Postmarketing research of the efficacy and tolerability of fluconazole and clotrimazole in the treatment of vulvovaginal Candidiasis

U ginekološkim ordinacijama primarne zdravstvene zaštite u Hrvatskoj, u razdoblju od 01.06.2006. do 31.07.2006. godine ispitano je 246 epizoda nekomplicirane vulvovaginalne kandidoze (VVK) u bolesnica dobi od 18 do 45 godina u kojih su simptomi trajali do dva tjedna prije početka liječenja. Pojavi VVK u 83 bolesnice prethodilo je uzimanje antibiotika, mjesečnica ili primjena oralnih kontraceptiva. Ostale bolesnice nisu imale predisponirajuće čimbenike. Seksualni partneri nisu imali balanitis. Bolesnice su liječene prema listi randomizacije klotrimazolom vaginalno – 1×0,2 g kroz 3 dana, odnosno flukonazolom peroralno – 1×150 mg jednokratno. Randomizacijom su određene bolesnice čiji su seksualni partneri primali peroralno flukonazol 1×150 mg jednokratno. Klinička djelotvornost antimikrobnog liječenja nekomplicirane VVK i učestalost pojave ponovnih epizoda VVK nisu se značajno razlikovale s obzirom na vrstu provedenog liječenja i istovremeno liječenje ili neliječenje partnera.Atotal of 246 episodes of uncomplicated vulvovaginal candidiasis (VVC) were examined at gynecological outpatient primary health care departments in the period from June 1, 2006 until July 31, 2006, in patients aged 18 to 45 years in whom the symptoms lasted up to two weeks before treatment. The occurrence of VVC in 83 patients was preceded by antibiotic consumption, menstruation or taking oral contraceptives. Other patients had no predisposing factors. Sexual partners did not experience balanitis. The patients were treated according to the randomization list with either clotrimazole 1×0,2 g vaginally for 3 days or a single dose of fluconazole 1×150 mg perorally. The randomization also determined patients whose sexual partners received a single dose of fluconazole 1×150 mg perorally. Clinical efficacy of antimicrobial treatment of uncomplicated VVC and the frequency of recurring episodes of VVC did not significantly differ with regards to the type of administered treatment or simultaneous treatment or no treatment of sexual partner

Research on the effectiveness and tolerability of vaginal administration of probiotic Lactobacillus acidophilus in women with symptoms of colpitis

Probiotici su živi mikroorganizmi koji primijenjeni u dostatnoj količini mijenjaju sastav i metaboličku aktivnost mikroflore ili utječu na imunološki sustav što djeluje povoljno na zdravlje čovjeka. Lactobacillus acidophilus je najbolje proučena acidofilna bakterija koju prirodno nalazimo u jogurtu i acidofilnom mlijeku. Cilj ovog ispitivanja je bio istražiti djelotvornost i podnošljivost vaginalne primjene probiotika Lactobacillus acidophilus u bolesnica sa simptomima kolpitisa. U ovom prospektivnom ispitivanju djelotvornosti i podnošljivosti sedmodnevne primjene Lactobacillus acidophilus solucije za vaginalnu primjenu u žena s kolpitisom – probiotik Lactobacillus acidophilus se pokazao djelotvoran s obzirom da je 42 od ukupno 50 liječenih žena bilo klinički izliječeno. Klinički uspjeh bio je češći u žena iznad 50 godina starosti, te u žena koje su imale simptome iritacije i svrbeža. Lactobacillus acidophilus solucija za vaginalnu primjenu se pokazala izrazito podnošljiva s obzirom da niti jedna od 50 liječenih žena nije imala nuspojave liječenja.Probiotics are live microorganisms which, when administered in adequate amounts, change the structure and metabolic activity of human microflora or affect the immune system in a way beneficial for human health. Lactobacillus acidophilus is the most studied acidophilus bacteria that is naturally found in yogurt and acidophilus milk. The aim of this research was to investigate the effectiveness and tolerability of vaginal administration of probiotic Lactobacillus acidophilus in patients with symptoms of colpitis. In this prospective research on the efficacy and tolerability of Lactobacillus acidophilus vaginal solution used for 7 days in women with colpitis – probiotic Lactobacillus acidophilus has proved effective in 42 out of 50 treated women. Clinical success was more common in women over 50 years of age and in women with symptoms of irritation and pruritis. Lactobacillus acidophilus vaginal solution has proved especially tolerable since not one among 50 treated women experienced treatmant side effects

Research on the effectiveness and tolerability of vaginal administration of probiotic Lactobacillus acidophilus in women with symptoms of colpitis

Probiotici su živi mikroorganizmi koji primijenjeni u dostatnoj količini mijenjaju sastav i metaboličku aktivnost mikroflore ili utječu na imunološki sustav što djeluje povoljno na zdravlje čovjeka. Lactobacillus acidophilus je najbolje proučena acidofilna bakterija koju prirodno nalazimo u jogurtu i acidofilnom mlijeku. Cilj ovog ispitivanja je bio istražiti djelotvornost i podnošljivost vaginalne primjene probiotika Lactobacillus acidophilus u bolesnica sa simptomima kolpitisa. U ovom prospektivnom ispitivanju djelotvornosti i podnošljivosti sedmodnevne primjene Lactobacillus acidophilus solucije za vaginalnu primjenu u žena s kolpitisom – probiotik Lactobacillus acidophilus se pokazao djelotvoran s obzirom da je 42 od ukupno 50 liječenih žena bilo klinički izliječeno. Klinički uspjeh bio je češći u žena iznad 50 godina starosti, te u žena koje su imale simptome iritacije i svrbeža. Lactobacillus acidophilus solucija za vaginalnu primjenu se pokazala izrazito podnošljiva s obzirom da niti jedna od 50 liječenih žena nije imala nuspojave liječenja.Probiotics are live microorganisms which, when administered in adequate amounts, change the structure and metabolic activity of human microflora or affect the immune system in a way beneficial for human health. Lactobacillus acidophilus is the most studied acidophilus bacteria that is naturally found in yogurt and acidophilus milk. The aim of this research was to investigate the effectiveness and tolerability of vaginal administration of probiotic Lactobacillus acidophilus in patients with symptoms of colpitis. In this prospective research on the efficacy and tolerability of Lactobacillus acidophilus vaginal solution used for 7 days in women with colpitis – probiotic Lactobacillus acidophilus has proved effective in 42 out of 50 treated women. Clinical success was more common in women over 50 years of age and in women with symptoms of irritation and pruritis. Lactobacillus acidophilus vaginal solution has proved especially tolerable since not one among 50 treated women experienced treatmant side effects