80 research outputs found
On the Use of Unmanned Aerial Systems for Environmental Monitoring
- Author
- Publication venue
- 'MDPI AG'
- Publication date
- 01/01/2018
- Field of study
[EN] Environmental monitoring plays a central role in diagnosing climate and management impacts on natural and agricultural systems; enhancing the understanding of hydrological processes; optimizing the allocation and distribution of water resources; and assessing, forecasting, and even preventing natural disasters. Nowadays, most monitoring and data collection systems are based upon a combination of ground-based measurements, manned airborne sensors, and satellite observations. These data are utilized in describing both small-and large-scale processes, but have spatiotemporal constraints inherent to each respective collection system. Bridging the unique spatial and temporal divides that limit current monitoring platforms is key to improving our understanding of environmental systems. In this context, Unmanned Aerial Systems (UAS) have considerable potential to radically improve environmental monitoring. UAS-mounted sensors offer an extraordinary opportunity to bridge the existing gap between field observations and traditional air-and space-borne remote sensing, by providing high spatial detail over relatively large areas in a cost-effective way and an entirely new capacity for enhanced temporal retrieval. As well as showcasing recent advances in the field, there is also a need to identify and understand the potential limitations of UAS technology. For these platforms to reach their monitoring potential, a wide spectrum of unresolved issues and application-specific challenges require focused community attention. Indeed, to leverage the full potential of UAS-based approaches, sensing technologies, measurement protocols, postprocessing techniques, retrieval algorithms, and evaluation techniques need to be harmonized. The aim of this paper is to provide an overview of the existing research and applications of UAS in natural and agricultural ecosystem monitoring in order to identify future directions, applications, developments, and challenges.The present work has been funded by the COST Action CA16219 "HARMONIOUS-Harmonization of UAS techniques for agricultural and natural ecosystems monitoring". B. Toth acknowledges financial support by the Hungarian National Research, Development and Innovation Office (NRDI) under grant KH124765. J. Millerovd was supported by projects GA17-13998S and RVO67985939. Isabel and Jodo de Lima were supported by project HIRT (PTDC/ECM-HID/4259/2014-POCI-0145-FEDER016668).Manfreda, S.; Mccabe, MF.; Miller, PE.; Lucas, R.; Pajuelo Madrigal, V.; Mallinis, G.; Ben Dor, E.... (2018). On the Use of Unmanned Aerial Systems for Environmental Monitoring. Remote Sensing. 10(4):1-28. https://doi.org/10.3390/rs10040641S12810
The extracellular-regulated protein kinase 5 (ERK5) enhances metastatic burden in triple-negative breast cancer through focal adhesion protein kinase (FAK)-mediated regulation of cell adhesion
- Author
- A Esparís-Ogando
- A Locatelli
- AJ Pearson
- Brabletz
- C Zhou
- CA Williams
- Cancer Genome Atlas Network.
- D Perez-Madrigal
- D Vuong
- E Villa-Moruzzi
- F Al-Ejeh
- F Liu
- FJ Sulzmaier
- GN Nithianandarajah-Jones
- GW Sledge
- HG Kasler
- I Tanjoni
- J Wang
- JC Barros
- JC Montero
- JC Wu
- JW Antoon
- K Brami-Cherrier
- M Ali
- M Miranda
- M Schramp
- MJ Ortiz-Ruiz
- MR Cronan
- NE Castro
- NK Zouq
- R Chen
- RK Goel
- RS Sawhney
- S Javaid
- S Pavan
- SA Narod
- VT Hoang
- W Jiang
- X Jiang
- Y Zuo
- Z Madak-Erdogan
- Publication venue
- Nature Publishing Group UK
- Publication date
- 14/04/2021
- Field of study
From Springer Nature via Jisc Publications RouterHistory: received 2020-04-21, rev-recd 2021-03-23, accepted 2021-04-14, registration 2021-04-15, pub-electronic 2021-05-12, online 2021-05-12, pub-print 2021-06-10Publication status: PublishedFunder: Worldwide Cancer Research; doi: https://doi.org/10.13039/100011713; Grant(s): 15-1283Funder: RCUK | MRC | Medical Research Foundation; doi: https://doi.org/10.13039/501100009187; Grant(s): MC_PC_18056Abstract: There is overwhelming clinical evidence that the extracellular-regulated protein kinase 5 (ERK5) is significantly dysregulated in human breast cancer. However, there is no definite understanding of the requirement of ERK5 in tumor growth and metastasis due to very limited characterization of the pathway in disease models. In this study, we report that a high level of ERK5 is a predictive marker of metastatic breast cancer. Mechanistically, our in vitro data revealed that ERK5 was critical for maintaining the invasive capability of triple-negative breast cancer (TNBC) cells through focal adhesion protein kinase (FAK) activation. Specifically, we found that phosphorylation of FAK at Tyr397 was controlled by a kinase-independent function of ERK5. Accordingly, silencing ERK5 in mammary tumor grafts impaired FAK phosphorylation at Tyr397 and suppressed TNBC cell metastasis to the lung without preventing tumor growth. Collectively, these results establish a functional relationship between ERK5 and FAK signaling in promoting malignancy. Thus, targeting the oncogenic ERK5-FAK axis represents a promising therapeutic strategy for breast cancer exhibiting aggressive clinical behavior
