Optimization of the mass ratio and melting temperature of PCMs integrated in Salt Gradient Solar Ponds

Phase Change Materials (PCMs) are promising materials to increase the storage capacity of solar energy-based systems, such as Salt Gradient Solar Ponds (SGSPs), as they are characterized by a large latent heat during the solid-liquid phase change. This paper introduces an optimization study for PCM integration in SGSP, in terms of PCM mass ratio (14 %, 19 %, 28 % and 47 %) in the lower convective zone and PCM melting temperature (35 °C, 44 °C and 50 °C). Numerically, a 2D model is developed, consisting in the continuity equation as well on momentum, thermal energy and diffusion equations. In order to validate this numerical model, an experimental campaign of a parallelepiped SGSP with PCM capsules in the bottom is constructed. The latter is tested for two PCMs (RT35HC and RT44HC) and under different climatic conditions of March and June. Numerical and experimental have been compared in which the maximum average relative error does not exceed 4.62 %, which ensures a positive validation. The optimization returns that the final liquid fraction of PCM decreases both increasing the mass ratio and melting temperature. Higher mass ratios reduce the final temperature of the PCM (49.5 °C with 14 % and 42 °C with 47 % for RT35HC), and also with higher melting temperatures reduce the thermal energy stored, since the pond tends to work only as a sensible energy storage system

Effects of Double-Diffusive Convection on Calculation Time and Accuracy Results of a Salt Gradient Solar Pond: Numerical Investigation and Experimental Validation

The main aim of this study is to investigate numerically and experimentally the effects of double-diffusive convection on calculation time and accuracy results of a Salt Gradient Solar Pond (SGSP). To this end, two-numerical models are developed based on the Fortran programming language. The first one is based on energy balance neglecting the development of double-diffusive convection, while the second is two-dimensional and is based on Navier-Stokes, heat, and mass transfer equations considering the development of double-diffusive convection. The heat losses via the upper part, bottom, and vertical walls, as well as the internal heating of saltwater, are considered. In order to validate and compare both numerical models, a laboratory-scale SGSP is designed, built, and tested indoors for 82 h. Results indicate that the two numerical models developed can predict the SGSP thermal behavior with good accuracy. Furthermore, the average relative error between experimental and numerical results is around 9.39% for Upper Convective Zone (UCZ) and 2.92% for Lower Convective Zone (LCZ) based on the first model. This error reduces to about 5.98% for UCZ and 3.74% for LCZ by using the second model. Consequently, the neglect of double-diffusive convection in the SGSP modeling tends to overestimate the thermal energy stored in the storage zone by about 4.3%. Based on the calculation time analysis, results show that the second model returns a calculation time hundreds of times larger than the first one and, accordingly, an increase in computational cost

Cancer stem cell biomarkers predictive of radiotherapy response in rectal cancer: A systematic review

Background: Rectal cancer (RC) is one of the most commonly diagnosed and particularly challenging tumours to treat due to its location in the pelvis and close proximity to critical genitouri-nary organs. Radiotherapy (RT) is recognised as a key component of therapeutic strategy to treat RC, promoting the downsizing and downstaging of large RCs in neoadjuvant settings, although its therapeutic effect is limited due to radioresistance. Evidence from experimental and clinical studies indicates that the likelihood of achieving local tumour control by RT depends on the complete eradica-tion of cancer stem cells (CSC), a minority subset of tumour cells with stemness properties. Methods: A systematic literature review was conducted by querying two scientific databases (Pubmed and Scopus). The search was restricted to papers published from 2009 to 2021. Results: After assessing the quality and the risk of bias, a total of 11 studies were selected as they mainly focused on biomarkers predictive of RT-response in CSCs isolated from patients affected by RC. Specifically these studies showed that elevated levels of CD133, CD44, ALDH1, Lgr5 and G9a are associated with RT-resistance and poor prognosis. Conclusions: This review aimed to provide an overview of the current scenario of in vitro and in vivo studies evaluating the biomarkers predictive of RT-response in CSCs derived from RC patients

