gravitational field

The gedanken experiment of the clock paradox is solved exactly using the general relativistic equations for a static homogeneous gravitational field. We demonstrate that the general and special relativistic clock paradox solutions are identical and in particular that they are identical for finite acceleration. Practical expressions are obtained for proper time and coordinate time by using the destination distance as the key observable parameter. This solution provides a formal demonstration of the identity between the special and general relativistic clock paradox with finite acceleration and where proper time is assumed to be the same in both formalisms. By solving the equations of motion for a freely falling clock in a static homogeneous field elapsed times are calculated for realistic journeys to the stars.Comment: Revision: Posted with the caption included with the figure

Deuterium-Stabilized (R)-Pioglitazone, PXL065, for Treatment of X-Linked Adrenoleukodystrophy (ALD)

Background and aims: X-linked Adrenoleukodystrophy (ALD) is a rare neurometabolic disorder caused by ABCD1- gene mutations, leading to Very-Long-Chain Fatty Acids (VLCFA; in particular C26:0) accumulation, inflammation, mitochondrial impairment and demyelination. PXL065, a clinical-stage deuterium-stabilized(R)-stereoisomer of pioglitazone, retains pioglitazone non-genomic actions but lacks PPARγ activity. As pioglitazone exhibits beneficial effects in ALD models and PXL065 may avoid PPARγ- related side effects, we investigated PXL065 effects of in preclinical models. Methods: Patient-derived fibroblasts and lymphocytes and Abcd1-KO mouse glial cells were exposed to PXL065 (5-10μM) and pioglitazone (10μM) for 7 days. VLCFA content was measured by mass spectrometry, selected gene expression by RT-qPCR, and mitochondrial function using a Seahorse Analyzer (after 72hr). PXL065 or pioglitazone (15mg/kg QD) were administered to 6-8-week or 13-month old Abcd1-KO mice for 8 and 12 weeks, respectively. VLCFA content (mass spectrometry), sciatic nerve axonal morphology (electronic microscopy), and locomotor function (open field test) were measured. Results: In patient and mouse glial cells, PXL065 and pioglitazone corrected C26:0, improved mitochondrial function, increased compensatory Abcd2-3 transporter gene expression, and decreased inflammatory gene expression. In Abcd1-KO mice, C26:0 levels were normalized in plasma and decreased in spinal cord (-55%, p\u3c0.01) and brain (-49%, p\u3c0.0001). Pioglitazone had no effect in spinal cord. Following PXL065 and pioglitazone treatment, abnormal axonal morphology (stellate-shaped cells) was improved but only PXL065 showed significantly improved locomotor test results. Conclusion: Despite reduced PPARγ activity, PXL065 showed substantial signs of efficacy and superior therapeutic potential vs. pioglitazone (in vivo) supporting clinical development for ALD. A Phase 2a study is planned in 2022

Ellipticals with Kinematically-Distinct Cores: (V-I) Color Images with WFPC2

We have analysed HST/WFPC2 F555W and F814W images for fifteen elliptical galaxies with kinematically-distinct cores. For each of them we have derived surface brightness and isophotal parameter profiles in the two bands, color maps, and radial profiles in (V-I). We have detected photometric evidence for faint stellar disks, on scales of a few tens to a few arcseconds, in seven galaxies, namely NGC 1427, 1439, 1700, 4365, 4406, 4494 and 5322. In NGC 1700, the isophotes are slightly boxy at the scale of the counter-rotating component, and disky at larger radii. We find no difference in (V-I) color greater than 0.02 mag between these disks and the surrounding galactic regions. Hence the stellar populations in the kinematically distinct cores are not strongly deviant from the population of the main body. For one galaxy, NGC 4365, the innermost region is bluer than the surrounding regions. This area extends to about 15pc, and contains a luminosity of 2.5x10^6 L$_\odot$. If interpreted as a stellar population effect, an age difference of $\sim$ 3-4 Gyrs, or an $[Fe/H]$ variation of about 0.2 dex, is derived. The nuclear intensity profiles show a large variety: some galaxies have steep cusp profiles, others have shallow cusps and a ``break radius''. The nuclear cusps of galaxies with kinematically-distinct cores follow the same trends as the nuclei of normal galaxies. We have not been able to identify a unique, qualifying feature in the WFPC2 images which distinguish the galaxies with kinematically distinct cores from the kinematically normal cores. [shortened]Comment: 56 pages, latex, 17 figures; figure 1 available upon request; ApJ, 481 in pres