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
- Author
- Abid M
- Accini JL
- Acuña S
- Adawi F
- Adenuga B
- Adina PM
- Ageev F
- Aguilar-Orozco R
- Ahmad Z
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- Aizenberg D
- Akahori H
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- Publication venue
- Springer Nature
- Publication date
- 01/01/2012
- Field of study
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
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- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
Effects of alirocumab on types of myocardial infarction: insights from the ODYSSEY OUTCOMES trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alings M
- Alonso Martin JJ
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Andersen K
- Andersen R
- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arango Benecke JL
- Arbel Y
- Arif I
- Armaganijan L
- Arroyo JAC
- Arstall MA
- Asanin MR
- Atar S
- Athyros V
- Auguadro C
- Ayala CAC
- Aylward PE
- Azizad MM
- Bagai A
- Bagriy A
- Bahit MC
- Bai F
- Balaguer Recena J
- Baldari D
- Balinovac J
- Ball E
- Bang LE
- Banuru S
- Barakovic F
- Baranov E
- Baranova E
- Barbarash OL
- Barbato E
- Barna OM
- Barone-Rochette G
- Barr C
- Barrucco R
- Bartels GL
- Bashir R
- Basson MMDV
- Bastos JM
- Bata I
- Batushkin V
- Bayat J
- Bayram Llamas EA
- Bayron C
- Beauloye C
- Bednarski J
- Behrens S
- Belhassane A
- Benedicto A
- Bengus CM
- Benov HO
- Berger R
- Berglund S
- Berk M
- Berland J
- Berli MA
- Berlowitz M
- Berman B
- Bernan A
- Berti S
- Bhagwat A
- Bhagwat R
- Bhansali P
- Bhatt DL
- Binder R
- Birchem J
- Bittner VA
- Blicharski T
- Blok T
- Blumberg EDS
- Boccara F
- Bodanese LC
- Bodi Peris V
- Boecker D
- Bojovski S
- Bokarev I
- Bokern MJJA
- Bonfanti AJC
- Bono JOE
- Bordonava AP
- Borse R
- Bortnick A
- Bos RJ
- Botas Rodriguez J
- Botelho A
- Botelho RV
- Botia DCL
- Bottcher M
- Bourgeois R
- Brabham D
- Braganza D
- Braun-Dullaeus R
- Breedveld RW
- Brennan JM
- Brodison A
- Bronzwaer PNA
- Brueren BRG
- Bruguera Cortada J
- Budaj A
- Bugan V
- Busmane A
- Bustamante Labarta MH
- Busz-Papiez B
- Butler R
- Bystryk L
- Caccavo A
- Caime GD
- Calabro P
- Camprubi Potau M
- Camsari A
- Caraco Y
- Carey C
- Carlson E
- Carnero GS
- Carranza Madrigal J
- Carrillo Calvillo J
- Carroll PA
- Cartasegna LR
- Carter L
- Caruso OC
- Cassimjee S
- Castadot M
- Cavallini C
- Cequier Fillat AR
- Cerqueira MJAG
- Cestari HG
- Cevc M
- Cha J
- Chae I-H
- Chaitman B
- Chalavarya G
- Chaleff F
- Chambilla JMC
- Chandna H
- Chane M
- Chang M
- Chaudhary S
- Chavez V-CER
- Chen D
- Chen J
- Chen Y
- Cheng S-C
- Cheng X
- Chiang C-E
- Chiang C-E
- Chizhov P
- Chopda M
- Chopra VK
- Christenson S
- Chu A
- Chua T
- Chumakova G
- Chumburidze V
- Civeira Murillo F
- Claeys M
- Clemmensen P
- Clerc J
- Cleveland D
- Clifford P
- Clifton S
- Coching RM
- Codutti OR
- Cohen S
- Collins N
- Colombo HR
- Colquhoun D
- Commerford PJ
- Concha YMR
- Conrad G
- Constantine G
- Constantinescu MCA
- Convens C
- Cools F
- Corbett C
- Cornel JH
- Correa Flores RM
- Cosavalente LAC
- Cosin Sales J
- Costa F
- Coste P
- Cottin Y
- Coufal Z
- Coverdale SGM
- Cristian G
- Cruz Fernandez JM
- Cuccia C
- Cui L
- Cyster HP
- Czerski T
- D'Urso M
- Daboul N
- Dagher G
- Dahl C
- Dai K
- Dalby AJ
- Dalby AJ
- Danchin N
- Dandillaya R
- Daniels C
- Das S
- Davidovic G
- Davidsen F
- Davies R
- Davis W
- De Berrazueta Fernandez JR
- De Cesare NB
- De Leo A
- De Luca G
- De Mora Martin M
- De Pellegrin A
- De Salazar DIM
- de Santos MON
- de Silva HA
- de Souza JA
- De Wolf L
- Delarche N
- Deloatch S
- Demirtas M
- Denham D
- Devarapalli SK
- DeVore AD
- Diamantis S
- Diaz Fernandez JF
- Diaz A
- Diaz R
- Dickey S
- Dilic M
- Dimkovic S
- Dimov BI
- Dincic DV
- Ding C
- Dion D
- Dodic S
- Dombrowski K
- Doncovska S
- Dong S
- Dong Y
- Dorobantu M
- Dorsel T
- Dran RD
- Drexel H
- Drzewiecka A
- Ducas J
- Ducrocq G
- Duda N
- Dujardin K
- Dukat A
- Dulak E
- Dupuis R
- Durak-Nalbantic A
- Duronto EA
- Dzupina A
- Dzyak G
- Eagerton D
- Eapen Z
- East C
- Eaton C
- Ebrahim IO
- Edelberg JM
- Edes I
- Egorova L
- Eisenberg S
- Ekanayaka R
- El Shahawy M
- El-Ahdab F
- Elias M
- Eliaschewitz FG
- Elliott J
- Endsley P
- Eppinger A
- Erglis A
- Erglis A
- Ersanli M
- Fadlallah H
- Faes D
- Faggiano P
- Fairlamb J
- Fajardo Campos P
- Falukozy J
- Fang C-Y
- Fang W
- Fanghanel Salmon G
- Farhat N
- Farrar M
- Fausto Ovando SR
- Fazekas F
- Fazlibegovic E
- Feitosa GS
- Fell D
- Feng Y
- Fernandes Manenti ERF
- Fernandez Portales J
- Fernandez AM
- Fernandez M
- Fernando N
- Ferrari E
- Ferratini M
- Ferrolino A
- Filardi PP
- Fischer S
- Fishberg R
- Fisher D
- Fisher N
- Fisher R
- Florenzano F
- Flores E
- Flores REO
- Fong P
- Forgosh L
- Foster M
- Foster R
- Francis A
- Franek E
- Fras Z
- French WJ
- Friedman D
- Frost L
- Fu G
- Fuchs S
- Fuentes Jimenez F
- Fujii K
- Fujimoto K
- Fujinaga H
- Fulop P
