677 research outputs found
Electric field effect modulation of transition temperature, mobile carrier density and in-plane penetration depth in NdBa2Cu3O(7-delta) thin films
We explore the relationship between the critical temperature, T_c, the mobile
areal carrier density, n_2D, and the zero temperature magnetic in-plane
penetration depth, lambda_ab(0), in very thin underdoped NdBa2Cu3O{7-delta}
films near the superconductor to insulator transition using the electric field
effect technique. We observe that T_c depends linearly on both, n_2D and
lambda_ab(0), the signature of a quantum superconductor to insulator (QSI)
transition in two dimensions with znu-bar where z is the dynamic and nu-bar the
critical exponent of the in-plane correlation length.Comment: 4 pages, 4 figure
On the origin of bimodal duration distribution of Gamma Ray Bursts
The modified version of a bullet model for gamma ray bursts is studied. The
central engine of the source produces multiple sub-jets that are contained
within a cone. The emission of photons in the source frame of a sub-jet either
takes part in an infinitesimally thin shell, or during its expansion for a
finite time. The analysis of the observed profiles of GRBs taken by BATSE leads
us to the conclusion that the latter possibility is much more favored. We also
study the statistical distribution of GRBs, in the context of their bimodality
of durations, taking into account the detector's capability of observing the
signal above a certain flux limit. The model with shells emitting for a finite
time is able to reproduce only one class of bursts, short or long, depending on
the adopted physical parameters. Therefore we suggest that the GRB bimodality
is intrinsically connected with two separate classes of sources.Comment: 12 pages, 12 figures; accepted by MNRAS. Small changes to match the
corre cted proof
Advice for Health Care Professionals and Users: An Evaluation of Websites for Perinatal Anxiety
Background: Many websites are available with information and resources for perinatal anxiety; however, there is limited research on the quality and content of these sites.
Objective: This study aims to identify what sites are available on perinatal anxiety, identify any information and therapeutic advice given, and review its accuracy and website design.
Methods: We conducted an evaluation of websites for perinatal anxiety. Eligible websites (N=50) were evaluated for accuracy of information, resources for mothers, website quality, and readability.
Results: Information was often incomplete and focused on symptoms rather than risk factors or impact of untreated perinatal anxiety. Websites often had information on treatment (46/50, 92%), but much less on screening (19/50, 38%). Most sites provided at least some resources to support mothers (49/50, 98%), but active, guided support was infrequent (25/50, 50%). Website quality was extremely variable and mostly difficult to read (42/50, 84%).
Conclusions: This study recommends the top 4 websites on perinatal anxiety for health care professionals and users. There is a need for websites to be developed that provide accurate, evidence-based information that women can relate to with quality support resources. Furthermore, these sites should be easy to use and readable
Endogenous GABA controls oligodendrocyte lineage cell number, myelination, and CNS internode length
Adjusting the thickness and internodal length of the myelin sheath is a mechanism for tuning the conduction velocity of axons to match computational needs. Interactions between oligodendrocyte precursor cells (OPCs) and developing axons regulate the formation of myelin around axons. We now show, using organotypic cerebral cortex slices from mice expressing eGFP in Sox10-positive oligodendrocytes, that endogenously released GABA, acting on GABAA receptors, greatly reduces the number of oligodendrocyte lineage cells. The decrease in oligodendrocyte number correlates with a reduction in the amount of myelination but also an increase in internode length, a parameter previously thought to be set by the axon diameter or to be a property intrinsic to oligodendrocytes. Importantly, while TTX block of neuronal activity had no effect on oligodendrocyte lineage cell number when applied alone, it was able to completely abolish the effect of blocking GABAA receptors, suggesting that control of myelination by endogenous GABA may require a permissive factor to be released from axons. In contrast, block of AMPA/KA receptors had no effect on oligodendrocyte lineage cell number or myelination. These results imply that, during development, GABA can act as a local environmental cue to control myelination and thus influence the conduction velocity of action potentials within the CNS. GLIA 2017;65:309-321
cis-Acting Complex-Trait-Associated lincRNA Expression Correlates with Modulation of Chromosomal Architecture.
Intergenic long noncoding RNAs (lincRNAs) are the largest class of transcripts in the human genome. Although many have recently been linked to complex human traits, the underlying mechanisms for most of these transcripts remain undetermined. We investigated the regulatory roles of a high-confidence and reproducible set of 69 trait-relevant lincRNAs (TR-lincRNAs) in human lymphoblastoid cells whose biological relevance is supported by their evolutionary conservation during recent human history and genetic interactions with other trait-associated loci. Their enrichment in enhancer-like chromatin signatures, interactions with nearby trait-relevant protein-coding loci, and preferential location at topologically associated domain (TAD) boundaries provide evidence that TR-lincRNAs likely regulate proximal trait-relevant gene expression in cis by modulating local chromosomal architecture. This is consistent with the positive and significant correlation found between TR-lincRNA abundance and intra-TAD DNA-DNA contacts. Our results provide insights into the molecular mode of action by which TR-lincRNAs contribute to complex human traits
Ambipolar gate effect and low temperature magnetoresistance of ultrathin La0.8Ca0.2MnO3 Films
Ultrathin La0.8Ca0.2MnO3 films have been measured in a field-effect geometry.
The electric field due to the gate produces a large ambipolar decrease in
resistance at low temperatures. This is attributed to the development of a
pseudogap in the density of states and the couple of localized charge to
strain. The gate effect and mangetoresistance are interpreted in a consistent
framework. The implications for the low temperature behavior of a manganite
film in the two dimensional limit are discussed.Comment: 4 pages, 3 figure
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