Characterisation of the fast-ion edge resonant transport layer induced by 3D perturbative fields in the ASDEX Upgrade tokamak through full orbit simulations

In recent experiments at the ASDEX Upgrade tokamak the existence of an Edge Resonant Transport Layer (ERTL) was revealed as the main transport mechanism responsible for the measured fast-ion losses in the presence of externally applied 3D fields. The Monte Carlo orbit-following code ASCOT was used to study the fast-ion transport including the plasma response calculated with MARS-F, reproducing a strong correlation of fast-ion losses with the poloidal mode spectra of the 3D fields. In this work, a description of the physics underlying the ERTL is presented by means of numerical simulations together with an analytical model and experimental measurements to validate the results. The degradation of fast-ion confinement is calculated in terms of the variation of the toroidal canonical momentum (δPϕ). This analysis reveals resonant patterns at the plasma edge activated by 3D perturbations and emphasizes the relevance of nonlinear resonances. The impact of collisions and the radial electric field on the ERTL is analysed.EUROfusion Consortium 633053French National Research Agency (ANR) ANR-11-IDEX-0001-0

A fast feedback controlled magnetic drive for the ASDEX Upgrade fast-ion loss detectors

A magnetically driven fast-ion loss detector system for the ASDEX Upgrade tokamak has been designed and will be presented here. The device is feedback controlled to adapt the detector head position to the heat load and physics requirements. Dynamic simulations have been performed taking into account effects such as friction, coil self-induction, and eddy currents. A real time positioning control algorithm to maximize the detector operational window has been developed. This algorithm considers dynamical behavior and mechanical resistance as well as measured and predicted thermal loads. The mechanical design and real time predictive algorithm presented here may be used for other reciprocating systems.EURATOM 63305

CD8 T cells are dispensable for experimental autoimmune prostatitis induction and chronic pelvic pain development

Impact Factor: 5.5Fil: Salazar, Florencia C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Salazar, Florencia C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Martínez, Maria S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Martínez, Maria S. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Paira, Daniela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Paira, Daniela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Chocobar, Yair A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Chocobar, Yair A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Olivera, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Godoy, Gloria J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Acosta, Rodríguez Eva V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Acosta, Rodríguez Eva V. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Rivero, Virginia E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Rivero, Virginia E. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Motrich, Rubén D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Motrich, Rubén D. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Introduction: Chronic Pelvic Pain Syndrome or Chronic Prostatitis (CPPS/CP) is the most prevalent urologic affliction among young adult men. It is a challenging condition to treat, which significantly decreases patient quality of life, mostly because of its still uncertain aetiology. In that regard, an autoimmune origin is a prominent supported theory. Indeed, studies in patients and in rodent models of Experimental Autoimmune Prostatitis (EAP) have provided compelling evidence suggesting a key role of CD4 Th1 cells in disease pathogenesis. However, the implication of other prominent effectors of the immune system, such as CD8 T cells, has yet to be studied. Methods: We herein analyzed the induction of prostatitis and the development of chronic pelvic pain in EAP using CD8 T cell-deficient animals. Results: We found similarly elevated PA-specific immune responses, with high frequencies of specific IFNg+CD4+ and IL17+CD4+ T cells in prostate draining lymph nodes from PA-immunized either CD8 KO or wild type animals with respect to controls. Moreover, these peripheral immune responses were paralleled by the development of significant chronic pelvic pain, and accompanied by prostate histological lesions, characterized by hemorrhage, epithelial cell desquamation, marked periglandular leukocyte infiltration, and increased collagen deposition in both, PA-immunized CD8 KO and wild type animals. As expected, control animals did not develop prostate histological lesions. Discussion: Our results indicate that CD8 T cells do not play a major role in EAP pathogenesis and chronic pelvic pain development. Moreover, our results corroborate the previous notion that a CD4 Th1 associated immune response drives the induction of prostate tissue inflammation and the development of chronic pelvic pain.info:eu-repo/semantics/publishedVersionFil: Salazar, Florencia C. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Salazar, Florencia C. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Martínez, Maria S. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Martínez, Maria S. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Paira, Daniela A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Paira, Daniela A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Chocobar, Yair A. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica; Argentina.Fil: Chocobar, Yair A. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Olivera, Carolina. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Olivera, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Godoy, Gloria J. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Godoy, Gloria J. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Acosta, Rodríguez Eva V. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Acosta, Rodríguez Eva V. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Rivero, Virginia E. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Rivero, Virginia E. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina.Fil: Motrich, Rubén D. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento de Bioquímica Clínica, Argentina.Fil: Motrich, Rubén D. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro de Investigaciones en Bioquímica Clínica e Inmunología, Argentina