- Fulwani MC
- Furukawa Y
- Galski T
- Galvani M
- Gapon L
- Garcia Brasca DF
- Garcia Castillo A
- Garcia Duran RO
- Garcia Lledo JA
- Garcia-Dorado D
- Gardner G
- Garrahy PJ
- Garrido M
- Garza Ruiz JA
- Gavish D
- Ge J
- Gelormini J
- Gerber J
- Gerber R
- Ghitis A
- Ghlonti R
- Gibson P
- Gielen S
- Giesler G
- Gil-Extremera B
- Gilbert JM
- Gillespie E
- Gilmore R
- Gimple L
- Giordano JA
- Giorgeto FE
- Gislason G
- Giuliano ME
- Gniot J
- Goch A
- Goloborodko B
- Gomez Vilamajo OA
- Gonsorcik J
- Gonzales RJV
- Gonzalez Diaz B
- Gonzalez Salas LG
- Gonzalez-Juanatey C
- Gonzalez-Juanatey JR
- Goodman SG
- Goodman SG
- Gordeev I
- Gordienko A
- Gorny J
- Gosselin G
- Gosselink ATM
- Gotcheva NN
- Gotcheva NN
- Govinda RA
- Goyal NK
- Gremmler U
- Grewal JS
- Griffiths H
- Gring C
- Groenemeijer BE
- Groutars RGEJ
- Guardigli G
- Guerrero De Leon M
- Guha S
- Gullestad L
- Guneri S
- Guneri S
- Guo Y
- Gurevich V
- Gusi Tragant G
- Guzman PN
- Haddad T
- Hagstrom E
- Hagstrom E
- Hahalis PIG
- Halabi M
- Halcox J
- Hald F
- Haldis T
- Hall J
- Halvorsen S
- Hameed A
- Haniffa R
- Hanotin C
- Hansen O
- Haraguchi T
- Harding S
- Harkut P
- Harrington RA
- Harris B
- Harris B
- Hart H
- Hata Y
- Hattler B
- Hedman A
- Heidenreich L
- Heinc P
- Heitzer T
- Hemetsberger R
- Henderson D
- Henkin Y
- Herath JI
- Herazo AS
- Hermans K
- Hermans WRM
- Hernandez HAA
- Herrman JPR
- Hersbach FMRJ
- Hess CN
- Higashikata T
- Higuera JD
- Hii CLS
- Hirayama A
- Hirooka K
- Hlatky MA
- Hoag G
- Hodes Z
- Hoffer E
- Hoffman D
- Hong T
- Hoogslag PAM
- Hoppe U
- Horak D
- Horowitz J
- Horvath I
- Horwitz P
- Hove JD
- Hrabar AD
- Hranai M
- Hsieh I-C
- Huang L
- Huang S
- Huang T-Y
- Huang W
- Huber K
- Huidobro L
- Huikuri H
- Hunter J
- Hurtig U
- Hussein O
- Huynh T
- Hwang J-J
- II TC
- III DG
- III KG
- Ilic S
- Ilieva-Pandeva KA
- Ince C
- Iniguez A
- Investigators ODYSSEYOUTCOMES
- Iqbal SMR
- Irimpen A
- Istratoaie O
- Ito K
- Ivanov IG
- Ivanova R
- Ivanovic N
- Iyengar SS
- Izzo M
- Jacoby D
- Jafar Z
- Jaffrani N
- Jain D
- Janik M
- Janosik D
- Jaramillo N
- Jatin FGM
- Jaworska K
- Jayawardena J
- Jensen SA
- Jensen SA
- Jeong MH
- Jeppesen J
- Jeserich M
- Jiang W
- Jintapakorn W
- Johansen PB
- Jonas M
- Jones WS
- Jordan JD
- Jortveit J
- Joshi AB
- Joshi P
- Jovin I
- Jr CE
- Jr HW
- Jr LC
- Jr MJ
- Jr PW
- Jr RW
- Jr SJ
- Jr SJF
- Jr WD
- Jujjuru S
- Jukema JW
- Juonala M
- Jure HO
- Jurgaitiene R
- Kadr H
- Kaewsuwanna P
- Kahali D
- Kaikkonen K
- Kaiser S
- Kalashetti S
- Kalil R
- Kamensky G
- Kamiya H
- Kandasamy B
- Kapin T
- Kaplan R
- Kapp IE
- Karalis I
- Karlsberg R
- Karna S
- Karpenko O
- Karpenko Y
- Karpov Y
- Karpov Y
- Kartalis A
- Kasim S
- Katona A
- Katsuda Y
- Katz A
- Kaucak V
- Kavaliauskiene R
- Kawasaki T
- Ke Y
- Keating F
- Kedev S
- Keen W
- Kehasukcharoen W
- Kelsey SF
- Kerkar P
- Khabeishvili G
- Khaira AS
- Khaisheva L
- Khan A
- Khan A
- Khan M
- Khasanov N
- Khintibidze I
- Khurana S
- Kibarskis A
- Kichukov KN
- Killat H
- Kim C
- Kim HS
- Kim MH
- Kim S-H
- Kimmelstiel C
- Kimura K
- Kimura T
- King M
- Kirma C
- Kishi K
- Kiss RG
- Kiss RG
- Kiviniemi T
- Kjovkaroski A
- Klancke K
- Klantsa A
- Klausen IC
- Kline G
- Klutstein M
- Knickelbine T
- Knowles JW
- Knutson T
- Koba S
- Kobalava Z
- Kobayashi J
- Koike A
- Koldas L
- Kolls BJ
- Kondo NI
- Kong DF
- Kopytsya M
- Koren M
- Kormann A
- Kornder J
- Kornowski R
- Korol M
- Kosinski E
- Kosmachova E
- Kostarska-Srokosz E
- Kostis J
- Kotha P
- Kouz S
- Kovalskyi I
- Kozuma K
- Krasowski W
- Krawczyk J
- Krichmar P
- Kristensen KS
- Kubica J
- Kubilius R
- Kuchar J
- Kuhlman P
- Kultursay H
- Kumar A
- Kumar P
- Kumbla M
- Kumkumian G
- Kuo J-Y
- Kurian J
- Kushnir M
- Kutniy O
- Kyiak Y
- Labroo A
- Lai C
- Lai W-T
- Landzberg J
- Larry J
- Larsen J
- Laucevicius A
- Laufs U
- Laxson D
- Lazov PV
- Leaes PE
- Leclercq F
- Lee K
- Lee K
- Lefevre T
- Leggewie S
- Lehman SJ
- Leimbach W
- Lekakis J
- Leon RPC
- Leonardi S
- Leone A
- Lepage S
- Lepor N
- Leshchuk O
- Lester FM
- Leung R
- Levy T
- Li H
- Li J
- Li X
- Li Y
- Lianopoulos E
- Liberman A
- Liberopoulos E
- Liberopoulos E
- Libov I
- Licciardello G
- Lieber I
- Liem AAH
- Liew HB
- Lillis L
- Lin J
- Lin W
- Lin WH
- Lin X
- Lindsey J
- Linhart A
- Link C
- Lip GYH
- Lipar L
- Lipko JA
- Liu M-E
- Liu S
- Llamas Esperon GA
- Loma-Osorio Rincon P
- Lomakin NV
- Lomholdt JD
- Lominadze Z
- Lopes RD
- Lopes RD
- Lopes RD
- Lopes RD
- Lopez Rosas E
- Lopez RB
- Lopez-Jaramillo P
- Lorenzatti AJ
- Lotan C
- Lottering H
- Lotun K
- Loussararian A
- Love M
- Lozada HJG
- Lozance N
- Lubinski A
- Luciardi HL
- Lui H
- Luis Zamorano J
- Luo Z
- Lupkovics G
- Lupovitch S
- Luquez HA
- Lyamina N
- Lysek R
- M Escudier J
- MacDonald P
- Macdonell A
- Mach F
- Machado L
- Machova V
- Mackinnon IJ
- Mahaffey KW
- Mahajan A
- Mahal S
- Maia LN
- Majercak I
- Makotoko EM
- Malhotra V
- Malik A
- Malozzi C
- Malynovsky Y
- Manakshe GV
- Mannucci JEB
- Mano T
- Manolis A
- Mansourati J
- Marais HJ
- Marcus J
- Marin Neto JA
- Marin F
- Markov DT
- Markov V
- Maron DJ
- Martinez Sanchez CR
- Martins D
- Martsin K
- Marusincova I
