17 research outputs found
Protective effect of carboxymethyl-glucan (CM-G) against DNA damage in patients with advanced prostate cancer
Carboxymethyl-glucan (CM-G) is a soluble derivative from Saccharomyces cerevisiae (1 → 3)(1 → 6)-β-D-glucan. The protective efficiency of CM-G against DNA damage in cells from patients with advanced prostate cancer (PCa), and undergoing Androgen Deprivation Therapy (ADT), was evaluated. DNA damage scores were obtained by the comet assay, both before and after treatment with CM-G. The reduction in DNA damage, ranging from 18% to 87%, with an average of 59%, was not related to the increased number of leukocytes in peripheral blood. The results demonstrate for the first time the protective effect of CM-G against DNA damage in patients with advanced PCa. Among smokers, three presented the highest reduction in DNA damage after treatment with CM-G. There was no observable relationship between DNA damage scores before and after treatment, and age, alcoholism and radiotherapy
Mesenchymal stem cell therapy promotes the improvement and recovery of renal function in a preclinical model
Cell-mediated DNA inhibition and 6-TG mutagenicity of V79 cells with chemical carcinogens
Application of the DNA synthesis inhibition test in the detection of different DNA-damaging factors
TNF-induced necroptosis and PARP-1-mediated necrosis represent distinct routes to programmed necrotic cell death
Anti-hepatocellular carcinoma activity and mechanism of chemopreventive compounds: ursolic acid derivatives
Protection of cyclophosphamide-induced toxicity in reproductive tract histology, sperm characteristics, and DNA damage by an herbal source; evidence for role of free-radical toxic stress
Aiweixin, a traditional Uyghur medicinal formula, protects against chromium toxicity in caenorhabditis elegans
Evaluation of DNA damage in an Ecuadorian population exposed to glyphosate
We analyzed the consequences of aerial spraying with glyphosate added to a surfactant solution in the northern part of Ecuador. A total of 24 exposed and 21 unexposed control individuals were investigated using the comet assay. The results showed a higher degree of DNA damage in the exposed group (comet length = 35.5 µm) compared to the control group (comet length = 25.94 µm). These results suggest that in the formulation used during aerial spraying glyphosate had a genotoxic effect on the exposed individuals