Eco Maps: A Tool to Bridge the Practice-Research Gap

The social work profession has played host to a continuing dialogue about the interplay between research and practice. Traditionally, practitioners collect data that have real-world usefulness and are relevant to the intervention process with particular clients. Researchers, on the other hand, are skilled in designing and conducting studies that result in data that can be generalized to build the profession\u27s foundation of knowledge. Data collection tools and techniques that are both relevant to practice and germane to knowledge-building are needed. This paper demonstrates the use of the eco map, a common practice tool, to collect and organize data about families, thus bridging a gap between practice and research functions

A comparison of multiple luminescence chronometers at Voordrag, South Africa

A suite of 10 samples collected from an 11 m thick colluvial sequence at Voordrag, KwaZulu-Natal, South Africa, have been used to undertake a comparison of different luminescence methods. Good agreement is found between single grain quartz optically stimulated luminescence (OSL) and single grain K-feldspar post-infrared infrared-stimulated luminescence (post-IR IRSL) ages, with the exception of the basal samples where the quartz OSL signal is saturated. Multiple grain quartz OSL consistently yields ages older than single grain OSL methods. Multiple grain feldspar ages derived from the IRSL50 signal are underestimated due to anomalous fading. A previously published radiocarbon chronology yields ages that are younger than those from single grain quartz OSL and post-IR IRSL, and this is most likely due to contamination with younger carbon. Identifying the effect of saturation on the quartz OSL signal remains challenging when quartz is dated in isolation. However, using a paired quartz/feldspar dating approach is an effective way of identifying the impact of saturation on the OSL signal

A targeted drilling and dating campaign to identify Stone Age archaeological sites before excavation in west coast southern Africa

Here we present the results of a targeted drilling campaign that facilitated a geochronological study with coarse sampling resolution inside a new cave site, Simons Cave, on the west coast of southern Africa. A combination of radiocarbon (14C) dating and optically stimulated luminescence (OSL) dating was used as a range-finder. Results confirmed preservation of Holocene and late Pleistocene sediments up to 133 ± 35 ka, overlapping with the ages of Middle Stone Age (MSA) occupations of the broader west coast region. A subsequent, systematic test- excavation at the site then embarked on a second geochronological study with a higher sampling resolution. Ultimately, the comparative study confirmed the potential of Simons Cave as a new site for the exploration of hominin occupation through the later Pleistocene and Holocene, yet raised several issues concerning the direct comparability of information deriving from drilled sediment cores and actual archaeological excavation

Recapitulating thyroid cancer histotypes through engineering embryonic stem cells

Thyroid carcinoma (TC) is the most common malignancy of endocrine organs. The cell subpopulation in the lineage hierarchy that serves as cell of origin for the different TC histotypes is unknown. Human embryonic stem cells (hESCs) with appropriate in vitro stimulation undergo sequential differentiation into thyroid progenitor cells (TPCs-day 22), which maturate into thyrocytes (day 30). Here, we create follicular cell-derived TCs of all the different histotypes based on specific genomic alterations delivered by CRISPR-Cas9 in hESC-derived TPCs. Specifically, TPCs harboring BRAFV600E or NRASQ61R mutations generate papillary or follicular TC, respectively, whereas addition of TP53R248Q generate undifferentiated TCs. Of note, TCs arise by engineering TPCs, whereas mature thyrocytes have a very limited tumorigenic capacity. The same mutations result in teratocarcinomas when delivered in early differentiating hESCs. Tissue Inhibitor of Metalloproteinase 1 (TIMP1)/Matrix metallopeptidase 9 (MMP9)/Cluster of differentiation 44 (CD44) ternary complex, in cooperation with Kisspeptin receptor (KISS1R), is involved in TC initiation and progression. Increasing radioiodine uptake, KISS1R and TIMP1 targeting may represent a therapeutic adjuvant option for undifferentiated TCs

Control of tumor and microenvironment cross-talk by miR-15a and miR-16 in prostate cancer