- Marx N
- Marx N
- Marx R
- Maskon O
- Matas Pericas L
- Matei AV
- Mathews R
- Mathur A
- Mathur R
- Matiga G
- May O
- May W
- Mayurathan G
- Mazur J
- Mcclure S
- Mcgough M
- Mclaurin B
- Medrano Allende JC
- Mehta RH
- Mehta S
- Meloni C
- Mendis S
- Mendonca C
- Mendoza JLA
- Mentz RJ
- Merkely B
- Michalaros YL
- Michaud N
- Michishita I
- Micko K
- Midzic Z
- Miguel SAN
- Miklaszewicz B
- Militaru C
- Mincheva VM
- Minescu B
- Mintale I
- Mirek-Bryniarska E
- Misonis N
- Moccetti T
- Mody F
- Mohamed WMIW
- Mohart AE
- Molchanova O
- Mollov MN
- Montalescot G
- Montana OR
- Monteiro MR
- Monteiro P
- Montenegro Valdovinos PC
- Montenegro Valdovinos PC
- Moodley R
- Morais J
- Morales DD
- Moran J
- Moreira HG
- Morel O
- Moriarty A
- Moriarty PM
- Moriarty PM
- Morino Y
- Moris De La Tassa C
- Morisset A
- Moryusef A
- Mosseri M
- Mostovoy Y
- Motovska Z
- Moura Jorge JC
- Mourtzinis G
- Mudawi T
- Mueller C
- Muenzel T
- Mulkay A
- Muller C
- Muller G
- Munk PS
- Munusamy V
- Murin J
- Muslibegovic A
- Musumeci G
- Muthusamy R
- Mutlu B
- Mynhardt JH
- Myshanych H
- Nacoud Ackar A
- Nager P
- Nagy L
- Nahhas A
- Nani S
- Naplava R
- Natour M
- Navarro NCL
- Nelson W
- Neuenschwander F
- Nicol P
- Nicolau JC
- Nielsen PK
- Nielsen T
- Nieminen MS
- Nigro F
- Nijmeijer R
- Nikolaev K
- Nikolov FP
- Nikolsky E
- Nishibe A
- Nociar J
- Nogareda G
- Norkiene S
- Novaretto LP
- Novo S
- Novoa F
- Novotny V
- Nowins R
- Nunez Fragoso JC
- Nunez CAZ
- Nygard O
- O'Donnell PJ
- Oklukar J
- Olivares C
- Oliver R
- Olsson AG
- Omran H
- Ong HY
- Ong TK
- Ono Y
- Oomen A
- Oomman A
- Orlikova O
- Osokina N
- Ostadal P
- Paganelli F
- Pagava Z
- Palimkar P
- Palka J
- Palmer B
- Palvarini M
- Panchal V
- Pancholy S
- Pandey A
- Pandurangi U
- Parada JC
- Parepa IR
- Park HS
- Park HT
- Parkhomenko A
- Parkhomenko A
- Parthenakis PIF
- Pasquini J
- Patange A
- Patel CB
- Paterlini GA
- Patil SN
- Patki N
- Patocchi CA
- Patsilinakos S
- Pawlowicz L
- Pearce S
- Pecin I
- Pella D
- Peng D
- Pepine C
- Pereira E
- Pereira HH
- Pereira SB
- Perez Rios JA
- Perez ESS
- Perez L
- Perkins L
- Perlmutter N
- Pesant Y
- Petranov SL
- Petrulioniene Z
- Piatti P
- Picone M
- Piepiorka M
- Pillay T
- Pimentel Filho P
- Pincetti C
- Piovaccari G
- Pirenne B
- Piyayotai D
- Plaza Perez I
- Podoleanu CGC
- Podpera I
- Poh K-K
- Pojskic B
- Pollock S
- Pontaga N
- Pope T
- Pordy R
- Porthan K
- Porwal S
- Posio P
- Pothineni RB
- Potthoff S
- Poulsen SH
- Povolny P
- Povsic TJ
- Povzun A
- Precoma DB
- Premchand RK
- Prieto J-C
- Probst V
- Proddutur NR
- Prokhorov A
- Puccioni E
- Puri S
- Purow J
- Putnikovic B
- Puymirat E
- Qu B
- Radin M
- Radovanovic S
- Raev DH
- Raffel O
- Raffo CA
- Raghuraman B
- Rahman A
- Raisinghani A
- Rajapaksha A
- Ramos Lopez GA
- Ranadive N
- Ranjith N
- Rao S
- Rasmanis G
- Rauch-Kroehnert U
- Raungaard B
- Ray KK
- Ray M
- Rech R
- Reiner Z
- Reis G
- Reis HJL
- Rensing BJWM
- Reshetko O
- Reshotko D
- Reuter H
- Reynolds T
- Rha S
- Rider J
- Rishko M
- Ristic AD
- Ritt LEF
- Roberts-Thomson P
- Robinson S
- Rodes-Cabau J
- Rodriguez De Leon ER
- Roe MT
- Rogelio G
- Rogers JF
- Rokyta R
- Romeo S
- Ronner E
- Roosen J
- Rosenberg M
- Rosenschein U
- Rosenson R
- Rossi P
- Rossi PRF
- Rosu D
- Rouleau J-L
- Rozenman Y
- Rubenstein H
- Rudenko A
- Rudenko L
- Ruiz RLF
- Saaiman JA
- Saathe S
- Saavedra SS
- Sabatino K
- Sabbah E
- Sader M
- Sakagami S
- Sakalyte G
- Sakamoto T
- Salcido Vazquez E
- Salvioni A
- Saminski K
- Sandhu M
- Sansanayudh N
- Santharaj W
- Saporito W
- Sarkar D
- Sarvan M
- Sassone SA
- Sastravaha K
- Savard D
- Sawhney J
- Schaeufele T
- Schellenberg D
- Schiavi LB
- Schiele F
- Schifferdecker B
- Schmalfuss C
- Schmidberg JM
- Schmidt E
- Schuchard T
- Schwartz GG
- Schwartz M
- Schwartz S
- Sciborski R
- Scott D
- Sebastian PJ
- Seferovic P
- Seixo F
- Selecky J
- Senaratne M
- Senaratne V
- Sethi S
- Shaburishvili T
- Shah AV
- Shah BR
- Shah V
- Shalaev S
- Sharman D
- Shaw J
- Shechter M
- Shehova-Yankova NS
- Sheldon W
- Sherwood MW
- Shetty S
- Shi X
- Shimizu M
- Shinde R
- Shinke T
- Shogenov Z
- Shou X
- Shoukfeh M
- Shustov S
- Shvarts Y
- Sijbrands EJG
- Silva PGMDB
- Silva RP
- Silva SIB
- Silveira JA
- Silver K
- Simaitis A
- Sime I
- Simic D
- Simonis G
- Simoons ML
- Singal D
- Singh N
- Sinha D
- Sinnaeve P
- Sionis D
- Sirisena T
- Siu DCW
- Skonieczny G
- Skorski M
- Skoumas I
- Slapikas R
- Smik R
- Soggia AP
- Soonfuang W
- Soopold S
- Soots M
- Soran H
- Soroka E
- Sotnikova T
- Sousa L
- Souza WKSB
- Soward A
- Sparby JA
- Speirs S
- Spinar J
- Sporn D
- Spriggs D
- Sritara P
- Sritara P
- Sritara P
- Staneta P
- Stanislavchuk M
- Stankovic A
- Starmer G
- Stasek J
- Stasiewski A
- Steg PG
- Steg PG
- Steiner S
- Stellbrink C
- Stewart R
- Stojic S
- Stone J
- Storey R
- Strain J
- Stratmann M
- Strbova J
- Strelnieks A
- Striekwold H
- Stringfellow K
- Stryuk R
- Su G
- Su X
- Suarez Otero R
- Subkovas E
- Sudnik W
- Sugino H
- Suh D
- Sujjavanich D
- Sukonthasarn A
- Suligoj NC
- Sumner A
- Sun Y
- Sundelin T
- Sundram PS
- Suryapranata H
- Sussex B
- Svab P
- Sy RAG
- Sy RG
- Sydow K
- Szarek M