Chloride Nutrition Regulates development, Water Balance and Drought Resistance in Plants

6 páginas.-- 5 figuras.-- 9 referencias.-- Poster presentado en el XII Luso-Spanish Symposium on Plant Water Relations – Water to Feed the World. 30th of September – 3rd of October (Evora) PortugalCl- is a strange micronutrient since actual Cl- concentration in plants is about two orders of magnitude higher than the content required as essential micronutrient. This accumulation requires a high cost of energy, and since Cl- is a major osmotically active solute in the vacuole, we propose that Cl- plays a role in the regulation of water balance in plants. We show here that, when accumulated to macronutrient levels, Cl- specifically regulates leaf cell elongation and water balance parameters, improving water relations at both the leaf tissue and the whole plant levels, increasing drought resistance in higher plants.This work was supported by the Spanish Ministry of Science and Innovation-FEDER grant AGL2009-08339/AGR.Peer Reviewe

PP2A is activated by cytochrome c upon formation of a diffuse encounter complex with SET/TAF-Iß

Intrinsic protein flexibility is of overwhelming relevance for intermolecular recognition and adaptability of highly dynamic ensemble of complexes, and the phenomenon is essential for the understanding of numerous biological processes. These conformational ensembles—encounter complexes—lack a unique organization, which prevents the determination of well-defined high resolution structures. This is the case for complexes involving the oncoprotein SET/template-activating factor-Iß (SET/TAF-Iß), a histone chaperone whose functions and interactions are significantly affected by its intrinsic structural plasticity. Besides its role in chromatin remodeling, SET/TAF-Iß is an inhibitor of protein phosphatase 2A (PP2A), which is a key phosphatase counteracting transcription and signaling events controlling the activity of DNA damage response (DDR) mediators. During DDR, SET/TAF-Iß is sequestered by cytochrome c (Cc) upon migration of the hemeprotein from mitochondria to the cell nucleus. Here, we report that the nuclear SET/TAF-Iß:Cc polyconformational ensemble is able to activate PP2A. In particular, the N-end folded, globular region of SET/TAF-Iß (a.k.a. SET/TAF-Iß ¿C)—which exhibits an unexpected, intrinsically highly dynamic behavior—is sufficient to be recognized by Cc in a diffuse encounter manner. Cc-mediated blocking of PP2A inhibition is deciphered using an integrated structural and computational approach, combining small-angle X-ray scattering, electron paramagnetic resonance, nuclear magnetic resonance, calorimetry and molecular dynamics simulations

NOCIONES EN ALIMENTACIÓN Y NUTRICIÓN INFANTIL DURANTE EL PRIMER AÑO DE VIDA.