The interaction between cancer cells and microenvironment has a critical role in tumor development and progression. Although microRNAs regulate all the major biological mechanisms, their influence on tumor microenvironment is largely unexplored. Here, we investigate the role of microRNAs in the tumor-supportive capacity of stromal cells. We demonstrated that miR-15 and miR-16 are downregulated in fibroblasts surrounding the prostate tumors of the majority of 23 patients analyzed. Such downregulation of miR-15 and miR-16 in cancer-associated fibroblasts (CAFs) promoted tumor growth and progression through the reduced post-transcriptional repression of Fgf-2 and its receptor Fgfr1, which act on both stromal and tumor cells to enhance cancer cell survival, proliferation and migration. Moreover, reconstitution of miR-15 and miR-16 impaired considerably the tumor-supportive capability of stromal cells in vitro and in vivo. Our data suggest a molecular circuitry in which miR-15 and miR-16 and their correlated targets cooperate to promote tumor expansion and invasiveness through the concurrent activity on stromal and cancer cells, thus providing further support to the development of therapies aimed at reconstituting miR-15 and miR-16 in advanced prostate cancer. © 2011 Macmillan Publishers Limited All rights reserved

URBAN CENTER. Una casa di vetro per le politiche urbane.

Nella cultura di governo della città, il termine "Urban Center" (o "Casa della città") designa una serie di strutture il cui denominatore comune risiede nello svolgimento di attività di servizio per le comunità urbane ai fini di soddisfare la crescente domenda di democrazia partecipativa e deliberativa nei processi di trasformazione degli insediamenti. Traendo spunto dalla storicizzazione del fenomeno e dal confronto tra i consolidati modelli statunitensi e le recenti esperienze in Italia, il volume si interroga sulla maturazione delle missioni dell' "Urban Center" nel passaggio da asettico spazio di informazione a luogo provilegiato per la costruzione trasparente di politiche urbane condivise. Il percorso logico del volume si sviluppa seguendo un fil rouge articolato in quattro parti. Il primo blocco si apre con due tematiche che costituiscono dialetticamente la cornice di riferimento entro cui può essere correttamente collocata la questione degli UC: l’urbanistica partecipata e il marketing urbano. Nella seconda parte attraverso lo studio di casi si ricostruisce il quadro delle articolate declinazioni statunitensi di Urban Center, consolidatesi in diversi decenni di storia. Sono strutture fortemente caratterizzate e autonome per stile, missioni, obiettivi, priorità, modalità operative, ma allo stesso tempo accomunate da un equilibrato mix di passione civile e pragmatismo professionale. Il terzo gruppo di saggi è dedicato alla condizione attuale e di prospettiva degli UC in Italia, delineando criticamente una sorta di “mappa dinamica” delle diverse strutture attivate e in divenire, caratterizzate per soggetti ispiratori, missioni “stili” e protagonismo degli attori coinvolti. Il cerchio delle riflessioni si chiude nella quarta parte discutendo la questione dell’innovazione di metodo per la costruzione di un UC sia attraverso la dimensione teoretica che le potenzialità operative. Testi in italiano e inglese di B. Monardo (curatore), M.C. Bizzarri, E. Carmagnani, M. Carta, F. Ceci, P. Colarossi, L. De Bonis, A. Dina, A. De Rossi, D. Filippi, A. Giorgi, P. Laconte, F. Lovato, L. J. Osmond, R. Shiffman, O Tommasi, A. Uttaro; postfazione di M. Ricci

Antibody Responses to NY-ESO-1 in Primary Breast Cancer Identify a Subtype Target for Immunotherapy

The highly immunogenic human tumor antigen NY-ESO-1 (ESO) is a target of choice for anti-cancer immune therapy. In this study, we assessed spontaneous antibody (Ab) responses to ESO in a large cohort of patients with primary breast cancer (BC) and addressed the correlation between the presence of anti-ESO Ab, the expression of ESO in the tumors and their characteristics. We found detectable Ab responses to ESO in 1% of the patients. Tumors from patients with circulating Ab to ESO exhibited common characteristics, being mainly hormone receptor (HR)− invasive ductal carcinomas of high grade, including both HER2− and HER2+ tumors. In line with these results, we detected ESO expression in 20% of primary HR− BC, including both ESO Ab+ and Ab− patients, but not in HR+ BC. Interestingly, whereas expression levels in ESO+ BC were not significantly different between ESO Ab+ and Ab− patients, the former had, in average, significantly higher numbers of tumor-infiltrated lymph nodes, indicating that lymph node invasion may be required for the development of spontaneous anti-tumor immune responses. Thus, the presence of ESO Ab identifies a tumor subtype of HR− (HER2− or HER2+) primary BC with frequent ESO expression and, together with the assessment of antigen expression in the tumor, may be instrumental for the selection of patients for whom ESO-based immunotherapy may complement standard therapy