- Szpajer M
- Taguchi S
- Takahashi T
- Takata T
- Takeda Y
- Tan E
- Tashchuk V
- Tasic N
- Taskinen M-R
- Taurio J
- Ternouth I
- Terzic I
- Tesloianu DN
- Tespili M
- Teufel E
- Thakkar M
- Thew S
- Ticona JRC
- Tirador L
- Tissera N
- Todorov GV
- Toma M
- Tomala T
- Tonnessen G
- Torstensson I
- Toursarkissian N
- Tov N
- Tretyakova TV
- Trevelyan J
- Triana MAU
- Tricoci P
- Troquay RPT
- Trotter C
- Tsai W-C
- Tse H-F
- Tseluyko V
- Tumbev HS
- Tunon Fernandez J
- Tunon J
- Turgeman Y
- Turi T
- Turk S
- Tyrenko VV
- Tzekova ML
- Ueda Y
- Uehara H
- Ueng K-C
- Ungi I
- Ural E
- Ushakov O
- Utsu N
- Vahula V
- Vakaluyk I
- Valgimigli M
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardi G
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velasquez JRD
- Velcheva ES
- Verdel GJE
- Vered Z
- Vervoort G
- Vico ML
- Vida M
- Videbaek L
- Vidotti MH
- Vidovich M
- Viergever EP
- Viigimaa M
- Vijay N
- Vijayaraghavan R
- Vikman S
- Viktorova I
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewoda P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Worner Diz F
- Wright S
- Xatzitolios A
- Xavier D
- Xenakis M
- Xu B
- Xu D
- Xu X
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zeiher AM
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu H
- Zirlik A
- Zizka J
- Zong W
- Zrazhevsky K
- Zuniga JDH
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2019
- Field of study
Aims The third Universal Definition of Myocardial Infarction (MI) Task Force classified MIs into five types: Type 1, spontaneous; Type 2, related to oxygen supply/demand imbalance; Type 3, fatal without ascertainment of cardiac biomarkers; Type 4, related to percutaneous coronary intervention; and Type 5, related to coronary artery bypass surgery. Low-density lipoprotein cholesterol (LDL-C) reduction with statins and proprotein convertase subtilisin–kexin Type 9 (PCSK9) inhibitors reduces risk of MI, but less is known about effects on types of MI. ODYSSEY OUTCOMES compared the PCSK9 inhibitor alirocumab with placebo in 18 924 patients with recent acute coronary syndrome (ACS) and elevated LDL-C (≥1.8 mmol/L) despite intensive statin therapy. In a pre-specified analysis, we assessed the effects of alirocumab on types of MI. Methods and results Median follow-up was 2.8 years. Myocardial infarction types were prospectively adjudicated and classified. Of 1860 total MIs, 1223 (65.8%) were adjudicated as Type 1, 386 (20.8%) as Type 2, and 244 (13.1%) as Type 4. Few events were Type 3 (n = 2) or Type 5 (n = 5). Alirocumab reduced first MIs [hazard ratio (HR) 0.85, 95% confidence interval (CI) 0.77–0.95; P = 0.003], with reductions in both Type 1 (HR 0.87, 95% CI 0.77–0.99; P = 0.032) and Type 2 (0.77, 0.61–0.97; P = 0.025), but not Type 4 MI. Conclusion After ACS, alirocumab added to intensive statin therapy favourably impacted on Type 1 and 2 MIs. The data indicate for the first time that a lipid-lowering therapy can attenuate the risk of Type 2 MI. Low-density lipoprotein cholesterol reduction below levels achievable with statins is an effective preventive strategy for both MI types.For complete list of authors see http://dx.doi.org/10.1093/eurheartj/ehz299</p
CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative
- Author
- A Mori M.
- Aguado Carmen
- Aguilera Paula
- Albiñana Virginia
- Almoguera Berta
- Alonso Javier
- Alonso-Ferreira Verónica
- Alías Laura
- Andrés Jimenez-Estrada J.
- Antiñolo Gil Guillermo
- Antonio Tenorio-Castaño J.
- Antón Puig-Butille J.
- Arbones ML.
- Arenas Joaquín
- Arjona Emilia
- Armangue Thais
- Armstrong Judith
- Arnedo María
- Artuch Rafael
- Artuch Rafael
- Aulinas-Masó Anna
- Avila-Fernandez Almudena
- Ayuso Carmen
- Badell Isabel
- Badenas Celia
- Baeza Maria Luisa
- Baiget Montserrat
- Balcells Susanna
- Ballesta Martínez María Juliana
- Barahona María-José
- Barros Francisco
- Bartoccioni Paola Chiara
- Bayona-Bafaluy María Pilar
- Benito Sanz Sara
- Bernabéu Carmelo
- Bernal Sara
- Blanco-Kelly Fiona
- Blázquez Alberto
- Bodoy Susanna
- Bogliolo Massimo
- Borralleras Cristina
- Borrego Salud
- Botella Luisa-Maria
- Bou de Pieri Francesc
- Bovolenta Paola
- Bravo Gil Nereida
- Brea-Fernández Alejandro
- Bueno-Lozano Gloria
- Bueren Juan
- Bueren Juan
- Bustamante Ana
- Caballero Teresa
- Camacho-Macorra Carlos
- Camats Tarruella Núria
- Campos-Barros Angel
- Campuzano Victoria
- Cantarero Abad Lara
- Cantó Judith
- Caparros-Martin Jose A.
- Cardellach Francesc
- Carlos Rodriguez-Aguilera J.
- Carmen Martínez-Romero M.
- Carmona Rosario
- Carracedo Angel
- Carrera Cristina
- Carretero Marta
- Casado Jose A.
- Casado Mercedes
- Casasnovas Pons Carlos
- Cascón Alberto
- Casino Patricia
- Castaño Luís Antonio
- Castilla-Vallmanya Laura
- Catala Albert
- Cayuela Maria Luisa
- Cediel R.
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- Codina-Solà M.
- Contreras J.
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- Universitat Autònoma de Barcelona
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- Webb S.M.
- Webb Susan
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- Álvarez-Mora María Isabel
- Ángel Medina M.