It is totally known the principle of the natural breastfeeding defence in the first stages of life, since its composition provides the healthiest growth. The natural breast milk is divided in preterm milk), colostrum, transition milk and mature milk. Additionally, depending on the kind of initial feeding, three types can be differentiated: natural breastfeeding, mixed breastfeeding and artificial breastfeeding. The nutritional basis of the mixed breastfeeding can in turn be separated in two Adapted Formulas (AF): Initiation milk, from 0 to 6 months and Continuation milk from 4 to 6 months. From this age, babies must take complementary feeding or “beikost”, in which cereals will be added firstly, going on with fruits, fish and at last, dairy products and junior milk, in a parallel way to the development of the child. A number of Special Formulas (SF) are recommended to be used for determined pathophisiology situations, such as: without lactose, protein-modified, soy-based, monomerics or elementals, anti-reflux, anti-constipation and last but not least, formulas made for congenital metabolism dysfunctions.Está ampliamente reconocido, el principio de la defensa de la lactancia natural en los primeros estadios de la vida, ya que su composición aporta el crecimiento más saludable. Dicha leche natural se divide atendiendo al tiempo que se lleve secretando en: leche pretérmino, calostro, leche de transición y leche madura. A su vez, dependiendo de que esta alimentación inicial sea con lactancia materna o no, se pueden diferenciar tres tipos: Lactancia natural, Lactancia mixta y Lactancia artificial. Partiendo de la base de la lactancia, nuestro objetivo ha sido el de iniciar una aproximación a la nutrición infantil durante el primer año de vida. Dentro de la Lactancia mixta indicar que su base alimenticia se divide en dos Fórmulas Adaptadas (FA): una de Inicio, desde 0 a 6 meses, y otra de Continuación, a partir de entre 4 y 6 meses. A partir de esta edad el bebé debe ingerir alimentación complementaria o de “beikost” en la cual se añadirán, paralelo al desarrollo del lactante, inicialmente cereales, pasando a frutas, verduras, pescados y por último derivados lácteos. Igualmente para determinadas situaciones fisio-patológicas están recomendadas una amplia gama de Fórmulas Especiales (FE) como es el caso de: las fórmulas sin lactosa, las modificadas en proteínas, de soja, las elementales o monoméricas, las antirreflujo, las anti-estreñimiento, las anti-cólico y por último y no menos importante las fórmulas para errores congénitos del metabolismo

Respiratory Syncytial Virus Seasonality:A Global Overview

Respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections (ALRI) in children. By the age of 1 year, 60-70% of children have been infected by RSV. In addition, early-life RSV infection is associated with the development of recurrent wheezing and asthma in infancy and childhood. The need for precise epidemiologic data regarding RSV as a worldwide pathogen has been growing steadily as novel RSV therapeutics are reaching the final stages of development. To optimize the prevention, diagnosis and treatment of RSV infection in a timely manner, knowledge about the differences in the timing of the RSV epidemics worldwide is needed. Previous analyses, based on literature reviews of individual reports obtained from medical databases, have fail to provide global country seasonality patterns. Until recently, only certain countries have been recording RSV incidence through their own surveillance systems. This analysis was based on national RSV surveillance reports and medical databases from 27 countries worldwide. This is the first study using original source high-quality surveillance data to establish a global, robust and homogeneous report on global country-specific RSV seasonality

Adaptation and Validation of QUick, Easy, New, CHEap, and Reproducible (QUENCHER) Antioxidant Capacity Assays in Model Products Obtained from Residual Wine Pomace

Evaluation of the total antioxidant capacity of solid matrices without extraction steps is a very interesting alternative for food researchers and also for food industries. These methodologies have been denominated QUENCHER from QUick, Easy, New, CHEap, and Reproducible assays. To demonstrate and highlight the validity of QUENCHER (Q) methods, values of Q-method validation were showed for the first time, and they were tested with products of well-known different chemical properties. Furthermore, new QUENCHER assays to measure scavenging capacity against superoxide, hydroxyl, and lipid peroxyl radicals were developed. Calibration models showed good linearity (R2 > 0.995), proportionality and precision (CV < 6.5%), and acceptable detection limits (<20.4 nmol Trolox equiv). The presence of ethanol in the reaction medium gave antioxidant capacity values significantly different from those obtained with water. The dilution of samples with powdered cellulose was discouraged because possible interferences with some of the matrices analyzed may take place.The autonomous government of Castilla y León (Project BU268A11-2

Search for New Physics with Jets and Missing Transverse Momentum in pp collisions at sqrt(s) = 7 TeV

A search for new physics is presented based on an event signature of at least three jets accompanied by large missing transverse momentum, using a data sample corresponding to an integrated luminosity of 36 inverse picobarns collected in proton--proton collisions at sqrt(s)=7 TeV with the CMS detector at the LHC. No excess of events is observed above the expected standard model backgrounds, which are all estimated from the data. Exclusion limits are presented for the constrained minimal supersymmetric extension of the standard model. Cross section limits are also presented using simplified models with new particles decaying to an undetected particle and one or two jets