13 research outputs found
Vicarious nucleophilic substitution of hydrogen vs. ANRORC-type ring transformation in reactions of 1,2,4-triazines with alpha-halocarbanions. Novel route to functionalized pyrazoles
A novel route to pyrazole derivatives bearing sulfonyl, aminosulfonyl, alkoxy- and aryloxysulfonyl groups at C-3 by ring transformation of 3-chloro-6-aryl-1,2,4-triazines 1a-c with alpha-halocarbanions 2a-h is described
Synthesis of Unsymmetrical Annulated 2,2’-Bipyridine Analogues with Attached Cycloalkene and Piperidine Rings via Sequential Diels-Alder Reaction of 5,5’-bi-1,2,4-triazines
Synthesis of bisfunctionalized unsymmetrical 2,2’-bipyridines 8 or their sulfonyl derivatives 12a,b are described. They were prepared via the Diels-Alder reaction of 1-methyl-4-pyrrolidin-1-yl-1,2,3,6-tetrahydropyridine (6) with 3,3’-bis(methyl- sulfanyl)-5,5’-bi-1,2,4-triazine (1). The reaction leads to the single cycloaddition product 7 which undergoes Diels-Alder reaction with cyclic enamines 2a,b to give unsymmetrical 2,2’-bipyridine derivatives 8, consisting of the two different heterocyclic units: cycloalkeno[c]pyridine and 2,6-naphthyridine
Biological activity and synthesis of sulfonamide derivatives: a brief review
Sulfonamidy (SO2-NH-) są lekami powszechnie stosowanymi
ze względu na ich trwałość i tolerancję przez organizm człowieka.
Stanowią dobrą grupę zabezpieczającą amin czyniąc je związkami
aktywnymi biologicznie. Aktywność ta jest wynikiem obecności różnych
grup funkcyjnych. Szerokie zastosowanie sulfonamidów stało
się przyczyną poszukiwania nowych metod ich syntezy. Artykuł
przedstawia krótki przegląd literaturowy najbardziej popularnych
i nowoczesnych metod syntezy pochodnych sulfonamidowych.Sulfonamides (SO2-NH-) have been the center of the drug structures
as they are quite stable and well tolerated in human beings. The
sulfonamides are very important protected intermediates of amines
with several types of biological activities. Activity of the sulfonamides
is due to different functional groups present in them. Due to the
broad applicability of sulfonamides, it is desirable to find general
and effective methods for their synthesis. Different methods have
been adopted to synthesize sulfonamides. Here is a short review
which provides several of the most common and recent methods of
sulfonamide synthesis
Synthesis of 4-functionalized terdendate pyridine-based ligands
Four different 4-functionalised pyridine-based ligands were synthesized with aminomethyl, oxazolinyl, pyrazolyl and methylimidazolyl groups at the 2- and 6-position. The nitrogens of these groups together with the pyridine nitrogen can act as terdendate ligands for metal ions. Synthetic handles on the 4-position of the pyridine :group were introduced via ether or ester bonds leading to monofunctional, bifunctional and amphiphilic ligands. (C) 2003 Published by Fisevier Science Ltd