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- Publication venue
- Publication date
- 01/01/2022
- Field of study
Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research
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- Zimmermann CM
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- Zorzano A
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- Zwerschke W
- Álvarez ÉMC
- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Genome reduction and potential metabolic complementation of the dual endosymbionts in the whitefly Bemisia tabaci
- Author
- A Dinsdale
- A Lamelas
- A Mahadav
- A Moya
- A Nakabachi
- ACC Wilson
- AE Douglas
- AE Douglas
- AK Hansen
- Amparo Latorre
- Andrés Moya
- B Wallace
- Cecilia C Klein
- CW Russell
- D Santos-Garcia
- D Wu
- Dan-Tong Zhu
- DB Sloan
- DB Sloan
- DB Sloan
- DB Sloan
- Diego Santos-Garcia
- DRG Price
- E Borenstein
- E Chiel
- E Lerat
- E Vautrin
- E Vautrin
- E Zchori-Fein
- E Zchori-Fein
- E Zientz
- F Husnik
- Fabrice Vavre
- FJ Silva
- Francisco J Silva
- G Csardi
- G Gueguen
- GM Bennett
- H Charles
- H Lin
- I Tamas
- J Ferrari
- J Hu
- JP McCutcheon
- JP McCutcheon
- JP McCutcheon
- JP McCutcheon
- JP Sandstrom
- K Lagesen
- L Cottret
- L Cottret
- Laurence Mouton
- M Brumin
- M Ghanim
- M Ghanim
- Marie-France Sagot
- ME Smoot
- MJ Lopez-Sanchez
- ML Thao
- MR Nandineni
- NA Moran
- NA Moran
- NA Moran
- P Baumann
- P Schattner
- PD Karp
- PH Degnan
- Pierre-Antoine Rollat-Farnier
- PJ Barro De
- PJ Barro De
- Q Rao
- Q Rao
- Q Rao
- Q Ren
- Q Su
- Qiong Rao
- RL Tatusov
- S Lopez-Madrigal
- S Shigenobu
- S Sintupachee
- Shu-Sheng Liu
- T Woyke
- V Perez-Brocal
- VJ Martin
- Xiao-Wei Wang
- XL Bing
- XL Bing
- XW Wang
- Y Gottlieb
- Y Gottlieb
- Y Moriya
- ZF Jiang
- ZL Sabree
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effect of alirocumab on mortality after acute coronary syndromes. An analysis of the ODYSSEY OUTCOMES randomized clinical trial
- Author
- Abbas J
- Abbate A
- Abdullakutty J
- Abdullkutty J
- Abhyanakar AD
- Aboyans V
- Abrantes JAM
- Abu-Fadel M
- Acevedo M
- Adamkova V
- Adamo A
- Adhyapak S
- Agarwal H
- Aggarwal R
- Aggarwal RK
- Agnetti V
- Aguirre A
- Ahmed H
- Ahremark U
- Ahuad Guerrero RA
- Aidar Ayoub JC
- Airaksinen JK
- Aitken D
- Akatova E
- Akhter F
- Ako J
- Akright L
- Akyea-Djamson A
- Al Joundi T
- Al-Windy NYY
- Alan D
- Alcocer Gamba MA
- Alexander JH
- Alexander K
- Alexandru TM
- Alexopoulos D
- Alings M
- Alonso Martin JJ
- Alonso Orcajo N
- Alsweiler C
- Alvarisqueta AF
- Alves De Lima AE
- Amarasekera S
- Amarasena N
- Amir O
- Amlani M
- Amosova E
- Amuchastegui M
- Anchante Hernandez HA
- Andersen D
- Andersen K
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- Anderson J
- Ando K
- Angel Hominal M
- Annam S
- Anscombe R
- Apostolovic SR
- Appel K-F
- Arandjelovic A
- Araneda G
- Arbel Y
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- Armaganijan L
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- Arstall MA
- Asanin MR
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- Athyros V
- Auguadro C
- Aylward P
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- Badreddine E
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- Baranov E
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- Barone-Rochette G
- Barr C
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- Barrucco R
- Bartels GL
- Bashir R
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- Batushkin V
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- Bayram Llamas EA
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- Repincay J
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- Rishko M
- Ristic AD
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- Sheldon W
- Sheller J
- Sherwood MW
- Shetty S
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- Sikic J
- Silva PGMDB
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- Silveira JA
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- Simaitis A
- Sime I
- Simic D
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- Simonis G
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- Singsaas EG
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- Siu DCW
- Skonieczny G
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- Skoumas I
- Slapikas R
- Smik R
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- Soonfuang W
- Soopold U
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- Sopena S
- Soran H
- Soroka E
- Sotnikova T
- Sotty M
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- Souza WKSB
- Soward A
- Sparby JA
- Speirs S
- Spinar J
- Sporn D
- Spriggs D
- Sritara P
- Stambuk K
- Staneta P
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- Tomulic V
- Tonnessen G
- Torstensson I
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- Tretyakova TV
- Trevelyan J
- Triana MAU
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- Tricoci P
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- Tsai W-C
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- Tseluyko V
- Tumbev HS
- Tunon Fernandez J
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- Tyrenko VV
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- Uehara H
- Ueng K-C
- Ungi I
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- Valdivielso P
- Valdovinos PCM
- Valdovinos PCM
- Valgimigli M
- Valiris J
- Vallejo GS
- Vallejos JA
- Van Der Wal RMA
- Van Der Zwaan CC
- Van Diepen SFP
- Van Huysduynen-Monraats PSH
- Van Zyl LJ
- Vardas P
- Vardi G
- Vargas Gonzales RJ
- Varleta P
- Vatutin M
- Vedere A
- Vejar M
- Velcheva ES
- Verdel GJE
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- Vikman S
- Viktorova I
- Vincendet M
- Violini R
- Vishnevsky AY
- Vizel S
- Vo A
- Voeller H
- Voevoda MI
- Vogel R
- Vohra R
- Vora K
- Voyce S
- Vrolix MCM
- Vulic D
- Vuurmans T
- Wada A
- Waider W
- Waisman GD
- Waites JH
- Wali A
- Walichiewicz PM
- Waltenberger J
- Waltman J
- Wang J
- Wang J
- Wang J
- Wattanakit K
- Wei M
- Weidinger F
- Weil J
- Weintraub H
- Weissbrodt M
- Welka S
- Welker J
- Wells T
- Werner N
- Westbrook M
- Westerhausen D
- Whitaker J
- White HD
- White L
- White M
- Wiersma JJ
- Wilkins G
- Wilkinson P
- Willems FF
- Wilson MD
- Winkelmann B
- Wiseman A
- Witt N
- Wlodarczak A
- Wojewod P
- Wollaert B
- Wong Y-K
- Wongpraparut N
- Wozniak J
- Wright S
- Wu C
- Xavier D
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- Xu B
- Xu D
- Xu X
- Xu Y
- Yagensky A
- Yakushin S
- Yan AT-K
- Yan BPY
- Yanez M
- Yang E
- Yang X
- Yang X
- Yao Z
- Yazdani S
- Yerra SK