The bright Gamma-Ray Burst of February 10, 2000: a case study of an optically dark GRB

The gamma-ray burst GRB000210 had the highest gamma-ray peak flux of any event localized by BeppoSAX as yet but it did not have a detected optical afterglow. It is therefore one of the events recently classified as dark GRBs or GHOST (GRB Hiding Optical Source Transient), whose origin is still unclear. Chandra observations allowed us to localize this GRB within ~1" and a radio transient was detected with the VLA. We identify the likely (P=0.01) host galaxy of this burst at z=0.846. The X-ray spectrum of the afterglow shows intrinsic absorption N_H=5x10**21 cm-2. The amount of dust needed to absorb the optical flux of this object is consistent with the above HI column density, given a dust-to-gas ratio similar to that of our Galaxy. We do not find evidence for a partially ionized absorber expected if the absorption takes place in a Giant Molecular Cloud. We therefore conclude that either the gas is local to the GRB, but is condensed in small-scale high-density (n>~10**9 cm-3) clouds, or that the GRB is located in a dusty, gas-rich region of the galaxy. Finally, if GRB000210 lies at z>5, its X-ray absorbing medium would have to be substantially different from that observed in GRBs with optical afterglows.Comment: 29 pages, 7 fig.s, some revisions, ApJ, in pres

Nuclei in Strongly Magnetised Neutron Star Crusts

We discuss the ground state properties of matter in outer and inner crusts of neutron stars under the influence of strong magnetic fields. In particular, we demonstrate the effects of Landau quantization of electrons on compositions of neutron star crusts. First we revisit the sequence of nuclei and the equation of state of the outer crust adopting the Baym, Pethick and Sutherland (BPS) model in the presence of strong magnetic fields and most recent versions of the theoretical and experimental nuclear mass tables. Next we deal with nuclei in the inner crust. Nuclei which are arranged in a lattice, are immersed in a nucleonic gas as well as a uniform background of electrons in the inner crust. The Wigner-Seitz approximation is adopted in this calculation and each lattice volume is replaced by a spherical cell. The coexistence of two phases of nuclear matter - liquid and gas, is considered in this case. We obtain the equilibrium nucleus corresponding to each baryon density by minimizing the free energy of the cell. We perform this calculation using Skyrme nucleon-nucleon interaction with different parameter sets. We find nuclei with larger mass and charge numbers in the inner crust in the presence of strong magnetic fields than those of the zero field case for all nucleon-nucleon interactions considered here. However, SLy4 interaction has dramatic effects on the proton fraction as well as masses and charges of nuclei. This may be attributed to the behaviour of symmetry energy with density in the sub-saturation density regime. Further we discuss the implications of our results to shear mode oscillations of magnetars.Comment: presented in "Exciting Physics Symposium" held in Makutsi, South Africa in November, 2011 and to be published in a book by Springer Verla

Statistics of Magnification Perturbations by Substructure in the Cold Dark Matter Cosmological Model

We study the statistical properties of magnification perturbations by substructures in strong lensed systems using linear perturbation theory and an analytical substructure model including tidal truncation and a continuous substructure mass spectrum. We demonstrate that magnification perturbations are dominated by perturbers found within a tidal radius of an image, and that sizable magnification perturbations may arise from small, coherent contributions from several substructures within the lens halo. We find that the root-mean-square (rms) fluctuation of the magnification perturbation is 10% to 20% and both the average and rms perturbations are sensitive to the mass spectrum and density profile of the perturbers. Interestingly, we find that relative to a smooth model of the same mass, the average magnification in clumpy models is lower (higher) than that in smooth models for positive (negative) parity images. This is opposite from what is observed if one assumes that the image magnification predicted by the best-fit smooth model of a lens is a good proxy for what the observed magnification would have been if substructures were absent. While it is possible for this discrepancy to be resolved via nonlinear perturbers, we argue that a more likely explanation is that the assumption that the best-fit lens model is a good proxy for the magnification in the absence of substructure is not correct. We conclude that a better theoretical understanding of the predicted statistical properties of magnification perturbations by CDM substructure is needed in order to affirm that CDM substructures have been unambiguously detected.Comment: ApJ accepted, minor change