- Yin W-H
- Yong H
- Yoon JH
- Younis L
- Yu Y
- Yuan Z
- Yusoff K
- Yusoff K
- Zahger D
- Zaidman CJ
- Zainea M
- Zaman A
- Zapata G
- Zdravko B
- Zea Nunez CA
- Zeiher AM
- Zeiher AM
- Zhang R
- Zhang W
- Zhang X
- Zhang Z
- Zhao X
- Zheleznyy V
- Zheng Y
- Zheng Z
- Zhou Y
- Zhu C
- Zhu H
- Zhu J
- Zirlik A
- Zizka J
- Zobouyan I
- Zong W
- Zrazhevsky K
- Zurakowski A
- Zuran I
- Zweiker R
- Publication venue
- 'Ovid Technologies (Wolters Kluwer Health)'
- Publication date
- 04/01/2019
- Field of study
Background: Previous trials of PCSK9 (proprotein convertase subtilisin-kexin type 9) inhibitors demonstrated reductions in major adverse cardiovascular events, but not death. We assessed the effects of alirocumab on death after index acute coronary syndrome. Methods: ODYSSEY OUTCOMES (Evaluation of Cardiovascular Outcomes After an Acute Coronary Syndrome During Treatment With Alirocumab) was a double-blind, randomized comparison of alirocumab or placebo in 18 924 patients who had an ACS 1 to 12 months previously and elevated atherogenic lipoproteins despite intensive statin therapy. Alirocumab dose was blindly titrated to target achieved low-density lipoprotein cholesterol (LDL-C) between 25 and 50 mg/dL. We examined the effects of treatment on all-cause death and its components, cardiovascular and noncardiovascular death, with log-rank testing. Joint semiparametric models tested associations between nonfatal cardiovascular events and cardiovascular or noncardiovascular death. Results: Median follow-up was 2.8 years. Death occurred in 334 (3.5%) and 392 (4.1%) patients, respectively, in the alirocumab and placebo groups (hazard ratio [HR], 0.85; 95% CI, 0.73 to 0.98; P=0.03, nominal P value). This resulted from nonsignificantly fewer cardiovascular (240 [2.5%] vs 271 [2.9%]; HR, 0.88; 95% CI, 0.74 to 1.05; P=0.15) and noncardiovascular (94 [1.0%] vs 121 [1.3%]; HR, 0.77; 95% CI, 0.59 to 1.01; P=0.06) deaths with alirocumab. In a prespecified analysis of 8242 patients eligible for ≥3 years follow-up, alirocumab reduced death (HR, 0.78; 95% CI, 0.65 to 0.94; P=0.01). Patients with nonfatal cardiovascular events were at increased risk for cardiovascular and noncardiovascular deaths (P<0.0001 for the associations). Alirocumab reduced total nonfatal cardiovascular events (P<0.001) and thereby may have attenuated the number of cardiovascular and noncardiovascular deaths. A post hoc analysis found that, compared to patients with lower LDL-C, patients with baseline LDL-C ≥100 mg/dL (2.59 mmol/L) had a greater absolute risk of death and a larger mortality benefit from alirocumab (HR, 0.71; 95% CI, 0.56 to 0.90; Pinteraction=0.007). In the alirocumab group, all-cause death declined wit h achieved LDL-C at 4 months of treatment, to a level of approximately 30 mg/dL (adjusted P=0.017 for linear trend). Conclusions: Alirocumab added to intensive statin therapy has the potential to reduce death after acute coronary syndrome, particularly if treatment is maintained for ≥3 years, if baseline LDL-C is ≥100 mg/dL, or if achieved LDL-C is low. Clinical Trial Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01663402
Early mobilisation in critically ill COVID-19 patients: a subanalysis of the ESICM-initiated UNITE-COVID observational study
- Author
- Abad-Motos Ane
- Abdalla Maged
- Abusalama Abdurraouf
- Achterberg Sefanja
- Acosta Guillermo Pérez
- Adrião Diana
- Ahmed Amna
- Aires Buenos
- Akbas Türkay
- Akkari Abdel Rauof
- Al-Bayati Sama
- Al-Sadawi Mohammed
- Alasia Datonye
- Aleef Mohamed
- Alfishawy Mostafa
- Aljuhani Ohoud
- Alkhalaf Amina
- Alkhatteb Mohamed
- Allan John
- Alsabbah Asad
- Alwraidat Mohamed
- Anselmo Mónica
- Antonelli Massimo
- Arabi Yaseen
- Assal Hebatallah
- Awad Ahmed K.
- Azab Mohammed A.
- Azoulay Elie
- Azzam Ahmed
- Baccanelli Federica
- Badie Julio
- Baiou Anas
- Bakdach Dana
- Barling Danny
- Barrueco-Francioni Jesús Emilio
- Beck Oliver
- Beishuizen Albertus
- Berdaguer Ferrari Fernando
- Berezo-Garcia José Angel
- Berkius Johan
- Bethlehem Carina
- Bihariesingh-Sanchit Rosita
- Binnie Alexandra
- Bintaher Awadh
- Biston Patrick
- Bonell-Goytisolo José M.
- Bota Marc
- Boulanger Carole
- Broadhurst Phil
- Bulpa Pierre
- Bílír Yelíz
- Cabrera Luciano Santana
- Cagova Lenka
- Campbell Zoë
- Camões João
- Canedo Nancy
- Catalan-Monzon Ignacio
- Cecconi Maurizio
- Ceruti Samuele
- Charron Mariane
- Chavez Alejandro Esquivel
- Chrisment Anne
- Chrysanthopoulou Evangelia
- Citerio Giuseppe
- Cochrane Anthony
- Collin Vincent
- Concha Pablo
- Cook Martin
- Cornet Alexander D.
- Cosar Ahmet
- Costa Vasco
- Cowton Amanda
- Crapelli Giulia Beatrice
- Cuadrado Marta Martin
- Cubero Patricia Jimeno
- Cudia Antonella
- Cuenca-Rubio Cristina
- Cunha Pedro
- Davey Miriam
- Davydova Liubov
- De Backer Daniel
- De Buyser Wim
- de Cabo Carlos Munoz
- De Corte Thomas
- de Groot Marcel
- de Jong Ben
- de Jong Celestine
- de Pablo Sánchez Raúl
- De Pascale Gennaro
- De Rosa Silvia
- De Schryver Nicolas
- De Waele Elisabeth
- De Waele Jan
- de Wijs Calvin
- Dean James T.
- del Carmen Conesa Maria Lorente
- del Pilar García-Bonillo Mª
- Delgado Maria Cruz Martin
- Dementienko Mariia
- den Boer Sylvia
- Dendane Tarek
- Dereli Necla
- Donadello Katia
- Donnelly Adrian
- Duric Natalie
- Duska Frantisek
- Ekren Pervin Korkmaz
- Eksarko Polikseni
- Elay Gülseren
- elbuzidi Abdurrahmaan Suei
- Eldaly Abdullah
- Elhadi Muhammed
- Eller Philipp
- Ellervee Anneli
- Ellis Caroline
- Elmandouh Omar
- Elrabi Omar
- Eroglu Ahmet
- Espina Lorena Forcelledo
- Eyüpolu Selin
- Ferrando Carlos
- Ferrigno Gerardo
- Fichtner Falk
- Ficial Barbara
- Florio Gaetano
- Foulon Pierre
- Fraga Xiana Taboada
- Fraile Virginia
- Franco Daniel Molano
- Franquesa-Gonzalez Enric
- Frenzel Tim
- Frutos-Vivar Fernando
- Fuest Kristina
- Galal Islam
- Galarza Laura
- García Raquel Rodrígez
- Gareth Allen
- Garrioch Sweyn
- Gavrilova Elena
- Geagea Anna
- Gervin Kevin
- Ghannam Madihah E.
- Ghozy Sherief
- Gira Alicia
- Girbes Armand R. J.
- Glotta Andrea
- Golden David
- Gonzalez Daniel Rodriguez
- Gonzalez Francisco Muñoyerro
- Gonçalves Celina
- Gottin Leonardo
- Gotz Vera Nina
- Grady Bart
- Graf Jerónimo
- Graham Sam
- Grauslyte Lina
- Greco Massimiliano
- Grecu Irina
- Grip Jonathan
- Groeneveld Melanie
- Grunow Julius J.
- Guzzardella Amedeo
- Haentjens Lionel
- Hagan Samantha
- Halacli Burcin
- Hall Chris
- Hamid Tarikul
- Hammouda Ahmed
- Hanlon Katie
- Haque Injamam Ull
- Harding Daniel
- Henning Jeremy
- Hernandez Aaron Mark
- Herrmann Johannes
- Higenbottam Caroline V.
- Ho Vui Kian
- Humaid Felwa Bin
- Husain Ahmed
- Hussein Aliae Mohamed
- Ilieva Viktoria
- Ioan Ana-Maria
- Isoni Paolo
- Izdes Seval
- Jain Susan
- Jawa Randeep
- Jayyab Mustafa Abu
- Jesus Montelongo Felipe De
- Jimenez Jorge
- Jog Sameer
- Jones Nicola
- Jubb Alasdair
- Kalvit Kushal
- Kamble Shruthi
- Kansal Amit
- Katz David
- Kaya Ebru
- Kent Melanie
- Kesecioglu Jozef
- Khlafalla Safa
- Kilsand Kristina
- Kloss Philipp
- Kranen Hetty
- Krupa Ivan
- Kuhail Ahmed
- Kumar Ashok
- Kviatkovske Orinta
- Labarca Eduardo
- Lago Gustavo
- Lahmer Tobias
- Larrañaga Leire
- Leganes Nieves Cruza
- Legaristi Noemi
- Linde Francisca Arbol
- Lindholz Maximilian
- Lorenz Marco
- Loveleena Gupta
- Lucas Juan Higuera
- Lumlertgul Nuttha
- Mahmoodpoor Ata
- Marczin Nandor
- Markou Nikolaos
- Martin Belén Civantos
- Martinez Felipe
- Maslamani Muna Al
- McCarthy Aine
- McMahon Sean
- Mehagnoul-Schipper Jannet
- Mellinghoff Johannes
- Mengi Tuçe
- Mensink Roos
- Meshchaninova Svetlana
- Mesland Jean-Baptiste
- Meybohm Patrick
- Milnik Annette
- Mir Antonia Socias
- Mirabella Lucia
- Montrucchio Giorgia
- Morais Rui
- Mullhi Randeep
- Mumelj Lana
- Mårtensson Johan
- Nainan Myatra Sheila
- Neporada Elena
- Ng Jensen
- Nichol Alistair
- Nielsen Nathan D.
- Nizzero Marta
- Noto Alberto
- Nunes Sandra
- Oddy Christopher
- Oliveira Ana
- Omrani Ali
- Ortiz Aaron Blandino
- Ostermann Marlies
- Padilla-Serrano Antonio
- Paleari Chiara
- Papamichalis Panagiotis
- Parra Juan Pablo Aviles
- Parra-Tanoux Daniela
- Patricio Patricia
- Pellegrini Mariangela
- Perez-Araos Rodrigo
- Perez-Calvo Cesar
- Petrisor Cristina
- Piagnerelli Michael
- Pinto André
- Polati Enrico
- Poliakov Igor
- Popov Evgeniy
- Popova Ksenia
- Potter Elizabeth
- Poulton Lottie
- Poyat Chrystelle
- Pravia Orville Victoriano Baez
- Purvis Sarah
- Pyregov Alexey
- Pérez-Torres David
- Póvoa Pedro
- Qayyum Ahad
- qudah Bara Mahmoud Al
- Ramires Tiago
- Rana Muhammad
- Reidinga Auke C.
- Reinhard Veronika
- Ripolles-Melchor Javier
- Robin Nicole
- Robles Victor Hugo Madrigal
- Rodriguez-Ruiz Emilio
- Rodríguez-Solis Carmen
- Romeu Juan Maria
- Roriz Carolina
- Rosenberger Dorothea
- Saha Rajnish
- Sahin Ayca Sultan
- Saif Ibrahim Abdulsalam
- Salaverria Iñigo
- Salciute-Simene Erika
- Sales Gabriele
- Santanilla Jairo
- Santos Arnoldo
- Santos Maria Lurdes
- Saraçolu Kemal Tolga
- Savi Marzia
- Schaller Stefan J.
- Schaller Stefan J.
- Schellenberg Clara
- Scholten Harm
- Serrano Ainhoa
- Shlyk Irina
- Shuker Benjamin
- Sierra Rosario Quispe
- Silva Catarina
- Singatullina Natalia
- Singatullina Natalia
- So Ralph K. L.
- Sokolov Dmitry
- Soultati Ioanna
- Spadaro Savino
- Spieth Peter
- Spivey Michael
- Spronk Peter E.
- Sri-Chandana Chunda
- Stubenrauch Peter
- Sulemanji Demet
- Suner Andrea Ortiz
- Suner Kezban Ozmen
- Szakmany Tamas
- Taborda Lúcia
- Teboul Jean-Louis
- Teplykh Boris
- Teruel Santiago Yus
- Tharwat Aisa
- Tharwat Samar
- Thoral Patrick
- Tirapegui Fernando
- Tomak Yakup
- Tonetti Tommaso
- Torlinski Tomasz
- Truman Nick
- Turan Işıl Özkoçak
- Vaccarini Barbara
- Valero Clara Martínez
- Valverde Virginia Hidalgo
- van Bussel Bas
- van den Bogaard Bas
- van der Heiden Eveline
- Van Hecke Jolien
- Van Leemput Jan
- Van Malderen Claire
- Vanhove Philippe
- Varela Ignacio Yago Martinez
- Vargas Patricio
- Vasileiadou Georgia
- Venkatesh Harish
- Vijayakumar Gopal
- Vlachou Aikaterini
- Vladislav Belskii
- Vlasova Marina
- Volta Carlo Alberto
- von Seth Magnus
- Weiss Björn
- Wentowski Catherine
- Wilting Rob
- Wong Adrian
- Yepes David
- Yilmaz Mehmet
- Zoerner Frank
- Zverev Ivan
- Österlind Jonas
- Publication venue
- SpringerOpen
- Publication date
- 14/11/2023
- Field of study
Background
Early mobilisation (EM) is an intervention that may improve the outcome of critically ill patients. There is limited data on EM in COVID-19 patients and its use during the first pandemic wave.
Methods
This is a pre-planned subanalysis of the ESICM UNITE-COVID, an international multicenter observational study involving critically ill COVID-19 patients in the ICU between February 15th and May 15th, 2020. We analysed variables associated with the initiation of EM (within 72 h of ICU admission) and explored the impact of EM on mortality, ICU and hospital length of stay, as well as discharge location. Statistical analyses were done using (generalised) linear mixed-effect models and ANOVAs.
Results
Mobilisation data from 4190 patients from 280 ICUs in 45 countries were analysed. 1114 (26.6%) of these patients received mobilisation within 72 h after ICU admission; 3076 (73.4%) did not. In our analysis of factors associated with EM, mechanical ventilation at admission (OR 0.29; 95% CI 0.25, 0.35; p = 0.001), higher age (OR 0.99; 95% CI 0.98, 1.00; p ≤ 0.001), pre-existing asthma (OR 0.84; 95% CI 0.73, 0.98; p = 0.028), and pre-existing kidney disease (OR 0.84; 95% CI 0.71, 0.99; p = 0.036) were negatively associated with the initiation of EM. EM was associated with a higher chance of being discharged home (OR 1.31; 95% CI 1.08, 1.58; p = 0.007) but was not associated with length of stay in ICU (adj. difference 0.91 days; 95% CI − 0.47, 1.37, p = 0.34) and hospital (adj. difference 1.4 days; 95% CI − 0.62, 2.35, p = 0.24) or mortality (OR 0.88; 95% CI 0.7, 1.09, p = 0.24) when adjusted for covariates.
Conclusions
Our findings demonstrate that a quarter of COVID-19 patients received EM. There was no association found between EM in COVID-19 patients' ICU and hospital length of stay or mortality. However, EM in COVID-19 patients was associated with increased odds of being discharged home rather than to a care facility.
Trial registration ClinicalTrials.gov: NCT04836065 (retrospectively registered April 8th 2021)
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